Buchan, Sarah A.; Booth, Stephanie; Scott, Allison N.; Simmonds, Kimberley A.; Svenson, Lawrence W.; Drews, Steven J.; Russell, Margaret L.; Crowcroft, Natasha S.; Loeb, Mark; Warshawsky, Bryna F.; Kwong, Jeffrey C.
2018 JAMA Pediatrics
doi: 10.1001/jamapediatrics.2018.1514pmid: 29971427
Key PointsQuestionDoes vaccine effectiveness differ between live attenuated influenza vaccine and inactivated influenza vaccine in children and adolescents? FindingsThis test-negative study compared health administrative data and laboratory test results on respiratory specimens from 10 169 children and adolescents across 4 influenza seasons and found no significant differences in the odds of influenza infection between children who received live attenuated and those who received inactivated influenza vaccine. The only exception was influenza B during the 2015-2016 season, for which live attenuated influenza vaccine provided better protection than inactivated influenza vaccine. MeaningThese results support receipt of either live attenuated influenza vaccine or inactivated influenza vaccine in this age group.