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The staging and treatment of ovarian cancer is reviewed with special attention to developments during the last decade. Pathways of spread, presurgical and surgical staging are described and discussed, as are the biologic characters of the different histologic subtypes. Principles of surgery,...
To elucidate the reasons for the undertreatment of cancer pain in Finland, a questionnaire survey was made of the experiences of 421 physicians. Their view on the role of the medical authorities, the problems experienced in pain treatment, their opinion about drug abuse and side effects of...
The survival of children with malignant germ cell sacrococcygeal tumors has improved during the last few years after introduction of a multidrug protocol including cisplatinum. Treatment for 10 patients registered in 1965-1978 was not uniform and consisted of surgical resection or biopsy and...
Mechanisms of DNA adduct formation by antineoplastic 2-chloroethyl-N-nitrosoureas (CNUs) and of DNA damage induced by these compounds are discussed. CNUs are alkylating agents that form DNA-DNA cross-links as well as 2-chloroethylated and 2-hydroxyethylated adducts, the N-7-position of guanine...
The applications of ultrasonography (US) in oncology have rapidly increased during the past few years. Technical improvements, development of new technologies, easy availability, and non-invasiveness are some of the reasons for the rapid diffusion of US. Nowadays a large number of malignancies,...
On the basis of dose readings in 102 patients treated with total body irradiation (TBI), a ‘tissue air ratio (TAR) curve’ has been produced. It could be useful to precalculate treatment time in TBI, for dose prescription to a specific point, provided the same source ( 60 Co) and treatment...
A retrospective Eortc study was carried out in order to evaluate the incidence, clinico-pathoiogical findings and outcome of non-Hodgkin lymphoma and Hodgkin's disease in patients 70 years of age or older. A significant proportion of non-Hodgkin lymphoma, mostly with high-intermediate grade of...
In 34 patients treated for acute lymphoblastic leukemia (ALL), central nervous system (CNS) damage was assessed by clinical evaluation and brain magnetic resonance imaging (MRI). Twenty-seven of them had been off therapy from 5 to 109 months (median 64 months) while 7 had not completed the...
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