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This study tested the effectiveness of the Serial Trial Intervention (STI), an innovative clinical protocol for assessment and management of unmet needs in people with late-stage dementia. A double-blinded randomized experiment was conducted in 14 nursing homes with 114 subjects. The treatment...
The objective of this study was to collect data on outcomes obtained when switching elderly nursing home residents with dementia from risperidone to quetiapine. Medical records were reviewed to identify dementia patients switched from risperidone to quetiapine. Clinical Global Impressions (CGI)...
Mild cognitive impairment (MCI) represents a transition between normal aging and Alzheimer’s disease (AD). The aim of this study was to investigate the predictive value of vitamin B 12 /folate, homocysteine, standard laboratory parameters, and concomitant diseases for development of AD in...
This study tested whether the laminar distribution of the ॆ-amyloid (Aॆ) deposits in dementia with Lewy bodies (DLB) cases with significant Alzheimer’s disease (AD) pathology (DLB/AD) was similar to “pure” AD. In DLB/AD, the maximum density of the diffuse and primitive deposits occurred...
This study compared patient and caregiver perceptions of natural health products (NHPs) and conventional medications in a memory clinic population. A total of 620 mildly cognitively impaired patients and their care-givers participated in interviews enquiring about their perceptions of NHPs in 4...
The purpose of this retrospective study of 116 dementia patients with and without accusatory behavior was to determine its frequency and evaluate its relationship to individual characteristics, behavioral and psychological symptoms, and certain dementia-related domains, namely, cognitive...
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