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Research highlights &z.rtrif; The ability to undergo class switch recombination (CSR) and produce IgG is decreased in aged stimulated human B cells. &z.rtrif; The transcription factor E47 and enzyme AID necessary for CSR are also decreased in these B cells. &z.rtrif; The numbers and percentages...
Research highlights ► Ageing of the population is a global pandemic that impose biomedical and socioeconomic challenges. ► A national priority supporting Human Ageing Research is key to improving quality of life of elders. ► The immunologic milieu of elders is substantially different from...
Research highlights &z.rtrif; Immune senescence leads to increased susceptibility to influenza and loss of vaccine efficacy. &z.rtrif; Age-related changes in innate and adaptive immune function challenge new vaccine development. &z.rtrif; Antibody titers as a sole measure of influenza vaccine...
Research highlights &z.rtrif; Vaccine preventable diseases remain a severe burden in aged population, and foremost amongst them is influenza. &z.rtrif; While it is widely believed that influenza vaccination safes many lives, the exact magnitude of its benefits is still debate in the aged...
Research highlights ► Dysregulation of Toll-like receptor function occurs in aging humans. ► Adjustment for potential confounding factors is critical in human aging studies. ► Both impaired and inappropriate persistence of TLR function occur in aging humans. ► Transcriptional and...
Aging is a paradox of reduced immunity and chronic inflammation. Dendritic cells are central orchestrators of the immune response with a key role in the generation of immunity and maintenance of tolerance. The functions of DCs are compromised with age. There is no major effect on the numbers and...
Research highlights &z.rtrif; Aging involves processes of deterioration as well as repair, regeneration, and remodeling. &z.rtrif; Immune aging involves TCR repertoire contraction, and functional deficits of T and NK cells. &z.rtrif; Exceptional health beyond the 7th decade among elders suggests...
Research highlights ► Markers of inflammation are elevated in older adults. ► Visceral abdominal fat and lower sex steroid hormones are associated with higher levels of inflammatory markers. ► Of the markers assessed, IL-6 most robustly predicts disease, disability and mortality in old age.
Research highlights &z.rtrif; Thymic involution reduces the output of naïve T cells during aging. &z.rtrif; Homeostatic forces maintain a diverse memory T cell pool. &z.rtrif; Persistent infection with CMV drives memory T cell exhaustion/inflation. &z.rtrif; CMV specific expansions acquired over...
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