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We have estimated the frequency of synonymous ( K S ) and amino acid replacement nucleotide substitutions ( K A ) among gag and env genes of published HIV sequences. The ratio of K S to K A , can be used as an indicator of the intensity of the selective constraints on the amino acid sequence of a...
We have compared the antigenic qualities of human immunodeficiency virus type 1 (HIV-1) gp41 glycoprotein with a synthetic oligopeptide (peptide R21S) and a bacterially synthesized protein (protein 566), which are homologous with the N-terminal region of gp41, in enzymelinked immunosorbent assays...
We serologically tested 140 female prostitutes (mean age, 30 years) from the port city of Callao, Peru, for evidence of infection with human immunodeficiency virus (HIV), Chlamydia trachomatis, Treponema pallidum , herpes simplex viruses (HSV) I and II, and hepatitis B virus. The women had worked...