1 - 5 of 5 articles
The members of the human epidermal growth factor receptor (HER) family are among the most intensely studied oncological targets. HER3 (ErbB3), which had long been neglected, has emerged as a key oncogene, regulating the activity of other receptors and being involved in progression and tumor...
The crystal structures of domain‐swapped tryptophan repressor (TrpR) variant Val58Ile before and after soaking with the physiological ligand l‐tryptophan (l‐Trp) indicate that l‐Trp occupies the same location in the domain‐swapped form as in native dimeric TrpR and makes equivalent residue...
Pivotal to the regulation of key cellular processes such as the transcription, replication and repair of DNA, DNA‐binding proteins play vital roles in all aspects of genetic activity. The determination of high‐quality structures of DNA‐binding proteins, particularly those in complexes with DNA,...
In macromolecular crystallography, paired refinement is generally accepted to be the optimal approach for the determination of the high‐resolution cutoff. The software tool PAIREF provides automation of the protocol and associated analysis. Support for phenix.refine as a refinement engine has...
Influenza A viruses of the H1N1 and H3N2 subtypes are responsible for seasonal epidemic events. The influenza nucleoprotein (NP) binds to the viral genomic RNA and is essential for its replication. Efforts are under way to produce therapeutics and vaccines targeting the NP. Despite this, no...
Read and print from thousands of top scholarly journals.
Continue with Facebook
Sign up with Google
Log in with Microsoft
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Sign Up Log In
To subscribe to email alerts, please log in first, or sign up for a DeepDyve account if you don’t already have one.
To get new article updates from a journal on your personalized homepage, please log in first, or sign up for a DeepDyve account if you don’t already have one.