Within the last year
Within the past 3 years
1 - 10 of 11 articles
Research highlights &z.rtrif; The ability to undergo class switch recombination (CSR) and produce IgG is decreased in aged stimulated human B cells. &z.rtrif; The transcription factor E47 and enzyme AID necessary for CSR are also decreased in these B cells. &z.rtrif; The numbers and percentages...
Research highlights &z.rtrif; Immune senescence leads to increased susceptibility to influenza and loss of vaccine efficacy. &z.rtrif; Age-related changes in innate and adaptive immune function challenge new vaccine development. &z.rtrif; Antibody titers as a sole measure of influenza vaccine...
Research highlights ► Ageing of the population is a global pandemic that impose biomedical and socioeconomic challenges. ► A national priority supporting Human Ageing Research is key to improving quality of life of elders. ► The immunologic milieu of elders is substantially different from...
Research highlights &z.rtrif; Vaccine preventable diseases remain a severe burden in aged population, and foremost amongst them is influenza. &z.rtrif; While it is widely believed that influenza vaccination safes many lives, the exact magnitude of its benefits is still debate in the aged...
Research highlights ► Dysregulation of Toll-like receptor function occurs in aging humans. ► Adjustment for potential confounding factors is critical in human aging studies. ► Both impaired and inappropriate persistence of TLR function occur in aging humans. ► Transcriptional and...
Aging is a paradox of reduced immunity and chronic inflammation. Dendritic cells are central orchestrators of the immune response with a key role in the generation of immunity and maintenance of tolerance. The functions of DCs are compromised with age. There is no major effect on the numbers and...
Research highlights &z.rtrif; Aging involves processes of deterioration as well as repair, regeneration, and remodeling. &z.rtrif; Immune aging involves TCR repertoire contraction, and functional deficits of T and NK cells. &z.rtrif; Exceptional health beyond the 7th decade among elders suggests...
Research highlights ► Markers of inflammation are elevated in older adults. ► Visceral abdominal fat and lower sex steroid hormones are associated with higher levels of inflammatory markers. ► Of the markers assessed, IL-6 most robustly predicts disease, disability and mortality in old age.
Research highlights &z.rtrif; Thymic involution reduces the output of naïve T cells during aging. &z.rtrif; Homeostatic forces maintain a diverse memory T cell pool. &z.rtrif; Persistent infection with CMV drives memory T cell exhaustion/inflation. &z.rtrif; CMV specific expansions acquired over...
Read and print from thousands of top scholarly journals.
Sign up with Facebook
Sign up with Google
Already have an account? Log in
Save this article to read later. You can see your Read Later on your DeepDyve homepage.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Sign Up Log In
To subscribe to email alerts, please log in first, or sign up for a DeepDyve account if you don’t already have one.
To get new article updates from a journal on your personalized homepage, please log in first, or sign up for a DeepDyve account if you don’t already have one.