Archives of Internal Medicine

EMERSON, HAVEN

doi: 10.1001/archinte.1911.00060040002001pmid: N/A

Abstract The presence of the tubercle bacillus, a local injury of tissue and diminished bodily resistance are accepted as a necessary trio of conditions which determine tuberculous infection. Clinicians for many centuries have recognized the third factor as important, while the first two have been accepted only in the present age of exact pathology. It is the hope of the modern student so to analyze the elusive complex of bodily or general resistance as to put preventive medicine, as applied to the individual, on a sound basis. One method of attacking this problem is to determine the functional changes which accompany or facilitate infection. In tuberculosis, the functions of the special tissue affected, of nutrition and of the circulation suffer chiefly. Of these three the local repair and correction of the error in nutrition are so dependent on efficient circulation that study of the functional errors of the cardiovascular system References 1. Arloing and Guinard: Cong. p. l'étude de la tuberc. chez l'homme et chez les animaux, 1898, 4th Session, p. 707. 2. Arloing, Rhodet and Courmont: Compt. rend. Cong. de la Tuberc., Paris , 1892, p. 32. 3. Auclair: Thèse, Paris, 1897. 4. Barach, J. H.: Physiological and Pathological Effects of Severe Exertion (the Marathon Race) on the Circulatory and Renal System , The Archives Int. Med. , 1910, v, 382.Crossref 5. Barbary, F.: Cong. internat. de la tuberc. , 1906, i, 566. 6. Battistessa, P.: Gaz. med. ital. , 1907, lviii, 91, 101. 7. Bauer, F.: Ztschr. f. klin. Med. , 1907, lvii, 368. 8. Bosc, M. F. J., and Vedel, M.: Cong. franç. de méd. , 1904, vii, i, 208, 337. 9. Boschi, G.: Gaz. d. osp. e d. clin. , 1906, xxvii, 1545. 10. Bouchard: Compt. rend. Acad. d. sc., Paris , 1888, cvi, 1582; 11. 1891, cxiii, 524. 12. Bouchard and Balthazard: Rev. de la tuberc. , 1903, x, i; 13. Cong. Internat. de la tuberc. , i, 550. 14. Brown, L.: Am. Jour. Med. Sc. Phila. , 1908, cxxxvi, 819.Crossref 15. Burckhardt: Ztschr. f. Tuberk. , 1906, viii, 459; 16. Deutsch. Arch. f. klin. Med. , 1901, lxx, 236. 17. Cazes, F.: These, Paris, 1889-1890, No. 236, Chap. V, p. 56. 18. Charrin and Le Noir: Compt. rend. Soc. de biol., Paris , (July 22) , 1893, series 9, 769. 19. Chon. H.: Thèse, Lyon, 1904-05, No. 32. 20. Crampton, C. W.: Med. News , 1905, lxxxviii, 529. 21. Fagart: Thèse, Paris, 1906, No. 141. 22. Faisans: Semaine méd., Paris , 1898, xviii, 305. 23. Fourmeaux: Cong. internat. de la tuberc. , 1906, i, 564. 24. Galecki: Beitr. z. Klin. d. Tuberk. , 1905-06, iv, 269.Crossref 25. Geisbock: Cong. f. inn. Med. , 1904, xxi, 97. 26. Gibson, A. M.: Tr. Am. Climat. Assn. , 1906, xxii, 96. 27. Grancher: Semaine méd. , 1890, x, 315. 28. Grosset, M.: Rev. de la tuberc. , 1905, series 2, ii, 243. 29. Henderson, Y.: Am. Jour. Physiol. 1906, xvi, 325. 30. Hensen: Deutsch. Arch. f. klin. Med. , 1900, lxvii, 436. 31. Homolle: Rev. de méd. , 1881, i, 252. 32. Igersheimer: Inaug. Diss. Tübingen, 1904. 33. John, M.: Ztschr. f. diät. u. physik. Therap. , 1902, v, 275. 34. Krehl, L.: Pathologische Physiologie , 1904, p. 77. 35. Lamy, H.: Tribune med. , 1904, new series, ii, 725. 36. Ledoux, S. A.: Thèse, Paris, 1902, No. 128. 37. Levy, L.: Beit. z. Klin. d. Tuberk. , 1905, iv, 99. 38. Maragliano, G.: Presse méd. , 1896, iv, 273. 39. Marfan, A. B.: Rev. d. méd. , 1907, xxvii, 1005. 40. Mathes: Thèse, Paris, 1905. 41. Naumann, H.: Ztschr. f. Tuberk. , 1903, v, 118. 42. New, M.: Inaug. Diss., Heidelberg, 1902. 43. Norris, G. W.: Ztschr. f. Tuberk. , 1905, vii, 295. 44. Papillon: Thèse, Paris, 1898. 45. Potain: La pression arterielle de l'homme à l'état normal et pathologique , Paris, 1902, Masson. 46. Pottenger, F. M.: The Effect of Tuberculosis on the Heart , The Archives Int. Med. , 1909, iv, 306.Crossref 47. Regnault: Thèse, Paris, 1898. 48. Reitter: Ztschr. f. klin. Med. , 1907, lxii, 358. 49. Reynaud, G.: Thèse, Paris, 1901. 50. Strandgaard, N. J.: Hosp.-Tid. , 1907, xv, 1041. 51. Schneider, H.: Deutsch. Aerzte-Ztg. , 1904, xxiii, 533. 52. Teissier, P.: Cong. Internat. de la Tuberc. , 1906, i, 554. 53. Tileston, W.: Passive Hyperemia of the Lungs and Tuberculosis , Jour. Am. Med. Assn. , 1908, L, 1179.Crossref 54. Turban, K.: Diagnosis of Tuberculosis of the Lungs , N. Y., 1906, Wm. Wood & Co. 55. Vialard, M. F.: Bull. gén. d. therapeutique , 1903, cxlv, 277.

HELMHOLZ, HENRY F.

doi: 10.1001/archinte.1911.00060040029002pmid: N/A

Abstract The recent publications of Meyer,1 Schloss,2 Friberger,3 and others have brought non-bacterial fevers again into the foreground. Numerous articles have appeared from the clinic of Finkelstein, which have shown that sugar and various salts given hypodermically or by mouth produce fever in young infants suffering from the acute gastro-intestinal disturbance called dyspepsia. In 1907 Schaps4 showed that, by the hypodermic injection of even so small an amount as 5 c.c. of physiological salt solution, a febrile temperature could be produced. Although these observations were denied by Weiland5 they have since been substantiated by a number of observers. Meyer and Rietschel6 showed that in about 40 per cent. of the cases which reacted to physiological salt solution, no reaction could be obtained by the injection of the same amount of a modified Ringer's solution. These were not the first experiments, however, on References 1. Meyer, L. F.: Experimentelle Untersuchungen zum alimentären Fieber , Deutsch, med. Wchnschr. , 1909, xxxv, 194.Crossref 2. Schloss, E.: Studien über Salzfieber , Biochem. Ztschr. , 1909, xviii, 14. 3. Friberger, H.: Untersuchungen über das sogenannte Salzfieber , München. med. Wchnschr. , 1909, lxi, 1946. 4. Schaps, L.: Salz- und Zuckerinjectionen beim Säugling , Berl. klin. Wchnschr. , 1907, xliv, 597. 5. Weiland, R.: Kochsalz- und Zuckerinfusionen beim Säugling , Berl. klin. Wchnschr. , 1908, xlv, 1309. 6. Meyer, L. F., and Rietschel, H.: Giftwirkung und Entgiftung des Kochsalzes bei subcutaner Infusion , Berl. klin. Wchnschr. , 1908, xlv, 2217. 7. Krehl, L.: Versuche über die Erzeugung von Fieber bei Tieren , Arch. f. exper. Path. u. Pharmakol. , 1895, xxxv, 222.Crossref 8. Lüdke, H.: Ueber Ursachen und Wirkungen der Fiebertemperature , Ergebn. d. inn. med. u. Kinderh. , 1909, iv, 493. 9. Bokai: Experimentelle Beiträge zur Kenntnis der Darmbewegungen , Arch. f. exper. Path. u. Pharmakol. , 1888, xxiv, 153. 10. Czerny, A., and Keller, A.: Des Kindes Ernährung, etc. , ed. 1, Leipsic, F. Deuticke, ii, 155. 11. Meyerhoefer, E., and Pribram, E.: Das Verhalten der Darmwand als osmotische Membran bei akuter und chronischer Enteritis. Wien. klin. Wchnschr. , 1909, xxii, 875. 12. Van den Velden, R.: Zur Wirkung intravenöser Zufuhr hypertonischer Kochsalzlösungen , Verhandl. d. Cong. f. inn. Med., Wiesbaden , 1909, xxvi, 155.

ADLER, HERMAN M.;BLAKE, GERALD

doi: 10.1001/archinte.1911.00060040040003pmid: N/A

Abstract For some time now the conception of an acid intoxication has been familiar to every student and practitioner of medicine. Since the first work of Naunyn on this subject in which many of the pathological phenomena of diabetes were explained by the demonstration of an acid intoxication to which the name ``acidosis'' was given, a great many facts have been collected and which support in all essentials the original investigations of Naunyn and his pupils. And it has become more and more evident that disturbances, both quantitative and qualitative, in the ability of the body to deal with varying amounts of acid, are not only important but by no means infrequent occurrences. Contrary to the assumptión of the early investigators, whose views are to some extent maintained by many at the present time, it may be stated as a demonstrated fact that the reaction of the blood, References 1. Henderson, L. J.: Ergebn. d. Physiol. , 1909, viii, 254-325, Bibliography.Crossref 2. Henderson, L. J., and Adler, H. M.: Jour. Biol. Chem. , 1909, vi, p. xxii. 3. Salm, E.: Ztschr. f. physik. Chem. , 1906, lvii, 471. 4. Folin, O.: Am. Jour. Physiol. , 1903, ix, 265. 5. Folin, Otto: Ztschr. f. physiol. Chem. , 1902, xxxvii, 161.

ROHDENBURG, G. L.;BULLOCK, F. D.;JOHNSTON, P. J.

doi: 10.1001/archinte.1911.00060040052004pmid: N/A

Abstract Several isolated observations have been made in connection with the effects of internal secretions on malignant tumors. Thus Cahen1 records cases of carcinoma of the breast in which after an incomplete breast amputation, the ovaries, too, were taken out. Of these cases he reports in some, a total disappearance of axillary nodes with gain in weight, the best results being obtained in young women, while the operation was valueless in women over 49 years of age. The significance of such absence of germ glands is somewhat diminished by the observations of Stickler,2 who reports 200 cases of tumors in bovines, 100 of which were in castrated animals; and 120 tumors in equines, ninety-one of which were in castrated animals. In connection with other secretions Gwyer3 has administered the thymus gland in cases of tumor and reports decrease in rate of growth, decrease in pain, decrease and in References 1. Cahen: Deutsch. Ztschr. f. Chir. , 1909, xcix, 415.Crossref 2. Stickler: Arch. f. klin. Chir. , 1902, lxv, 616. 3. Gwyer: Ann. Surg. , 1907, xlvi, 86;Crossref 4. 1908, xlvii, 506. 5. Stuart‐Low, W.: Lancet, London , 1909, ii, 1138.Crossref 6. Bell: Med. Rec. , 1907, lxxii, 306. 7. Lewin: Ergebn. d. inn. Med. u. Kinderh. , 1908, ii, 168. 8. Walker: Lancet, London , 1908, ii, 797.Crossref

TODD, JOHN L.

doi: 10.1001/archinte.1911.00060040061005pmid: N/A

Abstract I. INTRODUCTION It is well known that trypanosomes may be absent for long periods from the peripheral blood of an animal or of a person suffering from an infection by trypanosomes, and that although no treatment has been given. It also frequently happens that the parasites may reappear, after a more or less lengthy absence, in the blood of persons or of animals who have apparently been cured by appropriate treatment of an infection by trypanosomes. It is important to collect instances of such disappearances and recurrences of the parasites in order that an opinion may be formed as to the length of time during which a recurrence is possible in cases of apparent recovery from trypanosomiasis or apparent cure. II. HUMAN TRYPANOSOMIASIS The following observations prove that symptoms may be absent for long periods from persons who are infected with trypanosomes, and that those infected may die from References 1. Nabarro, D.: Trypanosomes and Trypanosomiasis , transl. by Laveran and Mesnil, London, 1907, Ballière, Tindall & Cox, p. 370. 2. Dutton, J. E. and Todd, J. L.: First Report of the Trypanosomiasis Expedition to Senegambia (1902) , Liverpool School of Tropical Medicine, Memoir XI, London, 1903, Williams and Norgate. 3. Todd, J. L.: A Review of the position of Gland Palpation in the Diagnosis of Human Trypanosomiasis , Jour. Trop. Med. and Hyg., London , 1908, xi, 229. 4. Nattan-Larrier, L.: Sur les résultats du traitement de la trypanosomiase chez le blanc , Bull. Soc. de path. exotique, Paris , 1908, i, 620. 5. Todd, J. L.: Trypanosomiasis in Europeans , Bull. Sleeping-Sickness Bureau, London , 1910, ii, 314. 6. Martin, L. and Darré, H.: Résultats éloignés du traitement dans la trypanosomiase humaine , Bull. Soc. path. exotique, Paris , 1910, iii, 333. 7. Martin, L., and Darré, H.: Résultats éloignés du traitement dans la trypanosomiase humaine , Bull. Sleeping-Sickness Bureau, London , 1910, ii, 212. 8. Hodges, A.: Progress Report on the Uganda Sleeping-Sickness Camps from December, 1906, to November, 1909 , Bull. Sleeping-Sickness Bureau, London , 1910, xix, 260. 9. Martin, G., and Leboeuf: Les rechutes dans le traitement de la trypanosomiase humaine; De l'association de la couleur de benzidine Ph. (Afridol violet) à l'atoxyl. Bull. Soc. pathol. exotique, Paris , 1909, ii, 54. 10. Kopke, A.: Traitement de la trypanosomiase humaine; Rapport présenté au XVI Congrès International de Médecine , Trav. de l'Ecole de méd. trop. de Lisbonne, Lisbonne, 1909. 11. Dutton, J. E., Todd, J. L., and Kinghorn, A.: Cattle Trypanosomiasis in the Congo Free State , Ann. Trop. Med. and Parasit., Liverpool , 1907, ii, 233. 12. Thomas, H. W., and Linton, S. F.: A Comparison of the Animal Reactions of the Trypanosomes of Uganda and the Congo Free State Sleeping-Sickness, with those of Trypanosoma gambiense , Liverpool School Trop. Med., Memoir xiii, London, 1904, Williams and Norgate. 13. Breinl, A.: Experiments on the Combined Atoxyl-Mercury Treatment in Monkeys Infected with Trypanosoma gambiense , Ann. Trop. Med. and Parasit., Liverpool , 1909, ii, 345. 14. Moore, B., Nierenstein, M., and Todd, J. L.: The Treatment of Experimental Trypanosomiasis, Part II , Ann. Trop. Med. and Parasit., Liverpool , 1908, iv, 265. 15. Campbell, R. P., and Todd, J. L.: The Action of Arsenophenylglycin on Trypanosoma brucei. Montreal Med. Jour. , 1909, xxxviii, 794. 16. Kinghorn, A., and Montgomery, R. E.: Human Trypanosomiasis in Rhodesia and Nyasaland , Ann. Trop. Med. and Parasit., Liverpool , 1909, ii, 277.

MARINE, DAVID;LENHART, C. H.

doi: 10.1001/archinte.1911.00060040067006pmid: N/A

Abstract INTRODUCTION Our conception of a satisfactory anatomical classification of thyroid changes is a scheme, composed of the major types of changes observed, arranged in the order of their manifestation and in which all separate or individual observations may find proper grouping. It is universally admitted that such a classification does not exist. It is, however, in connection with that group of anatomical changes embraced under the general term ``goiter'' that the greatest confusion exists.Studies based on large series of thyroids from the lower animals are still too few, though fortunately they are increasing because observers are realizing that human material is too complicated, and that the cataloguing of the almost infinite variety of possible histological variations has not simplified existing classifications or established the sequential relations of these changes. The multiplicity of terms now in use for each type of thyroid change is merely the result of References 1. Virchow: Die krankhaften Geschwülste , 1863, iii, 4. 2. Marine and Lenhart: Relation of Iodin to the Structure of Human Thyroid, etc. , The Archives Int. Med. , 1909, iv, 440.Crossref 3. The term ``goiter,'' being clinical, embraces several anatomical groups. These different groups represent different ``stages'' in the common process and it is therefore important to establish the sequence and logical order of these anatomical changes. In this way one can eliminate many of the terms now in use by demonstrating that they represent only minor or accidental changes. For the physiological stages of goiter this has been established. 4. Carlson and Woelfel ( Am. Jour. Physiol. , 1910, xxvi, 32) 5. Hunt and Seidell ( Jour. Pharmacol. and Exper. Therap. , 1910, ii, 15) 6. ``Active'' is used to distinguish this, the growing stage, from the colloid or quiescent stage. 7. Marine and Williams: The Archives Int. Med. , 1908, i, 349.Crossref 8. Marine and Lenhart, The Archives Int. Med. , 1909, iii, 66;Crossref 9. 1909, iv, 440; 10. Jour. Exper. Med. , 1910, xii, 311. 11. Ribbert: Virchow's Arch. f. path. Anat. , 1889, cxvii, 151.Crossref 12. Halsted: Johns Hopkins Hosp. Rep. , 1896, i, 373. 13. Ord: Brit. Med. Jour. , 1898, ii, 1473.Crossref 14. Mac Callum, W. G. ( Jour. Am. Med. Assn. , 1907, ii, 1158, 1160)Crossref 15. Stoffel: Virchows Arch. f. path. Anat. , 1910, cci, 245.Crossref 16. De Quervain ( Mitt. a. d. Grenzgeb. d. Med. u. Chir. , 1906, xv, 297) 17. Sarbach ( Mitt. a. d. Grenzgeb. d. Med. u. Chir. , 1906, xv, 213) 18. Aesbacher ( Mitt. a. d. Grenzgeb. d. Med. u. Chir. , 1906, xv, 269) 19. Roger and Garnier: Arch. gén. de méd. , 1900, clxxxv, 385 20. Davis: Tr. Chicago Path. Soc. , 1906-09, vi, 273. 21. Billroth: Müllers Arch. f. Anat. u. Physiol. , 1856, p. 144. 22. Bloodgood: Surg. Gynec. and Obst. , 1906, ii, 121. 23. Langhans ( Virchows Arch. f. path. Anat. , 1907, clxxxix, 69)Crossref

RULON, S.A.;HAWK, P. B.

doi: 10.1001/archinte.1911.00060040097007pmid: N/A

Abstract Considerable investigating has been done on the influence of copious water ingestion on the chlorid excretion of fasting animals. The work of Forster2 is often quoted in this connection. In one instance this investigator increased the urinary chlorid output from 0.175 gm. to 0.992 gm. by causing a dog to ingest 3 liters of water on the eighth day of the fast. This is the most pronounced increase in the chlorid excretion yet reported as following the ingestion of large volumes of water. From a series of investigations on dogs in which different animals were subjected to the influence of external hemorrhage or to the influence of poisoning by phosphorus or by carbon monoxid Kast3 later came to the conclusion that there was a very close relationship between increased protein catabolism and the augmented chlorin output accompanying such catabolism. Inasmuch as the procedure of Kast rendered his References 1. Hawk: Univ. Penn. Med. Bull. , 1905, xviii, 7; 2. Fowler and Hawk: Jour. Exper. Med. , 1910, xii, 388;Crossref 3. Rulon and Hawk: Jour. Am. Chem. Soc. , 1910, xxxii, 1686.Crossref 4. Forster: Ztschr. f. Biol. , 1873, ix, 364. 5. Kast: Ztschr. f. physiol. Chem. , 1888, xii, 267. 6. Heilner: Ztschr. f. Biol. , 1906, xlvii, 538. 7. Benedict: Carnegie Publication, No. 77. 8. Hawk: Loc. cit. 9. We are indebted to Dr. C. N. Sturtevant for specimens of these urines. 10. Heilner (loc. cit.) 11. This value, according to some investigators, should be 0.04 per cent. 12. Paton: Jour. Physiol. , 1910, xxxix, 485. 13. Pawlow: The Work of the Digestive Glands, p. 125. 14. Foster and Lambert: Jour. Exper. Med. , 1908, x, 820.Crossref 15. Wills and Hawk: Unpublished data. 16. Walter: Arch. f. exper. Path. , 1877, vii, 148.Crossref 17. Wills and Hawk: Unpublished data. 18. Howe, Mattie and Hawk: Unpublished. 19. Benedict: Carnegie Publication, No. 77.

BOOS, WILLIAM F.;NEWBURGH, L. H.;MARX, HENRY K.

doi: 10.1001/archinte.1911.00060040112008pmid: N/A

Abstract Digitalis leaf preparations from different localities show great differences in pharmacologic strength. This variation in pharmacologic efficiency is due to the fact that there are a number of factors, variations in which will modify the amount of the active substances contained in the leaves. Among these factors are the soil, the gathering season, the methods of collecting and drying the leaves and the methods used in preserving the dried product. Carefully trained apothecaries may render the conditions fairly constant for one locality, but even then the leaves themselves are found to vary greatly from year to year. This variation in strength will of course be found also in the Galenic preparations made from the dried leaves. In 1902 Fraenkel1 studied the strength of digitalis and strophanthus preparations obtainable in Heidelberg and the surrounding towns, that is, the leaf and seed preparations of practically one section. His material References 1. Fraenkel: Therap. d. Gegenw. , 1902, iv, 106. 2. Buehrer: Corr.-Bl. f. schweiz. Aerzte , 1900, xxx, 617. 3. Boos: Boston Med. and Surg. Jour. , 1909, clxi, 589. 4. Focke: Therap. d. Gegenw. , 1904, xlv, 250. 5. Hoepfner: München. med. Wchnschr. , 1908, lv, 1774. 6. Mueller: München. med. Wchnschr. , 1908, lv, 2651. 7. Tissot: Folia Serol. , 1909, iii, 1. 8. Clemens: Fortschr. d. Med. , 1908, xxvi, 1057.

GAGE, JOHN G.

doi: 10.1001/archinte.1911.00060040122009pmid: N/A

Abstract Although infection with Strongyloides intestinalis is by no means uncommon in the South, patients with larvæ in the stools being frequently observed by physicians, nevertheless the number of reported cases is not large and is not a true index of the prevalence of the disease. This is probably due to the fact that this parasite is usually considered harmless. In the case here reported the larvæ were discovered first in the sputum. The patient entered the hospital with a diagnosis of pneumonia. His temperature promptly dropped to normal but, because his general condition did not improve and because of impaired resonance and later expectoration, tuberculosis was suspected and his sputum examined. I saw the first larvæ while examining the fresh sputum, and thought they might be a contamination of some sort, because the patient had vomited that day and the sputum contained food particles and milk; but, on References 1. Braun: Animal Parasites of Man , 1899. 2. Richard: Post-Grad. , 1909, xxiv, 475. 3. Gage: Jour. Med. Research , 1910, xxiii, 177. 4. Leiper: Brit. Med. Jour. , (November) , 1909, p. 1332. 5. Thayer: Jour. Exper. Med. , 1901, vi, 75.Crossref 6. Strong: Johns Hopkins Hosp. Rep. , 1902, x, 91. 7. Perroncito: Quoted by Strong. 8. Baetjer: Bull. Johns Hopkins Hosp. , 1910, xxi, 118. 9. Ohlmacher: Am. Med. , 1903, v, 816. 10. Price, Marshall Langton: Occurrence of the Strongyloides Intestinalis in the United States , Jour. Am. Med. Assn. , 1903, xli, 651.Crossref 11. Moore: Am. Med. , 1903, v, 876. 12. Brown: Boston Med. and Surg. Jour. , 1903, cxlviii, 583.Crossref 13. Hall, J. N.: A Case of Infection by Strongyloides Intestinalis. Jour. Am. Med. Assn. , 1907, xlviii, 1182.Crossref 14. Brush: South. Med. Jour. , 1908, i, 248.Crossref 15. Cline: Post-Graduate , 1908, xxiii, 451. 16. Daland: New York Med. Jour. , 1908, lxxxvii, 761. 17. Dock: New York Med. Jour. , 1909, xc, 53. 18. Simon, Sidney K.: Amebic Dysentery , Jour. Am. Med. Assn. , 1909, liii, 1526.Crossref 19. Patterson, H. S.: Parasites Found in New York City , The Archives Int. Med. , 1908, ii, 185.Crossref 20. Wilms: Schmidt's Jahrb. , 1897, cclvi, 272. 21. Schlüter: Med. Klin. , 1905, i, 1305. 22. Van Durme: Thompson Yates Lab. Rep., Liverpool , 1902, iv, 471. 23. Marzocchi, V.: Gior. d. r. Accad. di med. di Torino , 1907, series 4, xiii, 3. 24. Looss, A.: Compt. rend. du 6 Cong. Internat. de Zool., Berne , 1905, p. 225. 25. Grassi: Grior. di r. Accad. di med. di Torino , 1883 series 3, xxxi, 119. 26. Ward: Reference Handbook of Medical Sciences. 27. Noc: Ann. de l'Inst. Pasteur , 1909, xxiii, 177. 28. Bass, C. C.: Mild Uncinaria Infections , The Archives Int. Med. , 1909, iii, 446.Crossref 29. Simon: Personal communication.

doi: 10.1001/archinte.1911.00060040141010pmid: N/A

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract Among those familiar with its predecessor, this second edition of Lusk's work will find a ready acceptance. The new volume differs from the other mainly in its consideration of facts which have been discovered during the past three years, and although there has been some increase in size, the book retains its compactness and character. Even more than before one is impressed by the fact that in this work we have to do with an unusual and significant type of American medical writing. Its character may be gleaned from the following excerpts from the preface, which are a true index of what follows in the text: ``The aim of the book is to review the scientific substratum on which rests the knowledge of nutrition, both in health and in disease.'' Throughout no statement has been made without endeavoring to give proof that it is true. ``The wide-spread