Intraoperative Infusion of Dexmedetomidine for Prevention of Postoperative Delirium and Cognitive Dysfunction in Elderly Patients Undergoing Major Elective Noncardiac SurgeryDeiner, Stacie; Luo, Xiaodong; Lin, Hung-Mo; Sessler, Daniel I.; Saager, Leif; Sieber, Frederick E.; Lee, Hochang B.; Sano, Mary; , ; Jankowski, Christopher; Bergese, Sergio D.; Candiotti, Keith; Flaherty, Joseph H.; Arora, Harendra; Shander, Aryeh; Rock, Peter
doi: 10.1001/jamasurg.2017.1505pmid: 28593326
Key PointsQuestionDoes intraoperative dexmedetomidine reduce postoperative delirium?
FindingsUnlike its use as a sedative in the intensive care unit, intraoperative dexmedetomidine did not significantly reduce the incidence of delirium over saline placebo (12.2% vs 11.4%) in this randomized clinical trial.
MeaningThe administration of dexmedetomidine in the operating room does not prevent postoperative delirium, which may be due to the short-acting nature of the drug and loss of salutary effects after discontinuation of the infusion.
Association of Preoperative Anti–Tumor Necrosis Factor Therapy With Adverse Postoperative Outcomes in Patients Undergoing Abdominal Surgery for Ulcerative ColitisKulaylat, Audrey S.; Kulaylat, Afif N.; Schaefer, Eric W.; Tinsley, Andrew; Williams, Emmanuelle; Koltun, Walter; Hollenbeak, Christopher S.; Messaris, Evangelos
doi: 10.1001/jamasurg.2017.1538pmid: 28614561
Key PointsQuestionAre adverse postoperative events higher among patients with ulcerative colitis who require anti–tumor necrosis factor (TNF) therapy?
FindingsIn this analysis involving the insurance claims records of 2476 patients who underwent colectomy or total proctocolectomy for ulcerative colitis, preoperative anti-TNF agent use was not associated with a significant increase in postoperative complications. However, anti-TNF agent use within 90 days of surgery among patients who underwent ileal pouch-anal anastomosis was associated with higher complication rates.
MeaningFor patients using anti-TNF therapy for ulcerative colitis, avoidance of ileal pouch-anal anastomosis during the initial ulcerative colitis–associated procedure may be warranted.
Vena Cava Filter Use in Trauma and Rates of Pulmonary Embolism, 2003-2015Cook, Alan D.; Gross, Brian W.; Osler, Turner M.; Rittenhouse, Katelyn J.; Bradburn, Eric H.; Shackford, Steven R.; Rogers, Frederick B.
doi: 10.1001/jamasurg.2017.1018pmid: 28492861
Key PointsQuestionAre temporal trends in vena cava filter placement and pulmonary embolism changing over time?
FindingsIn this cohort study using data from patients with traumatic injury from 3 databases, rates of vena cava filter placement showed an initial upward trend followed by a precipitous decline. Rates of pulmonary embolism demonstrated an initial increase and were followed by a reduction in the Pennsylvania Trauma Outcome Study and National Trauma Data Bank data sets, with no change in the National (Nationwide) Inpatient Sample data set.
MeaningVena cava filter use is not associated with rates of pulmonary embolism.