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Understanding direct salt effects on protein crystal polymorphism is addressed by comparing different crystal forms (triclinic, monoclinic, tetragonal and orthorhombic) for hen, turkey, bob white quail and human lysozymes. Four new structures of hen egg-white lysozyme are reported: crystals grown...
The crystal structure of a new polymorphic form of human transthyretin (hTTR) with a lattice containing a unique assembly of apo hTTR and TTR-T4 complex has been determined to 3 A resolution. The monoclinic form of human TTR reported here crystallizes in space group P21, with unit-cell parameters...
A new phase-extension procedure has been applied to isomorphous replacement data and shown to yield improved phases and maps compared with standard solvent flattening operating on a full set of centroid phases. In this procedure, a starting subset of core phases is selected based on the sharpness...