Archives of Internal Medicine

WARING, JAMES J.;NEUBUERGER, KARL;GEEVER, ERVING F.

doi: 10.1001/archinte.1942.00200150017002pmid: N/A

Abstract In 1873 Trousseau1 wrote in his famous work on clinical medicine: "No physician has ever seen a patient die of chickenpox, though, of course, there may be a fatal issue from some complication independent of the exanthematous fever." Today the benign nature of chickenpox and its infrequency in adults are emphasized in all textbooks of medicine. McKinley (1935)2 stated: "The disease is never fatal." Serious complications are rare and usually the result of secondary infection of the specific lesions with pyogenic organisms, especially streptococci. Bullowa and Wishik (1935)3 found a mortality rate of 0.4 per cent and complications in 5.2 per cent of 2,534 cases of chickenpox recorded at the Willard Parker Hospital during a five year period, Jan. 1, 1929, to Dec. 31, 1933. The most common complications were otitis media, abscess, pneumonia, lymphadenitis, cellulitis, septicemia and erysipelas. Among the 2,534 cases were 21 instances of References 1. Trousseau, A.: Clinical Medicine: Lectures Delivered at the Hotel-Dieu , Paris, translated from the third revised and enlarged edition by J. R. Cormack and P. V. Bazire, Philadelphia, P. Blakiston, 1882, vol. 1, p. 136. 2. McKinley, E. B., cited by Gay, F. P.: Agents of Disease and Host Resistance , Springfield, Ill., Charles C. Thomas, Publisher, 1935, p. 1220. 3. Bullowa, J. G. M., and Wishik, S. M.: Complications of Varicella , Am. J. Dis. Child. 49:923-932 ( (April) ) 1935. 4. Mitchell, A. G., and Fletcher, E. G.: Studies on Varicella , J. A. M. A. 89:279-280 ( (July 23) ) 1927.Crossref 5. Shuman, H. H.: Varicella in the Newborn , Am. J. Dis. Child. 58: 564-570 ( (Sept.) ) 1939. 6. von Genser, T.: Sind Varizellen eine ausschliessliche Kinderkrankheit? Wien. med. Wchnschr. 53:124-127 ( (Jan. 17) ) 1903. 7. Millous: Une épidémie de varicelle maligne au Cameroun , Bull. Acad. de méd., Paris 115:840-843 ( (June 16) ) 1936. 8. Baum, H. L.: A Method of Specific Treatment in Certain Streptococcic Infections , Arch. Otolaryng. 20:504-512 ( (Oct.) ) 1934Crossref 9. Specific Treatment of Various Streptococcic Infections with Human Convalescent Serum , Colorado Med. 32:876-881 ( (Nov.) ) 1935 10. Further Observations on the Use of Specific Immune Serums in the Treatment of Streptococcic Infections , Ann. Otol., Rhin. & Laryng. 45:969-978 ( (Dec.) ) 1936. 11. Platou, E. S.; Dwan, P. F., and Hoyt, R. E.: Streptococcus Convalescent Serums (Scarlatinal) , J. A. M. A. 116:11-15 ( (Jan. 4) ) 1941. 12. Lyons, C.: Immunotransfusion and Antitoxin Therapy in Hemolytic Streptococcus Infections , J. A. M. A. 105:1972-1975 ( (Dec. 14) ) 1935. 13. Hoyne, A. L.; Levinson, S. O., and Thalhimer, W.: Convalescent Scarlet Fever Serum , J. A. M. A. 105:783-789 ( (Sept. 7) ) 1935. 14. Stimson, P. M.: Some Aspects of the Common Contagious Diseases , Bull. New York Acad. Med. 17:532-547 ( (July) ) 1941. 15. MacCallum, W. G.: The Pathology of the Pneumonia in the United States Army Camps During the Winter of 1917-1918 , Monograph 10, Rockefeller Institute for Medical Research, 1919. 16. Güthert, H.: Die alveolarzellige Pneumonie bei Psittakose , Virchows Arch. f. path. Anat. 302:707-716, 1938. 17. Oberndorfer, S.: Pathologisch-anatomische Befunde bei Psittakosis (Papageienkrankheit) , München. med. Wchnschr. 77:311-312 ( (Feb. 21) ) 1930. 18. Fraser, A. D.: The Aschoff Nodule in Rheumatic Pneumonia , Lancet 1: 70-72 ( (Jan. 11) ) 1930. 19. Feyrter, F.: Ueber die pathologische Anatomie der Lungenveränderungen beim Keuchhusten , Frankfurt. Ztschr. f. Path. 35:213-255, 1927. 20. Goodpasture, E. W.; Auerbach, S. H.; Swanson, H. S., and Cotter, E. F.: Virus Pneumonia of Infants Secondary to Epidemic Infections , Am. J. Dis. Child. 57:997-1011 ( (May) ) 1939. 21. Adams, J. M.: Primary Virus Pneumonitis with Cytoplasmic Inclusion Bodies , J. A. M. A. 116:925-933 ( (March 8) ) 1941. 22. Olcott, C. T.: Friedländer Bacillus Pneumonia , Am. J. Path. 9:959 ( (Nov.) ) 1933. 23. Warren, S., and Gates, O.: Radiation Pneumonitis , Arch. Path. 30:440-460 ( (July) ) 1940. 24. Bosc, F. J.: Les épithéliomas parasitaires. La clavelée et l'épithélioma claveleux , Centralbl. f. Bakt. (Abt. 1) 34:517-526, 1903. 25. Borrel, A.: Épithélioses infectieuses et épithéliomas , Ann. Inst. Pasteur 17:81-122 ( (Jan.) ) 1903. 26. This disease is related to jagziekte, occurring in South Africa. 27. Cowdry, E. V., and Marsh, H.: Comparative Pathology of South African Jagziekte and Montana Progressive Pneumonia of Sheep , J. Exper. Med. 45:571-585 ( (April) ) 1927.Crossref 28. Rivers, T. M.; Berry, G. P., and Sprunt, D. H.: Psittacosis: I. Experimentally Induced Infections in Parrots , J. Exper. Med. 54:91-104 ( (July) ) 1931.Crossref 29. Straub, M.: The Microscopical Changes in the Lungs of Mice Infected with Influenza Virus , J. Path. & Bact. 45:75-78 ( (July) ) 1937. 30. Muckenfuss, R. S.; McCordock, H. A., and Harter, J. S.: A Study of Vaccine Virus Pneumonia in Rabbits , Am. J. Path. 8:63-71 ( (Jan.) ) 1932. 31. Dochez, A. R.; Mills, K. C., and Mulliken, B.: A Virus Disease of Swiss Mice Transmissible by Intranasal Inoculation , Proc. Soc. Exper. Biol. & Med. 36:683-686 ( (June) ) 1937. 32. Gordon, F. B.; Freeman, G., and Clampit, J. M.: A Pneumonia-Producing Filtrable Agent from Stock Mice , Proc. Soc. Exper. Biol. & Med. 39:450-453 ( (Dec.) ) 1938. 33. Weir, J. M., and Horsfall, F. L., Jr.: The Recovery from Patients with Acute Pneumonitis of a Virus Causing Pneumonia in the Mongoose , J. Exper. Med. 72:595-610 ( (Nov.) ) 1940. 34. Sprunt, D. H.; Martin, D. S., and Williams, J. E.: Interstitial Bronchopneumonia: I. Similarity of a Toxin Pneumonia to That Produced by the Viruses , J. Exper. Med. 62:73-83 ( (July) ) 1935. 35. Sprunt, D. H.; Martin, D. S., and Williams, J. E.: Interstitial Bronchopneumonia: II. Production of Interstitial Mononuclear Pneumonia by the Bordet-Gengou Bacillus , J. Exper. Med. 62:449-456 ( (Sept.) ) 1935. 36. Winternitz, M. C.; Smith, G. H., and McNamara, F. P.: Effect of Intrabronchial Insufflation of Acid , J. Exper. Med. 32:199-204 ( (Aug.) ) 1920. 37. Bergman, R., and Magnusson, J. H.: Studie über Enzephalitis bei Varizellen mit besonderer Berücksichtigung der Spätprognose , Acta pædiat. 26:31-61, 1939. 38. Underwood, E. A.: The Neurological Complications of Varicella: A Clinical and Epidemiological Study , Brit. J. Child. Dis. 32:83-107 ( (April) ); 177-196 (July); 241-263 (Oct.) 1935. 39. Ueber Enzephalitis nach Varicellae, Variola, nach Vaccination und nach Morbilli , Med. Klin. 28:1554-1557 (Nov. 4) ] 1932 40. pathologisch-anatomische Beiträge zur Frage: Varicellen und Nervensystem , in Volume jubilaire en l'honneur du Professeur G. Marinesco, Bucarest, Société Roumaine de Neurologie, Psychiatrie et Endocrinologie, 1933, pp. 683-697 41. Zimmerman, H. M., and Yannet, H.: Nonsuppurative Encephalomyelitis Accompanying Chickenpox , Arch. Neurol. & Psychiat. 26:322-332 ( (Aug.) ) 1931. 42. van Bogaert, L.: Histopathologische Studie über die Encephalitis nach Windpocken (Encephalitis postvaricellosa) , Ztschr. f. d. ges. Neurol. u. Psychiat. 140:201-217, 1932. 43. Eckstein, A.: Klinische und experimentelle Untersuchungen zur Frage der Varicellenencephalitis , Ztschr. f. d. ges. Neurol. u. Psychiat. 149:176-190, 1933. 44. Putnam, T. J.: Studies in Multiple Sclerosis: VII. Similarities Between Some Forms of "Encephalomyelitis" and Multiple Sclerosis , Arch. Neurol. & Psychiat. 35:1289-1308 ( (June) ) 1936. 45. Putnam, T. J., and Alexander, L.: Disseminated Encephalomyelitis , Arch. Neurol. & Psychiat. 41:1087-1110 ( (June) ) 1939. 46. Spielmeyer, W.: Vergleichend anatomische Betrachtungen über einige Encephalitiden, insbesondere über den Typus der Impfencephalitis , Ztschr. f. Hyg. u. Infektionskr. 113:170-191 ( (Nov.) ) 1931.Crossref 47. Henoch, E.: Nephritis nach Varicellen , Berl. klin. Wchnschr. 21:17, 1884. 48. Denny, E. R., and Baker, B. M., Jr.: Varicella Complicated by Acute Nephritis , Bull. Johns Hopkins Hosp. 44:201-206 ( (March) ) 1929. 49. Tilley, J. B., and Warin, J. F.: A Severe Case of Chicken-Pox with Some Unusual Features , Brit. M. J. 1:1265 ( (June 11) ) 1938. 50. Saphir, O.: Autopsy Diagnosis and Technique , New York, Paul B. Hoeber, Inc., 1937, p. 314. 51. Arnett, J. H.: Hematuria from Sulfathiazole Therapy in Pneumonia , J. A. M. A. 115:362-363 ( (Aug.) ) 1940.Crossref 52. Garvin, C. F.: Renal Complications Due to Sulfathiazole , J. A. M. A. 116:300-301 ( (Jan. 25) ) 1941.Crossref 53. Rake, G.; van Dyke, H. B.; Corwin, W. C.; McKee, C. M., and Greep, R. O.: Pathological Changes Following Prolonged Administration of Sulfathiazole and Sulfapyridine , J. Bact. 39:45-46 ( (Jan.) ) 1940. 54. van Dyke, H. B.; Greep, R. O.; Rake, G., and McKee, C. M.: Observations on the Toxicology of Sulfathiazole and Sulfapyridine , Proc. Soc. Exper. Biol. & Med. 42:410-416 ( (Nov.) ) 1939. 55. Gross, P.; Cooper, F. B., and Scott, R. E.: Urolithiasis Medicamentosa , Urol. & Cutan. Rev. 44:205-209 ( (April) ) 1940.

ABRAMSON, DAVID I.;FIERST, SIDNEY M.

doi: 10.1001/archinte.1942.00200150042003pmid: N/A

Abstract It is well established that cardiac output,1 blood volume,2 pulse pressure3 and pulse rate4 are significantly increased in the hyperthyroid state. In view of this, a corresponding augmentation in peripheral blood flow would also be expected. This concept has recently received support from the cutaneous temperature studies of Kirklin and his associates5 and from the work of Stewart and Evans,6 who measured heat loss in hyperthyroid patients with a Hardy-Soderstrom radiometer.7 By means of various calculations, the last-named authors expressed their data as blood flow to the skin in cubic centimeters per minute per square meter of body surface. Thus, they determined that the average blood flow was increased in the hyperthyroid state and decreased during iodine therapy and after subtotal thyroidectomy. Likewise, Kirklin and his associates5 reported that the cutaneous temperature of the big toe was significantly elevated before surgical treatment of exophthalmic goiter and that it References 1. Davies, H. W.; Meakins, J., and Sands, J.: The Influence of Circulatory Disturbances on the Gaseous Exchange of the Blood: V. The Blood Gases and Circulation Rate in Hyperthyroidism , Heart 11:299 ( (Dec.) ) 1924. 2. Fullerton, C. W., and Harrop, G. A., Jr.: The Cardiac Output in Hyperthyroidism , Bull. Johns Hopkins Hosp. 46:203 ( (Feb.) ) 1930. 3. Liljestrand, G., and Stenström, W.: Clinical Studies on the Work of the Heart During Rest: I. Blood Flow and Blood Pressure in Exophthalmic Goitre , Acta med. Scandinav. 63:99, 1925.Crossref 4. Chang, H.: Blood Volume in Hyperthyroidism , J. Clin. Investigation 10: 475 ( (Aug.) ) 1931.Crossref 5. Goldbloom, A. A., and Libin, I.: Clinical Studies in Circulatory Adjustments: I. Clinical Evaluation of Studies of Circulating Blood Volume , Arch. Int. Med. 55:484 ( (March) ) 1935.Crossref 6. Gibson, J. G., II, and Harris, A. W.: Clinical Studies of the Blood Volume: V. Hyperthyroidism and Myxedema , J. Clin. Investigation 18:59 ( (Jan.) ) 1939.Crossref 7. Sturgis, C. C., and Tompkins, E. H.: A Study of the Correlation of the Basal Metabolism and Pulse Rate in Patients with Hyperthyroidism , Arch. Int. Med. 26:467 ( (Oct.) ) 1920.Crossref 8. Read, J. M.: Basal Pulse Rate and Pulse Pressure Changes Accompanying Variations in the Basal Metabolic Rate , Arch. Int. Med. 34:553 ( (Oct.) ) 1924.Crossref 9. Sturgis and Tompkins.3 10. Kirklin, O. L.; Plummer, W. A., and Sheard, C.: Measurements of the Skin Temperatures of the Extremities in Exophthalmic Goitre, Before and After Medical and Surgical Treatment , Proc. Staff Meet., Mayo Clin. 15:774 ( (Dec. 4) ) 1940. 11. Stewart, H. J., and Evans, W. F.: The Peripheral Blood Flow in Hyperthyroidism , Am. Heart J. 20:715 ( (Dec.) ) 1940.Crossref 12. Hardy, J. D., and Soderstrom, G. F.: An Improved Apparatus for Measuring Surface and Body Temperature , Rev. Scient. Instruments 8:419 ( (Nov.) ) 1937.Crossref 13. Roberts, E., and Griffith, J. Q., Jr.: A Quantitative Study of Cutaneous Capillaries in Hyperthyroidism , Am. Heart J. 14:598 ( (Nov.) ) 1937.Crossref 14. Abramson, D. I., and Ferris, E. B., Jr.: Responses of the Blood Vessels in the Resting Hand and Forearm to Various Stimuli , Am. Heart J. 19:541 ( (May) ) 1940.Crossref 15. Abramson, D. I.; Zazeela, H., and Marrus, J.: Plethysmographic Studies of Peripheral Blood Flow in Man: I. Criteria for Obtaining Accurate Plethysmographic Data , Am. Heart J. 17:194 ( (Feb.) ) 1939Crossref 16. II. Physiologic Factors Affecting Resting Blood Flow in the Extremities , Abramson Am. Heart J. 17:206 ( (Feb.) ) 1939.Crossref 17. Ferris, E. B., Jr., and Abramson, D. I.: Description of a New Plethysmograph , Am. Heart J. 19:233 ( (Feb.) ) 1940.Crossref 18. Abramson, D. I.: Resting Peripheral Blood Flow in Hypertensive Subjects , Proc. Soc. Exper. Biol. & Med. 45:127 ( (Oct.) ) 1940. 19. Abramson, D. I., and Fierst, S. M.: Resting Blood Flow and Peripheral Vascular Responses in Hypertensive Subjects , Am. Heart J. 23:84 ( (Jan.) ) 1942. 20. Herrick, J. F.; Essex, H. E.; Mann, F. C., and Baldes, E. J.: The Effect of Feeding Desiccated Thyroid Gland on the Flow of Blood in the Femoral Artery of the Dog , Am. J. Physiol. 105:434 ( (Aug.) ) 1933. 21. Stewart, G. N.: Studies on the Circulation in Man: The Blood Flow in the Hands and Feet in Normal and Pathological Cases , in Harvey Lectures, 1912-1913 , Philadelphia, J. B. Lippincott Company, 1913, vol. 8, p. 86. 22. Grant, R. T., and Pearson, R. S. B.: The Blood Circulation in the Human Limb: Observations on the Differences Between the Proximal and Distal Parts and Remarks on the Regulation of Body Temperature , Clin. Sc. 3:119 ( (April) ) 1938. 23. Gerard, R. W., and McIntyre, M.: The Effect of Thyroid Feeding on Tissue Respiration , Am. J. Physiol. 103:225 ( (Jan.) ) 1933. 24. McEachern, D.: Direct Measurements of the Oxygen Consumption of Isolated, Beating Auricles from Normal and Thyrotoxic Guinea-Pigs , Bull. Johns Hopkins Hosp. 50:287 ( (April) ) 1932.

SEMISCH, CHARLES W.;MERVES, LOUIS

doi: 10.1001/archinte.1942.00200150050004pmid: N/A

Abstract The clinical differentiation between pulmonary artery occlusion and coronary artery occlusion is difficult, and at times impossible. In the past this was a matter purely of academic interest, since treatment of both consisted of complete rest and supportive care. Now, however, when the application of specific therapy is possible, early accurate diagnosis becomes imperative. The electrocardiograph is a physical apparatus which accurately records the curves of differences in electropotential generated by the functioning heart. With any appreciable obstruction to pulmonary artery circulation (as that produced by an embolus) there is a rise in the pulmonary artery pressure gradient, and therefore increased resistance is presented to the discharge of blood from the right ventricle. On this basis, it is, a priori, to be suspected that there would be a disturbance in the electropotential balance which would be reflected on the electrocardiogram. McGinn and White (1935)1 coined the term acute cor References 1. McGinn, S., and White, P. D.: Acute Cor Pulmonale Resulting from Pulmonary Embolism: Its Clinical Recognition , J. A. M. A. 104:1473 ( (April 27) ) 1935.Crossref 2. Barnes, A. R.: Proc. Staff Meet., Mayo Clin. 11:11, 1936 3. Pulmonary Embolism , J. A. M. A. 109:1347 ( (Oct. 23) ) 1937.Crossref 4. Love, W. S., Jr.; Brugler, G. W., and Winslow, N.: Ann. Int. Med. 11:2109, 1938.Crossref 5. Krumbhaar, E. B.: Am. J. M. Sc. 187:792, 1934.Crossref 6. Mosler, E.: Med. Klin. 43:1555, 1931. 7. Buchbinder, W. C., and Katz, L. W.: Am. J. M. Sc. 187:785, 1934.Crossref 8. Scherf, D., and Schönbrunner, E.: Ztschr. f. klin. Med. 128:455, 1935 9. Klin. Wchnschr. 16:340, 1937.Crossref 10. Haggart, G. E., and Walker, A. M.: Physiology of Pulmonary Embolism as Disclosed by Quantitative Occlusion of the Pulmonary Artery , Arch. Surg. 6:764 ( (May) ) 1923.Crossref 11. Love, W. S., Jr., and Brugler, G. W.: South. M. J. 30:371, 1937.Crossref 12. Durant, T. M.; Ginsburg, I. W, and Roesler, H: Am Heart J. 17:423, 1939.Crossref 13. Horn, H.; Dack, S., and Friedburg, C. K.: Cardiac Sequelae of Embolism of Pulmonary Artery , Arch. Int. Med. 64:296 ( (Aug.) ) 1939.Crossref 14. Sokolow, M.; Katz, L. W., and Muscovitz, A. W.: Am. Heart J. 19:166, 1940.Crossref 15. de Takats, G.; Beck, W. C., and Fenn, G. K.: Surgery 6:339, 1939. 16. Scherf and Schönbrunner.7 17. Fineberg, M. H., and Wiggers, C. J.: Am. Heart J. 11:255, 1936.Crossref 18. Gibbon, J. H., Jr.; Hopkinson, M., and Churchill, E. G.: J. Clin. Investigation 11:543, 1932.Crossref

GREGORY, RAYMOND

doi: 10.1001/archinte.1942.00200150062005pmid: N/A

Abstract Marshall, Emerson and Cutting1 have emphasized that the distribution of sulfanilamide is essentially equal in all the tissues of the body with the exception of bone and fat. They called attention to the slightly lower concentration of this substance in the saliva and pancreatic juice of the dog and in the spinal fluid of man as compared with its level in the blood. These workers studied the concentration of sulfanilamide in pleural fluid in a few instances. They found, for example, a level of 7.4 mg. of drug per hundred cubic centimeters of pleural exudate in a case of streptococcic empyema, with a corresponding blood level of 9.3 mg. per hundred cubic centimeters. In another case they found 11 mg. per hundred cubic centimeters in a pleural effusion from a patient to whom 0.10 to 0.12 Gm. of drug per kilogram of body weight was being administered daily. In References 1. Marshall, E. K., Jr.; Emerson, K., Jr., and Cutting, W. C.: The Distribution of Sulfanilamide in the Organism , J. Pharmacol. & Exper. Therap. 61:196, 1937. 2. Marshall, E. K., Jr.; Emerson, K., Jr., and Cutting, W. C.: Paraaminobenzenesulfonamide: Absorption and Excretion; Method of Determination in Urine and Blood , J. A. M. A. 108:953 ( (March 20) ) 1937. 3. Lester, C. W.: Sulfanilamide and Prontosil in the Treatment of Hemolytic Streptococcus Empyema in Children , Am. J. Surg. 43:153, 1939. 4. Oetken, H.: Uliron bei Meningokokken-Meningitis und post-pneumonischen Pneumokokkenpleuraempyem , Deutsche med. Wchnschr. 64:1683, 1938. 5. Gay, F. P., and Clark, A. R.: On the Mode of Action of Sulfanilamide in Experimental Streptococcus Empyema , J. Exper. Med. 66:535, 1937. 6. Leahy, L. J.: The Use of Sulfanilamide in the Treatment of Hemolytic Streptococcic Empyema , New York State J. Med. 40:347, 1940. 7. Long, P. H., and Bliss, E. A.: The Clinical and Experimental Use of Sulfanilamide, Sulfapyridine and Allied Compounds , New York, The Macmillan Company, 1939. 8. Mellon, R. R.; Gross, P., and Cooper, F. B.: Sulfanilamide Therapy of Bacterial Infections , Springfield, Ill., Charles C. Thomas, Publisher, 1938.

BUTTERWORTH, J. SCOTT;POINDEXTER, CHARLES A.

doi: 10.1001/archinte.1942.00200150070006pmid: N/A

Abstract Twelve years ago Wolff, Parkinson and White1 described a syndrome appearing in healthy young people subject to attacks of paroxysmal tachycardia. Electrocardiograms taken during the intervals between attacks showed wide QRS complexes with short PR intervals. Isolated cases had been previously reported by Wilson,2 Wedd3 and Hamburger,4 but the complete picture had not been appreciated. This syndrome, though uncommon, is now well known,5 and it is recognized that the bizarre electrocardiograms do not necessarily represent cardiac damage. It occurs in all age groups with the exception that it has not yet been recognized in a newborn infant. It is more common in males, and most persons have attacks of paroxysmal tachycardia of either supraventricular or ventricular origin. In some of the cases reported atropine or exercise has caused the electrocardiographic pattern to return to a normal configuration, but this is not an invariable finding. A References 1. Wolff, L.; Parkinson, J., and White, P. D.: Bundle Branch Block with Short P-R Interval in Healthy Young People Prone to Paroxysmal Tachycardia , Am. Heart J. 5:685 ( (Aug.) ) 1930.Crossref 2. Wilson, F. N.: A Case in Which the Vagus Influenced the Form of the Ventricular Complex of the Electrocardiogram , Arch. Int. Med. 16:1008 ( (Dec.) ) 1915.Crossref 3. Wedd, A. M.: Paroxysmal Tachycardia, with Reference to Nomotropic Tachycardia and the Role of the Extrinsic Cardiac Nerves , Arch. Int. Med. 27:571 ( (May) ) 1921.Crossref 4. Hamburger, W. W.: Bundle Branch Block: Four Cases of Intraventricular Block Showing Some Interesting and Unusual Clinical Features , M. Clin. North America 13:343 ( (Sept.) ) 1929. 5. Bishop, L. F., Jr.: Bundle Branch Block with Short P-R Interval in Individuals Without Organic Heart Disease: Case Report with Review of Literature , Am. J. M. Sc. 194:794 ( (Dec.) ) 1937.Crossref 6. Hunter, A.; Papp, C., and Parkinson, J.: The Syndrome of Short P-R Interval, Apparent Bundle Branch Block, and Associated Paroxysmal Tachycardia , Brit. Heart J. 2:107 ( (April) ) 1940.Crossref 7. Sigler, L. H.: Functional Bundle Branch Block (Partial) Paradoxically Relieved by Vagal Stimulation , Am. J. M. Sc. 185:211 ( (Feb.) ) 1933.Crossref 8. Wolferth, C. C.: Personal communication to the authors. 9. Bell & Howell Company lent us a standard amplifier, and Mr. Fred Brethauer and Mr. Bruce Beasley, of that company, assisted us. 10. Wolferth, C. C., and Wood, F. C.: The Mechanism of Production of Short P-R Intervals and Prolonged QRS Complexes in Patients with Presumably Undamaged Hearts: Hypothesis of an Accessory Pathway of A-V Conduction (Bundle of Kent) , Am. Heart J. 8:297 ( (Feb.) ) 1933.Crossref 11. Holzmann, M., and Scherf, D.: Ueber Elektrokardiogramme mit verkürzter Vorhof-Kammer-Distanz und positiven P-Zacken , Ztschr. f. klin. Med. 121:404, 1932. 12. Kent, A. F. S.: Observations on the Auriculo-Ventricular Junction of Mammalian Hearts , Quart. J. Exper. Physiol. 7:193, 1914. 13. Glomset, D. J., and Glomset, A. T. A.: A Morphologic Study of the Cardiac Conduction System in Ungulates, Dog, and Man , Am. Heart J. 20:389 ( (Oct.) ) 1940.Crossref 14. Ohnell, R. F.: Postmortem Examination and Clinical Report of a Case of the Short P-R Interval and Wide QRS Wave Syndrome (Wolff, Parkinson and White) , Cardiologia 4:249 ( (Aug.) ) 1940. 15. Scherf, D.: An Experimental Study of Reciprocating Rhythm , Arch. Int. Med. 67:372 ( (Feb.) ) 1941.

DICKES, ROBERT

doi: 10.1001/archinte.1942.00200150079007pmid: N/A

Abstract Among the metabolites which are retained in the body during renal insufficiency, the phenols have received relatively little attention. The fact that these compounds have practical significance because of their correlation with the depressive symptoms of uremia is confirmed by these studies at the Long Island College Hospital, Brooklyn. It is recognized, of course, that the phenols are only one of the various factors contributing to the symptoms noted in uremia. The phenols are compounds characterized by the presence of a free hydroxyl group and are divided into free and conjugated forms. The free phenols include both volatile and nonvolatile acids. Orthocresol and paracresol are examples of the free volatile phenols and parahydroxybenzoic acid of the free nonvolatile group. A conjugated phenol consists of a free phenol in combination with sulfuric or glycuronic acid. Attention was first drawn to the significance of the phenol bodies by Becher,1 who noted that References 1. Becher, E.: Studien über die Pathogenese der echten Urämie , Zentralbl. f. inn. Med. 46:369 ( (April 25) ) 1925 2. Pathogenese, Symptomatologie und Therapie der Urämie , Ergebn. d. ges. Med. 18:51, 1933. 3. Marcolongo, F.: Ricerche cliniche e sperimentali sui fenoli nell'uremia; alterazioni dei fenoli del sangue (volatili, non volatili ed eteroinsolubili) nell'uremia e loro relazione con i fenomeni clinici , Riv. di pat. sper. 8:450-490, 1937. 4. Mason, M. F.; Resnik, H.; Minot, A. S.; Rainey, J.; Pilcher, C., and Harrison, T.: Mechanism of Experimental Uremia , Arch. Int. Med. 60:312 ( (Aug.) ) 1937.Crossref 5. Peters, J. P., and Van Slyke, D. D.: Quantitative Clinical Chemistry , Baltimore, Williams & Wilkins Company, 1932, vol. 2, p. 658.

CANTAROW, A.;CUBBERLEY, C. L.;RAKOFF, A. E.

doi: 10.1001/archinte.1942.00200150089008pmid: N/A

Abstract It is commonly believed that sulfanilamide compounds diffuse readily from the blood into the tissue fluids and that an equilibrium between these two mediums is established rapidly. In commenting on this phenomenon, the majority of authors refer to the observations of Marshall and Long,1 which led to the conclusion that the distribution of sulfapyridine (2-[paraaminobenzenesulfonamido]-pyridine) between the blood and the tissues is "complete or nearly complete in five to ten minutes" after its administration intravenously. This conclusion was based on the observation that the most marked decrease in the concentration of sulfapyridine in the blood occurred during the first five to ten minutes, with only a relatively slight drop during the next hour. Review of their data, however, reveals that few determinations were made five and ten minutes after the compound was administered and that in the majority of instances sulfapyridine was present in the blood (and presumably in References 1. Marshall, E. K., Jr., and Long, P. H.: The Intravenous Use of Sodium Sulfapyridine , J. A. M. A. 112:1671 ( (April 29) ) 1939.Crossref 2. Marshall, E. K., Jr.; Emerson, K., Jr., and Cutting, W. C.: Para-Aminobenzenesulfonamide: Absorption and Excretion; Method of Determination in Urine and Blood , J. A. M. A. 108:953 ( (March 20) ) 1937.Crossref 3. Nathanson, M. H.: Diffusion of Sulfonamide Compounds into the Human Pericardium , J. A. M. A. 116:280 ( (Jan. 25) ) 1941.Crossref 4. Bellows, J., and Chinn, H.: The Distribution of Sulfanilamide in the Eye , J. A. M. A. 112:2023 ( (May 20) ) 1939.Crossref 5. Marshall, E. K., Jr.; Emerson, K., Jr., and Cutting, W. C.: Distribution of Sulfanilamide in the Organism , J. Pharmacol. & Exper. Therap. 61:196 ( (Oct.) ) 1937. 6. Sadusk, J. F., Jr.; Blake, F. G., and Seymour, A.: Observations on the Absorption, Excretion, Diffusion, and Acetylation of Sulfathiazole in Man , Yale J. Biol. & Med. 12:681 ( (July) ) 1940. 7. Bratton, A. C., and Marshall, E. K., Jr.: A New Coupling Component for Sulfanilamide Determination , J. Biol. Chem. 128:537 ( (May) ) 1939.

MOHR, CHARLES F.;PADGET, PAUL;HAHN, RICHARD;MOORE, JOSEPH EARLE

doi: 10.1001/archinte.1942.00200150103010pmid: N/A

Abstract The material for this article has been selected mainly from publications which have appeared from July 1940 to November 1941. As in previous reviews,1 it has been necessary rigidly to select material. Little attention has been paid to reports dealing with comparative serologic studies, and case reports have been almost entirely eliminated. Because of the difficulty of obtaining journals from the European continent, there is a striking decrease in the number of foreign articles reviewed. NEW BOOKS Since the publication of the last review, several important contributions have appeared in monographic form.Worster-Drought2 is responsible for a brief (241 pages) monograph entitled "Neurosyphilis." The book is a satisfactory condensation of the subject, more useful to the medical student and the general practitioner than to the specialist.Dennie and Pakula3 are the authors of "Congenital Syphilis." There is, as the preface says, much need for a "book... helpful References 1. Moore, J. E.: Syphilis: A Review of the Recent Literature , Arch. Int. Med. 56:1015 ( (Nov.) ) 1935.Crossref 2. Padget, P., and Moore, J. E.: Syphilis: A Review of the Recent Literature , Arch. Int. Med. 58:901 ( (Nov.) ) 1936Crossref 3. 60:887 (Nov.) 1937. 4. Padget, P.; Sullivan, M., and Moore, J. E.: Syphilis: A Review of the Recent Literature , 62:1029 ( (Dec.) ) 1938. 5. Moore, J. E., and Mohr, C. F.: Syphilis: A Review of the Recent Literature , 64:1053 ( (Nov.) ) 1939. 6. Mohr, C. F.; Padget, P., and Moore, J. E.: Syphilis: A Review of the Recent Literature , 66:1112 ( (Nov.) ) 1940. 7. Worster-Drough, C.: Neurosyphilis , London, John Bale & Staples, Ltd., 1940. 8. Dennie, C. C., and Pakula, S. F.: Congenital Syphilis , Philadelphia, Lea & Febiger, 1940. 9. Moore, J. E.: Modern Treatment of Syphilis , Springfield, Ill., Charles C. Thomas, Publisher, 1941. 10. Parran, T., and Vonderlehr, R. A.: Plain Words About Venereal Disease , New York, Reynal & Hitchcock, Inc., 1941. 11. Kemp, J. E.: Outline of History of Syphilis , Am. J. Syph., Gonor. & Ven. Dis. 24:759 ( (Nov.) ) 1940. 12. Simon, C., and Mollinedo, R.: Diagnostic de la syphilis par la recherche du granule spirochétogène , Presse méd. 48:513 ( (May 21) ) 1940. 13. Wile, U. J., and Snow, J. S.: The Chick Embryo as a Culture Medium for Spirocheta Pallida , J. Invest. Dermat. 4:103 ( (April) ) 1941. 14. Reynolds, F. W.: Fate of Treponema Pallidum Inoculated Subcutaneously into Immune Rabbits , Bull. Johns Hopkins Hosp. 69:53 ( (July) ) 1941. 15. Schamberg, I. L.: The Effect of Early Subcurative Arsenical and Thermal Treatment on the Development of Specific Immunity in Syphilitic Rabbits , Am. J. Syph., Gonor. & Ven. Dis. 24:401 ( (July) ) 1940. 16. Frazier, C. N., and Hu, C.: Increased Resistance to Syphilis in the Rabbit Following Prolonged Administration of Urinary Estrogens: I. Feminizing Effects of Estrogens on Adult Male Rabbits , Endocrinology 28:283 ( (Feb.) ) 1941. 17. Frazier, C. N., and Hu, C.: Increased Resistance to Syphilis in the Rabbit Following Prolonged Administration of Urinary Estrogen: II. Character of the Reaction to Treponema Pallidum in Feminized Male Rabbits , Endocrinology 28:294 ( (Feb.) ) 1941. 18. Longley, B. J.; Clausen, N. M., and Tatum, A. L.: Comparison of Response of Yaws and Syphilis in Rabbit to Mapharsen (Arsenic Preparation) and Neoarsphenamine , J. Pharmacol. & Exper. Therap. 71:49 ( (Jan.) ) 1941. 19. MacLachlan, P. L.: Effect of Arsenicals on Liver Lipids of Rabbits , Proc. Soc. Exper. Biol. & Med. 44:429 ( (June) ) 1940. 20. Jahnel, F.: Experimentelle Untersuchungen über den Einfluss des Hungerns auf den Syphilisverlauf , Ztschr. f. Immunitätsforsch. u. exper. Therap. 98:97 ( (June 12) ) 1940 21. Untersuchungen über die Einwirkung des Giftes der Sandotter Vipera ammodytes ammodytes Linnaeus bei experimenteller Syphilis , Ztschr. f. Immunitätsforsch. u. exper. Therap. 98:144 ( (June 12) ) 1940 22. Ueber die Unwirksamkeit verschiedener Schlangengifte bei experimenteller Syphilis , Ztschr. f. Immunitätsforsch. u. exper. Therap. 98:344 ( (Sept. 28) ) 1940. 23. Brown, H., and Kolmer, J. A.: Studies on Chemical Constitution of Antigenic Substance in Alcoholic Tissue Extracts Concerned in Serum Diagnosis of Syphilis , J. Biol. Chem. 137:525 ( (Feb.) ) 1941. 24. Kolmer, J. A.; Kast, C. C., and Lynch, E. R.: Studies on the Role of Spirochaeta Pallida in the Wassermann Reaction: II. The Relation of Spirochetal Antibodies to the Wassermann Reagin , Am. J. Syph., Gonor. & Ven. Dis. 25:412 ( (July) ) 1941. 25. Hazen, H. H.; Parran, T.; Mahoney, J. F.; Sanford, A. H.; Senear, F. E.; Simpson, W. M., and Vonderlehr, R. A.: Serodiagnostic Tests for Syphilis as Performed in State Laboratories in 1938 and 1939 , South. M. J. 33:633 ( (June) ) 1940. 26. Mallory, T. B.: The Interpretation and Reliability of Reports of Serological Tests for Syphilis , New England J. Med. 223:441 ( (Sept. 19) ) 1940. 27. Moore, J. E., and Eagle, H.: The Confusing Multiplicity of Serologic Tests for Syphilis: Standardization of the Serologic Report as a Possible Solution , J. A. M. A. 117:243 ( (July 26) ) 1941. 28. Moore, J. E., and Eagle, H.: The Quantitative Serologic Test for Syphilis: Its Variability, Usefulness in Routine Diagnosis, and Possible Significance; a Study of 1,665 Cases , Ann. Int. Med. 14:1802 ( (April) ) 1941. 29. Crosby, E. L., and Campbell, A. D.: The Quantitatively Titered Serologic Test in Early Syphilis and Its Response to Treatment , Am. J. Syph., Gonor. & Ven. Dis. 25:566 ( (Sept.) ) 1941. 30. Greene, R. A.; Breazeale, E. L., and Croft, C. C.: A Quantitative Study of Syphilitic Serum , J. Lab. & Clin. Med. 25:972 ( (June) ) 1940. 31. Sherwood, N. P.; Bond, G. C., and Clark, H. F.: Results Obtained with Kolmer, Kahn, Kline and Eagle Tests on Animal Sera , Am. J. Syph., Gonor. & Ven. Dis. 25:93 ( (Jan.) ) 1941. 32. Greene, R. A., and Harding, H. B.: Absence of Heterophile Antibodies in Cow Sera and Occurrence of Positive Kline Reactions , Am. J. Syph., Gonor. & Ven. Dis. 25:89 ( (Jan.) ) 1941. 33. Kemp, J. E.; Fitzgerald, E. M., and Shepherd, M.: Occurrence of Positive Serologic Tests for Syphilis in Animals Other Than Man, with Review of Literature , Am. J. Syph., Gonor. & Ven. Dis. 24:537 ( (Sept.) ) 1940. 34. Browning, C. H.: Biochemistry of Immune Reactions , Brit. M. J. 1:239, 1915. 35. Meinicke, E.: Zur Theorie und Methodik der serologischen Luesdiagnostik , Deutsche med. Wchnschr. 45:178 ( (Feb. 13) ) 1919. 36. Hinkleman, A. J.: Biochemistry of the Wassermann Reaction , Am. J. Syph., Gonor. & Ven. Dis. 11:594 ( (Oct.) ) 1927. 37. Malloy, A. M., and Kahn, R. L.: The Ultramicroscopic Precipitation Reaction in Syphilis , J. Infect. Dis. 48:243 ( (March) ) 1931. 38. Schreus, H., and Foerster, R.: Spezifische Sensibilisierung von serologischen Reaktionen: Grundlage und Methodik der spezifisch sensibilisiertern Wassermann-Reaktion (WSR.) , Ztschr. f. Immunitätsforsch. u. exper. Therap. 82:53, 1934. 39. Barnett, C. W.; Jones, R. B., and Kulchar, G. V.: Measurement of Reagin in Nonsyphilitic Sera , Proc. Soc. Exper. Biol. & Med. 33:214 ( (Nov.) ) 1935. 40. Sherwood, N. P.; Bond, G. C., and Canuteson, R. I.: Possible Presence of Reagin-Like Factor in Normal Human Serum , Am. J. Syph., Gonor. & Ven. Dis. 25:179 ( (March) ) 1941. 41. Eagle, H.: On Specificity of Serologic Tests for Syphilis as Determined by 40,545 Tests in College-Student Population , Am. J. Syph., Gonor. & Ven. Dis. 25:7 ( (Jan.) ) 1941. 42. Thomas, G. E., and Garrity, R. W.: Routine Kahn Blood Reactions: Report of Ten Thousand Tests Made on Naval Recruits , U. S. Nav. M. Bull. 39:72 ( (Jan.) ) 1941. 43. Thomas, G. E., and Garrity, R. W.: Routine Kahn Blood Reactions: Supplementary Report on Twenty Thousand Tests Made on Naval Recruits, with Observations on the Relationship of Cowpox Vaccination to the False Positive , U. S. Nav. M. Bull. 39:272 ( (April) ) 1941. 44. Lynch, F. W.; Boynton, R. E., and Kimball, A.: False Positive Serologic Reactions for Syphilis Due to Smallpox Vaccinations (Vaccinia) , J. A. M. A. 117:591 ( (Aug. 23) ) 1941. 45. Werlin, S. J.; Dolgopol, V. B., and Stern, M. E.: Infectious Mononucleosis: A Diagnostic Problem , Am. J. M. Sc. 201:474 ( (April) ) 1941. 46. Kaufman, R. E.: False Positive Serologic Reactions for Syphilis in Infectious Mononucleosis , J. Lab. & Clin. Med. 26:1439 ( (June) ) 1941. 47. Warren, E. W.: Observations on Infectious Mononucleosis , Am. J. M. Sc. 201:483 ( (April) ) 1941. 48. Sadusk, J. F., Jr.: The Skin Eruption and False-Positive Wassermann in Infectious Mononucleosis (Glandular Fever) , Internat. Clin. 1:239 ( (March) ) 1941. 49. Eagle, H.; Hogan, R. B.; Mohr, C. F., and Black, S. H.: On the Reactivity of the Serum and Spinal Fluid of Leprous Patients with Spirochetal Suspensions , Am. J. Syph., Gonor. & Ven. Dis. 25:397 ( (July) ) 1941. 50. Eagle, H.; Mays, J. R. S.; Hogan, R. B., and Burney, L. E.: The Reactivity of the Serum of Malarial Patients with Spirochetal Suspensions , Am. J. Syph., Gonor. & Ven. Dis. 25:406 ( (July) ) 1941. 51. Moore, J. E.; Eagle, H., and Mohr, C. F.: Biologic False Positive Serologic Tests for Syphilis: Suggested Method of Approach to Their Clinical Study , J. A. M. A. 115:1602 ( (Nov. 9) ) 1940. 52. Kahn, R. L.; McDermott, E. B., and Marcus, S.: Effect of Temperature on Kahn Reaction, with Serologically Positive Sera of Lower Animals , Am. J. Syph., Gonor. & Ven. Dis. 25:151 ( (March) ) 1941. 53. Kahn, R. L.; McDermott, E. B., and Marcus, S.: Effect of Temperature on Kahn Reaction, with Serologically Positive Sera of Human Syphilis , Am. J. Syph., Gonor. & Ven. Dis. 25:157 ( (March) ) 1941. 54. Kahn, R. L.; McDermott, E. B., and Marcus, S.: Effect of Temperature on Kahn Reaction, with Serologically Negative Sera in Absence of Syphilis , Am. J. Syph., Gonor. & Ven. Dis. 25:173 ( (March) ) 1941. 55. Young, H.: A Surgeon's Autobiography , New York, Harcourt, Brace & Company, Inc., 1940. 56. Moore, J. E.: Venereal Diseases and National Defense , J. A. M. A. 117: 255 ( (July 26) ) 1941. 57. Stephenson, C. S.: The Naval Medical Officer's Public Health Activity , South. M. J. 34:90 ( (Jan.) ) 1941. 58. Heller, J. R., Jr.: Progress in Syphilis Control in the Southern States , South. M. J. 33:681 ( (July) ) 1940. 59. Osborne, E. D.; Traenkle, H. L., and Dolce, F. A.: Syphilis in Industry , New York State J. Med. 40:1362 ( (Sept. 15) ) 1940. 60. Cormia, F. E.: Direct Cost of Syphilis to City of Montreal , Canad. M. A. J. 43:278 ( (Sept.) ) 1940. 61. Guy, W. H.; Goldmann, B. A.; Gannon, G. P., and Slone, J.: Acetylglycarsenobenzene (Arsphenamine Derivative) in the Treatment of Syphilis: Preliminary Report , Arch. Dermat. & Syph. 42:1046 ( (Dec.) ) 1940. 62. Hahn, R. D.: Solusalvarsan (3, 41-Diacetylamino-4-Hydroxyarsenobenzene-21-Sodium Glycolate) in the Treatment of Early Syphilis, with Some Observations on the Rate of Fall of Serum Reagin , Am. J. Syph., Gonor. & Ven. Dis. 25:628 ( (Sept.) ) 1941. 63. Friedheim, E. A. H.: Contribución a la quimioterapía por los arsenicales orgánicos. El azo-arsenobenzole en el tratamiento de la sifilis y de la enfermedad del sueno africana , Rev. argent. dermatosif. 25:66, 1941. 64. Spiegel, L., and Liefer, W.: Treatment of Neurosyphilis with a New Pentavalent Arsenical, Aldarsone , Am. J. Syph., Gonor. & Ven. Dis. 25:472 ( (July) ) 1941. 65. Kolmer, J. A.; Brown, H., and Rule, A. M.: The Therapeutic Activity of the Organic Arsenical Compounds in Syphilis of Rabbits in Relation to the Urinary Excretion of Arsenic , Am. J. Syph., Gonor. & Ven. Dis. 25:486 ( (July) ) 1941. 66. Eagle, H.: The Toxicity, Treponemicidal Activity, and Potential Therapeutic Utility of Substituted Phenylarsenoxides: I. Methods of Assay , J. Pharmacol. & Exper. Therap. 69:342 ( (Aug.) ) 1940. 67. Eagle, H.; Doak, G. O.; Hogan, R. B., and Steinman, H. G.: Toxicity, Treponemicidal Activity and Potential Therapeutic Utility of Substituted Phenylarsenoxides: Monosubstituted Phenylarsenoxides (Cl; NO2; CH3; C2H4OH; C(CH3); NOH; NH2, OH, CH2NH2 and Derivatives) , J. Pharmacol. & Exper. Therap. 70:211 ( (Oct.) ) 1940. 68. Eagle, H.; Hogan, R. B.; Doak, G. O., and Steinman, H. G.: Toxicity. Treponemicidal Activity and Potential Therapeutic Utility of Substituted Phenylarsenoxides: Monosubstituted Compounds; Acids, Esters, Benzophenone, Methylsulfone , J. Pharmacol. & Exper. Therap. 70:221 ( (Oct.) ) 1940. 69. Hanzlik, P. J.; Lehman, A. J., and van Winkle, W., Jr.: Protective Value of Bismuth in Syphilis: Experimental Results with Drinking of Sobisminol , Am. J. Syph., Gonor. & Ven. Dis. 24:468 ( (July) ) 1940. 70. Hanzlik, P. J., and van Winkle, W., Jr.: Effects of Sobisminol Solution Orally in Experimental Syphilis , Am. J. Syph., Gonor. & Ven. Dis. 25:508 ( (July) ) 1941. 71. Kolmer, J. A.; Brown, H., and Rule, A. M.: Sobisminol Solution and Water-Soluble Potassium Bismuth Tartrate by Oral and Intramuscular Administration in the Treatment of Experimental Rabbit Syphilis , Am. J. Syph., Gonor. & Ven. Dis. 25:595 ( (Sept.) ) 1941. 72. Kolmer, J. A.; Brown, H., and Rule, A. M.: Therapeutic Activity of Bismuth in Rabbits in Relation to Its Urinary Excretion , Am. J. Syph., Gonor. & Ven. Dis. 24:415 ( (July) ) 1940. 73. Thurmon, F. M., and Benotti, N.: Excretion of Bismuth in Urine of Patients Treated with Bismuth Ethyl Camphorate , Arch. Dermat. & Syph. 42: 1073 ( (Dec.) ) 1940. 74. Kolmer, J. A.; Kast, C. C., and Rule, A. M.: Spirocheticidal and Mechanism of Activity of Bismuth Compounds in Vitro and in Vivo in Relation to Therapeutic Effectiveness , Am. J. Syph., Gonor. & Ven. Dis. 24:439 ( (July) ) 1940. 75. Corson, E. F.; Decker, H. B., and Williams, T. L.: Mobilization of Bismuth Produced by Ammonium Chloride , Arch. Dermat. & Syph. 42:868 ( (Nov.) ) 1940. 76. Kirkham, D., and Perlmutter, M.: Fatal Aplastic Anemia Following the Use of Mapharsen: Report of Case , Arch. Dermat. & Syph. 43:111 ( (Jan.) ) 1941. 77. Creswell, G. W., and Roth, G. B.: Further Experiences with Mapharsen in Syphilis: Report of Fatality , M. Ann. District of Columbia 10:230 ( (June) ) 1941. 78. Epstein, N. N., and Falconer, E. H.: Effects of Neoarsphenamine and Mapharsen (Arsenic Preparation) on Formed Elements of Blood: Granulocytopenia Following Neoarsphenamine Therapy in Patient Who Subsequently Received Mapharsen Without Untoward Reaction , Arch. Dermat. & Syph. 42:909 ( (Nov.) ) 1940. 79. Falconer, E. H.; Epstein, N. N., and Mills, E. S.: Purpura Haemorrhagica Due to the Arsphenamines: Sensitivity in Patients as Influenced by Vitamin C Therapy , Arch. Int. Med. 66:319 ( (Aug.) ) 1940. 80. Peters, E. E.: The Syndrome of Milian's Erythema of the Ninth Day: Report of Fifty-Four Cases , Am. J. Syph., Gonor. & Ven. Dis. 25:527 ( (Sept.) ) 1941. 81. Hanger, F. M., Jr., and Gutman, A. B.: Postarsphenamine Jaundice Apparently Due to Obstruction of Intrahepatic Biliary Tract , J. A. M. A. 115: 263 ( (July 27) ) 1940. 82. Thomas, E. W., and Cañizares, O.: Relapsing Early Acute Arsenical Erythema: Report of Two Cases , Arch. Dermat. & Syph. 42:30 ( (July) ) 1940. 83. Alessi, D.: Encefalite arsenobenzolica con esantema del nono giorno. Lesione pontina definitiva , Minerva med. 1:445 ( (May 26) ) 1940. 84. Cormia, F. E.: Etiologic Considerations in Postarsphenamine Dermatitis, Am. J. Syph. , Gonor. & Ven. Dis. 25:189 ( (March) ) 1941. 85. Cormia, F. E.: Cutaneous Sensitization to Arsphenamine: Attempts to Induce Anaphylactic State with Different Arsphenamines: Production with Conjugate Arsphenamine Antigen, and Incidental Relation Between Anaphylactic and Cutaneous Hypersensitivity , Arch. Dermat. & Syph. 43:103 ( (Jan.) ) 1941. 86. Frei, W.: Further Studies in Arsphenamine Hypersensitiveness in Guinea Pigs: II. Attempts at Experimental Specific Sensitization of Guinea Pigs to Quinine, to Acetyl Salicylic Acid, and to Barbital, With and Without Preceding or Concomitant Arsphenamine Sensitization , J. Invest. Dermat. 4:111 ( (April) ) 1941. 87. Olin, T. E.: Sur l'intradermo-réaction comme critérium de l'intolérance à l'égard du salvarsan , Acta dermat.-venereol. 22:176 ( (March) ) 1941. 88. Chargin, L., and Leifer, W.: Fixed Eruptions Due to Arsphenamines , J. Invest. Dermat. 3:443 ( (Dec.) ) 1940. 89. Franks, A. G., and Fisher, S.: Sensitization to Arsenical Compounds: Sensitization to a Pentavalent Arsenical Following Use of a Trivalent Arsenical , Arch. Dermat. & Syph. 42:808 ( (Nov.) ) 1940. 90. Schoch, A. G.; Alexander, L. J., and Long, W. E.: Mapharsen in Treatment of Forty Patients Following Arsphenamine Dermatitis , Arch. Dermat. & Syph. 42:919 ( (Nov.) ) 1940. 91. Horne, G., and Scarborough, H.: Capillary Resistance in Toxic Manifestations of Antisyphilitic Therapy (Use of Vitamin P) , Lancet 2:66 ( (July 20) ) 1940. 92. Gott, J. R., Jr.: The Incidence of Latent Jaundice During Antisyphilitic Treatment: An Analysis of Routine Bilirubin Studies , Internat. Clin. 4:181 ( (Dec.) ) 1940. 93. Horne, G. O.: Levulose Tolerance Test in Intolerance to Antisyphilitic Therapy , Edinburgh M. J. 47:801 ( (Dec.) ) 1940. 94. Rosahn, P. D.: Fatal Hemorrhagic Encephalitis Following Arsenical Treatment of Syphilis: Two Cases with Autopsy Findings , Urol. & Cutan. Rev. 44:488 ( (Aug.) ) 1940. 95. Levy, N. A.: Encephalopathy: Unusual Clinical and Histologic Observations , Arch. Dermat. & Syph. 42:814 ( (Nov.) ) 1940. 96. Cormia, F. E.: Postarsphenamine Dermatitis: Relation of Vitamin C to Production of Arsphenamine Sensitiveness, and Its Use as Adjunct to Further Arsphenamine Therapy in Patients with Cutaneous Hypersensitiveness to Arsphenamines , J. Invest. Dermat. 4:81 ( (Feb.) ) 1941. 97. Farmer, C. J.; Abt, A. F., and Aron, H. C. S.: Influence of Arsenicals, Bismuth and Iron on Plasma Ascorbic Acid Level , Proc. Soc. Exper. Biol. & Med. 44:495 ( (June) ) 1940. 98. Welcker, A.: Salvarsanunverträglichkeit und Vitamin C , Klin. Wchnschr. 19:1281 ( (Dec. 14) ) 1940. 99. McDonald, F. M., and Johnson, H. H.: Ascorbic Acid and Arsphenamine Dermatitis: An Experimental Study , Arch. Dermat. & Syph. 43:682 ( (April) ) 1941. 100. MacKee, G. M., and Astrachan, G. D.: Value of Liver Extract in Cases Intolerant to Arsenicals, Heavy Metals and Radiation , J. Invest. Dermat. 3:409 ( (Oct.) ) 1940. 101. Doak, G. O.: On the Supposed Detoxifying Effect of Various Substances Used in Association with the Arsphenamines , Am. J. Syph., Gonor. & Ven. Dis. 25:286 ( (May) ) 1941. 102. Waugh, J. R., and Milovich, E.: Severe Reactions to Arsphenamine Among 3,050 Previously Untreated Patients , Ven. Dis. Inform. 21:389 ( (Dec.) ) 1940. 103. Stephenson, C. S.; Chambers, W. M., and Anderson, L. T.: Toxic Effects of Arsenical Compounds as Administered in United States Navy in 1939 , U. S. Nav. M. Bull. 38:587 ( (Oct.) ) 1940. 104. Stephenson, C. S.; Chambers, W. M., and Anderson, L. T.: Toxic Effects of Arsenical Compounds as Employed in Treatment of Diseases in United States Navy , 1939, U. S. Nav. M. Bull. 39:139 ( (Jan.) ) 1941. 105. Powell, L. S., and Smith, H. S.: Studies of the Visual Fields in Connection with Tryparsamide Therapy , Arch. Ophth. 24:276 ( (Aug.) ) 1940. 106. Downs, W. G.; McDermott, W., and Webster, B.: Reactions to Tryparsamide , Am. J. Syph., Gonor. & Ven. Dis. 25:16 ( (Jan.) ) 1941. 107. Beerman, H., and Shaffer, B.: Reaction to Tryparsamide: Review of Ten Years' Experience , Brit. J. Ven. Dis. 16:145 ( (July-Oct.) ) 1940. 108. Turvey, S. E. C.: Rare Ocular Reactions to Tryparsamide , Am. J. Syph., Gonor. & Ven. Dis. 25:623 ( (Sept.) ) 1941. 109. Stewart, H. J., and Smith, J. J.: Changes in the Electrocardiogram and in the Cardiac Rhythm During the Therapeutic Use of Potassium Salts , Am. J. M. Sc. 201:177 ( (Feb.) ) 1941. 110. Dyar, R., and Guthrie, N. W.: Factors Affecting Results of Contact Investigation in Syphilis Clinic of Johns Hopkins Hospital , Am. J. Syph., Gonor. & Ven. Dis. 25:215 ( (March) ) 1941. 111. Clark, E. G.: Epidemiologic Investigations in Series of Nine Hundred and Ninety-Six Cases of Acquired Syphilis , Ven. Dis. Inform. 21:349 ( (Nov.) ) 1940. 112. Pariser, H.: Transmissibility of Syphilis: Infectiousness of Vaginal Secretions and Menstrual Blood of Women , J. Invest. Dermat. 3:375 ( (Oct.) ) 1940. 113. Thurmon, F. M.: The Clinical Manifestations of Primary Syphilis , New England J. Med. 223:439 ( (Sept. 19) ) 1940. 114. Tello, E. E.: Sífilis primaria de vagina (chancro ulceroso de fondo de saco anterior) , Rev. argent. dermatosif. 24:567, 1940. 115. Thomas, E. W., and Goldstein, D. H.: Chronic Tonsillitis in Secondary Syphilis: Differential Diagnosis from Diphtheria and Vincent's Infection; a Report of Twenty-Three Cases , New York State J. Med. 41:256 ( (Feb. 1) ) 1941. 116. Wile, U. J.; Isaacs, R., and Knerler, C. W.: Blood Cells in Early Syphilis , Am. J. Syph., Gonor. & Ven. Dis. 25:133-141 ( (March) ) 1941. 117. Merritt, H. H.: The Early Clinical and Laboratory Manifestations of Syphilis of the Central Nervous System , New England J. Med. 223:446 ( (Sept. 19) ) 1940. 118. Padget, P.: (a) Long Term Results in the Treatment of Early Syphilis , Am. J. Syph., Gonor. & Ven. Dis. 24:692 ( (Nov.) ) 1940 119. Long-Term Results in the Treatment of Early Syphilis , J. A. M. A. 116:7 ( (Jan. 4) ) 1941. 120. Vonderlehr, R. A.: Continuous Alternating Scheme in Control of Acquired Syphilis , Illinois M. J. 79:80 ( (Jan.) ) 1941. 121. The Treatment of the Peripatetic Patient, editorial , Am. J. Syph., Gonor. & Ven. Dis. 25:643 ( (Sept.) ) 1941. 122. Baehr, G.: Massive Arsenotherapy in Early Syphilis by Continuous Intravenous Drip Method: Preliminary Work with Neoarsphenamine , Arch. Dermat. & Syph. 42:239 ( (Aug.) ) 1940. 123. Leifer, W.: Massive Arsenotherapy (Using Mapharsen) in Early Syphilis by Continuous Intravenous Drip Method: Technic , Arch. Dermat. & Syph. 42:245 ( (Aug.) ) 1940. 124. Chargin, L.: Massive Arsenotherapy (Using Mapharsen) in Early Syphilis by Continuous Intravenous Drip Method: Toxicologic Manifestations , Arch. Dermat. & Syph. 42:248 ( (Aug.) ) 1940. 125. Hyman, H. 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doi: 10.1001/archinte.1942.00200150179011pmid: N/A

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract Fellowships for Research in Nutrition. —Scientific attack on problems of the American diet was furthered recently by a series of fellowships established by Swift and Company for research in nutrition to aid the federal government in its long range national nutrition program.The fellowships provide for special research to be undertaken in laboratories of universities and medical schools with funds which the company has set aside as grants in aid beginning Nov. 1, 1941. The fellowships will be for one year but may be renewed if the project warrants.Any fundamental study of the nutritive properties of foods or the application of such information to improvement of the American diet and health will be eligible for consideration for a grant, according to Dr. R. C. Newton, vice president in charge of the company's research laboratories, who will coordinate the program.

doi: 10.1001/archinte.1942.00200150180012pmid: N/A

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract In the general opinion of radiologists and urologists and according to current expressions of opinion in textbooks, cystine calculi are difficult to visualize on roentgenologic examination. In a review of 37 cases of cystinuria reported in Sweden, the author found that the condition in 27 was complicated by the formation of calculi. In 18 of the 27 cases a roentgenologic study had been made prior to operation, and in 15 of these 18 cases available cystine calculi were examined roentgenographically with respect to structure and investigated photometrically for the purpose of studying their roentgen density. In the 18 cases 13 patients were men and 5 were women. The first symptoms of lithiasis usually appeared between the ages of 20 and 25 years, although the age at onset varied from 1I/2 to 64 years. As a rule, the patient had stone symptoms for four or five years before a diagnosis of