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doi: 10.1001/jamadermatol.2020.2398pmid: 32697281
This cost-utility analysis compares the cost-utility of these novel agents and their combinations with or without BRAF gene testing guidance for treating newly diagnosed advanced melanoma with unknown BRAF status.
Lukowiak, Tess M.; Aizman, Leora; Perz, Allison; Miller, Christopher J.; Sobanko, Joseph F.; Shin, Thuzar M.; Giordano, Cerrene N.; Higgins, H. William; Etzkorn, Jeremy R.
doi: 10.1001/jamadermatol.2020.2571pmid: 32845319
Haugaard, Jeanette Halskou; Kofoed, Kristian; Gislason, Gunnar; Dreyer, Lene; Egeberg, Alexander
doi: 10.1001/jamadermatol.2020.2786pmid: 32876672
Key PointsQuestionWhat is the association between drug use and a subsequent diagnosis of cutaneous lupus erythematosus or systemic lupus erythematosus? FindingsIn this nationwide case-control study, many significant associations were found between the use of a variety of drugs and a subsequent diagnosis of cutaneous lupus erythematosus or systemic lupus erythematosus. Relatively well-established causal associations together with some new plausible causal associations were observed. MeaningThe findings indicate that physicians must be aware that a newly diagnosed case of cutaneous lupus erythematosus or systemic lupus erythematosus could be drug induced.
Poizeau, Florence; Nowak, Emmanuel; Kerbrat, Sandrine; Le Nautout, Béranger; Droitcourt, Catherine; Drici, Milou-Daniel; Sbidian, Emilie; Guillot, Bernard; Bachelez, Hervé; Ait-Oufella, Hafid; Happe, André; Oger, Emmanuel; Dupuy, Alain
Benzian-Olsson, Natashia; Dand, Nick; Chaloner, Charlotte; Bata-Csorgo, Zsuzsa; Borroni, Riccardo; Burden, A. David; Cooper, Hywel L.; Cornelius, Victoria; Cro, Suzie; Dasandi, Tejus; Griffiths, Christopher E. M.; Kingo, Külli; Koks, Sulev; Lachmann, Helen;
Stapleton, Jerod L.; Hrywna, Mary; Coups, Elliot J.; Delnevo, Cris; Heckman, Carolyn J.; Xu, Baichen
doi: 10.1001/jamadermatol.2020.2935pmid: 32876658
Key PointsQuestionAre state restrictions that ban minors from using indoor tanning beds effective in reducing the prevalence of indoor tanning among high school students? FindingData from cross-sectional surveys conducted between 2012, the year prior to indoor tanning restrictions, and 2018 showed that the prevalence of tanning decreased among all minors younger than the legal tanning age and among female students older than the legal tanning age. The prevalence among minors of tanning in salons and nonsalon unregulated locations was similar. MeaningThis study provides unique evidence supporting the benefit of enacting new regulatory efforts that restrict indoor tanning access among minors and extending existing restrictions to address unsupervised nonsalon tanning.
Showing 1 to 10 of 24 Articles
Key PointsQuestionWhat are the defining clinical and dermoscopic features and natural history of vulvar melanosis? FindingsIn this cohort study of 129 patients with vulvar melanosis and 5 to 20 years of follow-up, 67% of vulvar melanotic lesions appeared in premenopausal patients, and 65% of all patients had received some type of hormone therapy; in about 30% of patients, the lesions increased in size and changed color after initial evaluation but ultimately stabilized. Vulvar melanosis is characterized by asymmetrical, tan-brown to black, irregularly bordered macules of variable size on the vulvar mucosa. MeaningHormonal status may play a role in the pathogenesis of vulvar melanosis; enlargement or pigmentary changes in the brown-black spectrum without additional colors were not associated with malignant evolution in this study.
This cross-sectional study defines differences in the ratio of basal cell to cutaneous squamous cell carcinomas in US adults in a large database of patients with commercial insurance and Medicare Advantage coverage.
doi: 10.1001/jamadermatol.2020.2977pmid: 32902568
Key PointsQuestionIs the risk of severe cardiovascular events increased after the initiation of treatment with the anti–interleukin 12/23p40 (IL-12/23p40) monoclonal antibody ustekinumab? FindingsThis case-time-control analysis based on data from 9290 patients with records in the French national health insurance database from 2010 to 2016 suggests that the initiation of ustekinumab treatment is associated with increased risk of acute coronary syndrome or stroke in patients with a high baseline cardiovascular risk. MeaningThe results of this case-time-control analysis suggest that ustekinumab should be prescribed with caution to patients at high cardiovascular risk.
doi: 10.1001/jamadermatol.2020.3275pmid: 32936291
Key PointsQuestionAre clinical and demographic factors associated with the severity of palmoplantar pustulosis? FindingsIn a cross-sectional study of 203 patients in the UK, the Palmoplantar Pustulosis Psoriasis Area Severity Index score was significantly higher in women compared with men and in current smokers vs former and never smokers. Both of these findings were replicated in an independently ascertained, Northern European cohort including 159 patients. MeaningThe findings of this study suggest that smoking cessation interventions may be beneficial in patients with palmoplantar pustulosis and should be investigated in clinical studies.