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Drug Metabolism and Personalized Therapy Volume 33 Issue 2

Subject Areas: Pharmacology (medical)
Publisher: De Gruyter - de Gruyter
ISSN: 2191-0162
SJR: 36

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Frontmatter

2018 Drug Metabolism and Drug Interactions

doi:10.1515/dmpt-2018-frontmatter2
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New perspectives in personalised medicine for ethnicity in cancer: population pharmacogenomics and pharmacometrics

Nair, Sujit; LLerena, Adrián

2018 Drug Metabolism and Drug Interactions

doi:10.1515/dmpt-2018-0008 pmid:29688886
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Which cytochrome P450 metabolizes phenazepam? Step by step in silico, in vitro, and in vivo studies

Ivashchenko, Dmitriy V.; Rudik, Anastasia V.; Poloznikov, Andrey A.; Nikulin, Sergey V.; Smirnov, Valeriy V.; Tonevitsky, Alexander G.; Bryun, Eugeniy A.; Sychev, Dmitriy A.

2018 Drug Metabolism and Drug Interactions

doi:10.1515/dmpt-2017-0036 pmid:29727298

AbstractBackground:Phenazepam (bromdihydrochlorphenylbenzodiazepine) is the original Russian benzodiazepine tranquilizer belonging to 1,4-benzodiazepines. There is still limited knowledge about phenazepam’s metabolic liver pathways and other pharmacokinetic features.Methods:To determine...
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Correlation between plasma concentrations of tramadol and its metabolites and the incidence of seizure in tramadol-intoxicated patients

Ahmadimanesh, Mahnaz; Shadnia, Shahin; Rouini, Mohammad Reza; Sheikholeslami, Behjat; Ahsani Nasab, Sara; Ghazi-Khansari, Mahmoud

2018 Drug Metabolism and Drug Interactions

doi:10.1515/dmpt-2017-0040 pmid:29727299

AbstractBackground:Seizure is one of the important symptoms of tramadol poisoning, but its causes are still unknown. The aim of this study is to find a relationship between tramadol and the concentrations of its metabolites versus the incidence of seizures following the consumption of high doses...
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Effect of the African-specific promoter polymorphisms on the SLC22A2 gene expression levels

Pearce, Brendon; Abrahams-October, Zainonesa; Xhakaza, Lettilia; Jacobs, Clifford; Benjeddou, Mongi

2018 Drug Metabolism and Drug Interactions

doi:10.1515/dmpt-2017-0039 pmid:29624501

AbstractBackground:Single nucleotide polymorphisms in promoter regions have been shown to alter the transcription of genes. Thus, SNPs in SLC22A2 can result in inter-individual variable response to medication.Methods:The objective of the study was to investigate the effect of the African-specific...
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Pharmacogenetic testing by polymorphic markers 681G>A and 636G>A CYP2C19 gene in patients with acute coronary syndrome and gastric ulcer in the Republic of Sakha (Yakutia)

Fedorinov, Denis S.; Mirzaev, Karin B.; Ivashchenko, Dmitriy V.; Temirbulatov, Ilyas I.; Sychev, Dmitriy A.; Maksimova, Nadezda R.; Chertovskih, Jana V.; Popova, Nyurguiana V.; Tayurskaya, Ksenia S.; Rudykh, Zoya A.

2018 Drug Metabolism and Drug Interactions

doi:10.1515/dmpt-2018-0004 pmid:29738309

AbstractBackground:The focus of the study is to determine the prevalence of CYP2C19 alleles, associated with the risk of changes in the pharmacological response to clopidogrel and proton pump inhibitors in patients with acute coronary syndrome (ACS) and gastric ulcer from Russian and Yakut ethnic...
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Homocysteine is the confounding factor of metabolic syndrome-confirmed by siMS score

Srećković, Branko; Soldatovic, Ivan; Colak, Emina; Mrdovic, Igor; Sumarac-Dumanovic, Mirjana; Janeski, Hristina; Janeski, Nenad; Gacic, Jasna; Dimitrijevic-Sreckovic, Vesna

2018 Drug Metabolism and Drug Interactions

doi:10.1515/dmpt-2017-0013 pmid:29624500

AbstractBackground:Abdominal adiposity has a central role in developing insulin resistance (IR) by releasing pro-inflammatory cytokines. Patients with metabolic syndrome (MS) have higher values of homocysteine. Hyperhomocysteinemia correlates with IR, increasing the oxidative stress. Oxidative...
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Remission of relapsing polychondritis after successful treatment of myelodysplastic syndrome with azacitidine: a case and review of the literature

Erden, Abdulsamet; Bilgin, Emre; Kılıç, Levent; Sarı, Alper; Armağan, Berkan; Büyükaşık, Yahya; Kalyoncu, Umut

2018 Drug Metabolism and Drug Interactions

doi:10.1515/dmpt-2018-0002 pmid:29715182

AbstractBackground:Relapsing polychondritis (RP) is a rare autoimmune disorder, and myelodysplastic syndrome (MDS) is accompanied by RP at variable rates. Herein, we report a case with RP and MDS who responded dramatically to 5-azacitidine for MDS.Case presentation:With conventional...

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