Archives of Internal Medicine

PUPPEL, ITALO D.;CURTIS, GEORGE M.

doi: 10.1001/archinte.1936.00170160003001pmid: N/A

Abstract A disturbance of the calcium balance has been found in thyroid disease.1 Apparently there is a relationship between the calcium and iodine intake, the normal function of the thyroid gland and the development of goiter.2 Consequently, we became interested in determining any existing correlation between the total calcium and iodine metabolism and thyroid disease in man. For at least a century calcium has been considered a factor in the production of goiter. As early as 1837 McClelland3 reported this belief. The iodine deficiency theory of goiter, which has been accepted by many, was advocated by Maffoni4 in 1846, by Prevost5 in 1849 and by Chatin6 in 1852. Reviews of the earlier literature on calcium metabolism in thyroid disease have been presented.7 However, until Aub and his associates1 reported their systematic studies in 1929, the evidence for a disturbance of calcium metabolism remained inconclusive. The true nature of this References 1. Aub, J. C.; Bauer, W.; Heath, C., and Ropes, M.: Studies of Calcium and Phosphorus Metabolism: III. The Effects of the Thyroid Hormone and Thyroid Disease , J. Clin. Investigation 7:97, 1929.Crossref 2. Tanabe, H.: Experimenteller Beitrag zur Aetiologie des Kropfes , Beitr. z. path. Anat. u. z. allg. Path. 73:415, 1925. 3. Hellwig, C. A.: Iodine Deficiency and Goiter: Influence of a Diet Poor in Iodine on the Thyroid Gland in White Rats , Arch. Path. 11:709 ( (May) ) 1931 4. Experimental Goiter: Functional, Chemical and Histologic Studies , Hellwig Arch. Path. 19:364 ( (March) ) 1935. 5. Thompson, J.: Influence of the Intake of Calcium on the Thyroid Gland of the Albino Rat , Arch. Path. 16:211 ( (Aug.) ) 1933 6. The Influence of Calcium and Iodine on Growing Rats , Endocrinology 17:537, 1933.Crossref 7. Klein, J.: The Effect of Calcium on the Storage of Colloid in the Thyroid Gland , Ann. Int. Med. 7:1080, 1934Crossref 8. The Correlation of Mineral Metabolism and the Vegetative Nervous System in Thyroid Disease , Klein Ann. Int. Med. 8:798, 1935.Crossref 9. McClelland, J. W.: On the Connection Between Goiter and Cretinism: Their Nature and Causes; Some Inquiries in the Province of Kemaon Relative to Geology and Other Branches of Natural Science, Including an Inquiry into the Causes of Goiter, Calcutta, 1835 , Dublin J. M. Sc. 11:295, 1837.Crossref 10. Maffoni, A. C.: Brevi cenni sullo stato sanitario del piemonte con proposta di alcuni mezzi per giungere a migliorarlo , Atti d. Accad. di med. di Torino 2:453, 1846. 11. Prevost, J. L., quoted by Orr and Leitch.18 12. Chatin, A.: Recherche de l'iode dans l'air, les eaux, le sol et les produits alimentaires des alpes de la France et du Piédmont , Compt. rend. Acad. d. sc. 33:529, 1851 13. 34:14 and 51, 1852. 14. Golden, R., and Abbott, H.: The Relation of the Thyroid, the Adrenals and the Islands of Langerhans to Malacic Diseases of Bone , Am. J. Roentgenol. 30:641, 1933. 15. Aub and others.1 16. Hansman, F. S., and Wilson, F. H.: Calcium and Phosphorus Metabolism in Diseases of the Thyroparathyroid Apparatus: I. Calcium, Phosphorus and Total Metabolism in Hyperthyroidism and the Part Played by the Parathyroid Glands , M. J. Australia 1:37, 1934. 17. Albright, F.; Bauer, W., and Aub, J. C.: Studies of Calcium and Phosphorus Metabolism: VIII. The Influence of the Thyroid Gland and the Parathyroid Hormone upon the Total Acid-Base Metabolism , J. Clin. Investigation 10:187, 1931.Crossref 18. Tibbetts, D. M.; McLean, R., and Aub, J. C.: Studies of Calcium and Phosphorus Metabolism: XX. The High Calcium Excretion in Exophthalmic Goiter Is Not Due to Vitamine D Deficiency , J. Clin. Investigation 11:1273, 1932.Crossref 19. Phillips, F. J.; Erf, O., and Curtis, G. M.: The Effects of Prolonged Increased Iodine Feeding , Ohio J. Sc. 35:286, 1935. 20. Cole, V. V.; Dunn, R. H., and Curtis, G. M.: The Intrapulmonic Absorption of Iodine , J. Pharmacol. & Exper. Therap. 53:327, 1935. 21. Cole, V. V.; Curtis, G. M., and Bone, M. L.: The Iodine Content of Hospital Foods , J. Am. Dietet. A. 10:200, 1934. 22. Davis, C. B.; Curtis, G. M., and Cole, V. V.: Blood Iodine Studies: II. The Normal Iodine Content of Human Blood , J. Lab. & Clin. Med. 19:818, 1934. 23. Curtis, G. M.; Cole, V. V., and Phillips, F. J.: The Blood Iodine in Thyroid Disease , West. J. Surg. 42:435, 1934. 24. Curtis, G. M.: Iodine Metabolism in Toxic Goiter , J. Med. 15:294, 1934. 25. Curtis, G. M., and Phillips, F. J.: The Urinary Excretion of Iodine: I. The Loss of Iodine in the Urine Following Thyroidectomy , J. Clin. Investigation 13:777, 1934.Crossref 26. Curtis, G. M.; Davis, C. B., and Phillips, F. J.: Significance of the Iodine Content of Human Blood , J. A. M. A. 101:901 ( (Sept. 16) ) 1933.Crossref 27. Curtis, G. M.; Barron, L. E., and Phillips, F. J.: Blood Iodine Studies: V. Blood Iodine After Total Thyroidectomy in Man , J. Lab. & Clin. Med. 20:813, 1935. 28. Matthews, N. L.; Cole, V. V., and Curtis, G. M.: The Urinary Excretion of Iodine: II. The Normal Urinary Iodine in Central Ohio, to be published. 29. Cole, V. V., and Curtis, G. M.: Cyclic Variations in Urinary Excretion of Iodine in Women , Proc. Soc. Exper. Biol. & Med. 31:29, 1933. 30. von Fellenberg, T.: Untersuchungen über den Jodstoffwechsel: I. Versuche mit physiologischen Jodmengen beim Erwachsenen , Biochem. Ztschr. 142: 246, 1923 31. Das Vorkommen, der Kreislauf und der Stoffwechsel des Jods , Ergebn. d. Physiol. 25:176, 1926. 32. Scheffer, L.: Ueber die Jodbilanz normaler Menschen , Biochem. Ztschr. 11:259, 1933 33. Jodstoffwechsel bei Schilddrüsenkranken , Klin. Wchnschr. 12:1285, 1933 34. Jodstoffwechsel bei Hyperthyreosen , Klin. Wchnschr. 13:1570, 1934. 35. Cole, V. V., and Curtis, G. M.: Human Iodine Balance , J. Nutrition 10: 493, 1935. 36. Zondek, H., and Reiter, I., quoted by Marine, D.: The Pathogenesis and Prevention of Simple and Endemic Goiter , J. A. M. A. 104:2334 ( (June 29) ) 1935. 37. Abelin, I.: Schilddrüse und Mineralstofwechsel: Einfluss des Dinatriumphosphats und der Calciumsalze auf die Wirkung der Schilddrüsensubstanzen , Biochem. Ztschr. 199:72, 1928. 38. Remington, R. E., and Levine, H.: Personal communication to the authors. 39. Bauer, W.; Albright, F., and Aub, J. C.: Studies of Calcium and Phosphorus Metabolism: II. The Calcium Excretion of Normal Individuals on a Low Calcium Diet , J. Clin. Investigation 7:75, 1929. 40. Lusk, G.: The Science of Nutrition , ed. 4, Philadelphia, W. B. Saunders Company, 1928. 41. Barker, L. F.; Hoskins, R. G., and Mosenthal, H. O.: Endocrinology and Metabolism , ed. 1, New York, D. Appleton & Co., 1922. 42. Stewart, C. P., and Percival, G. H.: Calcium Metabolism , Physiol. Rev. 8:283, 1928. 43. Sherman, H. C.: The Chemistry of Food and Nutrition , ed. 4, New York, The Macmillan Company, 1933. 44. Hansman and Wilson.8 45. Orr, J. B., and Leitch, I.: Iodine in Nutrition , Medical Research Council, Special Report Series, no. 123, London, His Majesty's Stationery Office, 1929. 46. Eggenberger, H., cited by Marine, D.: The Pathogenesis and Prevention of Simple or Endemic Goiter , J. A. M. A. 104:2334 ( (June 29) ) 1935. 47. McCrudden, F. H.: The Determination of Calcium in the Presence of Magnesium and Phosphates: The Determination of Calcium in Urine , J. Biol. Chem. 10:187, 1911-1912. 48. Van Slyke, D. D., and Sendroy, J., Jr.: Gasometric Determination of Oxalic Acid and Calcium, and Its Application to Serum Analysis , J. Biol. Chem. 84:217, 1929. 49. Shohl, A. T., and Pedley, F. G.: A Rapid and Accurate Method for Calcium in Urine , J. Biol. Chem. 50:537, 1922. 50. Stearns, G.: A Rapid Method for the Preparation of Fecal Digests Suitable for Use in Nitrogen and Mineral Analyses , J. Lab. & Clin. Med. 14:954, 1929. 51. Neumann, A.: Eine Veraschungsmethode (Säuregemisch-Veraschung) und vereinfachte Bestimmungen von Eisen, Phosphorsäure, Salzsäure und anderen Aschenbestandteilen unter Benutzung dieser Säuregemisch-Veraschung , Ztschr. f. physiol. Chem. 37:115, 1902.Crossref 52. Stearns.21b 53. The pyrex centrifuge tube is conical, with a capacity of 75 cc., and sufficiently narrow at the bottom (2 or 3 mm., inner diameter) to hold together the precipitate and permit none to escape when the fluid is decanted. It has a tip of thick glass. This tube may be purchased from the Kauffman-Lattimer Co., Columbus, Ohio. 54. Clark, E. P., and Collip, J. B.: A Study of the Tisdall Method for the Determination of Blood Serum Calcium with a Suggested Modification , J. Biol. Chem. 63:461, 1925. 55. Shohl, A. T.: The Effect of Hydrogen Ion Concentration upon the Determination of Calcium , J. Biol. Chem. 50:527, 1922. 56. King, E. J.: The Colorimetric Determination of Phosphorus , Biochem. J. 26:292, 1932. 57. Phillips, F. J., and Curtis, G. M.: Blood Iodine Studies: IV. The Clinical Determination of Iodine in Blood, Urine and Feces , Am. J. Clin. Path. 4:346, 1934. 58. Dr. Versa V. Cole gave permission for us to use these data. 59. McCullagh, D. R.: A New Method for the Determination of Iodine , J. Biol. Chem. 107:35, 1934. 60. Sherman, H. C.: Calcium Requirements of Maintenance in Man , J. Biol. Chem. 44:21, 1920. 61. Rose, M. S.: Experiments on the Utilization of the Calcium of Carrots by Man , J. Biol. Chem. 41:349, 1920. 62. Bogert, L. J., and Kirkpatrick, E. E.: Studies in Inorganic Metabolism: II. The Effects of Acid Forming and Base Forming Diets upon Calcium Metabolism , J. Biol. Chem. 54:375, 1922. 63. Sherman, H. C.; Wheeler, L., and Yates, A. B.: Experiments on the Nutritive Value of Maize Protein and on the Phosphorus and Calcium Requirements of Healthy Women , J. Biol. Chem. 34:383, 1918. 64. Sherman, H. C.; Gillett, L. H., and Pope, H. M.: Monthly Metabolism of Nitrogen, Phosphorus and Calcium in Healthy Women , J. Biol. Chem. 34: 373, 1918. 65. Sherman, H. C.; Winters, J. C., and Phillips, V.: Efficiency of Oat Protein in Adult Human Nutrition , J. Biol. Chem. 34:53, 1919. 66. Curtis, G. M.; Barron, L. E., and Matthews, N. L.: The Urinary Excretion of Iodine: II. The Loss of Iodine in the Urine Following Total Thyroidectomy in Man, to be published. 67. Plummer, W. A., and Dunlap, H. F.: Cases Showing Osteoporosis Due to Decalcification in Exophthalmic Goiter , Proc. Staff Meet., Mayo Clin. 3:119, 1928. 68. Pugsley, L. I., and Anderson, E.: The Effect of Desiccated Thyroid, Irradiated Ergosterol and Ammonium Chloride on the Excretion of Calcium in Rats , Biochem. J. 28:754, 1934. 69. Aub, Bauer, Heath and Ropes.1 70. Hansman and Wilson.8 71. Albright, Bauer and Aub.9 72. Tibbetts, McLean and Aub.10 73. Scheffer, L.: Ueber die Rolle des Jods bei der Entstehung von Schilddrüsenkrankheiten , Schweiz. med. Wchnschr. 64:969, 1934. 74. Scheffer.12c 75. Schittenhelm, A., and Eisler, B.: Der Jodstoffwechsel des Myxödematösen , Ztschr. f. d. ges. exper. Med. 80:589, 1932.Crossref 76. Curtis, Barron and Phillips.11i 77. Curtis, Barron and Matthews.31 78. Abelin, I.: Ueber die extrathyreoidale Entstehung thyroxinartig wirkender Jodverbindungen , Klin. Wchnschr. 13:940, 1934.Crossref 79. Greenbaum, E. R., and Raiziss, G. W.: The Elimination of Iodine After Oral or Intravenous Administration of Various Iodine Compounds in Single Massive Doses , J. Pharmacol. & Exper. Therap. 30:407, 1927. 80. Elmer, A. W.; Rychlik, W., and Scheps, M.: L'hyperthyroxinémie dans la thyréotoxicose , Compt. rend. Soc. de biol. 117:533, 1934. 81. Elmer, A. W., and Luczynski, Z.: Sur l'élimination par la bile de la thyroxine administrée par voie entérale , Compt. rend. Soc. de biol. 115:647, 1933 82. Sur la décomposition par le foie de la thyroxine injectée dans les veines , Elmer Compt. rend. Soc. de biol. 114:351, 1933. 83. Asimoff, G., and Estrin, E.: Ueber das Schicksal des Schilddrüsenhormons im Organismus hyperthyreoidisierter Tiere; der Charakter des Ausscheidung des Schilddrüsenhormons nach peroraler Einführung getrockneter Schilddrüse beim Hunde , Ztschr. f. d. ges. exper. Med. 76:380, 1931Crossref 84. Ueber das Schicksal des Schilddrüsenhormons im Organismus hyperthyreoidisierter Tiere; der Charakter der Ausscheidung des Schilddrüsenhormons nach Einführung von Thyroxin per os , Asimoff Ztschr. f. d. ges. exper. Med. 76:399, 1931.Crossref 85. Elmer, A. W.: Di-Iodotyrosine and Thyroid Function , Quart. J. Exper. Physiol. 24:95, 1934.

JOHNSTON, LELAND M.

doi: 10.1001/archinte.1936.00170160024002pmid: N/A

Abstract The purpose of this paper is to present an unusual and, as far as I know, unique infectious disease, which was characterized especially by a peculiar type of ulceration of the small intestine, from which a specific bacillus was isolated. This organism was capable of reproducing the disease and causing similar lesions in the monkey (Macacus rhesus). In addition to enteritis there were other specific lesions, such as cholecystitis, cholangeitis, pneumonitis, necrosis of the bone marrow and interstitial nephritis, all of which were reproduced in the monkey after the intravenous injection of the gram-negative bacillus isolated from the patient's bile and intestine. The clinical features of the case also were anomalous and presented many problems of diagnostic interest, as the following abstract will show. History. —Mrs. E. B., a 54 year old inhabitant of a small town in the middle of the state of Tennessee, was admitted to the Vanderbilt

SPIEGEL, ROSE

doi: 10.1001/archinte.1936.00170160039003pmid: N/A

Abstract In the sixty-five years since periarteritis nodosa was presented as a disease entity by Kussmaul and Maier, the accrued pathologic and clinical material has helped to clarify the conception of its symptomatology and pathogenesis. First considered solely as a medical curiosity, periarteritis nodosa now is known to be of significance in relation to certain other syndromes which, though more familiar, are none the less still obscure. In the classic case of Kussmaul and Maier1 the condition was at first considered clinically to be trichiniasis. These observers, therefore, regarded the diagnosis of periarteritis nodosa as possible if symptoms suggesting trichiniasis occurred in association with nephritis and enteritis and if biopsy of a muscle nodule showed pericapillary cellular infiltration but no trichinas. Since then, however, every discussion has emphasized the protean manifestations and the rarity of a correct diagnosis during life. P. S. Meyer (1878) suggested as the diagnostic formula of References 1. Kussmaul, A., and Maier, R.: Ueber eine bisher nicht beschriebene eigenthümliche Arterienerkrankung (Periarteritis nodosa), die mit Morbus Brightii und rapid fortschreitender allgemeiner Muskellähmung einhergeht , Deutsches Arch. f. klin. Med 1:484, 1866. 2. Harbitz, F.: Different Forms of Arteritis, Especially "Periarteritis Nodosa," Internat. Clin. 3:130, 1927. 3. Singer, H.: Periarteritis Nodosa, with Special Reference to the Acute Abdominal Manifestations: Report of Two Cases , Arch. Int. Med. 39:865 ( (June) ) 1927.Crossref 4. Manges, M., and Baehr, G.: Periarteritis Nodosa , Am. J. M. Sc. 162: 162 ( (Aug.) ) 1921.Crossref 5. Fishberg, A.: Zur Kenntnis der Periarteritis nodosa insbesondere der Histiopathogenese , Virchows Arch. f. path. Anat. 240:483, 1923.Crossref 6. Joest, E., and Harzer, J.: Ueber Periarteriitis nodosa beim Schwein , Beitr. z. path. Anat. u. z. allg. Path. 69:85, 1921. 7. Chvostek and Weichselbaum: Herdweise syphilitische Endarteritis mit Aneurysmenbildung , Allg. Wien. med. Ztg. 22:257, 275 and 294, 1877. 8. Schmorl, cited by Gruber;9 Verhandl. d. deutsch. path. Gesellsch. 6:203, 1903. 9. Gruber, G. B.: Zur Frage der Periarteriitis nodosa , Virchows Arch. f. path. Anat. 258:441, 1925.Crossref 10. Eppinger, cited by Gruber.9 11. Dietrich, K.: "Periarteritis Nodosa" der Haut des Vorderarmes nach Erysipelen derselben , Ztschr. f. Kreislaufforsch. 25:305, 1933. 12. Harris and Friedreich, cited by Gruber.9 13. Klotz, O.: Periarteritis Nodosa , J. M. Research 37:1, 1917. 14. Some of the necropsy material has been reported in other papers from the hospital in different connections (cases 1, 5, 6, 8, 10, 11 and 17). 15. Dr. Margot Freund gave permission for the use of these case reports. 16. Rothstein, J. L., and Welt, S.: Periarteritis Nodosa in Infancy and in Childhood , Am. J. Dis. Child. 45:1277 ( (June) ) 1933.Crossref 17. Thinnes, cited by Rothstein and Welt.16 18. Powell, R. E., and Pritchard, J. E.: Report of a Case of Periarteritis Nodosa Involving One Kidney , Brit. J. Urol. 4:317 ( (Dec.) ) 1932.Crossref 19. Jäger, E.: Zur histologischen Ausheilung der Periarteritis nodosa und deren Beziehung zur juvenilen Atherosclerose , Virchows Arch. f. path. Anat. 288: 833, 1933.Crossref 20. Master, A. M., and Jaffe, H.: Electrocardiographic Evidence of Cardiac Involvement in Acute Diseases , Proc. Soc. Exper. Biol. & Med. 31:931 ( (May) ) 1934. 21. Gross, L.: The Heart in Atypical Verrucous Endocarditis , in Contribution to the Medical Sciences in Honor of Dr. Emanuel Libman by His Pupils, Friends and Colleagues, New York, International Press, 1932, vol. 2, p. 527. 22. Mönckeberg, cited by Ceelen, W.: Die Kreislaufstörungen der Lunge , in Henke, F., and Lubarsch, O.: Handbuch der speziellen pathologischen Anatomie und Histologie , Berlin, Julius Springer, 1931, vol. 3, pt. 3, p. 33. 23. Herrman, W.: Pulmonary Changes in Case of Periarteritis Nodosa , Am. J. Roentgenol. 29:607 ( (May) ) 1933. 24. von Conta: Periarteritis nodosa der Lungengefässe und Lungenröntgenbild , Fortschr. a. d. Geb. d. Röntgenstrahlen 47:506, 1933. 25. Matillon, B.: La périartérite noueuse, Thèse de Paris, no. 460, 1928. 26. Ophüls, W.: Periarteritis Acuta Nodosa , Arch. Int. Med. 32:870 ( (Dec.) ) 1923. 27. Arkin, A.: A Clinical and Pathological Study of Periarteritis Nodosa , Am. J. Path. 6:401, 1930. 28. Otani, cited by Gruber.9 29. Versé: Periarteriitis nodosa und Arteriitis syphilitica cerebralis , Beitr. z. path. Anat. u. z. allg. Path. 40:409, 1907. 30. Gruber, G.: Ueber die Pathologie der Periarteritis nodosa , Zentralbl. f. Herz.-u. Gefässkr. 9:45 ( (April) ) 1917. 31. Kengyel: Centralbl. f. allg. Path. u. path. Anat. 53:137 ( (Dec.) ) 1930. 32. Plaut, A.: Proc. New York Path. Soc. 14:13 ( (Nov.) ) 1931. 33. Kountz, W. B.: Periarteritis Nodosa , Arch. Path. 10:55 ( (July) ) 1930. 34. Pass, I.: Infarction of the Liver , Am. J. Path. 11:503 ( (May) ) 1935. 35. Hampel, E.: Zwei ungewöhnliche Fälle von Periarteriitis nodosa , Ztschr. f. ges. Neurol. u. Psychiat. 146:355, 1933. 36. Bennett, G. A., and Levine, S. A.: Two Cases of Periarteritis Nodosa , Am. J. M. Sc. 177:853, 1929.Crossref 37. Vance, B. M., and Graham, J. E.: Periarteritis Nodosa Complicated by Fatal Intrapericardial Hemorrhage , Arch. Path. 12:521 ( (Oct.) ) 1931. 38. Bogaert, L.; Stolz, B., and Ley, R. A.: Sur une observation de périartérite noueuse a localisation neuro-cutanée , Ann. de méd. 31:530, 1932. 39. Alkiewicz, J.: Multiple nekrotisierende Periarteriitis nodosa der Haut , Arch. f. Dermat. u. Syph. 168:522, 1933.Crossref 40. Lindberg, K.: Ueber eine subkutane Form der Periarteriitis nodosa mit langwierigen Verlauf , Arb. a. d. path. Inst. d. Univ. Helsingfors 7:159, 1933. 41. Hutinel, J.; Coste, F., and Arnaudet, A.: Périartérite noueuse de Kussmaul . Bull. et mém. Soc. méd. d. hôp. de Paris 54:46 ( (Jan. 27) ) 1930. 42. Gray, cited by Rothstein and Welt.16 43. Goldstein, I., and Wexler, D.: The Ocular Pathology of Periarteritis Nodosa , Arch. Ophth. 2:288 ( (Sept.) ) 1929.Crossref 44. Krahulik, L.; Rosenthal, M., and Loughlin, E. H.: Periarteritis Nodosa in Childhood with Meningeal Involvement , Am. J. M. Sc. 190:308 ( (Sept.) ) 1935.Crossref 45. Helpern, M., and Trubek, M.: Necrotizing Arteritis and Subacute Glomerulonephritis in Gonococcic Endocarditis , Arch. Path. 15:35 ( (Jan.) ) 1933. 46. King, E. F.: Ocular Involvement in Periarteritis Nodosa , Tr. Ophth. Soc. U. Kingdom 55:246, 1935. 47. Friedenwald, J. S., and Rones, B.: Ocular Lesions in Septicemia , Arch. Ophth. 5:175 ( (Feb.) ) 1931.Crossref 48. Lamb, A. R.: Periarteritis Nodosa: A Clinical Pathological Review of the Disease , Arch. Int. Med. 14:481 ( (Oct.) ) 1914.Crossref 49. Middleton, W. S., and McCarter, J. C.: Diagnosis of Periarteritis Nodosa , Am. J. M. Sc. 190:291 ( (Sept.) ) 1935.Crossref 50. Strong, G. F.: Periarteritis Nodosa , Canad. M. A. J. 19:534, 1928. 51. Erlandsson, S.: Neurologische Krankheitsbilder bei Periarteriitis nodosa , Acta psychiat. et neurol. 6:369, 1931.Crossref 52. Carling, E. R., and Hicks, J. A. B.: Periarteritis Nodosa, Accidently Recognized During Life , Lancet 1:1001, 1923.Crossref 53. Benedict, H.: Ueber Periarteriitis nodosa , Ztschr. f. klin. Med. 64:405, 1907. 54. Von Haun, F.: Pathologische-histologische und experimentelle Untersuchungen über Periarteriitis nodosa , Virchows Arch. f. path. Anat. 227:90, 1920.Crossref 55. Schottstaedt, W.: Case of Periarteritis Nodosa with Remission of Symptoms , California & West. Med. 36:186, 1932. 56. Christian, H.: Visceral Disturbances in Patients with Cutaneous Lesions of the Erythema Group , J. A. M. A. 69:325 ( (Aug. 4) ) 1917. 57. Trimble, I. R.: Erythematous Group of Skin Diseases with Especial Reference to Abdominal Pain , J. A. M. A. 96:2010 ( (June 13) ) 1931. 58. Osler, W.: Purpura with Visceral Lesions , Brit. M. J. 1:517, 1914. 59. Osier, W.: On the Visceral Manifestations of the Erythema Group of Skin Diseases , Am. J. M. Sc. 127:1 ( (Jan.) ) 1904. 60. Pratt, J. H.: Purpura and Hemophilia , in Osier, W., and McCrae, T.: Modern Medicine , Philadelphia, Lea & Febiger, 1927, vol. 5, chap. 3, p. 117. 61. Morawitz, P., and Denecke, G.: Blut und Blutkrankheiten , in von Bergmann, G., and Staehelin, R.: Handbuch der inneren Medizin , Berlin, Julius Springer, 1926, vol. 2, p. 262. 62. Glanzmann, E.: Beiträge zur Kenntnis der Purpura im Kindesalter , Jahrb. f. Kinderh. 83:271 and 379, 1916. 63. Goldstein, E.: Schönlein-Henoch's Purpura , M. Clin. North America 12:869 ( (Nov.) ) 1928. 64. Moolten, Sylvan: Personal communication to the author. 65. Sigmund, H.: Gefässveränderungen bei chronische streptokokken Sepsis , Centralbl. f. allg. Path. u. path. Anat. 35:276, 1924. 66. Friedberg, C. K., and Gross, L.: Periarteritis Nodosa (Necrotizing Arteritis) Associated with Rheumatic Heart Disease , Arch. Int. Med. 54:170 ( (Aug.) ) 1934. 67. Schloss, O.: Association of Rheumatic Fever and the Erythema Group of Skin Diseases , Am. J. M. Sc. 140:226, 1910. 68. Coburn, A.: Factor of Infection in the Rheumatic State , Baltimore, Williams & Wilkins Company, 1931. 69. Jacobsen, V. C.: Periarteritis Nodosa , with Report of Two Cases Associated with Clinical Syphilis, in Medical Papers Dedicated to Henry Asbury Christian, Baltimore, The Waverly Press, Inc., 1936, p. 820. 70. Harbitz, F.: Unknown Forms of Arteritis with Special Reference to Their Relation to Syphilitic Arteritis and Periarteritis Nodosa , Am. J. M. Sc. 163:250 ( (Feb.) ) 1922. 71. Derick, C. L., and Hass, G. M.: Diffuse Arteritis of Syphilitic Origin , Am. J. Path. 11:291 ( (March) ) 1935. 72. Gerber, cited by Baehr, Klemperer and Schifrin.73 73. Cohen, M. B.; Kline, B. S., and Young, A. M.: The Clinical Diagnosis of Periarteritis Nodosa , J. A. M. A. 107:1555 [ (Nov. 7) ] 1936 74. Fishberg, A. M.: Hypertension and Nephritis , Philadelphia, Lea & Febiger, 1931, p. 355. 75. Baehr, G.: Glomerular Lesions of Subacute Bacterial Endocarditis , Am. J. M. Sc. 44:327, 1912. 76. Richet, C., and Dublineau, J.: Le purpura rhumatöide de nature anaphylactique , J. méd. franç. 19:182 ( (May) ) 1930. 77. Damblé, K.: Beitrag zur Pathologie der Periarteriitis nodosa , Beitr. z. path. Anat. u. z. allg. Path. 85:619, 1930. 78. Baehr, G.; Klemperer, P., and Schifrin, A.: A Diffuse Disease of the Peripheral Circulation (Usually Associated with Lupus Erythematosus and Endocarditis) , Tr. A. Am. Physicians 50:139, 1935. 79. Keegan, J. J.: Primary Vascular Nephritis or Renal Periarteritis Nodosa , Arch. Int. Med. 36:189 ( (Aug.) ) 1925.Crossref 80. Fahr, cited by Gruber.9

GOLDSMITH, GRACE

doi: 10.1001/archinte.1936.00170160087004pmid: N/A

Abstract Determinations of the cardiac output have not often been made in cases of polycythaemia vera. Early workers, who used unreliable methods, reported no marked deviation from normal. In 1925 Liljestrand and Stenström1 found that the cardiac output was 10 per cent below normal in one case; the patient had a low basal metabolic rate (85 per cent of normal). The concentration of hemoglobin was 135 per cent, and the erythrocytes numbered 6,800,000 per cubic millimeter of blood. There was no enlargement of the spleen. The blood volume apparently was not determined. Ernst2 in 1930 reported a cardiac output 10 per cent above normal in a case in which there was a 10 to 15 per cent increase in the basal metabolic rate. A diagnosis of polycythaemia vera was not warranted in this case, as the total blood volume, instead of being increased, was low, only 70 cc. per References 1. Liljestrand, G., and Stenström, N.: Clinical Studies on the Work of the Heart During Rest: II. The Influence of Variations in the Haemoglobin Content on the Blood Flow , Acta med. Scandinav. 63:130-131, 1925.Crossref 2. Ernst, Curt: Beitrag zur Frage des Kreislaufes bei der Polycythaemia vera , Ztschr. f. klin. Med. 114:757-764, 1930. 3. Grollman, Arthur: The Cardiac Output of Man in Health and Disease , Springfield, Ill., Charles C. Thomas, Publisher, 1932. 4. Grollman, Arthur: Solubility of Gases in Blood and Blood Fluids , J. Biol. Chem. 82:317-325 ( (May) ) 1929. 5. Boothby, W. M., and Rynearson, E. H.: Increase in Circulation Rate Produced by Exophthalmic Goiter, Compared with That Produced in Normal Subjects by Work , Arch. Int. Med. 55:547-557 ( (April) ) 1935.Crossref 6. Gregg, D. E., and Wiggers, C. J.: The Circulatory Effects of Acute Experimental Hypervolemia , Am. J. Physiol. 104:423-432 ( (May) ) 1933.

KLUMPP, THEODORE G.;EVANS, THEODORE S.

doi: 10.1001/archinte.1936.00170160094005pmid: N/A

Abstract In 1913 Reschad and Schilling-Torgau1 reported the first case of monocytic leukemia. Two years later the second case was described by Fleischmann.2 In 1930 Dameshek3 reviewed the literature and found only ten acceptable case reports. Clough4 in 1932 brought the number up to twenty-three. On a subsequent examination of the literature a total of seventyseven reports of well established cases were found. Of these four had not been available to previous reviewers, and seventy-three have appeared since Clough's report. The addition of eight cases which have come under our observation and which are herein presented brings the total number of acceptable cases described to eighty-five. In addition to these, approximately twenty-five case reports have been rejected because of insufficient or unconvincing data. Monocytic leukemia has always been regarded as an exceedingly rare disease. However, the many case reports which have been published since interest in the References 1. Reschad, H., and Schilling-Torgau, V.: Ueber eine neue Leukämie durch echte Uebergangsformen (Splenozytenleukämie) und ihre Bedeutung für die Selbständigkeite dieser Zellen , München. Wchnschr. 60:1981 ( (Sept. 9) ) 1913. 2. Fleischmann, P.: Der zweite Fall von Monozytenleukämie , Folia haemat. 20:19 ( (Oct. 1) ) 1915. 3. Dameshek, W.: Acute Monocytic (Histiocytic) Leukemia , Arch. Int. Med. 46:718 ( (Oct.) ) 1930.Crossref 4. Clough, P. W.: Monocytic Leukemia , Bull. Johns Hopikins Hosp. 51:148 ( (Sept.) ) 1932. 5. Levine, V.: Monocytic Leukemia , Folia haemat. 52:305 ( (Sept.) ) 1934. 6. Doan, C. A., and Wiseman, B. K.: The Monocyte, Monocytosis and Monocytic Leukosis: A Clinical and Pathological Study , Ann. Int. Med. 8:383 ( (Oct.) ) 1934.Crossref 7. Dameshek.3 8. Clough.4 9. Weissenbach, R. J.; Bourdillon, C.; Martineau, J., and David, J.: Leucémie aiguë à monocytes , Sang 7:371, 1933. 10. Fowler, W. M.: Monocytic Leukemia , J. Lab. & Clin. Med. 18:1260 ( (Sept.) ) 1933.

SOLLMANN, TORALD;SCHREIBER, NORA E.

doi: 10.1001/archinte.1936.00170160113006pmid: N/A

Abstract An increase in the flow of urine is produced by suitable doses of any of the mercurial compounds that have been studied with this in mind, but for therapeutic use certain organic compounds are employed almost exclusively at present, largely in order to avoid other actions of mercury, which are practically inevitable with the inorganic mercurials. That the diuretic potency of the organic compounds is superior is probably often assumed, but without adequate evidence. The few quantitative clinical data are very inadequate, and quantitative comparisons on animals also are scanty, as may be seen from the review by Fourneau and Melville1 (1931). These investigators confirmed with intravenous injections into rabbits the diuretic effect for all the inorganic and organic compounds of mercury which they tried, except colloidal suspensions, with quantitative differences that appeared related to the chemical constitution. Data on animals, however, cannot be transferred quantitatively to the clinic References 1. Fourneau, E., and Melville, K. I.: Studies in Mercurial Chemotherapy: Concerning Mercurial Toxicity, Its Evaluation, Mechanism, and Relation to Chemical Constitution , J. Pharmacol. & Exper. Therap. 41:21 ( (Jan.) ) 1931 2. Studies in Mercurial Chemotherapy: Quantitative Evaluation of Mercurial Diuresis and Its Relation to Chemical Constitution , Fourneau J. Pharmacol. & Exper. Therap. 41:47 ( (Jan.) ) 1931. 3. Sollmann, Torald, and Schreiber, Nora E.: The Diuretic Effects of Various Mercurial Treatments , Am. J. Physiol. 93:689 ( (June) ) 1930. 4. Sollmann, Torald; Schreiber, Nora E., and Cole, H. N.: Excretion of Mercury After Clinical Intramuscular and Intravenous Injections , Arch. Dermat. & Syph. 32:1 ( (July) ) 1935. 5. Mercurosal has not been accepted by the Council on Pharmacy and Chemistry of the American Medical Association. 6. This term is used rather loosely in the sense that the compounds yield reacting mercuric ions. 7. Bichloridol has not been accepted by the Council on Pharmacy and Chemistry of the American Medical Association. 8. Mercodel has not been accepted by the Council on Pharmacy and Chemistry of the American Medical Association. 9. Mersulfol has not been accepted by the Council on Pharmacy and Chemistry of the American Medical Association.

POLL, DANIEL;STERN, J. EDWARD

doi: 10.1001/archinte.1936.00170160133007pmid: N/A

Abstract The syndrome to be discussed in this paper is seen in connection with diuresis and is characterized by preliminary symptoms of weakness, restlessness and mental confusion (sometimes progressing to delirium and psychosis), which may be followed by apathy, coma and in some cases death. The turgor of the tissues may become poor, the tongue exceedingly dry and thirst extreme. In some instances the premonitory symptoms of restlessness and confusion do not appear, the syndrome being ushered in by apathy. Simple though profound weakness often follows marked diuresis, and when it occurs alone, it is not to be considered as an alarming or serious symptom. It is the mildest expression of this clinical picture but is not significant because the organism automatically reestablishes its equilibrium after a longer or shorter time. Any or all of these phenomena may appear concomitantly with complications inherent in the underlying disease process or in association References 1. Eichhorst, H.: Toxämische Delirien bei Herzkranken , Deutsche med. Wchnschr. 24:389 ( (June 23) ) 1898.Crossref 2. Sprague, H. B., and Graybiel, A.: Salyrgan as a Diuretic: Report of Sixty Cases , New England J. Med. 204:154 ( (Jan. 22) ) 1931.Crossref 3. Srnetz, K.: Vorsicht mit Salyrgan bei schwerer Herzschwäche , München. med. Wchnschr. 81:1891 ( (Dec. 6) ) 1934. 4. Blumgart, H. L.; Gilligan, D. R.; Levy, R. C.; Brown, M. G., and Volk, M. C.: Action of Diuretic Drugs , Arch. Int. Med. 54:40 ( (July) ) 1934.Crossref 5. Loeb, R. F.; Atchley, D. W., and Stahl, J.: The Rôle of Sodium in Adrenal Insufficiency , J. A. M. A. 104:2149 [ (June 15) ] 1935Crossref 6. Talbott, J. H.: Heat Cramps , Medicine 14:323 [ (Sept.) ] 1935Crossref 7. Chabanier, H.; Lebert, M., and Lumière, F.: Analyse physiologique de l'action du 440-B (ou neptal) , Bull. Soc. franç. d'urol. 6:259 ( (Dec. 19) ) 1927. 8. Keith, N. M.; Barrier, C. W., and Whelan, M.: The Diuretic Action of Ammonium Chloride and Novasurol in Cases of Nephritis with Edema , J. A. M. A. 85:799 ( (Sept. 12) ) 1925.Crossref 9. Blumgart and others.4 The presence of edema is no assurance that the patient is not suffering from salt and water deprivation. He may complain of great thirst and present poor turgor of the tissues over the upper half of the body. The mechanism of this clinical fact is a moot point. 10. Fourneau, E., and Melville, K. I.: Studies in Mercurial Chemotherapy: I. Concerning Mercurial Toxicity; Its Evaluation, Mechanism, and Relation to Chemical Constitution , J. Pharmacol. & Exper. Therap. 41:21, 1931. 11. Gunsberg, H.: Diureseversuche , Arch. f. exper. Path. u. Pharmakol. 69: 381, 1912. 12. Treatment of Cardiac Decompensation, Queries and Minor Notes , J. A. M. A. 103:858 ( (Sept. 15) ) 1934. 13. Fishberg, A. M.: Hypertension and Nephritis , ed. 3, Philadelphia, Lea & Febiger, 1934. 14. Brown, G. E.; Eusterman, G. B.; Hartman, H. R., and Rowntree, L. G.: Toxic Nephritis in Pyloric and Duodenal Obstruction: Renal Insufficiency Complicating Gastric Tetany , Arch. Int. Med. 32:425 [ (Sept.) ] 1923. 15. Zeman, F. D.; Friedman, W., and Mann, L. T.: Kidney Changes in Pyloric Obstruction , Proc. Soc. Exper. Biol. & Med. 21:179, 1923 16. Lande, H.: Uncontrollable Causes of Death in Diabetic Coma , J. A. M. A. 101:9 [ (July 1) ] 1933 17. Saxl, P.: Letale Quecksilberintoxikation nach einmaliger Novasurol Injektion , Wien. klin. Wchnschr. 16:437, 1925. 18. Talbott, J. H.: Heat Cramps , Medicine 14:323 ( (Sept.) ) 1935. 19. The various mercurial diuretics mentioned in these case reports were supplied in the form of approximately 10 to 13.5 per cent aqueous solutions.

WELCH, C. STUART;WAKEFIELD, ELMER G.;ADAMS, MILDRED

doi: 10.1001/archinte.1936.00170160141008pmid: N/A

Abstract The object of this study was to determine the function of the large intestine as an excretory organ and to consider its probable rôle in absorption under normal conditions. The opportunity for such a study was presented by a young woman who had been subjected to a single barrel permanent ileostomy which had left an isolated large intestine. At operation the ileum, which had been severed close to the ileocecal junction, had been brought out through the abdominal wall. Hereditary polyposis of the colon had constituted the indication for this operation, which had been performed as a preliminary measure to colectomy. This procedure permitted the collection of the excreta of the small intestine, and the products of the isolated colon could be recovered at the same time. In this manner it was possible to determine the composition of the intestinal material that normally is delivered to the large intestine and, References 1. Starling, E. H.: Principles of Human Physiology , ed. 6, Philadelphia, Lea & Febiger, 1933, pp. 1 and 136. 2. Peters, J. P., and Van Slyke, D. D.: Quantitative Clinical Chemistry , Baltimore, Williams & Wilkins Company, 1932, vol. 2, p. 829. 3. Saxon, G. J.: A Method for the Determination of the Total Fats of Undried Feces and Other Moist Masses , J. Biol. Chem. 17:99-102, 1914. 4. Shaffer, P. A., and Somogyi, Michael: Copper-Iodometric Reagents for Sugar Determination , J. Biol. Chem. 100:695713 ( (May) ) 1933. 5. Fiske, C. H., and Subbarow, Y.: The Colorimetric Determination of Phosphorus , J. Biol. Chem. 66:375-400 ( (Dec.) ) 1925. 6. Tisdall, F. F., and Kramer, Benjamin: Methods for the Direct Quantitative Determination of Sodium, Potassium, Calcium, and Magnesium in Urine and Stools , J. Biol. Chem. 48:1-12 ( (Sept.) ) 1921. 7. Butler, A. M., and Tuthill, Elizabeth: An Application of the Urynal Zinc Acetate Method for Determination of Sodium in Biological Material , J. Biol. Chem. 93:171-180 ( (Sept.) ) 1931. 8. Barber, H. H., and Kolthoff, I. M.: A Specific Reagent for the Rapid Gravimetric Determination of Sodium , J. Am. Chem. Soc. 50:1625-1631 ( (June) ) 1928.Crossref 9. Klumpp, T. G.: The Determination of Iron in Biological Materials , J. Biol. Chem. 107:213-223 ( (Oct.) ) 1934. 10. Hawk, P. B., and Bergeim, Olaf: Practical Physiological Chemistry , ed. 10, Philadelphia, P. Blakiston's Sons & Co., 1931, p. 355. 11. Peters, J. P., and Van Slyke, D. D.: Quantitative Clinical Chemistry . Baltimore, Williams & Wilkins Company, 1931, vol. 1, p. 766. 12. Holt, L. E.; Courtney, Angelia M., and Fales, Helen L.: The Chemical Composition of Diarrheal as Compared with Normal Stools in Infants , Am. J. Dis. Child. 9:213-224 ( (March) ) 1915. 13. Peters, J. P.: The Distribution and Movement of Water and Solutes in the Human Body , Yale J. Biol. Med. 5:431-467 ( (May) ) 1933. 14. Steele, J. D.: The Method of Determining the Total Amount of the Fecal Bacteria by Weight and Its Clinical Significance , J. A. M. A. 49:647-649 ( (Aug. 24) ) 1907.Crossref 15. DeBeer, E. J.; Johnston, C. G., and Wilson, D. W.: The Composition of Intestinal Secretions , J. Biol. Chem. 108:113-120 ( (Jan.) ) 1935. 16. Bauer, W.; Albright, F., and Aub, J. G.: Studies of Calcium and Phosphorus Metabolism: Calcium Excretion of Normal Individuals on Low Calcium Diet; Also Data on Case of Pregnancy , J. Clin. Investigation 7:75-96 ( (April) ) 1929.Crossref 17. Gottlieb, R.: Beiträge zur Kenntnis der Eisenausscheidung durch den Harn , Arch. f. exper. Path. u. Pharmakol. 26:139-146, 1890.Crossref 18. Taylor, A. E.: Digestion and Metabolism: The Physiological and Pathological Chemistry of Nutrition , Philadelphia, Lea & Febiger, 1912, pp. 212 and 215. 19. Canavero, M.: Studio dell'assorbimento dei grassie delle sostanze proteiche dopo la colectomia (ricerche sperimentali) , Policlinico (sez. chir.) 40:629-641 ( (Nov.) ) 1933. 20. Heile, B.: Experimentelle Beobachtungen über die Resorption im Dünn- und Dickdarm , Mitt. a. d. Grenzgeb. d. Med. u. Chir. 14:474-486, 1905. 21. Landt, H., and Daum, K.: Physical Characteristics of Residues from the Small Intestine , Arch. Int. Med. 52:96-104 ( (July) ) 1933.Crossref 22. Lehmann, Curt; Mueller, Friedrich; Muck, Immanuel; Senator, H., and Zuntz, N.: Untersuchungen an zwei hungernden Menschen , Virchows Arch. f. path. Anat. ( (supp.) ) 131:107, 1893.Crossref 23. Hunter, Donald: Critical Review: The Metabolism of Calcium and Phosphorus and the Parathyroids in Health and Disease , Quart. J. Med. 24:393-446 ( (April) ) 1931.Crossref 24. Walsh, E. L., and Ivy, A. C.: Calcium Excretion by the Alimentary Tract , Proc. Soc. Exper. Biol. & Med. 25:839-840, 1928. 25. Stewart, C. P., and Percival, G. H.: Studies on Calcium Metabolism: I. The Action of the Parathyroid Hormone on the Calcium Content of the Serum and on the Absorption and Excretion of Calcium , Biochem. J. 21:301-313, 1927. 26. Taylor, N. B., and Fine, A.: The Excretion of Calcium Through the Intestine , Am. J. Physiol. 93:544-553 ( (June) ) 1930. 27. Mann, F. C., and Bollmann, J. L.: The Reaction of the Content of the Gastro-Intestinal Tract , J. A. M. A. 95:1722-1724 ( (Dec. 6) ) 1930.Crossref 28. Heupke, W.: Ueber die Sekretion und Excretion des Dickdarmes , Ztschr. f. d. ges. exper. Med. 75:83-125, 1931.Crossref 29. Robscheit-Robbins, F. S.: The Regeneration of Hemoglobin and Erythrocytes , Physiol. Rev. 9:666-709 ( (Oct.) ) 1929. 30. Bidder, F., and Schmidt, C.: Die Verdauungssäfte und der Stoffwechsel: Eine physiologisch-chemische Untersuchung , Leipzig, G. A. Reyher, 1852. 31. Gottlieb, R.: Ueber die Ausscheidungsverhältnisse des Eisens , Ztschr. f. physiol. Chem. 15:371-386, 1891. 32. Hochhaus, H., and Quincke, H.: Ueber Eisen-Resorption und Ausscheidung im Darmkanal , Arch. f. exper. Path. u. Pharmakol. 37:159-182, 1896.Crossref 33. Meyer, Erich: Ueber die Resorption und Ausscheidung des Eisens , Ergebn. d. Physiol. 5:698-745, 1906.Crossref 34. Kobert, R., and Koch, W.: Einiges über die Functionen des menschlichen Dickdarmes , Deutsche med. Wchnschr. 47:883-886 ( (Nov. 22) ) 1894.Crossref 35. Chevalier, Paul: Recherches sur l'élimination intestinale du fer , Arch. de méd. expér. et d'anat. path. 26:277-305 ( (May) ) 1914. 36. M'Gowan, J. P.: The Absorption and Excretion of Iron by the Intestines and the Nutritional and Therapeutic Value of Its Salts , Edinburgh M. J. 37: 85-96 ( (Feb.) ) 1930.

COBB, STANLEY

doi: 10.1001/archinte.1936.00170160157009pmid: N/A

Abstract HEREDITY The inheritance of nervous diseases has long been a question which has attracted interest. The fear of inheriting epilepsy or insanity still haunts many persons unnecessarily. Fortunately, scientific investigation is beginning to clarify the problem, and recent political events, such as the Nazi drive for "race purity," have made the problem a timely issue. Since May 1934 a committee of the American Neurological Association has been at work evaluating available data, and a preliminary report on sterilization has been made to the association. The chairman, Dr. Abraham Myerson, has had wide experience in this field and has been assisted by a professional geneticist, Dr. Keeler, and three neurologists, Drs. Ayer, Putnam and Alexander. The report1 makes a pamphlet of one hundred and thirty-two pages and is full of important data, references and good sense.Of course there is no doubt about the inheritance of certain neurologic disorders, such References 1. Report of the Committee for the Investigation of Sterilization , American Neurological Association, Boston, 1935. 2. Stein, C.: Am. J. Psychiat. 12:989, 1933. 3. Lennox, W. G., in Nelson Loose-Leaf Living Medicine , New York, Thomas Nelson & Sons, 1933, vol. 6, chap. 31 . 4. Rosanoff, A. J.; Handy, L. M., and Plesset, I. R.: Am. J. Psychiat. 91:725, 1935. 5. White, W. A.: Twentieth Century Psychiatry , New York, W. W. Norton & Company, Inc., 1936. 6. Meyer, A., quoted by Muncie, W., and White, P.: The Mood-Content Problem and Thymonoic Reactions , Arch. Neurol. & Psychiat. , to be published. 7. Lewis, N. D. C.: Research in Dementia Praecox , New York, National Committee for Mental Hygiene, 1936. 8. Jung, C. G.: Modern Man in Search of a Soul , New York, Harcourt, Brace and Company, Inc., 1934. 9. Hoffmann, H.: Familienpsychosen im schizophrenen Erbkreis , Berlin, S. Karger, 1926. 10. Elvidge: Tr. Am. Neurol. A. , to be published. 11. Whitehorn, J. C., and Richter, H.: The Unsteadiness of the Heart Rate in Psychotic and Neurotic States , Arch. Neurol. & Psychiat. , to be published. 12. Gildea, E. F.; Mailhouse, V. L., and Morris, D. P.: Am. J. Psychiat. 92:115, 1935. 13. Hoskins, cited by Lewis,7 chap. 4. 14. Campbell, C. M.: Destiny and Disease in Mental Disorders , New York, W. W. Norton & Company, Inc., 1935. 15. Skalweit, W.: Fortschr. d. Neurol., Psychiat. 8:256, 1936. 16. Benedek, L.: Insulin-Schock-Wirkung auf die Wahrnehmung , Berlin, S. Karger, 1935. 17. Diethelm, O.: Influence of Emotions on Dextrose Tolerance , Arch. Neurol. & Psychiat. 36:342 ( (Aug.) ) 1936. 18. Gildea, E. F.; Kahn, E., and Man, E. B.: Am. J. Psychiat. 92:1247, 1936. 19. Ranson, S. W.; Kabat, H., and Magoun, H. W.: Autonomic Responses to Electrical Stimulation of Hypothalamus, Preoptic Region and Septum , Arch. Neurol. & Psychiat. 33:467 ( (March) ) 1935. 20. Ingram, W. R.; Hannet, F. I., and Ranson, S. W.: J. Comp. Neurol. 55:333, 1932. 21. Kabat, H.; Magoun, H. W., and Ranson, S. W.: Electrical Stimulation of Points in the Forebrain and Midbrain: The Resultant Alterations in Blood Pressure , Arch. Neurol. & Psychiat. 34:931 ( (Nov.) ) 1935. 22. Lhermitte, J.: Rev. neurol. 1:809, 1934. 23. Kennard, M. A.: Vasomotor Disturbances Resulting from Cortical Lesions , Arch. Neurol. & Psychiat. 33:537 ( (March) ) 1935. 24. Ellis, L. B., and Weiss, S.: Vasomotor Disturbance and Edema Associated with Cerebral Hemiplegia , Arch. Neurol. & Psychiat. 36:362 ( (Aug.) ) 1936. 25. Ross, T. A.: An Enquiry into Prognosis in the Neuroses , London, Cambridge University Press, 1936. 26. Freud, S.: Autobiography , translated by J. Strachey, ed. 2, New York, W. W. Norton & Company, Inc., 1935. 27. Mann, T.: Life and Letters Today 15:80, 1936.

doi: 10.1001/archinte.1936.00170160170012pmid: N/A

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract This book is a reprint of an article in Acta Medica Scandinavica, written by Dr. Anton Jervell, first assistant in Professor Müller's clinic in Oslo. Electrocardiographic-minded physicians will appreciate it. In brief, Jervell describes the electrocardiographic findings which he observed in a series of sixty-five patients with coronary thrombosis, thirty-six of whom were followed up to section. The book is attractively arranged; the reports of the cases are short and to the point, and the illustrations, which comprise tracings and diagrams of the heart, are admirably clear. A bibliography of two hundred and seventy-two references to the recent literature on coronary thrombosis concludes the volume. On the whole, this monograph represents excellent workmanship and is an admirable contribution to the subject of cardiovascular disease.