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Summary To test the hypothesis that the antioxidant enzyme superoxide dismutase (SOD) mimetic TEMPOL improves arterial aging, young (Y, 4–6 months) and old (O, 26–28 months) male C57BL6 mice received regular or TEMPOL‐supplemented (1mM) drinking water for 3 weeks (n = 8 per group). Aortic...
Summary Recently, it has been proposed that age‐related X chromosome inactivation (XCI) skewing can clinically result in late‐onset X‐linked disorders. This observation leads to hypothesize that age‐related skewed XCI might also influence lifespan in women. To investigate this issue, we...
Summary The African annual fish Nothobranchius furzeri emerged as a new model for age research over recent years. Nothobranchius furzeri show an exceptionally short lifespan, age‐dependent cognitive/behavioral decline, expression of age‐related biomarkers, and susceptibility to lifespan...
Summary Oxidative stress (OS) resulting from an imbalance between antioxidant defenses and the intracellular accumulation of reactive oxygen species (ROS) contributes to age‐related memory deficits. While impaired synaptic plasticity in neuronal networks is thought to underlie cognitive...
Summary Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disorder because of a LMNA gene mutation that produces a mutant lamin A protein (progerin). Progerin also has been correlated to physiological aging and related diseases. However, how progerin causes the progeria remains...
Summary Telomerase is of key importance for telomere maintenance, and variants of the genes encoding its major subunits, telomerase reverse transcriptase (TERT) and telomerase RNA component (TERC), are candidates for interindividual variation in telomere length. Recently, the two SNPs rs3772190...
Summary Changes in epigenetic status and chromatin structure have been shown to associate with aging in many organisms. Here, we report an RNAi screen of putative histone methyltransferases and demethylases in wild‐type Caenorhabditis elegans using reproduction inhibitor. We identified six...
Summary The human cornea is a tri‐laminar structure composed of several cell types with substantial mitotic potential. Age‐related changes in the cornea are associated with declining visual acuity and the onset of overt age‐related corneal diseases. Corneal transplantation is commonly used...
Summary Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin signaling and a therapeutic target for type 2 diabetes (T2DM). In this study, we have evaluated the role of PTP1B in the development of aging‐associated obesity, inflammation, and peripheral insulin resistance by...
Summary Naked mole‐rats (Heterocephalus glaber), the longest‐lived rodents, live 7–10 times longer than similarly sized mice and exhibit normal activities for approximately 75% of their lives. Little is known about the mechanisms that allow them to delay the aging process and live so long....
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