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You can now keep track of new articles from American Journal of Medical Genetics part B on your personalized homepage!
Mutations in the coding sequence of the methyl‐CpG‐binding protein 2 gene (MECP2), which cause Rett syndrome (RTT), have been found in male and female autistic subjects without, however, a causal relation having unequivocally been established. In this study, the MECP2 gene was scanned in a...
Autism is a pervasive neurodevelopmental disorder, with a significant role of genetic factors in its development. The neuropilin‐2 (NRP2) gene is localized to 2q34, an autism susceptibility locus. NRP2 has been demonstrated to both guide axons and to control neuronal migration in the central...
GABAA receptor subunit genes clustered on 5q33 play a role in the development of alcoholism and methamphetamine use disorder without psychosis. The present study explored the possible contribution of the same subunit genes to the development of heroin dependence. Single nucleotide polymorphisms...
Association analysis has suggested that common sequence variants of genes that affect monoamine function can affect substance use and abuse. Demonstration of these associations has been inconsistent because of limited sample sizes and phenotype definition. Drawing on the life course perspective,...
Cigarette smoking is a complex behavior to which environmental, psychological, and genetic factors contribute. Applying a multifactorial model, we examined the role of genetic variation in the dopamine transporter (DAT1) in smoking initiation (SI) and nicotine dependence. The participants were...
Dyslexia is a common heterogeneous disorder with a significant genetic component. Multiple studies have replicated the evidence for linkage between variously defined phenotypes of dyslexia and chromosomal regions on 15q21 (DYX1) and 6p22.2 (DYX2). Based on association studies and the possibility...
Obsessive–compulsive disorder (OCD) is a heterogeneous disorder of unknown etiology. Phenotypic studies of affected sib‐pairs (SPs) may help to characterize familial components of the phenotype. To determine whether SPs affected with OCD are similar in age at onset of obsessive–compulsive...
Epidemiological evidence supports the existence of a possible link between type II diabetes mellitus (T2DM) and late‐onset Alzheimer's disease (LOAD). Polymorphisms from candidate genes for T2DM were genotyped in a two‐stage approach to identify novel risk factors for LOAD. One hundred...
In this study we investigated interactions between the 5‐HTTLPR genotype and environmental risk factors (G × E) on symptoms of depression in two large Australian community samples of adolescents and young adults. We postulated that a significant interaction between the 5‐HTTLPR genotype and...
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