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Folate absorption is primarily mediated by a membrane transporter with micro-molar affinities for folates. Paradoxically, folates are only present at low nanomolar concentrations in extracellular milieus; membrane folate receptors (FRs) with nanomolar affinities for folates are likely to...
Folate receptor alpha (FRα), a glycosyl phosphatidylinositol linked protein with a great affinity for folic acid and some reduced folates such as 5-methyltetrahydrofolate and tetrahydrofolate is present on a limited number of epithelial cells, especially the kidney, placenta and choroid plexus....
The vitamin, folic acid, has become a useful ligand for targeted cancer therapies because it binds to a tumor-associated antigen known as the folate receptor (FR). By linking folic acid to therapeutic agents, folate-targeted cancer therapies can deliver therapeutic drugs specifically to...
Rheumatoid arthritis (RA) is an autoimmune disease that is characterized by inflammation of the joints and destruction of cartilage and bone, often compromising both the quality and duration of life. The disease pathology is complex, involving the infiltration and activation of various...
Most antifolate drugs are efficiently transported by the reduced-folate carrier (RFC). However, several also bind with high affinity to the α-isoform of the folate receptor (α-FR) and there is evidence to suggest that this transport mechanism may contribute to their activity when the receptor...
The folate receptor (FR) is a confirmed tumor-associated antigen that binds folate and folate–drug conjugates with very high affinity and shuttles these bound molecules inside cells via an endocytic mechanism. Using folate (or an analog thereof) as the ligand, a wide variety of drug payloads...
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