JAMA Ophthalmology

Muz, Omer Ersin; Elner, Victor M.; Demirci, Hakan

doi: 10.1001/jamaophthalmol.2018.6228pmid: 31600376

This case report describes a peripapillary yellow-white iris lesion with multiple overlying cystoid abnormalities and intrinsic vessels and glandular tissue with follicles containing colloid, fibrosis, and calcification.

Chen, Kuan-Jen

doi: 10.1001/jamaophthalmol.2019.3129pmid: 31600377

This case report describes a peau d'orange pattern of diffuse mottling of the outer retina demonstrating dark spots on a normal-appearing fundus, angioid streaks, peripapillary comet lesions, and a peripheral comet rain in both eyes.

Aronow, Mary E.; Crowell, Eric L.; Reddy, Ashvini K.

doi: 10.1001/jamaophthalmol.2018.5998pmid: 31600375

A healthy 7-year-old boy was referred for bilateral white-colored papillomacular lesions and was diagnosed as having choroidal osteoma.

Breazzano, Mark P.; Gangaputra, Sapna; Shieh, Christine

doi: 10.1001/jamaophthalmol.2018.5935pmid: 31600373

This case report describes an elderly man with neovascular age-related macular degeneration with a new spot on his eye.

Ryoo, Na-Kyung; Gu, Bon Hyeok; Lee, Phil Young

doi: 10.1001/jamaophthalmol.2018.5991pmid: 31600374

This case report describes an incidental finding of retinal whitening along the inferotemporal vascular arcade.

doi: 10.1001/jamaophthalmol.2018.4793pmid: N/A

doi: 10.1001/jamaophthalmol.2018.4794pmid: 31600379

Husain, Rahat; Do, Tan; Lai, Jimmy; Kitnarong, Naris; Nongpiur, Monisha E.; Perera, Shamira A.; Ho, Ching L.; Lim, Sheng K.; Aung, Tin

doi: 10.1001/jamaophthalmol.2019.2493pmid: 31294768

Key PointsQuestionWhat is the efficacy of phacoemulsification combined with goniosynechialysis compared with phacoemulsification without goniosynechialysis in lowering of intraocular pressure after 1 year? FindingsIn this randomized clinical trial of 78 patients with synechial primary angle-closure disease, lowering of intraocular pressure of approximately 7 to 8 mm Hg was achieved by both phacoemulsification alone and phacoemulsification with goniosynechialysis after 1 year. MeaningThis randomized clinical trial was unable to show that goniosynechialysis with phacoemulsification provided additional lowering of the intraocular pressure compared with phacoemulsification without goniosynechialysis.

Xu, Benjamin Y.; Varma, Rohit

doi: 10.1001/jamaophthalmol.2019.2503pmid: 31294767

Johnson, Scott; Buessing, Marric; O’Connell, Thomas; Pitluck, Sarah; Ciulla, Thomas A.

doi: 10.1001/jamaophthalmol.2019.2512pmid: 31318398

Key PointsQuestionIs bilateral voretigene neparvovec-rzyl cost-effective compared with standard care for treating RPE65-mediated inherited retinal disease in the United States over a lifetime horizon? FindingsIn this economic analysis of data from 70 patients with genetically confirmed RPE65-mediated inherited retinal disease, voretigene neparvovec-rzyl was associated with lower total costs and higher quality-adjusted life-years compared with standard care. In addition, voretigene neparvovec-rzyl was cost-effective over a lifetime horizon using a threshold of $50 000 to $150 000 per quality-adjusted life-year, assuming that the health states across patients in year 3 subsequently did not change over a lifetime. MeaningThese findings, with their assumptions and using a lifetime horizon, suggest that bilateral voretigene neparvovec-rzyl is cost-effective given its efficacy and the quality-of-life decrement associated with the natural course of inherited retinal disease.