Archives of Ophthalmology

Klein, Michael L.;Van Buskirk, E. Michael;Friedman, Ephraim;Gragoudas, Evangelos;Chandra, Suresh

1974 Archives of Ophthalmology

doi: 10.1001/archopht.1974.03900060257001pmid: 4621147

Abstract Data are presented from 27 patients (34 eyes) with central serous choroidopathy who were followed up for an average of 23 months without therapeutic intervention. The detachment completely resolved in all cases. The average duration of detachment was three months. In all eyes, the visual acuity returned to 20/40 or better, and in all but two eyes, the final visual acuity was 20/30 or better. Central serous choroidopathy is essentially a benign and self-limited disorder, and treatment by photocoagulation is seldom needed. References 1. Gass JDM: Pathogenesis of disciform detachment of the neuroepithelium: II. Idiopathic central serous choroidopathy . Am J Ophthalmol 63:587-615, 1967. 2. Gass JDM: Photocoagulation of macular lesions . Trans Am Acad Ophthalmol Otolaryngol 75:580-608, 1971. 3. L'Esperance FA: Argon and ruby laser photocoagulation of disciform macular disease . Trans Am Acad Ophthalmol Otolaryngol 75:609-625, 1971. 4. Peabody RR, Zweng HC, Little HL: Treatment of persistent central serous retinopathy . Arch Ophthalmol 79:166-169, 1968.Crossref 5. Spalter HF: Photocoagulation of central serous retinopathy . Arch Ophthalmol 79:247-253, 1968.Crossref 6. Wise GN, et al: Photocoagulation of vascular lesions of the macula . Am J Ophthalmol 66:452-459, 1968. 7. Godde-Jolly D, Bonnin P: Two cases of ventral serous choroiditis treated by light coagulation of chorio-retinal lesions located far from the macula . Bull Soc Ophtalmol Fr 68:8-13, 1968. 8. Hirose I: Therapy of central serous retinopathy . Folia Ophthalmol Jap 20:1003-1034, 1969. 9. Maumenee AE: Discussion of the two preceding papers . Trans Am Acad Ophthalmol Otolaryngol 75:626-628, 1971. 10. Walsh FB, Sloan LL: Idiopathic flat detachment of the macula . Am J Ophthalmol 19:195-208, 1936. 11. Gifford SR, Marquardt G: Central angiospastic retinopathy . Arch Ophthalmol 21:211-228, 1939.Crossref 12. Klien BA: Macular lesions of vascular origin: II. Functional vascular conditions leading to damage of the macula lutea . Am J Ophthalmol 36:1-13, 1953. 13. Klien BA: Macular and extramacular chorioretinopathy . Am J Ophthalmol 51:231-242, 1961. 14. von Graefe A: Über centrale recidivirende Retinitis . Arch Ophthalmol 12:211, 1866. 15. Sie-Boen-Lian: The etiologic agent of serous central chorioretinitis . Ophthalmologica 148:263-270, 1964.Crossref 16. Fukunaga K: Central chorioretinopathy with disharmony of the autonomic nervous system . Acta Soc Ophthalmol Jap 73:1468-1477, 1969. 17. Lipowski ZJ: Psychosomatic aspects of central serous retinopathy . Psychosomatics 12:398-401, 1971.Crossref 18. Asayama I: Über retinitis centralis . Nippon Gankag Z , 1892. 19. Norholm I: Central serous retinitis: A follow-up study . Acta Ophthalmol 47:890-899, 1969.Crossref 20. Straatsma B, Allen PA, Pettit TH: Central serous retinopathy . Trans Pac Coast Otoophthalmol Soc 47:107-127, 1966. 21. Tsukahara I, Miki M, Kowhawa Y: Unusual postoperative course after photocoagulation for macular lesions . Folia Ophthalmol Jap 22:141-146, 1971. 22. Kanagawa M, Matsubara M: Xenon light exposure as a treatment of central serous retinopathy . Folia Ophthalmol Jap 21:451-453, 1970.

Rosenbaum, Arthur L.;Jampolsky, Arthur;Scott, Alan B.

1974 Archives of Ophthalmology

doi: 10.1001/archopht.1974.03900060261002pmid: 4621148

Abstract Esotropia with high AC/A may be corrected by bimedial recessions of 4 to 5 mm without fear of overcorrection at distance. Small angle deviations at distance were not overcorrected and should not deter correcting large near deviations. The near deviations should be at least 20 prism diopters of esotropia. Smaller deviations were undercorrected or unchanged by this surgery. Potential exotropia producing factors must be avoided in patient selection. Recession of less than 4 mm proved ineffective regardless of the deviation, while bilateral recession of 4 or 5 mm produced accurate correction. The procedure was equally effective for constant and intermittent deviations. The relationship of the preoperative deviations to the amount of correction obtained per millimeter of recession was analyzed. This may be an accurate method of predicting surgical results. References 1. Parks MM: Abnormal accommodative convergence in squint . Arch Ophthalmol 59:364-380, 1958.Crossref 2. Manley DR: Accommodative esodeviations , in Manley DR (ed): Symposium on Horizontal Ocular Deviations . St. Louis, CV Mosby Co, 1971. 3. Breinin GM: Accommodative strabismus in the AC/A ratio . Am J Ophthalmol 71:303-311, 1971. 4. Knapp P: The clinical management of accommodative esotropia . Am Orthopt J 16:8-13, 1967. 5. Swann KC: Classification and diagnosis . Trans Am Acad Ophthalmol Otolaryngol 61:383-389, 1957. 6. Breinin GM, Swann KC, Costenbader FD: Symposium: Accommodative esotropia . Trans Am Acad Ophthalmol Otolaryngol 61:375-396, 1957. 7. Khaouam E, Jampolsky A: Non-surgical consecutive exotropia , in Proceedings of IV Afro-Asian Congress of Ophthalmology . Saleeby SS (ed): Beirut, Lebanon, Imprimerie Express, 1969, pp 255-265. 8. Scott AB: Strabismus Postgraduate Course . San Francisco, Pacific Medical Center, 1965.

Seelenfreund, Morton H.;Kraushar, Marvin F.;Schepens, Charles L.;Freilich, Dennis B.

1974 Archives of Ophthalmology

doi: 10.1001/archopht.1974.03900060264003pmid: 4621149

Abstract Fifty cases of choroidal detachment associated with primary retinal detachment were studied. The sex and age distribution, ocular history, clinical data, and surgical management of these cases were tabulated. The chance of developing a choroidal detachment with a retinal detachment is increased in patients who have had previous ocular surgical trauma and is probably greater in the older age group. Hypotony is a constant finding in these cases, and a discussion of the possible pathophysiologic process of this entity is given. An attempt to decrease the choroidal detachment prior to retinal surgery should be made, and careful monitoring of cryo or diathermy applications should be performed during the operation. References 1. Swyers EM: Choroidal detachment immediately following cataract extraction . Arch Ophthalmol 88:632-634, 1972.Crossref 2. Forster HW Jr: A case of `total' choroidal detachment following cataract surgery . Arch Ophthalmol 62:731, 1959.Crossref 3. Makley TA, Willard R: Postoperative choroidal detachment . Arch Ophthalmol 72:234-237, 1964.Crossref 4. Chandler PA, Grant WM: Lectures on Glaucoma . Philadelphia, Lea & Febiger, 1965, pp 236-237. 5. Hawkins WR, Schepens, CL: Choroidal detachment and retinal surgery. A clinical and experimental study . Amer J Ophthal 62:813-819, 1966. 6. Schepens CL, Brockhurst RJ: Uveal effusion: Clinical picture . Arch Ophthalmol 70:189-201, 1963.Crossref 7. Rosen E, Lyne A: Uveal effusions . Am J Ophthalmol 65:509-518, 1968. 8. McDonald PR, De la Paz V, Sarin LK: Non-rhegmatogenous retinal separation associated with choroidal detachment . Trans Am Ophthalmol Soc 62:226-247, 1964. 9. Weve HJM: Spontaneous choroidal detachment . Ned Tijdschr Geneesk 85:1124-1125, 1941. 10. Gass JD: Bulbous retinal detachment . Am J Ophthalmol 75:810-821, 1973. 11. Gottlieb F: Combined choroidal and retinal detachment . Arch Ophthalmol 88:481-486, 1972.Crossref 12. Schepens CL, Marden D: Data on the natural history of retinal detachment: I. Age and sex relationships . Arch Ophthalmol 66:631-642, 1961.Crossref 13. Schepens CL, Marden D: Data on the natural history of retinal detachment. Further characterization of certain unilateral nontraumatic cases . Am J Ophthalmol 61:213-226, 1966. 14. Margherio RR, Schepens CL: Macular Breaks. I. Diagnosis, Etiology, and Observations . Am J Ophthalmol 74:219-232, 1972. 15. Scheie HG, Morse PH, Aminlari A: Incidence of retinal detachment following cataract extraction . Arch Ophthalmol 89:293-295, 1973.Crossref 16. Smolin G: Statistical analysis of retinal holes and tears . Am J Ophthalmol 60:1055-1059, 1965. 17. Brockhurst RJ: The uveal tract . Arch Ophthalmol 69:393-408, 1963.Crossref 18. Schepens CL: Importance of choroidal detachment in fundus diagnosis . Am J Ophthalmol 51:333-334, 1961. 19. Graham PA: Unusual evolution of retinal detachments . Trans Ophthalmol Soc UK 78:359-368, 1958. 20. Dobbie cited in: Hypotensive mechanism in retinal detachments, Society Proceedings . Am J Ophthalmol 57:1059-1060, 1964. 21. Strampelli B: Pathogenetic and therapeutic considerations on detachment of the choroid . Ann Ottal 89:772-777, 1963. 22. Velzeboer CMJ: Spontaneous choroidal detachment . Am J Ophthalmol 49:898-902, 1960. 23. Brav SS: Serous choroidal detachment . Survey Ophthalmol 6:395-415, 1961. 24. Spaeth EB, DeLong P: Detachment of the choroid: A clinical and histopathologic analysis . Arch Ophthalmol 32:217-238, 1944.Crossref 25. Dobbie JG: A study of the intraocular fluid dynamics in retinal detachment . Arch Ophthalmol 69:159-164, 1963.Crossref 26. Rousseau AP, Regan CDJ: Pressure cup studies in eyes with retinal detachment . Arch Ophthalmol 73:803-809, 1965.Crossref 27. Regan CDJ, Rousseau AP: The intraocular dynamics of eyes with retinal detachment . Am J Ophthalmol 61:696-702, 1966. 28. Langham ME, Regan CDJ: Circulatory changes associated with onset of primary retinal detachment . Arch Ophthalmol 81:820-829, 1969.Crossref 29. Dobbie JG: in discussion, in Schepens CL, Regan CDJ (eds): Controversial Aspects of the Management of Retinal Detachment . Boston, Little Brown & Company, 1965, pp 73-74. 30. Yoshioka H, Endo Y: Clinical observations on ocular tension in cases of retinal detachment . Rinsho Ganka 20:193-201, 1966. 31. Capper SA, Leopold IH: Mechanism of serous choroidal detachment . Arch Ophthalmol 55:101-113, 1956.Crossref 32. Swan KG, Christensen L, Weisel JT: Choroidal detachment in the surgical treatment of retinal separation . Arch Ophthalmol 55:240-245, 1956.Crossref 33. Friedman E, Smith TA, Kuwabara T: Senile choroidal vascular patterns and drusen . Arch Ophthalmol 69:220-230, 1963.Crossref 34. Brockhurst RJ, et al: Scleral buckling procedures: VIII. Preoperative complications . Arch Ophthalmol 74:792-798, 1965.Crossref 35. Pollalis C: Factors influencing the prognosis of retinal detachment . Bull Soc Hellen Ophthalmol 36:109-126, 1968. 36. Cook C, MacDonald RK: Effect of cortisone on the permeability of the blood-aqueous barrier to fluorescein . Br J Ophthalmol 35:730-740, 1951.Crossref

Shields, Jerry A.;McDonald, P. Robb

1974 Archives of Ophthalmology

doi: 10.1001/archopht.1974.03900060269004

Abstract A total of 1,398 consecutive enucleations performed at Wills Eye Hospital between 1962 and 1972 were reviewed. There were 188 eyes containing a visible fundus lesion which prompted enucleation because of a suspected malignant melanoma. On histologic examination, seven of these eyes (3.7%) were found to harbor a simulating lesion, rather than a melanoma. During the last six years of this study such simulating lesions were present in only two of 103 enucleated eyes, or 1.9%. Several factors accounted for the decreased incidence of eyes enucleated for such simulating lesions. The most important factor was careful clinical observation, but other diagnostic adjuncts were useful in arriving at the diagnosis. In order to prevent unnecessary enucleations, it is recommended that every patient with a suspected fundus lesion be managed by the approach outlined. References 1. Ferry AP: Lesions mistaken for malignant melanoma of the posterior uvea . Arch Ophthalmol 72:463-469, 1964.Crossref 2. Blodi FC, Roy PE: The misdiagnosed melanoma . Can J Ophthalmol 2:209-211, 1967. 3. Howard GM: Erroneous clinical diagnosis of retinoblastoma and uveal melanoma . Trans Am Acad Ophthalmol Otolaryngol 73:199-203, 1969. 4. Shields JA, Zimmerman LE: Lesions simulating malignant melanoma of the posterior uvea . Arch Ophthalmol 89:466-471, 1973.Crossref 5. Zimmerman LE: Problems in the diagnosis of malignant melanoma of the choroid and ciliary body: The Arthur J. Bedell Lecture, 1972 . Am J Ophthalmol 75:917-929, 1973. 6. Zimmerman LE: Symposium: Macular diseases, macular lesions mistaken for malignant melanoma of the choroid . Trans Am Acad Ophthalmol Otolaryngol 69:623-629, 1965. 7. Rones B, Zimmerman LE: An unusual choroidal hemorrhage simulating a malignant melanoma . Arch Ophthalmol 70:30-32, 1963.Crossref 8. Ferry AP: Macular detachment associated with congenital pit of the optic nerve head . Arch Ophthalmol 70:346-357, 1963.Crossref 9. Gordon E: Nevus of the choroid and pars plana . Survey Ophthalmol 3:507-511, 1963. 10. Shields JA, Font RL: Melanocytoma of the choroid clinically simulating a malignant melanoma . Arch Ophthalmol 87:396-400, 1972.Crossref 11. Tredici TJ, Fenton RH: Hematoma beneath the retinal pigment epithelium: Report of a case mistaken clinically for a malignant melanoma of the choroid . Arch Ophthalmol 72:796-799, 1964Crossref 12. Vogel M, Zimmerman LE, Gass JDM: Proliferation of the juxtapapillary retinal pigment epithelium simulating a malignant melanoma . Doc Ophthalmol 4:469-481, 1969. 13. Berkow JW, Font RL: Disciform macular degeneration with subpigment epithelial hematoma . Arch Ophthalmol 82:51-56, 1969.Crossref 14. Zimmerman LE, Spencer WH: The pathologic anatomy of retinoschisis, with a report of two cases diagnosed clinically as malignant melanoma . Arch Ophthalmol 63:10-19, 1960.Crossref 15. Ryan SJ, Zimmerman LE, King SM: Reactive lymphoid hyperplasia: An unusual form of intra-ocular pseudotumor . Trans Am Acad Ophthalmol Otolaryngol 76:652-671, 1972. 16. Norton EWD, et al: Fluorescein fundus photography: An aid in the diagnosis of posterior ocular lesions . Trans Am Acad Ophthalmol Otolaryngol 68:755-765, 1964. 17. Hagler WS, Jarrett WH II, Humphrey WT: The radioactive phosphorus uptake test in the diagnosis of uveal melanoma . Arch Ophthalmol 83:548-557, 1970.Crossref 18. Shields JA, Green WR, McDonald PR: Uveal pseudomelanoma due to posttraumatic pigmentary migration . Arch Ophthalmol 89:519-522, 1973.Crossref 19. Flocks M, Gerende JH, Zimmerman LE: The size and shape of malignant melanomas of the choroid and ciliary body in relation to the prognosis and cystologic characteristic: A statistical study of 210 tumors . Trans Am Acad Ophthalmol Otolaryngol 59:740-758, 1955. 20. Makley TA, Teed RW: Unsuspected intraocular malignant melanomas . Arch Ophthalmol 60:475-478, 1958.Crossref 21. Jensen OA: Malignant melanomas of the uvea in Denmark 1943-1952: A clinical, histopathological and prognostic study . Acta Ophthalmol , (suppl 75) , pp 1-220, 1963.

Abraham, Fabian A.;Yatziv, Shaul;Russell, Alexander;Auerbach, Edgar

1974 Archives of Ophthalmology

doi: 10.1001/archopht.1974.03900060275005pmid: 4220270

Abstract Two siblings of normal intelligence, belonging to a nonconsanguineous marriage, had their conditions diagnosed as mucopolysaccharidosis (MPS) type IV—the so-called Morquio syndrome. Despite corneal cloudiness, no other ophthalmological abnormalities or complaints emerged, the visual acuity, fields, and color vision being normal. The electroretinogram, recorded during dark adaptation, pointed to slight photopic impairment, and its amplitudes were normal in the one and supernormal in the other case. The psychophysical dark adaptation also indicates some scotopic impairment. In view of the normal electrooculogram, the scotopic deficiency should be located in the inner retina. Conduction in the optic pathways and the information processing in the striate cortex examined by the visual evoked potential were normal. No ophthalmological and electrophysiological deficiencies have been found in other members of the family, including the carrier. References 1. Morquio L: Sur une forme de dystrophie osseuse familiale . Bull Soc Pediat Paris 27:145-152, 1929. 2. Brailsford JF: Chondro-osteo-dystrophy: Roentgenographic and clinical features of child with dislocation of vertebrae . Am J Surg 7:404-410, 1929.Crossref 3. Ruggles HE: Dwarfism due to disordered epiphyseal development . Am J Roentgenol 25:91-94, 1931. 4. Einhorn NH, Moore JR, Ostrum HW, et al: Osteochondrodystrophia deformans (Morquio's disease): Report of three cases . Am J Dis Child 61:776-794, 1941.Crossref 5. Ullrich O: Die Pfaundler-Hurlersche Krankheit . Ergeb Inn Med Kinderheilkd 63:929-1000, 1943. 6. Wiedemann HR: Ausgedehnte und allgemeine erblich bedingte Bildungs- und Wachstumsfehler des Knochengerüstes . Monatsschr Kinderheilkd 102:136-148, 1954. 7. von Noorden GK, Zellweger H, Ponseti IV: Ocular findings in Morquio-Ullrich's disease . Arch Ophthalmol 64:585-591, 1960.Crossref 8. Zellweger H, Ponseti IV, Pedrini V, et al: Morquio-Ullrich's disease: Report of two cases . J Pediatr 59:549-561, 1961.Crossref 9. Andersson CE, Crane JT, Harper HA, et al: Morquio's disease and dysplasia epiphysalis multiplex . J Bone Joint Surg 44A:295-306, 1962. 10. Bartman J, Mandelbaum IM, Gregoire PE: Les mucopolysaccharides du sérum et de l'urine dans un cas de maladie de Morquio . Rev Franc Etud Clin Biol 8:250-254, 1963. 11. Robins MM, Stevens HE, Linker A: Morquio's disease: An abnormality of mucopolysaccharide metabolism . J Pediatr 62:881-889, 1963.Crossref 12. McKusick VA, Kaplan D, Wise D, et al: The genetic mucopolysaccharidoses . Medicine 44:445-483, 1965.Crossref 13. Maroteaux P, Lamy M: Hurler's disease, Morquio's disease, and related mucopolysaccharidoses . J Pediatr 67:312-323, 1965.Crossref 14. Langer LO Jr, Carey LS: The roentgenographic features of the KS mucopolysaccharidosis of Morquio (Morquio-Brailsford's disease) . Am J Roentgenol 97:1-20, 1966.Crossref 15. McKusick VA: Heritable Disorders of Connective Tissue , ed 4. St. Louis, CV Mosby Co, 1972, pp 583-611. 16. Kenyon KR, Quigley HA, Hussels IE, et al: The systemic mucopolysaccharidoses: Ultrastructural and histochemical studies of conjunctiva and skin . Am J Ophthalmol 73:811-833, 1972. 17. Danes BS, Bearn AG: Cellular metachromasia, a genetic marker for studying the mucopolysaccharidoses . Lancet 1:241-243, 1967.Crossref 18. Gills JP, Hobson R, Hanley WB, et al: Electroretinography and fundus oculi findings in Hurler's disease and allied mucopolysaccharidoses . Arch Ophthalmol 74:596-603, 1965.Crossref 19. Leung LE, Weinstein GW, Hobson RR: Further electroretinographic studies of patients with mucopolysaccharidoses . Birth Defects 7:32-40, 1971. 20. Abraham FA, Yatziv S, Russell A, et al: Electrophysiological and psychophysical findings in the visual system of a family with two siblings affected by mild type Hunter's syndrome (MPS II). Arch Ophthalmol, to be published. 21. Auerbach E: The value of the different components for clinical electroretinography , ISCERG Symp Ghent 1966 . Basel/New York, S Karger, 1968, pp 162-173. 22. Creutzfeldt O, Rosina A, Ito M, et al: Visual evoked response of single cells and of EEG in primary visual area of the cat . J Neurophysiol 32:127-139, 1969. 23. Auerbach E, Beller AJ, Henkes HE, et al: Electric potentials of retina and cortex of cats evoked by monocular and binocular photic stimulation . Vision Res 1:166-182, 1961.Crossref 24. Cigánek L: Binocular addition of the visually evoked response with different stimulus intensities in man . Vision Res 10:479-487, 1970.Crossref 25. Arden GB, Barrada A, Kelsey JH: New clinical test of retinal function based upon the standing potential of the eye . Br J Ophthalmol 46:449-467, 1962.Crossref 26. Linker A, Evans LR, Langer LO: Morquio's disease and mucopolysaccharide excretion . J Pediatr 77:1039-1047, 1970.Crossref 27. Berman ER, Vered J, Bach G: A reliable spot test for mucopolysaccharidoses . Clin Chem 17:886-890, 1971. 28. Robertson W, Van B, Harvey J: The determination of galactose in urinary acidic glycos-aminoglycans as a measure of keratan sulfate-like substances in urine . Biochem Med 6:246-256, 1972.Crossref 29. François J, De Rouck A: L'électro-rétinoencephalographie dans la maladie de Hurler . Ophthalmologica 139:45-55, 1960.Crossref 30. Feinsod M, Rowe H, Auerbach E: Changes in the electroretinogram in patients with optic nerve lesions . Doc Ophthalmol 29:169-200, 1971.Crossref

Sanderson, Paul O.;Kuwabara, Toichiro;Stark, Walter J.;Wong, Vernon G.;Collins, Eleanor M.

1974 Archives of Ophthalmology

doi: 10.1001/archopht.1974.03900060280006pmid: 4621151

Abstract Maculopathy is reported for the first time in cystinosis. Two siblings were found to show a conspicuous yellow mottling of the macular region by ophthalmoscopy. In addition, there were widespread pigmentary changes in the fundi which have been previously described. Clinically, both patients also had crystalline deposits in the conjunctiva, cornea, and iris. Histopathologic and ultrastructural examination of both eyes from one patient showed degeneration and loss of the retinal pigment epithelial cells. Intracellular crystals were found in the keratocytes, iris epithelium, pigmented and nonpigmented epithelium of the ciliary body, choroid, and retinal pigment epithelium. References 1. Bürki E: Uber die cystinkrankheit im kleinkindesalter unter besonderar berucksichtigung des augenbefundes . Ophthalmologica 101:257-333, 1941.Crossref 2. Garron LK: Cystinosis . Trans Am Acad Ophthalmol Otolaryngol 63:99-108, 1959. 3. Cogan DG, Kuwabara T, Kinoshita J, et al: Ocular manifestations of systemic cystinosis . Arch Ophthalmol 55:36-41, 1956.Crossref 4. Cogan DG, Kuwabara T: Ocular pathology of cystinosis, with particular reference to the elusiveness of corneal crystals . Arch Ophthalmol 63:51-57, 1960.Crossref 5. Wong VG, Leitman PS, Seegmiller JE: Alterations of pigment epithelium in cystinosis . Arch Ophthalmol 77:361-369, 1967.Crossref 6. Francois J, Hanssens M, Coppiters R, et al: Cystinosis, a clinical and histopathologic study . Am J Ophthalmol 73:643-650, 1972. 7. Wong VG, Kuwabara T, Brubaker R, et al: Intralysosomal cystine crystals in cystinosis . Invest Ophthalmol 9:83-88, 1970. 8. Kenyon KR, Sensenbrenner JA: Electron-microscopy of cornea and conjunctiva in childhood cystinosis. Am J Ophthalmol, to be published. 9. Chan AM, Lynch NJG, Bailey JD, et al: Hypothyroidism in cystinosis, a clinical endocrinologic and histologic study involving 16 patients with cystinosis . Am J Med 48:678-692, 1970.Crossref 10. Gunkel RD: Retinal profiles, a psychophysical test of rod and cones sensitivity . Arch Ophthalmol 77:22-25, 1967.Crossref 11. Schneider JA, Bradley K, Seegmiller JE: Increased cystine in leukocytes from individuals homozygous and heterozygous for cystinosis . Science 157:1321-1322, 1967.Crossref 12. Schneider JA, Rosenbloom FN, Bradley KH, et al: Increased free-cystine content of fibroblasts cultured from patients with cystinosis . Biochem Biophys Res Commun 29:527-531, 1967.Crossref 13. Schneider JA, Wong VG, Bradley K, et al: Biochemical comparisons of the adult and childhood forms of cystinosis . N Engl J Med 279:1253-1257, 1968.Crossref 14. Seegmiller JE, Friedman T, Harrison HE, et al: Cystinosis, combined clinical staff conference at the National Institutes of Health . Ann Intern Med 68:883-905, 1968.Crossref 15. Schulman JD, Wong VG, Kuwabara T, et al: Intracellular cystine content in leukocyte populations in cystinosis . Arch Intern Med 125:660-664, 1970.Crossref 16. Patrick AE, Lake BB: Cystinosis, electron-microscopic evidence of lysosomal storage of cystine in lymph node . J Clin Pathol 21:571-575, 1968.Crossref 17. Schulman JD, Wong VG, Olsen WH, et al: Lysosomal site of crystalline deposits in cystinosis as shown by ferritin uptake . Arch Pathol 90:259-264, 1970. 18. Spear GS, Slusser RJ, Tousimis AJ, et al: Cystinosis, ultrastructural and electron probe study of the kidney with unusual findings . Arch Pathol 91:206-221, 1971. 19. Wong VG: The eye in cystinosis , in Schulman JD (ed): Cystinosis . DHEW publication No. (NIH) 72-249, chap 3, pp 23-35.

Brown, Stuart I.;Bloomfield, Stephen;Pearce, David B.;Tragakis, Michael

1974 Archives of Ophthalmology

doi: 10.1001/archopht.1974.03900060285007pmid: 4621152

Abstract Six of 36 severely diseased eyes wearing soft contact lenses for therapy for at least two months developed corneal infections. An additional two eyes developed severe conjunctival infections. In eyes wearing soft lenses, treatment with corticosteroids and antibiotics should be avoided, if possible. References 1. Tragakis MP, Brown SI, Pearce DB: Bacteriological studies associated with the soft contact lenses . Am J Ophthalmol 70:496-499, 1973. 2. Gasset AR: Griffin Naturalens in treatment of bullous keratopathy, dry eyes, and corneal ulcers , in Gasset AR, Kaufman HE (eds): Soft Contact Lens . St. Louis, CV Mosby Co, 1972.

Antine, Bartley E.;Brown, Francis M.;Arisco, Martin J.

1974 Archives of Ophthalmology

doi: 10.1001/archopht.1974.03900060288008pmid: 4621153

Abstract The multiple organ system involvement of congenital generalized fibromatosis is usually severe enough to result in the demise of the infant within the first few months of life. The present case is an exception. It represents what appears to be the first report of a primary fibrous tumor of the cornea and the first report of ocular involvement in this uncommon syndrome. The infiltrative nature of fibromatosis makes complete excision difficult and recurrences common. A cure could not be obtained by either radiation or excision. References 1. Duke-Elder S: System of Ophthalmology . St Louis, CV Mosby Co, 1968, vol 8, pp 1226, 1241, 1186. 2. Reese AB: Tumors of the Eye , ed 2. New York, Paul B Hoeber Inc, 1963, p 456. 3. Smith HC: Keloid tumors of the cornea . Trans Am Ophthalmol Soc 38:519-538, 1940. 4. Stout AP: Juvenile fibromatosis . Cancer 7:953-978, 1954.Crossref 5. Shnitka TK, Asp DM, Horner RH: Congenital generalized fibromatosis . Cancer 11:627-639, 1958.Crossref 6. Connolly NK: Juvenile fibromatosis . Arch Dis Child 36:171, 1961.Crossref 7. Condon VR, Allen RP: Congenital generalized fibromatosis: Case report with roentgen manifestations . Radiology 76:444, 1961.Crossref 8. Beatty EC Jr: Congenital generalized fibromatosis in infancy . Am J Dis Child 103:620, 1962. 9. Tend P, Warden MJ, Cohn WJ: Congenital generalized fibromatosis (renal and akeletal) with complete spontaneous regression . J Pediatr 62:748, 1963.Crossref 10. Levkoff AH, Gonzalez CG, Neher JL, Congenital diffuse fibromatosis: A case report . Pediatrics 35:331, 1965.

Ferry, Andrew P.;Gordon, Bruce L.

1974 Archives of Ophthalmology

doi: 10.1001/archopht.1974.03900060291009pmid: 4621154

Abstract The presently reported case is the eighth in which a cornea subjected to implantation of a keratoprosthesis has subsequently been examined pathologically. Among the several well-recognized complications of prosthokeratoplasty illustrated here is epithelialization of the anterior chamber. Ingrowth of surface epithelium has been found in six of the seven previously reported cases, the epithelium having proliferated along a track formed between the keratoprosthesis and the adjacent corneal stroma. References 1. Alamillo Torres M, Gomez Leal A: A human cornea with a keratoprosthesis: A case report and histopathologic study . Am J Ophthalmol 59:1127-1130, 1965. 2. Girard LJ, et al: Prosthetosclerokeratoplasty: Implantation of a keratoprosthesis using full-thickness onlay sclera and sliding conjunctival flap . Trans Am Acad Ophthalmol Otolaryngol 73:936-961, 1969. 3. Barraquer J, Mestre J, Rutllan J: Estudio histologico de dos fragmentos de cornea con implante acrilico . An Inst Barraquer 1:498-510, 1959-1960. 4. Hayano S: Histological study on a human cornea with a keratoprosthesis . Acta Soc Ophthalmol Jap 70:8-10, 1966. 5. Polack FM: Corneal optical prostheses . Br J Ophthalmol 55:838-843, 1971.Crossref 6. Morgan G: The pathology of ocular implants . Proc R Soc Med 63:317-318, 1970. 7. Ferry AP, Barnert AH: Granulomatous keratitis resulting from use of cyanoacrylate adhesive for closure of perforated corneal ulcer . Am J Ophthalmol 72:538-541, 1971.

Craig, Elson L.;Suie, Ted

1974 Archives of Ophthalmology

doi: 10.1001/archopht.1974.03900060295010pmid: 4621155

Abstract Histoplasma capsulatum cells were identified in the choroid of a patient who died with the disseminated form of the disease. The fungus was cultured from the retina and choroid and identified by light and electron microscopy within the cytoplasm of macrophages in the choroid. These were the only cells in which the fungus could be found. Histoplasma capsulatum cells were not seen histologically in the retina or other ocular tissues, and the positive cultures obtained from the retina in this case were thought to be due to contamination. The duration of the disease and the poor immunologic and hematologic state of the patient probably prevented the formation of choroidal granulomas. References 1. Van Metre TE, Maumenee AE: Specific ocular uveal lesions in patients with evidence of histoplasmosis . Arch Ophthalmol 71:314-324, 1964.Crossref 2. Makley TA, et al: Presumed histoplasmic chorioretinitis with special emphasis on the present modes of therapy . Trans Am Acad Ophthalmol Otolaryngol 69:443-457, 1965. 3. Woods AC, Wahlen HE: The probable role of benign histoplasmosis in the etiology of granulomatous uveitis . Am J Ophthalmol 49:205-220, 1960. 4. Maumenee AE: Clinical entities in "uveitis": An approach to the study of intraocular inflammation . Am J Ophthalmol 69:1-27, 1970. 5. Walma D, Schlaegel TF: Presumed histoplasmic choroiditis: A clinical analysis of 43 cases . Am J Ophthalmol 57:107-110, 1964. 6. Jarvis GJ, McCulloch C: Ocular histoplasmosis . Can Med Assoc J 89:1270-1273, 1963. 7. Smith RE, Knox DL, Jensen AD: Ocular histoplasmosis: Significance of asymptomatic macular scars . Arch Ophthalmol 89:296-300, 1973.Crossref 8. Duke-Elder S, Perkins ES: System of ophthalmology: Diseases of the uveal tract . St. Louis, CV Mosby Co, 1966, p 408. 9. Reed JD, et al: Systemic histoplasmosis diagnosed before death and produced experimentally in guinea pigs . J Lab Clin Med 27:419-434, 1972. 10. Hoefnagels KLJ, Pijpers PM: Histoplasma capsulatum in a human eye . Am J Ophthalmol 63:715-722, 1967. 11. Woods AC: Endogenous inflammations of the uveal tract . Baltimore, Williams & Wilkins Co, 1961, pp 108-109. 12. Wong VG, et al: Focal choroidopathy in experimental ocular histoplasmosis . Trans Am Acad Ophthalmol Otolaryngol 76:1591, 1972. 13. Krill AE, et al: Multifocal inner choroiditis . Trans Am Acad Ophthalmol Otolaryngol 73:222-245. 1969. 14. Wong VG: Clinical trends . 9:8, 1971. 15. Schwartz RS: Scope monograph on immunology . Kalamazoo, Mich, Upjohn Co, 1970, pp 51-52