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The proximal tubule (PT) is major site for the reabsorption of filtered HCO 3 – . Previous work on the rabbit PT showed that 1 ) increases in basolateral (BL) CO 2 concentration (CO 2 BL ) raise the HCO 3 – reabsorption rate ( J HCO 3 ), and 2 ) the increase that luminal angiotensin II (ANG...
Claudins form a family of transmembrane tight junction proteins that play a key role in control and selectivity of paracellular transport. Mutations in claudin-19, which is expressed in kidney, retina, and myelinated peripheral neurons, were identified in familial hypomagnesemia with...
The roles of epithelial sodium channel (ENaC) subunits (α, , and γ) in the impaired renal reabsorption of sodium and water were examined in rat models with bilateral (BUO) or unilateral ureteral obstruction (UUO) for 24 h or with BUO followed by release of obstruction and 3 days of observation...
Loop diuretics like furosemide have been shown to cause renal vasodilatation in dogs and humans, an effect thought to result from both a direct vascular dilator effect and from inhibition of tubuloglomerular feedback. In isolated perfused afferent arterioles preconstricted with angiotensin II or...
Studies done in cell culture have demonstrated that insulin activates the epithelial sodium channel (ENaC) via a variety of mechanisms. However, to date, upregulation of ENaC in native renal tissue by in vivo administration of insulin has not been demonstrated. To address this, we injected...
Interstitial fibrosis is a universal feature of progressive kidney disease. Urokinase-type plasminogen activator (uPA) is thought to participate for several reasons: 1 ) uPA is produced predominantly in kidney, 2 ) its inhibitor plasminogen activator inhibitor-1 (PAI-1) is a strong promoter of...
We previously reported that hypotonic stress stimulated transepithelial Na + transport via a pathway dependent on protein tyrosine kinase (PTK; Niisato N, Van Driessche W, Liu M, Marunaka Y. J Membr Biol 175: 63–77, 2000). However, it is still unknown what type of PTK mediates this stimulation....
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