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Biochemical studies have indicated changes in anti-oxidant enzyme activities and increased oxidative damage products in many disease states, particularly aging and diseases associated with aging, such as neurodegenerative diseases and cancer. To try to determine cellular and subcellular...
Ames dwarf mice, which are small and deficient in growth homone (GH), prolactin (PRL), and thyroid stimulating hormone (TSH) live much longer (1–1.25 years) than their normal siblings. It was of interest to examine the response of these animals to caloric restriction (CR) because of the...
Ingestion of antioxidant supplements by the United States (US) population has increased steadily since the mid-1950’s. This review tried to determine if the supplements have contributed significantly to beneficial changes in the US during this period. Experimental animal studies have...
Several recent studies in Caenorhabditis elegans have reported significant extension of the lifespan by probable loss of function mutations in various genes. When sequenced, many of these genes exhibited significant homology to genes in the mammalian insulin signaling cascade. For example, the...
In this study we have investigated the occurrence of “classical” Amadori rearrangement products of AGE-proteins in the vascular mesenteric bed and in the lens of Golden Syrian hamsters (12 weeks old) rendered simultaneous hyperlipidemics-diabetics (HD), or hyperlipidemics (H) for 24 weeks....
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