journal article
LitStream Collection
doi: 10.1039/b921381npmid: 20023715
M. Madan Babu and Hirotada Mori introduce this themed issue of Molecular BioSystems focusing on Computational and systems biology
Schaerli, Yolanda; Hollfelder, Florian
doi: 10.1039/b907578jpmid: 20023716
Droplets with femto- to nanolitre volumes, handled in microfluidic devices, are an increasingly popular platform for high-throughput experiments that can be carried out under controlled conditions with a quantitative readout.
doi: 10.1039/b903580jpmid: 19593473
Extracellular glycoprotein interactions are not detected by most high throughput assays creating “blind-spots” in protein interaction maps. This review examines this problem and discusses recent advances that have begun to address it.
Foster, Samuel D; Oram, S. Helen; Wilson, Nicola K; Göttgens, Berthold
doi: 10.1039/b907225jpmid: 19763334
Many important questions in the haematopoietic system remain unanswered or even unanswerable with current experimental tools. Scientists have therefore increasingly turned to modelling to tackle complexity at multiple levels ranging from networks of genes to the behaviour of cells and tissues.
Aleksic, Jelena; Russell, Steven
doi: 10.1039/b906179gpmid: 19617957
Mapping protein–DNA interactions in vivo via chromatin immunoprecipitation and microarrays or sequencing provides powerful insights into genome organisation and transcriptional regulation.
Fu, Audrey Qiuyan; Adryan, Boris
doi: 10.1039/b906880epmid: 19763325
We review existing quantitative methods to score overlaps, and to cluster binding events in ChIP and DamID profiles. We provide a simple guide to some of the statistical tools used by these methods.
Babu, Mohan; Musso, Gabriel; Díaz-Mejía, J. Javier; Butland, Gareth; Greenblatt, Jack F; Emili, Andrew
doi: 10.1039/b907407dpmid: 19763343
Escherichia coli may hold the key to understanding the unique biomolecular properties of prokaryotic cells. Recent advances in high-throughput screening techniques and subsequent results are discussed here.
Showing 1 to 10 of 57 Articles