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in a population based case-control study the association between female lung cancer and some possible etiological agents was investigated; 210 incident cases in Stockholm county, Sweden, and 209 age-matched population controls were interviewed about their exposure experiences according to a...
The relationship between the cardiotoxicity and the haemodynamics/ pharmacokinetics of clinical concentrations of doxorubi-cin and 4′′epi-doxorubicin was studied. Twelve pigs were randomized to receive i.v. infusions of either drug of 50 mg/m z over 3.0 min. Aortic, pulmonary arterial,...
During the years 1979––1981, a population-based study of 388 patients with bladder cancer, including papilloma, and of 790 controls was conducted in Greater Copenhagen. No pronounced difference between cases and controls of either sex was observed for bladder infection, kidney infection or...
Twenty-seven fully evaluable patients with advanced ovarian cancer and documented disease progression despite cytotoxic treatment were treated with mitozolomide (NCS-353451) 90 mg/m 2 as a 1-h infusion once every 6 weeks. None of the patients responded, one had stabilization of disease for 4...
Regional and overall lung function was studied in 14 women during a one-year follow-up after postmastectomy irradiation for cancer of the breast. the dose was 40 Gy in the chest wall and 20––40 Gy in the apex of the lung. Immediately after irradiation there was a slight increase in pulmonary...
The conclusion of two biostatisticians that ‘‘with respect to cancer as a whole we have lost ground’’ was based on the rise in the age-standardized mortality from cancer. Trends in mortality at all ages combined may be misleading, as the effect of recent progress may be obscured by the...
Results from experimental tumours suggest that the mechanism of action of photodynamic therapy (PDT) involves both a direct killing of tumour cells, and a secondary effect −− resulting from vascular damage. We have investigated the possible vascular changes induced by PDT in an intraocular...
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