JAMA Neurology

doi: 10.1001/jamaneurol.2018.3001pmid: 31403692

doi: 10.1001/jamaneurol.2018.3002pmid: 31403693

Lemmon, Monica E.; Ubel, Peter A.; Janvier, Annie

doi: 10.1001/jamaneurol.2019.1157pmid: 31081869

This Viewpoint describes the challenges and opportunities in estimating neurologic prognoses to inform families and encourages engaging families in outcomes development.

Duong, Michael Tran

doi: 10.1001/jamaneurol.2019.1599pmid: 31206149

This essay discusses lessons learned by being a caretaker for a grandparent with Alzheimer disease.

Whitmer, Rachel A.

doi: 10.1001/jamaneurol.2019.0846pmid: 31107521

Guterman, Elan L.; Betjemann, John P.

doi: 10.1001/jamaneurol.2019.0844pmid: 31135816

Redelmeier, Donald A.; Manzoor, Fizza; Thiruchelvam, Deva

doi: 10.1001/jamaneurol.2019.1148pmid: 31107515

Key PointsQuestionIs statin use associated with an increased or decreased risk of subsequent dementia after a concussion? FindingsIn this large extended population-based double cohort study following 28 815 patients after a concussion, the 5-year incidence of dementia was substantial and statin use was associated with a significantly reduced risk of subsequent dementia. MeaningConcussions are associated with an increased long-term risk of dementia, which is modestly reduced for patients receiving a statin.

Neligan, Aidan; Noyce, Alastair John; Gosavi, Tushar Divakar; Shorvon, Simon D.; Köhler, Sebastian; Walker, Matthew C.

doi: 10.1001/jamaneurol.2019.1268pmid: 31135807

Key PointsQuestionHas the mortality associated with convulsive status epilepticus (SE) changed over time? FindingsThis systematic review and meta-analysis of 61 SE studies conducted between 1990 and 2017 did not demonstrate definitive evidence of improved SE prognosis over time. MeaningChanges in definition and treatment approaches in high-income countries have not been significantly associated with the mortality of convulsive status epilepticus.

Huang, Wen-Yi; Saver, Jeffrey L.; Wu, Yi-Ling; Lin, Chun-Jen; Lee, Meng; Ovbiagele, Bruce

doi: 10.1001/jamaneurol.2019.1120pmid: 31081871

Key PointsQuestionDoes preventive, low-dose aspirin increase the frequency of intracranial hemorrhage in the general population? FindingsIn this systematic review and meta-analysis that included 13 randomized clinical trials, low-dose aspirin was associated with an increased risk of any intracranial bleeding. MeaningUse of low-dose aspirin was associated with an overall increased risk of intracranial hemorrhage among people without symptomatic cardiovascular disease.

Hanseeuw, Bernard J.; Betensky, Rebecca A.; Jacobs, Heidi I. L.; Schultz, Aaron P.; Sepulcre, Jorge; Becker, J. Alex; Cosio, Danielle M. Orozco; Farrell, Michelle; Quiroz, Yakeel T.; Mormino, Elizabeth C.; Buckley, Rachel F.; Papp, Kathryn V.; Amariglio, Rebecca A.; Dewachter, Ilse;