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On 28–29 September 2004, the National Institute on Aging (NIA) convened scientists for a workshop on the aging female brain focused on translating into clinical practice discoveries concerning estrogens and progestogens. Workshop objectives were to examine effects of estrogen and progestogen on...
Sarcopenia has been associated with systemic inflammation and a range of other biological risk factors. The purpose of this study was to assess the systemic inflammation–muscle strength relationship in a large representative community-based cohort of older adults, and to determine the...
Androgen levels decline with aging. Some androgens may exert anti-anxiety and cognitive-enhancing effects; however, determining which androgens have anxiolytic-like and/or mnemonic effects is of interest given the different mechanisms that may underlie some of their effects. For example, the...
Aging is associated with an increased production of free radicals and alterations in the mechanisms of adaptation to stress. A number of studies have shown a causal connection between age-related oxidant/antioxidant imbalance and the diminution of an organism’s melatonin levels in old age....
Although estradiol (E 2 ) may have some beneficial effects as a treatment for menopause symptoms, E 2 also has trophic effects that can increase vulnerability to some cancers, such as breast cancer. In the present study, a model to investigate the concomitant behavioral and proliferative effects...
Studies in humans suggest that lifestyle factors can have a beneficial impact on the risk for developing cognitive decline and dementia with age. There is growing evidence that maintaining a physically and intellectually active lifestyle can positively impact cognitive ability in older...
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