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Summary Caloric restriction (CR) retards aging in laboratory rodents. No information is available on the effects of long‐term CR on physiologic markers of aging and longevity in humans. Heart rate variability (HRV) is a marker for cardiac autonomic functioning. The progressive decline in HRV...
Summary Heat shock response (HSR) that protects cells from proteotoxic stresses is downregulated in aging, as well as upon replicative senescence of cells in culture. Here we demonstrate that HSR is suppressed in fibroblasts from the patients with segmental progerioid Werner Syndrome, which...
Summary In organisms with a soma–germ demarcation, the germline must be ‘preserved’ such that harmful damage is not transmitted to the offspring. Keeping the progeny free of damage may be achieved by gametes enjoying elevated, and/or more functional, homeostatic maintenance systems. This...
Summary In normal retinas, amyloid‐β (Aβ) accumulates in the subretinal space, at the interface of the retinal pigment epithelium, and the photoreceptor outer segments. However, the molecular and cellular effects of subretinal Aβ remain inadequately elucidated. We previously showed that...
Summary Previous work has shown that primary skin‐derived fibroblasts from long‐lived pituitary dwarf mutants resist the lethal effects of many forms of oxidative and nonoxidative stress. We hypothesized that increased autophagy may protect fibroblasts of Pit‐1dw/dw (Snell dwarf) mice from...
Summary The accumulation of epigenetic changes was proposed to contribute to the age‐related increase in the risk of most common diseases. In this study on 230 monozygotic twin pairs (MZ pairs), aged 18–89 years, we investigated the occurrence of epigenetic changes over the adult lifespan....
Summary Stress‐activated protein kinase (SAPK) pathways are evolutionarily conserved signaling modules that orchestrate protective responses to adverse environmental conditions. However, under certain conditions, their activation can be deleterious. Thus, activation of the c‐Jun N‐terminal...
Summary Little is known about the functions of miRNAs in human longevity. Here, we present the first genome‐wide miRNA study in long‐lived individuals (LLI) who are considered a model for healthy aging. Using a microarray with 863 miRNAs, we compared the expression profiles obtained from...
Summary The cause of elevated level of amyloid β‐peptide (Aβ42) in common late‐onset sporadic (Alzheimer’s disease (AD)) has not been established. Here, we show that the membrane lipid peroxidation product 4‐hydroxynonenal (HNE) is associated with amyloid and neurodegenerative...
Summary Accumulation of DNA damage is implicated in aging. This is supported by the fact that inherited defects in DNA repair can cause accelerated aging of tissues. However, clear‐cut evidence for DNA damage accumulation in old age is lacking. Numerous studies report measurement of DNA damage...
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