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Susceptibility to schizophrenia is considered familial, but the mechanism for transmission has not been found. Since widespread cognitive deficits have been found in patients with schizophrenia, several of these have been proposed as candidate familial endophenotypes that may or may not be...
Two putatively functional polymorphisms of the serotonin transporter gene (HTT, SLC6A4) were examined for associations with risk for pervasive developmental disorders (PDDs) and specific autism phenotypes. Dutch patients diagnosed with PDD (N = 125, age range 5–20 years, DSM‐IV‐TR based...
A substantial proportion of schizophrenia patients also has obsessive‐compulsive disorder (OCD). To further validate the clinical validity of a schizo‐obsessive diagnostic entity, we assessed morbid risks for schizophrenia‐spectrum disorders and OC‐associated disorders in first‐degree...
Attention deficit hyperactivity disorder (ADHD) is a highly heritable and common disorder thought to arise, in part, from alterations in dopamine function. NR4A2, or Nurr1, is an orphan nuclear receptor implicated in the development of dopaminergic cells of the ventral tegmental area (VTA) and...
The μ‐opioid receptor (MOR) mediates reward and dependence associated with opioids and other commonly abused substances. Variability in the MOR gene, OPRM1, may influence risk for opioid dependence. In this study, associations between two single nucleotide polymorphisms (SNPs), dbSNP rs540825...
Sleep timing is influenced by the circadian system. Morningness‐eveningness (ME) preference in humans is affected by the free‐running period, which is determined by circadian clock‐relevant genes. In this study, we investigated association between the 3111T/C polymorphism in the...
Family, twin, and adoption studies show that psychiatric diseases including bipolar disorder (BP) and unipolar disorder (UP) have a substantial genetic component. For these illnesses, both positive and negative associations have been reported for two polymorphisms located in the serotonin...
N‐Methyl‐D‐aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily, are generally inhibited by alcohol. The expression and alternative splicing of the obligatory NR1 subunit is altered by alcohol exposure, emphasizing the involvement of the NR1 subunit, which is...
Recent advances have facilitated the use of blood‐derived RNA to conduct genomic analyses of human diseases. This emerging technology represents a rigorous and convenient alternative to traditional tissue biopsy‐derived RNA, as it allows for larger sample sizes, better standardization of...
The neurotransmitter serotonin (5‐HT) has been shown to regulate alcohol consumption in both animals and humans. Since activity of the 5‐HT transporter protein (5‐HTT) regulates 5‐HT levels, the gene encoding this protein may contribute to the risk of alcohol dependence (AD). Studies of...
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