Archives of Dermatology

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020007012

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract Seminar.— The 1981 Advanced Seminars in Dermatology will, in addition to its regular program, offer category 1 and IAE credit for two special seminars: "Cutaneous Viral Disease" and "Dermatopathology and Immunopathology." Special guest speakers include Drs S. Jablonska and A. Ackerman. These seminars will be conducted Sept 16-20, 1981, in Carmel-Monterey, Calif. For a program and registration information, write Advanced Seminars in Dermatology, University of California Medical School, Dermatology Department, San Francisco, CA 94143. Fourth Annual Meeting: Call for Abstracts.— The American College of Cryosurgery wants abstracts for its fourth annual meeting, June 12-14, 1981, at the Marriott Crystal City, Arlington, Va.During the first part of the meeting, experts from various specialties will provide a practical overview of cryosurgery in clinical practice. The session will include in-depth symposia and demonstrations that outline new cryosurgical advances developed in various specialties of medicine. A preview of experimental research and clinical practice

Aronberg, Jerome M.

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020003003

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract To the Editor.— I note with interest, as well as anger, the recent trend in medical journals to include as many names as possible on every article. The aggregation of names at the beginning of articles is mildly irritating; the use of a manuscript typist's name at the end of articles is most aggravating. With journal space at a premium, I believe that this unnecessary usage of possible information space at the end of articles does not disseminate any medical knowledge and its continued practice should be reconsidered by the editors of the medical journals.This letter to the editor has been prepared by Doris Johnston.

Dupré, André;Viraben, Roland;Bonafe, Jean-Louis;Touron, Paul;Lamon, Pierre

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020003006pmid: 7469439

Abstract To the Editor.— Dermatomyositis is characterized by a heliotrope eruption on the face and the upper part of the trunk, with or without edema. Therefore, in typical cases, the diagnosis is clear. However, other kinds of lesions have occasionally been reported in dermatomyositis.1 These include dermatographism, bullous lesions, urticarial lesions, photosensitivity, erythema nodosum, erythema multiforme, follicular keratosis, hypertrichosis, hyperhidrosis, psoriasiform eruptions, pitting of the fingernails, exfoliative dermatitis, hyperpigmentation, erythema of the scalp, livedo reticularis, ulcers, and panniculitis. We are reporting a case with an unusual feature, ie, a generalized erythematous rash that formed parallel zebra-like stripes, so that the patient had the appearance of being flogged. We have found no similar cases in the literature.Fig 1.—Zebra-like dermatomyositis.Fig 2.—Fir-like pattern on back.Fig 3.—Striped erythema in suborbital area. Report of a Case.— A 14-year-old girl was seen for nonpruritic skin lesions of dermatomyositis (Fig 1 through 3). On References 1. Callen JP: Dermatomyositis . Int J Dermatol 1979;18:423-433.Crossref 2. Wong KO: Dermatomyositis: A clinical investigation of 23 cases in Hong Kong . Br J Dermatol 1969;81:544-547.Crossref 3. Dupré A, Floutard M, Christol B, et al: Dermatomyosite avec spinulosisme (dermatomyosite type Wong): Etude histologique. Essai d'interprétation pathogénique . Ann Dermatol Syphil 1976;103:141-149.

Christensen, Ole B.

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020003005

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract To the Editor.— I read with interest the recent reports of unilateral nevoid telangiectasia by Jucas et al in the March 1979 Archives (115:359-360) and by Person et al in the September 1979 Archives (115:1034). In the last three months I have seen a 10-year-old girl and a 26-year-old man with typical clinical signs of unilateral nevoid telangiectasia. The girl had noted skin changes for only two months and she was otherwise healthy. The man had had his eruption for as long as he could remember; he was also healthy and was nonalcoholic. I fully agree with the final remarks of Person et al about the frequency of the disorder. It could be a coincidence, but I have seen the patients described here from a population of about 240,000, which indicates that the disorder is more common than previously recognized.

Fusaro, Ramon M.

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020003002

Abstract To the Editor.— In the April Archives (1980;116:433-444), Trau et al stated their case was the 12th case report of a patient with multiple clear cell acanthomas. Their case was the 11th. In their Table of the summary of previously reported cases, cases 4 and 5 are the same patient. The age in case 4 is not 59 years, as they reported, but 63 years, and he had his skin nodules four years, not five months. This patient was seen and his case was reported by myself and Dr Thorne1 at the University of Minnesota Hospitals. One year later, he was seen at the Mayo Clinic and described by Landry and Winkelmann.2 Dr Trau and co-workers could not have been aware of this information. References 1. Thorne EG, Fusaro RM: Multiple clear cell acanthomas in a patient with lamellar ichthyosis . Dermatologica 1971;143:105-110.Crossref 2. Landry M, Winkelmann RK: Multiple clear cell acanthomas and ichthyosis . Arch Dermatol 1972;105:371-383.Crossref

Malkinson, Frederick D.

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020003004

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract In Reply.— The acknowledgment of secretarial help in the preparation of manuscripts accepted for Archives publication was abondoned for articles accepted after May 15, 1980. The above letter is the last of the species!

Kocsard, E.

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020003001

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract To the Editor.— I read with great interest the article entitled "Diminished Immune Response in Sun-Damaged Skin" by O'Dell et al in the May Archives (1980;116:559-561).Seventeen years ago, I did a similar study with my colleague the late Dr F. Ofner, which I presented at the annual meeting of the Dermatological Association of Australia in Melbourne in 1964. This work was published in the Australian Journal of Dermatology (1964;7:203-205) under the title "Contact Eczematous Sensitisation and Sensitivity of the Solar Elastotic Skin." Our experiments were carried out on 75 male volunteers. We also came to the conclusion that the solar elastotic skin seemed to be less responsive when tested for eczematous sensitivity. We also found, however, that the elastotic change increased the resistance to irritants.Letters will be published as space permits and at the discretion of the editor. All components of letters, including references, must be typewritten, double-spaced.

Bremers, Harold H.

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020004007

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract To the Editor.— I read with interest your editorial entitled "The Heat's On" in the August 1980 Archives (116:885-887). Thirty years ago, when I was a dermatology resident at Case Western Reserve, Cleveland, Drs George Binkley and Herbert Johnson used hyperthermia successfully for severe cases of psoriasis.Hospitalized patients were given two intravenous doses of killed typhoid bacilli at half-hour intervals; 10 to 15 million units at first, and then (usually) increasing amounts (depending on the fever obtained) every few days for three or four courses of treatment. A temperature of approximately 39 †C was sought. The psoriasis would often go into remission for several months. This therapy also helped psoriatic arthritis.

Kanwar, Amrinder J.;Majid, Abdul;Garg, Misrilal P.;Singh, Gurmohan

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020005009

Abstract To the Editor.— Cimetidine, a histamine H2-receptor antagonist, is now being widely used in the treatment of peptic ulcer and other conditions where reduction of gastric acid secretion is likely to be beneficial. So far, few side effects have been observed in the recommended dosage of 1 g/day given in divided doses. Muscle pain, fatigue, gynecomastia (when 1.6 g/day was used), and dermatitis have been reported, but occur in less than 5% of the patients.1 The nature of the rash, however, has not been specified. We recently had the opportunity of observing a drug eruption simulating seborrheic dermatitis in a patient who had been receiving cimetidine for treatment of a duodenal ulcer. Report of a Case.— A 45-year-old man with an active duodenal ulcer had been given 200 mg of oral cimetidine three times daily with meals and 400 mg at bedtime. Two days later, itchy, red, References 1. Colin-Jones DG: Cimetidine: A new treatment for peptic ulceration . Med Digest 1978;3:6. 2. Baker H: Drug reactions , in Rook A, Wilkinson DS, Ebling FJG (eds): Textbook of Dermatology . Oxford, England, Blackwell Scientific Publications, 1972, p 1025. 3. Domonkos AN: Andrews' Diseases of the Skin , ed 6. Philadelphia, WB Saunders Co, 1971, p 204.

Kassab, Hannah Jane;Franklin, Edward C.;Prose, Philip;Gorevic, Peter D.

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020005008

Abstract To the Editor.— The following patient was first described in the Archives in March 1953 (67:429-430) as a case of "essential" cryoglobulinemia. Follow-up evaluation was obtained in the course of a retrospective review of 40 patients with this syndrome seen at our medical center during the past 20 years.1 This case illustrates the coexistence of clinical features of systemic vasculitis and lymphoproliferative disease in some patients with serum cryoglobulins. Report of a Case.— A 33-year-old woman had recurrent purpura and arthralgias develop three years earlier during pregnancy. The rash was aggravated by cold exposure and initially involved the legs but later spread to the arms and buttocks. A skin biopsy specimen showed leukocytoclastic angiitis. Eventually, a left lateral malleolar leg ulcer developed, but the condition responded gradually to bed rest. Two years previously, hepatosplenomegaly had been noted. A liver biopsy specimen indicated portal infiltration by lymphocytes and plasma cells, consistent References 1. Gorevic PD, Kassab HJ, Levo Y, et al: Mixed cryoglobulinemia: Clinical aspects and long-term follow-up . Am J Med 1980;69:287-308.Crossref 2. Lospalluto J, Dorward B, Miller W Jr, et al: Cryoglobulinemia based on interaction between a macroglobulin and 7S gamma globulin . Am J Med 1962;32:142-152.Crossref 3. Meltzer M, Elias K, McCluskdy RT, et al: Cryoglobulinemia: A clinical and laboratory study . Am J Med 1966;40:837-856.Crossref 4. Levo Y, Gorevic PD, Kassab HJ, et al: The association between hepatitis B virus and essential mixed cryoglobulinemia . N Engl J Med 1977;296:1501-1504.Crossref

Kaminester, Lewis H.

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020006011

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract To the Editor.— I would like to record my clinical findings regarding the use of combination sunscreening products that combine both aminobenzoic acid (PABA) and a physical blocking agent (titanium dioxide) for use in patients who have had positive results to a skin for patch test PABA.In the past five years, I have had several patients in whom a patch test-confirmed photoallergic contact dermatitis developed after the use of products containing 5% PABA in an alcohol base (Pre-Sun). Initially, I gave such patients sunscreens containing only benzophenones (Uval) or zinc oxide pastes. The latter were cosmetically unacceptable, and use of the former still resulted in sunburn in some patients. I then had them use a PABA-containing product together with titanium dioxide in a cream base (Solar Cream). The preparation was not only effective as a total ultraviolet light blocker, but also the PABA-sensitive patients had no allergic reaction from

Brauner, Gary

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020006010

Abstract To the Editor.— "Keratosis Punctata of the Palmar Creases," by Weiss and Rasmussen in the Archives (1980;116:669-671), presents an interesting but often described entity (as those authors, too, have emphasized).1 In 1970, Smith and Jetton2 reviewed 125 consecutive outpatients at Charity Hospital in New Orleans. They found 47 patients who had punctate lesions of the palms, 29 had only creases involved and 11 had involvement outside of the creases as well. Seven had keratoses, but not in the creases at all. The lesions were mostly bilateral. Here, too, there was no history of arsenic ingestion and no demonstrable history of keratoses in the family. When they combined those patients who had keratoses and those with discrete pits in the palmar creases, the authors found an astounding incidence of these characteristics in 69% of black patients and 42% of white patients. These authors also established a statistically significant association References 1. Arnold H: Hyperkeratosis penetrans: Report of a case of a probable variant of Kyrle's disease . Arch Dermatol 1947;55:633-638. 2. Smith E, Jetton R: Punctate pits and keratoses of the palmar creases . South Med J 1970;63:1291-1293.Crossref 3. Montgomery R: Porokeratosis plantaris discreta . Cutis 1977;20:711-713. 4. Limmer B: Cryosurgery of porokeratosis plantaris discreta . Arch Dermatol 1979;115:582-583.Crossref

Anderson, Philip C.

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020009013

Abstract Peritoneal dialysis is wholly an experimental technique for the treatment of psoriasis and will remain so for several more years. Much more needs to be known about the effects of dialysis on the skin, although, in nephrology, the safety of the basic technology is well established. Physicians whose only recollections are of primitive dialysis, seen even less than a decade ago, need to become reacquainted.1,2 Worldwide, the anecdotal reports of success in the treatment of psoriasis have been encouraging, but the next important phase in our evaluation of dialysis requires well-controlled clinical studies. Some months ago, at the University of Missouri Medical Center, Columbia, we began admitting patients to the first double-blinded, flipflop, comparative study of dialysis for psoriasis. Results are expected by the middle of 1981. The first studies of dialysis of patients entirely disabled only by psoriasis and unresponsive to all other therapy were done in 1977 References 1. Nolph KD, Popovich RP, Moncrief JW: Theoretical and practical implications of continuous ambulatory peritoneal dialysis . Nephron 1978;21:117-122.Crossref 2. Burton BT, Hirschman GH: Demographic analysis: End-stage renal disease . Clin Nephrol 1979;11:47-51. 3. Twardowski ZJ: Abatement of psoriasis and repeated dialysis . Ann Intern Med 1977;86:509-510.Crossref 4. Twardowski ZJ, Nolph KD, Rubin J, et al: Peritoneal dialysis for psoriasis . Ann Intern Med 1978;88:349-351.Crossref 5. Anderson PC: Dialysis for psoriasis . Artif Organs 1978;2:202-203.Crossref 6. Anderson PC: Progress concerning dialysis of psoriatics . Artif Organs 1979;3:382-383.Crossref 7. Anderson PC: National Institutes of Health Conference on Psoriasis and Dialysis . J Am Acad Dermatol 1979;1:565-566.Crossref 8. Wei-Tzouh C, Chung HH, Schitz SN: In search of `psoriasis factors': A new approach by extracorporeal treatment . Artif Organs 1978;2:203-205.Crossref 9. Nissensen AR, Rapaport M, Gordon A, et al: Hemodialysis in the treatment of psoriasis: A controlled study . Ann Intern Med 1979;91:218-220.Crossref 10. Nissensen AR, Rapaport MJ, Norins RG: Dialysis and psoriasis . Ann Intern Med 1980;92:709-710.Crossref 11. Rubin J, Rust P, Brown P, et al: A comparison of peritoneal transport in patients with psoriasis and uremia . Nephron , to be published. 12. Glinski W, Jablonska S, Imiela J, et al: Continued peritoneal dialysis for treatment of psoriasis: I. Depletion of PMNL as a possible factor for clearing of psoriatic lesions . Arch Dermatol Res 1979;265:337-341.Crossref 13. Nolph KD, Popovich RP, Ghods AJ, et al: Determinants of low clearances of small solutes during peritoneal dialysis . Kidney Int 1978;13:117-123.Crossref 14. Bass OE, Nolph KD, Maher JF: Dialysance and clearance measurements during clinical dialysis: A plea for standardization . J Lab Clin Med 1975;86:378-385. 15. Villarroel F, Popovich RP, Nolph KD: Evaluation of permeance in peritoneal dialysis . J Dial 1978;2:361-378.

Halevy, Sima;Halevy, Jonathan;Boner, Geoffrey;Rosenfeld, Joseph B.;Feuerman, Eleasar J.

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020011014

Abstract • Three patients with psoriasis, who were resistant to all modes of accepted therapy, underwent 32 hours of peritoneal dialysis weekly for ten weeks. In two patients, there was a clearing of 80% of the psoriatic lesions after completion of therapy. In one of these patients, there was a recurrence of the lesions two months later, but the other patient is still in relative remission after 12 months. The third patient had clearing of 50% of the lesions, but there was recurrence two months after cessation of treatment. This experience as well as a review of the literature indicates that dialysis may have a positive effect on psoriasis and that the effect obtained is more prominent with peritoneal dialysis than with hemodialysis. (Arch Dermatol 117:69-72. 1981) References 1. McEvoy J, Kelly AMT: Psoriatic clearance during hemodialysis . Ulster Med J 1976;45:76-78. 2. Nissenson AR, Rapaport M, Gordon A, et al: Hemodialysis in the treatment of psoriasis. A controlled trial . Ann Intern Med 1979;91:218-220.Crossref 3. Twardowski ZJ: Abatement of psoriasis and repeated dialysis . Ann Intern Med 1977;86:509-510.Crossref 4. Twardowski ZJ, Nolph KD, Rubin J, et al: Peritoneal dialysis for psoriasis . Ann Intern Med 1978;88:349-351.Crossref 5. Buselmeier TJ, Kjellstrand CM, Dahl MV, et al: Treatment of psoriasis with dialysis . Proc Eur Dial Transplant Assoc 1978;15:171-177. 6. Muston HL, Conceicao S: Remission of psoriasis during haemodialysis . Br Med J 1978;1:480-481.Crossref 7. Brunner F: Treatment of psoriasis with dialysis . Proc Eur Dial Transplant Assoc 1978;15:176. 8. Dowzenko A: Treatment of psoriasis with dialysis . Proc Eur Dial Transplant Assoc 1978;15:176. 9. Farr MJ: Treatment of psoriasis with dialysis . Proc Eur Dial Transplant Assoc 1978;15:176. 10. Klinkmann H: Treatment of psoriasis with dialysis . Proc Eur Dial Transplant Assoc 1978;15:176. 11. Chugh KS, Nath IVS, Bedi TR, et al: Dialysis and psoriasis . Ann Intern Med 1978;88:842-843.Crossref 12. Rose I: Dialysis for psoriasis . Can Med Assoc J 1979;120:1209-1212. 13. Maeda K, Saito A, Kawaguchi S, et al: Psoriasis treatment with direct hemoperfusion , in Abstract Book International Symposium on Hemoperfusion Kidney and Liver Supports and Detoxification . Haifa, Israel, 1979. 14. Halevy J, Halevy S, Feuerman EJ, et al: Dialysis for psoriasis . JAMA 1979;241:2141.Crossref 15. Halevy J, Halevy S, Feuerman EJ, et al: Dialysis for psoriasis . Br Med J 1979;1:1490.Crossref 16. Anderson PC: Dialysis for psoriasis . Artif Organs 1978;2:202-203.Crossref 17. Chen WT, Hu CH, Schiltz JR, et al: In search of `psoriasis factor(s)': A new approach by extracorporeal treatment . Artif Organs 1978;2:203-205.Crossref 18. Kramer P: Dialysis for Psoriasis Patients . Proceedings of the 11th 19. Annual Contractors' Conference . National Institutes of Health No. 79-1442. US Department of Health, Education, and Welfare, Public Health Service, 1978, p 217. 20. Miller L: Dialysis for Psoriatic Patients . Proceedings of the 11th Annual Contractors' Conference . National Institutes of Health No. 79-1442. US Department of Health, Education, and Welfare, Public Health Service, 1978, p 215. 21. Friedman EA, Delano BG: Psoriasis developing de novo during hemodialysis . Ann Intern Med 1979;90:132.Crossref 22. Breathnach SM, Boon NA, Black MM, et al: Psoriasis developing during dialysis . Br Med J 1979;1:236-237.Crossref 23. Wilson LM: Dialysis and psoriasis . Ann Intern Med 1978;88:842.Crossref 24. Macaulay JC: Psoriasis and hemodialysis . Ann Intern Med 1978;89:430. 25. Voorhees JJ, Marcelo C: Molecular Mechanism and the Cyclic Nucleotide Cascade in Psoriasis . Proceedings of the Second International Psoriasis Symposium, 1976 , p 91. 26. Cormane RH, Hunyaoi J, Hamerlinck F: Mecaisme immunologiques de psoriasis . Ann Dermatol Syphiligr 1976:103:567-572. 27. Hopsu-Havu VK, Helander I: Cell-mediated autohypersensitivity in psoriasis: In vitro tests with extracts from psoriatic skin and scales . Acta Derm Venereol 1974;54:333-337. 28. Beutner EH, Jablonska S, Jarzabek-Chorzelska M, et al: Studies in immunodermatology: VI. IF studies of autoantibodies to the stratum corneum and of in vivo fixed IgG in stratum corneum of psoriatic lesions . Int Arch Allergy Appl Immunol 1975;48:301-323.Crossref 29. Nolph KD: Peritoneal dialysis , in Drukker W, Parsons FM, Maher JF (eds): Replacement of Renal Function by Dialysis . The Hague, Martinus Nijhoff Publishers, 1979, p 306. 30. Vaamonde CS, Michael UF, Metzger RA, et al: Complication of acute peritoneal dialysis . J Chronic Dis 1975;28:637-659.Crossref 31. Rubin J, Oreopoulos DG, Lio TT, et al: Management of peritonitis and bowel perforation during chronic peritoneal dialysis . Nephron 1976;16:220-225.Crossref

Jorgenson, Ronald J.;Levin, L. Stefan

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020015015

Abstract † White sponge nevus (WSN) is one of a number of white lesions of the oral mucosa. It is an autosomal dominant disorder of wide variability and high penetrance. White sponge nevus is characterized by white, spongy lesions of the oral mucosa, although extraoral mucosae may also be affected. Onset is early in life, and both sexes are affected equally. There are no extramucosal lesions associated with WSN. The plaques of WSN are benign and may undergo alternate periods of remission and exacerbation. In two of our cases from an affected family, penicillin precipitated remission of the plaques. (Arch Dermatol 117:73-76, 1981) References 1. O'Leary PA, Montgomery H, Brunsting LA, et al: White sponge nevus: Moniliasis? Arch Dermatol Syphilol 62:608, 1950. 2. Browne WG, Isatt MM, Renwick JH: White sponge naevus of the mucosa: Clinical and linkage data . Ann Hum Genet 32:271-281, 1969.Crossref 3. Everett FG, Noyes HJ: White folded gingivostomatitis . J Periodont 24:32-41, 1953. 4. Zagarelli EV, Kutscher AH: Familial white folded hypertrophy of the mucous membranes . Oral Surg 10:262-270, 1957.Crossref 5. Archard HO: Stomatologic manifestations of internal and integumental disorders , in Fitzpatrick TB, Arndt KA, Clark WH, et al (eds): Dermatology in General Medicine . New York, McGraw-Hill Book Co, 1971, p 915. 6. Orban BJ, Wentz FM: Atlas of Clinical Pathology of the Oral Mucous Membranes . St Louis, CV Mosby Co, 1955, p 94. 7. Shafer WG, Hine MK, Levy BM: A Textbook of Oral Pathology , ed 3. Philadelphia, WB Saunders Co, 1974. 8. Colby RA, Kerr DA, Robinson HBG: Color Atlas of Oral Pathology , ed 3. Philadelphia, JB Lippincott Co, 1971, p 167. 9. Cooke BED: Keratinizing lesions affecting the oral mucosa . Proc R Soc Med 60:819-822, 1967. 10. Whitten JB: The electron microscopic examination of congenital keratoses of the oral mucous membranes: I. White sponge nevus . Oral Surg 29:69-84, 1970.Crossref 11. Frithiof L, Bánóczy J: White sponge nevus (leukoedema exfoliativum mucosae oris): Ultrastructural observations . Oral Surg 41:607-622, 1976.Crossref 12. Ludy TB, Shirazy E: Congenital leukokeratosis mucosa oris (keratosis diseminée de muquese) . New Int Clin 4:38-41, 1941. 13. Kinney RC, Derifield RS: Pachyderma oralis: Report of a case . J Oral Surg 14:71-73, 1956. 14. Simpson HE: White sponge nevus: Report of three cases . J Oral Surg 24:463-466, 1966. 15. Darling AI, Fletcher JP: Familial white folded gingivostomatitis . Oral Surg 11:296-301, 1958.Crossref 16. Cannon AB: White sponge nevus of the mucosa (naevus spongiosus albus mucosae) . Arch Dermatol Syphilol 31:365-370, 1935.Crossref 17. Zagarelli EV, Everett FG, Kutscher AH, et al: Familial white folded dysplasia of the mucous membranes . Arch Dermatol 80:59-65, 1959.Crossref 18. Cooke BED, Morgan J: Oral epithelial naevi . Br J Dermatol 71:134-138, 1959.Crossref 19. Haye KR, Whitehead FIH: Hereditary leukokeratosis of the mucous membranes . Br J Dermatol 80:529-533, 1968.Crossref 20. Cohen L, Young AH: The white sponge naevus . Br J Oral Surg 5:206-210, 1968.Crossref 21. Scott CR: Hereditary leukokeratosis: White mouth . J Pediatr 68:768-772, 1966.Crossref 22. Gandy DT: Nevus spongiosus albus mucosae: Report of a case . Tex J Med 48:145, 1952. 23. Degos R, Ebrard G: Leucokeratose papillomateuse buccogénitale familiale . Bull Soc Dermatol Syphiligr 65:242-243, 1958. 24. Cooke BED: Leucoplakia buccalis and oral epithelial naevi; a clinical and histological study . Br J Dermatol 68:151-174, 1956.Crossref 25. Bolgert M, Friez P, Laroche JF, et al: A propos de trois cas de leucokératoses buccales exfoliantes . Rev Stomatol 67:405-415, 1966. 26. Tarel A, Donazzan M, Carlier C: Un cas de leukokératose généralisée de la muqueuse buccale . Rev Stomatol 67:398-404, 1966. 27. Stewart WM, Thorel M, Lauret PH, et al: Nevus blanco esponjoso . Med Cutan 5:269-275, 1971. 28. Pindborg JJ: Atlas of Diseases of the Oral Mucosa . Philadelphia, WB Saunders Co, 1968, p 114. 29. Stiff RH, Ferraro E: Hereditary keratosis . Oral Surg 28:697-701, 1969.Crossref 30. Hyde JN: An unusual naevus of the tongue in a 5 year old boy . J Cutan Dis 27:25-26, 1909. 31. Stuttgen G, Berres HH, Will W: Leukoplakische, epitheliale Naevi der Mundschleimhaut und ihre Keratinisierungsform . Arch Klin Exp Dermatol 221:433-446, 1965.Crossref 32. DeGraciansky P, Taieb M, Mathieu C: Naevus epithelial de la muqueuse buccale . Bull Soc Fr Dermatol 69:592-593, 1962. 33. Werner AL: White sponge nevus: Familial-congenital leukokeratosis mucosa oris . Cutis 5:555-558, 1969. 34. Ritger M: Naevus spongiosus albus mucosae (white sponge nevus) . Tandlaegebladet 75:690-703, 1971. 35. Smith JF: White sponge nevus: Report of a case . J Oral Surg Anesth 20:153-155, 1962. 36. McCarthy PL, Shklar G: Disease of the Oral Mucosa . New York, McGraw-Hill Book Co, 1964, pp 108-110. 37. Kamalamma MK, Paobhu SR, Shetty JN, et al: The white sponge nevus . Oral Surg 30:51-54, 1970.Crossref 38. Bernstein HF, Lewin RW: White sponge nevus . Oral Surg 12:1200-1202, 1959.Crossref 39. McGinnis JP Jr, Turner JE: Ultrastructure of the white sponge nevus . Oral Surg 40:644-651, 1975.Crossref 40. Burket LW: Oral Medicine, Diagnosis and Treatment , ed 5. Philadelphia, JB Lippincott Co, 1965, p 80. 41. Butterworth T, Strean LP: Clinical Genodermatology . Baltimore, Williams & Wilkins Co, 1962, p 141. 42. Zegarelli EV, Everett FG, Kutscher AH: Familial white folded dysplasia of the mucous membranes . Oral Surg 14:1436-1443, 1961.Crossref 43. Hermann D: Leukoedema exfoliativum Mucosae oris . Dtsch Zahnaerztl Z 29:38-45, 1974. 44. Bánóczy J, Sugar L: Leukoedema exfoliativum Mucosae oris . Dtsch Zahnaerztl Z 23:478-484, 1968. 45. Sugar L, Bánóczy J: Observatii asupra unei boli a mucoase bucale: Leucoedema exfoliativum mucosae oris . Stomatologia 7:199-204, 1970. 46. Sugar L, Bánóczy J: Leukoedema exfoliativum mucosae oris . Fogow Izle 64:377-379, 1971. 47. Bánóczy J, Sugar L, Frithiof L: White sponge nevus: Leukoedema exfoliativum mucosae oris; report of 45 cases . Swed Dent J 66:481-483, 1973. 48. Witkop CJ: Genetic disease of the oral cavity , in Tiecke RW (ed): Oral Pathology . New York, McGraw-Hill Book Co, 1965, p 827. 49. Witkop CJ Jr, Gorlin RJ: Four hereditary mucosal syndromes . Arch Dermatol 84:762-771, 1961.Crossref 50. Gorlin RJ: Genetic disorders affecting mucous membranes . Oral Surg 28:512-525, 1969.Crossref 51. Gorlin RJ: Heritable mucocutaneous disorders , in Stewart RE, Prescott GH (eds): Oral Facial Genetics . St Louis, CV Mosby Co, 1971, pp 360-365.

Kaidbey, Kays H.;Allen, Herbert

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020019016

Abstract † A photodermatitis developed in two patients after the use of commercial sunscreens and a topical anesthetic lotion containing benzocaine. Photopatch testing indicated the presence of photocontact allergy to benzocaine. One patient had a positive photopatch test to a commercial glyceryl para-aminobenzoic acid (PABA) preparation that was heavily contaminated with benzocaine, but not to a benzocaine-free sample of glyceryl PABA. Benzocaine failed to produce phototoxic reactions in normal volunteers. Efforts to induce photocontact allergy in guinea pigs were unsuccessful. (Arch Dermatol 117:77-79, 1981) References 1. Berger DS: Specification and design of solar ultraviolet simulators . J Invest Dermatol 53:192-199, 1969.Crossref 2. Kaidbey KH, Kligman AM: Photocontact allergy to 6-methylcoumarin . Contact Dermatitis 4:277-282, 1978.Crossref 3. Kaidbey KH, Kligman AM: The photomaximization test for identifying photoallergic contact sensitizers . Contact Dermatitis 6:161-169, 1980.Crossref 4. Kaidbey KH, Kligman AM: Identification of topical photosensitizing agents in humans . J Invest Dermatol 70:149-151, 1978.Crossref 5. Fisher AA: Contact Dermatitis , ed 2. Philadelphia, Lea & Febiger, 1973, pp 42-44. 6. Epstein S: Photocontact dermatitis from benzocaine . Arch Dermatol 92:591, 1965.Crossref 7. Caro I: Contact allergy/photo allergy to glyceryl PABA and benzocaine . Contact Dermatitis 4:381-382, 1978.Crossref 8. Fisher AA: The presence of benzocaine in sunscreens containing glyceryl PABA (Escalol 106) . Arch Dermatol 113:1299-1300, 1977.Crossref 9. Meltzer L, Baer RL: Sensitization to monoglycerol para-aminobenzoate . J Invest Dermatol 12:31-39, 1949. 10. Curtis GH, Crawford PF: Cutaneous sensitivity to monoglyceryl para-aminobenzoate . Cleve Clin Q 18:35-38, 1951. 11. Fisher AA: Sunscreen dermatitis due to glyceryl PABA: Significance of cross-reactions to this PABA ester . Cutis 18:495-500, 1976. 12. Mathias CGT, Maibach HI, Epstein J: Allergic contact photodermatitis to para-aminobenzoic acid . Arch Dermatol 114:1665-1666, 1978.Crossref 13. Fisher AA: Dermatitis due to benzocaine present in sunscreens containing glyceryl PABA . Contact Dermatitis 3:170-171, 1977.Crossref 14. Hjorth N, Wilkinson D, Magnusson B, et al: Glyceryl p-aminobenzoate patch testing in benzocaine-sensitive subjects . Contact Dermatitis 4:46-48, 1978.Crossref 15. Satulsky EM: Photosensitization induced by monoglycerol paraaminobenzoate: A case report . Arch Dermatol 62:711-713, 1950. 16. Goldman GC, Epstein E Jr: Contact photosensitivity dermatitis from sun-protective agent . Arch Dermatol 100:447-449, 1969.Crossref 17. Horio T, Higuchi T: Photocontact dermatitis from p-aminobenzoic acid . Dermatologica 156:124-128, 1978.Crossref

Krakauer, Randall S.;Sundeen, Jim;Sauder, Daniel N.;Scherbel, Arthur

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020022017

Abstract • We investigated immunoregulatory function in patients with progressive systemic sclerosis (PSS) in terms of in vitro IgM synthesis. Suppressor-cell function seems normal in regard to the ability of concanavalin A—treated cells to inhibit IgM synthesis by normal cells. At 4 × 105 T cells to 3 × 105 allogeneic normal B cells per milliliter, T cells from patients with PSS induce significantly more IgM synthesis by normal B cells than do normal T cells. This increased helper T-cell function might be involved in the pathogenesis of the disease. (Arch Dermatol 117:80-82, 1981) References 1. Fleischmajer R: Pathophysiology of scleroderma . Int J Dermatol 16:310-314, 1977.Crossref 2. Betschler JW: Induratio telae cellulosae (scleroderma) . Annal Klin Anstalten Universitat Breslau Geburtshulfe Krankheiten Weiben Kinder 1:209, 1832. 3. Jordon RE, DeLeer D, Schracter A, et al: Antinuclear antibodies: Their significance in scleroderma . Mayo Clin Proc 46:111-113, 1971. 4. Clark JA, Winkelmann RK, Ward LE: Serologic alterations in scleroderma and sclerodermatomyositis . Mayo Clin Proc 46:104-107, 1971. 5. Zvaifler NJ: Cryofibrinogens in scleroderma . Arthritis Rheum 15:133-134, 1972. 6. Alarcón-Segovia D, Fishbein E, Estrada-Parra S, et al: Immunochemical characterization of the anti-RNA antibodies found in scleroderma and systemic lupus erythematosus: II. Reactivity with hsa-coupled, uridinecontaining monophosphoric ribodinucleotides . Immunology 30:413-418, 1976. 7. Hughes P, Holt S, Rowell NR, et al: Thymus-dependent lymphocyte deficiency in progressive systemic sclerosis . Br J Dermatol 95:469-473, 1976.Crossref 8. Jesus DG, Clancy RL: Circulating T and B lymphocytes in progressive systemic sclerosis . J Rheumatol 2:336-339, 1975. 9. Horwitz DA, Garrent MA: Lymphocyte reactivity to mitogens in subjects with SLE, RA and scleroderma . Clin Exp Immunol 27:92-99, 1977. 10. Winkelstein A, Rodnan GP, Heilman JD: Cellular immunity in progressive systemic sclerosis (scleroderma) . Ann Rheum Dis 31:126-128, 1972.Crossref 11. Hughes P, Gelsthorpe K, Doughty RW, et al: The association of HLA-B8 with visceral disease in systemic sclerosis . Clin Exp Immunol 31:351-356, 1978. 12. Prystowsky SD, Gilliam JN, Tuffanelli DL: Epidermal nucleolar IgG deposition in clinically normal skin: Clinical and serologic features of eight patients . Arch Dermatol 114:536-538, 1978.Crossref 13. Scott DG, Rowell NR: Immunohistological studies of the kidney in SLE and systemic sclerosis using antisera to IgG, C3, fibrin, and human renal glomeruli . Ann Rheum Dis 33:473-481, 1974.Crossref 14. Hughes P, Holt S, Rowell NR: Leukocyte migration inhibition in progressive systemic sclerosis . Br J Dermatol 91:1-6, 1974.Crossref 15. Keyser AJ, Cooper SM, Ruoslahti E, et al: Scleroderma: Enhancement of connective tissue biosynthesis by a circulating factor , abstracted. Fed Proc 38:1339, 1979. 16. Wahl SM, Wahl LM, McCarthy JB: Lymphocyte mediated activation of fibroblast proliferation and collagen production . J Immunol 121:942-946, 1978. 17. Sundeen JT, Krakauer RS: A quantitative assay for low levels of IgM by solid-phase immunofluorescence . J Immunol Methods 26:229-244, 1979.Crossref 18. Krakauer RS, Clough JD, Frank S: Suppressor cell defect in systemic lupus erythematosus . Clin Immunol Immunopathol 14:327-333, 1979.Crossref 19. Broder S, Edelson RL, Lutzner MA, et al: The Sézary syndrome: A malignant proliferation of helper T cells . J Clin Invest 58:1297-1306, 1976.Crossref 20. Krakauer RS: Suppressor cell function in autoimmunity . Ann Intern Med 89:426, 1978. 21. Falkoff RM, Scarvelli JF: Suppressor cell function in autoimmunity . Ann Intern Med 89:426, 1978.Crossref 22. Johnson RL, Ziff M: Lymphokine stimulation of collagen accumulation . J Clin Invest 58:240-252, 1976.Crossref

Honma, Takayoshi;Saito, Taiichi;Fujioka, Yukio

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020025018

Abstract • Atypical lymphocytes with deep nuclear indentations, identical to those observed in Sézary syndrome and mycosis fungoides, were demonstrated by electron microscopy in the prickle-cell layer of the oral epithelium of patients with Behçet's syndrome. Many of these cells were present in association with macrophages. (Arch Dermatol 117:83-85, 1981) References 1. Lutzner MA, Jordan HW: The ultrastructure of an abnormal cell in Sézary's syndrome . Blood 31:719-726, 1968. 2. Brownlee TR, Murad TM: Ultrastructure of mycosis fungoides . Cancer 26:686-698, 1970.Crossref 3. Flaxman BA, Zelazny G, Van Scott EJ: Nonspecificity of characteristic cells in mycosis fungoides . Arch Dermatol 104:141-147, 1971.Crossref 4. Chapman JA, Elves MW, Gough J: An electron-microscope study of the in vitro transformation of human leucocytes: I. Transformation of lymphocytes to blastoid cells in the presence of phytohaemagglutinin . J Cell Sci 2:359-370, 1967. 5. Douglas SD, Cohnen G, Brittinger G: Ultrastructural comparison between phytomitogen transformed normal and chronic lymphocytic leukemia lymphocytes . J Ultrastruct Res 44:11-26, 1973.Crossref 6. Yeckley JA, Weston WL, Thorne EG, et al: Production of Sézary-like cells from normal human lymphocytes . Arch Dermatol 111:29-32, 1975.Crossref 7. Meyer CJ, van Leeuwen AW, van der Loo EM, et al: Cerebriform (Sézary like) mononuclear cells in healthy individuals, a morphologically distinct population of T cells: Relationship with mycosis fungoides and Sézary's syndrome . Virchows Arch Cell Pathol 25:95-104, 1977. 8. Rosas-Uribe A, Variakojis D, Molnar Z, et al: Mycosis fungoides: An ultrastructural study . Cancer 34:634-645, 1974.Crossref 9. Van Leeuwen AW, Meyer CJ, van de Putte LB, et al: Sézary type cells in rheumatoid synovial fluid . Lancet 1:248-249, 1976.Crossref 10. De Vries EA, van Leeuwen AW, van de Putte LB, et al: Atypical T cells in rheumatoid synovial membranes . Virchows Arch Cell Pathol 24:19-26, 1977. 11. Van Leeuwen AW, Meyer CJ, van Vloten WA, et al: Further evidence for the T-cell nature of the atypical mononuclear cells in mycosis fungoides . Virchows Arch Cell Pathol 21:179-187, 1976. 12. Zucker-Franklin D, Melton JW, Quagliata F: Ultrastructural, immunologic, and functional studies on Sézary cells: A neoplastic variant of thymus-derived (T) lymphocytes . Proc Natl Acad Sci USA 71:1877-1881, 1974.Crossref 13. Stanley HR: Aphthous lesion . Oral Surg 33:407-416, 1972.Crossref 14. Lehner T: Pathology of recurrent oral ulceration and oral ulceration in Behçet's syndrome: Light, electron and fluorescence microscopy . J Pathol Bacterial 97:481-494, 1969.Crossref 15. Saito T, Honma T, Sato T, et al: Auto-immune mechanisms as a probable aetiology of Behçet's syndrome, an electron microscopic study of the oral mucosa . Virchows Arch Pathol Anat 353:261-272, 1971.Crossref 16. Honma T: Electron microscopic study on the pathogenesis of recurrent aphthous ulceration as compared to Behçet's syndrome . Oral Surg 41:366-377, 1976.Crossref 17. Lutzner MA, Hobbs JW, Horvath P: Ultrastructure of abnormal cells in Sézary syndrome, mycosis fungoides, and parapsoriasis en plaque . Arch Dermatol 103:375-386, 1971.Crossref 18. Broder S, Edelson RL, Lutzner MA, et al: The Sézary syndrome: A malignant proliferation of helper T cells . J Clin Invest 58:1297-1306, 1976.Crossref

Barsky, Sidney;Doyle, John A.;Winkelmann, Richard K.

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020028019

Abstract • Four patients with nevus comedonicus (NC) and the histological changes of epidermolytic hyperkeratosis (EH) are described. The relationship between NC and other epidermal nevi in which EH may occur is further emphasized by this finding. (Arch Dermatol 117:86-88, 1981) References 1. Kofmann S: Ein Fall von Seltener Localisation and Verbreitung von Komedonen . Arch Dermatol Syphilidologie 32:177-178, 1895.Crossref 2. Beerman H, Homan JB: Naevus Comedonicus . Arch Klin Exp Dermatol 208:325-342, 1959.Crossref 3. Wood MG, Thew MA: Nevus comedonicus: A case with palmar involvement and review of the literature . Arch Dermatol 98:111-116, 1968.Crossref 4. Leppard B, Marks R: Comedone naevus: A report of nine cases . Trans St Johns Hosp Dermatol Soc 59:45-51, 1973. 5. Nabai H, Mehregan AH: Nevus comedonicus: A review of the literature and report of twelve cases . Acta Derm Venereol 53:71-74, 1973. 6. Sweitzer SE, Winer LH: Naevus unilateralis comedonicus: Naevus follicularis keratosus of White . Arch Dermatol 26:694-705, 1932. 7. Montgomery H: Dermatopathology . Hagerstown, Md, Harper & Row Publishers Inc, 1967, vol 1, p 64. 8. Winkelmann RK: Dermatopathology . J Invest Dermatol 67:188-194, 1976.Crossref 9. Piers F: Linear comedo nevus and ichthyosis . Br J Dermatol 57:138-147, 1945.Crossref 10. Rupee M: Naevus follicularis keratosus (Naevus comedonicus) mit Elastoma intrapapillare . Derm Wochenschr 147:141-148, 1963. 11. Burgreen BL, Ackerman AB: Acneform lesions in Becker's nevus . Cutis 21:617-619, 1978. 12. Leppard BJ: Trichilemmal cysts arising in an extensive comedo nevus . Br J Dermatol 96:545-548, 1977.Crossref 13. Carneiro SJC, Dickson JE, Knox JM: Familial dyskeratotic comedones . Arch Dermatol 105:249-251, 1972.Crossref 14. Ackerman AB: Histopathologic concept of epidermolytic hyperkeratosis . Arch Dermatol 102:253-259, 1970.Crossref 15. Degos R, Civatte J, Belaïch S, et al: Image histologique particulière de certains naevi verruqueux systématisés . Ann Dermatol Venereol 96:361-374, 1969.

Bondi, Edward E.;Clark, Wallace H.;Elder, David;Guerry, DuPont;Greene, Mark H.

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020031020

Abstract • A therapeutic response to topical fluorouracil in a patient with the large atypical nevus syndrome is presented. Six of the patients' dysplastic melanocytic nevi were treated with topical fluorouracil. Four common acquired melanocytic nevi from normal individuals were also treated. All six dysplastic nevi responded with inflammation, ulceration, and subsequent disappearance of the lesion, while the four control melanocytic nevi remained unchanged. Although we do not presently advocate the therapeutic use of fluorouracil for large atypical nevi until its safety and efficacy have been established, the response reported herein may herald an important advance in the therapy of these troublesome lesions that are known to be histogenetic precursors of malignant melanoma. (Arch Dermatol 117:89-92, 1981) References 1. Elder DE, Greene MH, Clark WH: The relationship of nevi and melanoma: The large atypical nevus syndrome . Am J Dermatopathol , to be published. 2. Elder DE, Goldman LI, Goldman SC, et al: The large atypical nevus syndrome: A phenotypic association of malignant melanoma . Cancer 1980;46:73-80.Crossref 3. Clark WH, Reimer RR, Greene MH, et al: Origin of familial malignant melanomas from heritable melanocytic lesions: `The B-K Mole Syndrome .' Arch Dermatol 1978;114:732-738.Crossref 4. Greene MH, Fraumeni JF: The hereditary variant of malignant melanoma , in Clark WH, Goldman LI, Mestrangelo MJ (eds): Human Malignant Melanoma . New York, Grune & Stratton Inc, pp 139-165. 5. Greene MH, Clark WH, Kraemer KH, et al: New observations in heritable melanoma . Cancer Res 1980;21:323. 6. Munro DD: Multiple junctional nevi with familial history of malignant melanoma . Proc R Soc Med 1974;67:594-595. 7. Dillaha CJ, Jansen GT, Honeycutt WM, et al: Selective cytotoxic effect of topical 5-fluorouracil . Arch Dermatol 1963;88:247-256.Crossref 8. Dillaha CJ, Jansen GT, Honeycutt WM, et al: Further studies with topical 5-fluorouracil . Arch Dermatol 1965;92:410-417.Crossref 9. Klein E, Stoll HL, Milgrom H, et al: Tumors of the skin: XII. Topical 5-fluorouracil for epidermal neoplasms . J Surg Oncol 1971;3:331-349.Crossref 10. Litwin MS, Krementz ET, Mansell PW, et al: Topical chemotherapy of lentigo maligna with 5-fluorouracil . Cancer 1975;35:721-733.Crossref 11. Heidelberger C, Ansfield FJ: Experimental and clinical use of fluorinated pyrimidines in cancer chemotherapy . Cancer Res 1963;23:1226-1243. 12. Cohen SS, Flaks JG, Barner HD, et al: The mode of action of 5-fluorouracil and its derivatives . Proc Natl Acad Sci USA 1958;44:1004-1012.Crossref 13. Calabresi P, Parks RE: Alkylating agents, antimetabolites, hormones, and other antiproliferative agents , in Goodman LS, Gilman S (eds): The Pharmacologic Basis of Therapeutics , ed 5. New York, Macmillan Publishing Co Inc, pp 1274-1275.

McGeady, Stephen J.;Buella, Ofelia;Heimer, Ralph;Mansmann, Herbert C.

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020035021

Abstract • A girl had opportunistic infections and was found to have T-cell dysfunction. During a period of months, recurrent staphylococcal infections, polyclonal hyperglobulinemia, eosinophilia, and peripheral, necrotizing, cutaneous lesions developed. Circulating immune complexes were demonstrated, and abnormal suppressor-cell function was found. At age 36 months, the child died of a staphylococcal pneumonia. At postmortem examination, the thymus gland was found to be histologically abnormal, lacking corticomedullary differentiation. We propose that this patient had a syndrome in which lymphocyte abnormalities and dysfunction of suppressor T cells permitted hyperresponsiveness of antibody-forming cells. Large amounts of circulating antibody and immune complexes were formed, and their deposition led to peripheral tissue injury. (Arch Dermatol 117:93-98, 1981) References 1. Gershon RK: T cell control of antibody production . Contemp Top Immunobiol 3:1-40, 1974. 2. Waldmann TA, Blaese RM, Broder S, et al: Disorders of suppressor immunoregulatory cells in the pathogenesis of immunodeficiency and autoimmunity . Ann Intern Med 88:226-238, 1978.Crossref 3. Waldmann TA, Broder S, Blaese RM, et al: Role of suppressor T cells in pathogenesis of common variable hypogammaglobulinemia . Lancet 2:609-613, 1974.Crossref 4. Waldmann TA, Broder S, Krakauer R, et al: Defect in IgA secretion and in IgA specific suppressor cells in patients with selective IgA deficiency . Trans Assoc Am Physicians 89:215-244, 1976. 5. Bresnihan B, Jasin HE: Suppressor function of peripheral blood mononuclear cells in normal individuals and in patients with systemic lupus erythematosus . J Clin Invest 59:106-115, 1977.Crossref 6. Abdou NI, Sagawa A, Pascual E, et al: Suppressor T cell abnormality in idiopathic systemic lupus erythematosus . Clin Immunol Immunopathol 6:192-199, 1976.Crossref 7. Okumura K, Tada T: Regulation of homocytotropic antibody formation in the rat: III. Effect of thymectomy and splenectomy . J Immunol 106:1019-1025, 1971. 8. Gifford RJ, Malawista SE: A simple rapid micro-method for detecting chronic granulomatous disease of childhood . J Lab Clin Med 75:511-519, 1970. 9. Jacobs JC, Norman ME: A familial defect of neutrophil chemotaxis with asthma, eczema, and recurrent skin infections . Pediatr Res 11:732-736, 1977.Crossref 10. Larhuma AZ, Cambiaso CL, Masson PT, et al: Detection of circulating antigen-antibody complexes by their inhibitory effect on the agglutination of IgG-coated particles by rheumatoid factor or Clq . Clin Exp Immunol 25:212-226, 1976. 11. Theofilopoulois AN, Wilson CB, Dixon FJ: The Raji cell radioimmune assay for detecting immune complexes in human sera . J Clin Invest 57:169-182, 1976.Crossref 12. Stiehm ER: Immunodeficiency disorders: General considerations , in Stiehm ER, Fulginiti V (eds): Immunologic Disorders in Infants and Children . Philadelphia, WB Saunders Co, 1973, p 145. 13. Mendes NF, Tolnoi MEA, Silveira NP, et al: Technical aspects of the rosette tests used to detect human complement receptor (B) and sheep erythrocyte binding (T) lymphocytes . J Immunol 111:860-867, 1973. 14. McGeady SJ, Buckley RH: Depression of cell mediated immunity in atopic eczema . J Allergy Clin Immunol 56:393-406, 1975.Crossref 15. Goldstein AL, Cohen GH, Rossio JL, et al: Use of thymosin in the treatment of primary immunodeficiency diseases and cancer . Med Clin North Am 60:591-606, 1976. 16. Shou L, Schwartz SA, Good RA: Suppressor cell activity concanavalin A treatment of lymphocytes from normal donors . J Exp Med 143:1100-1110, 1976.Crossref 17. Waldmann TA, Broder S: Suppressor cells in the regulation of the immune response . Prog Clin Immunol 3:155-199, 1977. 18. Pierce CW, Kapp JA: Regulation of immune response by suppressor T cells , in Weigle WO (ed): Contemporary Topics in Immunobiology . New York, Plenum Press, 1976, vol 5, p 91. 19. Haynes BF, Fauci AS: Activation of human B lymphocytes: III. Concanavalin A-induced generation of suppressor cells of the plaqueforming cell response to normal human B lymphocytes . J Immunol 118:2281-2287, 1977. 20. Fiser PM, Buckley RH: Human IgE biosynthesis in vitro: Studies with atopic and normal blood mononuclear cells and subpopulations . J Immunol 123:1788-1794, 1979. 21. Buckley RH, Wray BB, Belmaker EZ: Extreme hyperimmunoglobulinemia E and undue susceptibility to infection . Pediatrics 49:59-70, 1972. 22. Clark RA, Root RK, Kimball HR, et al: Defective neutrophil chemotaxis and cellular immunity in a child with recurrent infections . Ann Intern Med 78:515-519, 1973.Crossref 23. Hill HR, Quie PG: Raised serum-IgE levels and defective neutrophil chemotaxis in three children with eczema and recurrent bacterial infections . Lancet 1:183-187, 1974.Crossref 24. Van Scoy RE, Hill HR, Ritts RE Jr, et al: Familial neutrophil chemotaxis defect, recurrent bacterial infections, mucocutaneous candidiasis, and hyperimmunoglobulinemia E . Ann Intern Med 82:766-771, 1975.Crossref 25. Church JA, Frenkel LD, Wright DG, et al: T lymphocyte dysfunction, hyperimmunoglobulinemia E, recurrent bacterial infections, and defective neutrophil chemotaxis in a Negro child . J Pediatr 88:982-986, 1976.Crossref 26. Hanifin JM, Rogge JL: Staphylococcal infections in patients with atopic dermatitis . Arch Dermatol 113:1383-1386, 1977.Crossref 27. Wyre, HW Jr, Johnson WT: Clinical syndrome of chemotaxis defect, infections, and hyperimmunoglobulinemia E: A case report . Arch Dermatol 114:74-77, 1978.Crossref 28. DeCree J, Emmery L, Timmermans J, et al: Defective neutrophil chemotaxis and raised serum IgE levels in a child with recurrent bacterial infections and eczema . Arch Dis Child 53:144-149, 1978.Crossref 29. Altman LC, Snyderman R: Defective leukocyte chemotaxis associated with hyperimmunoglobulinemia E , in Frazier CA (ed): Annual Review of Allergy . New York, Medical Examination Publishing Co Inc, 1978, p 260. 30. Snyderman R, Buckley RH: Defects of monocyte chemotaxis in patients with hyperimmmunoglobulinemia E and undue susceptibility to infection . J Allergy Clin Immunol 55:102-103, 1975. 31. Snyderman R, Rogers E, Buckley RH: Abnormalities of leukotaxis in atopic dermatitis . J Allergy Clin Immunol 60:121-126, 1977.Crossref 32. Weston WL, Humbert JR, August CS, et al: A hyperimmunoglobulinemia E syndrome with normal chemotaxis in vitro and defective leukotaxis in vivo . J Allergy Clin Immunol 59:115-119, 1977.Crossref 33. Rogge JL, Hanifin JM: Immunodeficiencies in severe atopic dermatitis: Depressed chemotaxis and lymphocyte transformation . Arch Dermatol 112:1391-1396, 1976.Crossref 34. Tsuda S, Sasai Y, Minami K, et al: Contributions of T cell mediated immunity to the resistance to staphylococcal infection . J Invest Dermatol 70:345-347, 1978.Crossref 35. Schopfer K, Baerlocher K, Price P, et al: Staphylococcal IgE antibodies, hyperimmunoglobulinemia E and staphylococcus aureus infections . N Engl J Med 300:835-838, 1979.Crossref 36. Sams WM Jr, Claman HN, Kohler PF, et al: Human necrotizing vasculitis: Immunoglobulins and complement in vessel walls of cutaneous lesions and normal skin . J Invest Dermatol 64:441-445, 1975.Crossref 37. Mackel SE, Tappeiner G, Brumfield H: Circulating immune complexes in cutaneous vasculitis: Detection with Clq and monoclonal rheumatoid factor . J Clin Invest 64:1652-1660, 1979.Crossref

Bechtel, Mark A.;Bertolone, S. J.;Hodge, Steven J.

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020041022

Abstract • An 8-year-old boy with erythropoietic protoporphyria had a marked decrease in photosensitivity symptoms after several transfusions with washed, packed RBCs. The reduction in photosensitivity was associated with a decline in free erythrocyte protoporphyrin levels. (Arch Dermatol 117:99-101, 1981) References 1. Harber LC: Porphyria , in Demis DJ, Dobson RL, McGuire J (eds): Clinical Dermatology . Hagerstown, Md, Harper & Row Publishers Inc, 1976, vol 2, pp 13-17. 2. DeLeo VA, Poh-Fitzpatrick M, Mathews-Roth M, et al: Erythropoietic protoporphyria . Am J Med 1976;60:8-22.Crossref 3. Bottomley SS, Tanaka M, Everett MA: Diminished bone marrow ferrochelatase activity in protoporphyria . Clin Res 1974;22:384a. 4. Mathews-Roth MM, Pathak MA, Fitzpatrick TB, et al: Beta carotene therapy for erythropoietic protoporphyria and other photosensitivity diseases . Arch Dermatol 1977;113:1229-1232.Crossref 5. Moshell A, Bjornson L: Protoporphyria: Mechanism of photoprotection by beta-carotene . J Invest Dermatol 1977;68:157-160.Crossref 6. Scholnick P, Marven HS, Schmid R: Erythropoietic protoporphyria: Evidence for multiple sites of excess protoporphyrin formation . J Clin Invest 1971;50:203-207.Crossref 7. Piomelli S, Lamola AA, Poh-Fitzpatrick MB, et al: Erythropoietic protoporphyria and lead intoxication: The molecular basis for difference in cutaneous photosensitivity . J Clin Invest 1971;56:1519-1527.Crossref 8. Russell MO, Goldberg HI, Reis L, et al: Transfusion therapy for cerebrovascular abnormalities in sickle cell disease . J Pediatr 1976;88:382-387.Crossref 9. Beard MEJ, Necheles TF, Allen DM: Intensive transfusion therapy in thalassemia major . Pediatrics 1967;40:912-913. 10. Miao LL, Mathews-Roth MM, Poh-Fitzpatrick MB: Beta carotene treatment and erythrocytic protoporphyrin levels . Arch Dermatol 1979;115:818.Crossref 11. Giblett ER: Blood groups and blood transfusion , in Isselbacher KJ, Adams RD, Braunwald E (eds): Harrison's Principles of Internal Medicine , ed 9. New York, McGraw-Hill Book Co, 1975, pp 1575-1576.

Burkhart, Craig G.;Gohara, Amira

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020044023

Abstract • An 18-month-old infant had diffuse, gray-blue pigmentation on the buttocks bilaterally, extending the entire length of his right leg in a dermatomal pattern. In the lesion there were several conspicuous macules of considerably darker hue. Histologic and ultrastructural examinations revealed numerous dermal melanocytes. Clinically and pathologically, the patient had a distinctive type of dermal melanocytosis for which we propose the name "dermal melanocyte hamartoma." (Arch Dermatol 117:102-104, 1981) References 1. Rook AJ: Progression in the Biological Sciences in Relation to Dermatology . Cambridge, Mass, Cambridge University Press, 1960, p 3. 2. Mishima Y, Mevorah B: Nevus of Ota and nevus of Ito in American blacks . J Invest Dermatol 1961;36:133-154. 3. Kopf AW, Weidman AI: Nevus of Ota . Arch Dermatol 1962;85:195-208.Crossref 4. Cole HN Jr, Hubler WR, Lund HZ: Persistent, aberrant mongolian spots . Arch Dermatol 1950;61:244-260.Crossref 5. Pariser H, Beerman H: Extensive blue patchlike pigmentation: A morphologic variant of blue nevus? Persistent extrasacral mongolian blue spot? Diffuse mesodermal pigmentation? Arch Dermatol 1949;59:396-404. 6. Pratt AG: Birthmarks in infants . Arch Dermatol 1953;67:302-305.Crossref 7. Larsen NP, Godfrey LS: Sacral pigment spots . Am J Phys Anthropol 1927;10:253-274.Crossref 8. Dorsey CS, Montgomery H: Blue nevus and its distinction from mongolian spot and the nevus of Ota . J Invest Dermatol 1954;22:225-236.Crossref 9. Rodriguez HA, Ackerman LV: Cellular blue nevus: Clinicopathologic study of 45 cases . Cancer 1968;21:393-405.Crossref 10. Okawa Y, Yokota R, Yamauchi A: On the extracellular sheath of dermal melanocytes in nevus fuscoceruleus acromiodeltoideus (Ito) and mongolian spot . J Invest Dermatol 1979;73:224-230.Crossref 11. Mishima Y: Macromolecular changes in pigmentary disorders . Arch Dermatol 1965;91:519-557.Crossref 12. Ingue S, Kuwahara H, Kikuch I: Electron microscopic studies on stromal melanocytosis . Kumamoto Med J 1973;26:126-137. 13. Mishima Y: Melanotic tumors , in Zelickson A (ed): Ultrastructure of Normal and Abnormal Skin . Philadelphia, Lea & Febiger, 1967, pp 418-420. 14. Konrad K, Hönigsmann H, Wolff K: Bindegewebsmelanocyten beim Menschen: Elektronenmikroskopische und histochemische Untersuchungen beim Mongolenfleck und blauem Naevus . Arch Dermatol Forsch 1972;244:273-275.Crossref

Lang, Pearon G.

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020047024

Abstract • A man with keratosis lichenoides chronica is described who, unlike previously described patients, had had his eruption since infancy. Moreover, this patient had prominent oral involvement resembling lichen planus. Typically, keratosis lichenoides chronica is recalcitrant to all forms of treatment, but this patient responded substantially to psoralen-ultraviolet-A therapy. Several weeks after treatment was completed, he showed no signs of relapse. (Arch Dermatol 117:105-108, 1981) References 1. Margolis MH, Cooper GA, Johnson SAM: Keratosis lichenoides chronica . Arch Dermatol 105:739-743, 1972.Crossref 2. Petrozzi JW: Keratosis lichenoides chronica: possible variant of lichen planus . Arch Dermatol 112:709-711, 1976.Crossref 3. Menter MA, Morricon JGL: Lichen verrucosus et reticularis of Kaposi (porokeratosis striata of Nekam): A manifestation of acquired adult toxoplasmosis . Br J Dermatol 94:645-654, 1975.Crossref 4. Duperrat B, Carton FX, Denceux JP, et al: Kératose lichénoide striée . Ann Derm Venereol 104:564-566, 1977. 5. Barriere H, Litoux P, Bureau B, et al: Kératose lichénoide striée: Forme congenitale . Ann Derm Venereol 104:767-769, 1977. 6. Goldberg L: Keratosis lichenoides chronica and treatment with PUVA . Presented at the Annual Meeting of the American Academy of Dermatology, San Francisco, Dec 2 , 1978. 7. Ortonne JP, Thivolet J, Sannwald C: Oral photochemotherapy in the treatment of lichen planus (L.P.) . Br J Dermatol 99:77-88, 1978.Crossref

Redman, Robert S.;Thorne, E. George

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020051025

Abstract • Three years after the onset of lupus erythematosus, blisters, erosions, and erythema of the gingivae developed in a 31-year-old man. A diagnosis of cicatricial pemphigoid was established by routine and immunofluorescence microscopy studies. An association between cicatricial pemphigoid and other autoimmune disorders seems to be rare. This case demonstrates the importance of performing immunofluorescence microscopy studies, as well as routine histologic assessments, of conditions that resemble desquamative gingivitis. (Arch Dermatol 117:109-110, 1981) References 1. Salo OP, Räsänen JA: Pemphigoid and rheumatoid arthritis . Ann Clin Res 4( (suppl 9) ):173-177, 1972. 2. Jordan RE, Muller SA, Hale WL, et al: Bullous pemphigoid associated with systemic lupus erythematosus , Arch Dermatol 99:17-25, 1969.Crossref 3. Kumar V, Binder WL, Schotland E, et al: Coexistence of bullous pemphigoid and systemic lupus erythematosus . Arch Dermatol 114:1187-1190, 1978.Crossref 4. Spigel GT, Winkelmann RK: Cicatricial pemphigoid and rheumatoid arthritis . Arch Dermatol 114:415-417, 1978.Crossref 5. Cohen AS, Reynolds WE, Franklin EC, et al: Preliminary criteria for the classification of systemic lupus erythematosus . Bull Rheum Dis 21:643-648, 1971. 6. Nisengard RJ, Jablonska S, Beutner EH, et al: Diagnostic importance of immunofluorescence in oral bullous diseases and lupus erythematosus . Oral Surg 40:365-375, 1975.Crossref 7. Ullman S, Dahl MV: Direct immunofluorescence in oral pathology . Northwest Dent 54:16-20, 1975. 8. Andreasen JO: Oral manifestations in discoid and systemic lupus erythematosus: I. Clinical investigation . Acta Odontol Scand 22:295-310, 1964.Crossref 9. Andreasen JO, Poulsen HE: Oral manifestations in discoid and systemic lupus erythematosus: II. Histologic investigation . Acta Odontol Scand 22:389-400, 1964.Crossref 10. Edwards MB, Gayford JJ: Oral lupus erythematosus: Three cases demonstrating three variants . Oral Surg 31:332-342, 1971.Crossref 11. Person JR, Rogers RS: Bullous and cicatricial pemphigoid: Clinical, histopathologic, and immunopathologic correlations . Mayo Clin Proc 52:54-66, 1977. 12. Rogers RS, Sheridan PJ, Jordan RE: Desquamative gingivitis: Clinical, histopathologic, and immunopathologic investigations . Oral Surg 42:316-327, 1976.Crossref 13. Forman L, Nally FF: Oral non-dystrophic bullous eruption mainly limited to the gingivae: A mechano-bullous response. A variant of cicatricial mucous membrane pemphigoid? Br J Dermatol 96:111-117, 1977.Crossref

Davies, Michael G.;Greaves, Malcolm W.;Coutts, Angela;Black, Ann Kobza

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020053026

Abstract • A man had a long history of a persistent, fixed area of livid erythema on the trunk. The distribution of hair, sweat, and sensation were normal as were the histologic findings in the affected skin. The involved area had a decreased total skin blood flow and a lower surface temperature compared with surrounding uninvolved skin, but showed normal responses to vasoconstrictor and vasodilator stimuli. Incomplete sympathetic blockade partially abolished the erythema. We suggest that the appearance of the nevus is caused by increased vasoconstrictor tone in the thermoregulatory vessels of the involved skin, leading to relative stasis in the superficial "nutritional" vasculature. This would seem to be a new example of a "pharmacological nevus" showing similarities to and differences from nevus anemicus. (Arch Dermatol 117:111-113, 1981) References 1. Vorner F: Uber naevus anaemicus . Arch Dermatol 1906;82:391-398.Crossref 2. Greaves MW, Birkett D, Johnson C: Nevus anemicus: A unique catecholamine-dependent nevus . Arch Dermatol 1970;102:172-176.Crossref 3. Daniel RH, Hubler WR, Wolf JE Jr, et al: Nevus anemicus: Donordominant defect . Arch Dermatol 1977;113:53-56.Crossref 4. Rothman S: Physiology and Biochemistry of the Skin . Chicago, Chicago University Press, 1954. 5. Challoner AVJ, Ramsay CA: A photoelectric plethysmograph for the measurement of cutaneous blood flow . Phys Med Biol 1974;19:317-328.Crossref 6. Black AK, Greaves MW, Hensby CN, et al: A new method of recovery of exudates from normal and inflamed human skin . Clin Exp Dermatol 1977;2:209-216.Crossref 7. Holton P: The liberation of adenosine triphosphate on antidromic stimulation of sensory nerves . J Physiol 1959;145:494-504.

Taulbee, Kent S.;Johnson, Sylvia C.

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020056027

Abstract • We report two cases of Kaposi's varicelliform eruption that occurred in patients with cutaneous T-cell lymphoma. The purpose of this report is to emphasize that cutaneous T-cell lymphoma is among the chronic skin disorders that may predispose to cutaneous dissemination of viral infections. (Arch Dermatol 117:114-115, 1981) References 1. Wheeler CE Jr, Abele DC: Eczema herpeticum, primary and recurrent . Arch Dermatol 1966;93:162-173.Crossref 2. Scully RE, Galdabini JJ, McNeely BU: Case 37-1975, case records of Massachusetts General Hospital: Weekly clinicopathologic exercises . N Engl J Med 1975;293:598-603.Crossref 3. Segal RT, Watson W: Kaposi's varicelliform eruption in mycosis fungoides . Arch Dermatol 1978; 114:1067-1069.Crossref 4. McDonald CJ, Bertino JR: Treatment of mycosis fungoides lymphoma: Effectiveness of infusions of methotrexate followed by oral citrovorum factor . Cancer Treat Rep 1978;62:1009-1014. 5. Kaposi M: Pathology and Treatment of Diseases of the Skin , Johnston JC (trans-ed). London, Bailliere Tindall & Cox, 1895, p 346. 6. Martin HA: A most rare, possibly unique, case of general eruption of vaccinia . Med Rec 1882;21:393-396. 7. Esser ME, Seldenberg S, quoted by Lynch FW, Steves RJ: Kaposi's varicelliform eruption . Arch Dermatol Syphilol 1947;55:327-336.Crossref 8. Lamberg SI, Bunn PA Jr: Cutaneous T-cell lymphomas . Arch Dermatol 1979;115:1103-1105.Crossref 9. Lutzner M, Edelson R, Schein P, et al: Cutaneous T-cell lymphomas: The Sézary syndrome, mycosis fungoides, and related disorders . Ann Intern Med 1975;83:534-552.Crossref 10. Nordquist GC, Kinney JP: T and B cells and cell-mediated immunity in mycosis fungoides . Cancer 1976;37:714-718.Crossref 11. DuVivier A, Harper RA, Vonderheid E, et al: Lymphocyte transformation in patients with staged mycosis fungoides and Sézary syndrome . Cancer 1978;42:209-213.Crossref 12. Nahmias AJ, Roizman B: Infection with herpes simplex viruses 1 and 2 (part 2) . N Engl J Med 1973;289:719-725.Crossref 13. Bierman SM: The mechanism of recurrent infection by Herpesvirus hominis . Arch Dermatol 1976;112:1459-1461.Crossref 14. Nahmias AJ, Roizman B: Infection with herpes simplex viruses 1 and 2 (part 3) . N Engl J Med 1973;289:781-789.Crossref 15. Epstein EH Jr, Levin DL, Craft JD, et al: Mycosis fungoides: Survival, prognostic features, response to therapy, and autopsy findings . Medicine 1972;15:61-72.Crossref 16. Chien LT, Whitley RJ, Nahmias AJ, et al: Antiviral chemotherapy and neonatal herpes simplex virus infection: A pilot study—experience with adenine arabinoside (ARA-A) . Pediatrics 1975;55:678-685. 17. Whitley RJ, Ch'ien LT, Dolin R, et al: Adenine arabinoside therapy of herpes zoster in the immunosuppressed . N Engl J Med 1976;294:1193-1199.Crossref

WALTER, JOSEPH F.

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020058028

Abstract PATHOLOGY QUIZ CASE 1 LT Kenneth J. Folsom, MC, USNR, Naval Regional Medical Center, San Diego A 59-year-old man had a several-year history of slightly inflamed, translucent, 3- to 5-mm papules that first developed on the backs of his hands (Fig 1) and later appeared on his face and ears. These lesions tended to coalesce and were asymptomatic except for some transient pruritus. The patient's family history and a review of symptoms were noncontributory. Photomicrographs of a skin biopsy specimen are shown in Fig 2 and 3. What is your diagnosis? PATHOLOGY QUIZ CASE 2 LCDR Barbara G. Anderson, MC, USNR, Naval Regional Medical Center, San Diego A 24-year-old man had blue-gray tender lesions on his trunk and thighs that had gradually appeared during 1½ years. He was adopted and knew nothing of his family history. The lesions were 2 to 5 mm, slightly elevated, compressible, and tender on References 1. Mehregan AH: Actinic (senile) elastosis and colloid milium , in Fitzpatrick TB, Eisen AZ, Wolff K, et al (eds): Dermatology in General Medicine , ed 2. New York, McGraw-Hill Book Co, 1979, p 689. 2. Hashimoto K, Miller F, Bereston ES: Colloid milium: Histochemical and electron microscopic studies . Arch Dermatol 105:684-694, 1972.Crossref 3. Apfelberg DB, Druker D, Maser MR, et al: Treatment of colloid milium of the hand by dermabrasion . J Hand Surg 3:98-100, 1978.Crossref 4. Goodman TF, Abele DC: Multiple glomus tumors: A clinical and electron microscopic study . Arch Dermatol 103:11-23, 1971.Crossref 5. Rettig AC, Strickland JW: Glomus tumor of the digits . J Hand Surg 2:261-265, 1977.Crossref 6. Laymon CW, Peterson WC: Glomangioma (glomus tumor): A clinicopathologic study with special reference to multiple lesions appearing during pregnancy . Arch Dermatol 92:509-514, 1965.Crossref 7. Gupta RK, Gilbert EF, English RS: Multiple painful glomus tumors of the skin: Views on histogenesis: Case report . Arch Dermatol 92:670-673, 1965.Crossref

Smith, Francis D.;Shaffer, Kenton L.;Gasseling, Philip A.;McFadden, Harry W.

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020061029pmid: 7469433

Abstract Furuncular lesions in infants may, on rare occasions, be caused by penetration or scarification of the skin by larvae of the sarcophagid fly Wohlfahrtia vigil. The present case is considered worthy to record because of two unique features—the involvement of the youngest infant reported to date, and, to our knowledge, the report of the first case in Nebraska. Report of a Case The patient was a male infant born on June 10, 1979, and discharged from the hospital in his home community of Kearney, Neb, three days after birth. He appeared normal in every respect, and his neonatal course in the hospital was unremarkable. On the night of his fourth day of age, the mother noted a lesion on his right side, which was thought to be an insect bite. The next day this lesion had increased in size and two more lesions were discovered on the buttocks. The patient References 1. Eschile JL, DeFoliat GR: Rearing and biology of Wohlfahrtia vigil (Diptera: Sarcophagidae) . Ann Entomol Soc Am 1965;58:849-855. 2. Burgess NRH, McDermott SN, Chetwyn KN: A laboratory culture of Wohlfahrtia pattoni . Trans R Soc Trop Med Hyg 1972;66:800-801.Crossref 3. DeGiusti DL, Zuckheim H: A first report of Wohlfahrtia vigil (Walker) myiasis in man in Michigan . JAMA 1963; 184:782-783.Crossref 4. Ford N: Observations on the behaviour of the sarcophagid fly, Wohlfahrtia vigil (Walker) . J Parasitol 1932;19:106-111.Crossref 5. Ford N: Further observations on the behaviour of Wohlfahrtia vigil (Walk.) with notes on the collecting and rearing of the flies . J Parasitol 1936;22:309:328.Crossref 6. Staub HP, Kimmel GC, Berglund EB, et al: Cutaneous myiasis due to Wohlfahrtia vigil . Pediatrics 1964;34:880-884.

Tschen, Eduardo H.;Apisarnthanarax, Prapand

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020062030

Abstract Inflammatory metastatic carcinoma of the breast is an uncommon but well-known entity. Since it clinically can stimulate an inflammatory or infectious process, eg, erysipelas or cellulitis, it is frequently misdiagnosed.1 We report a rare case of carcinoma of the breast in which the initial-appearing sign for a short period was an inflammatory site of metastatic carcinoma on the left forearm. Report of a Case A 62-year-old woman was first seen in January 1979 at the Dermatology Clinic of the University of Texas Medical Branch, Galveston, with a four-month history of edema and pruritus in an inflammatory plaque of the left forearm. A month after onset, she noticed a small nodule on the left breast that grew rapidly and eventually ulcerated. Physical examination showed a well-nourished patient with normal vital signs. A 2 × 2-cm ulcer in the lateral upper quadrant of the left breast and a 2 × 2-mm References 1. Brownstein MH, Helwig EB: Metastatic tumors of the skin . Cancer 1972;29:1298-1307.Crossref 2. Hazelrigg DE, Rudolph AH: Inflammatory metastatic carcinoma . Arch Dermatol 1977;113:69-70.Crossref 3. Mehregan A: Metastatic carcinoma to the skin . Dermatologica 1961;123:311-325.Crossref 4. Brownstein MH, Helwig EB: Patterns of cutaneous metastasis . Arch Dermatol 1972;105:862-868.Crossref 5. Reingold IM: Cutaneous metastases from internal carcinoma . Cancer 1966;19:162-168.Crossref 6. Rasch C: Carcinoma erysipelatoides . Br J Dermatol Syphilol 1931;43:351-354.Crossref 7. Siegel JM: Inflammatory carcinoma of the breast . Arch Dermatol Syphilol 1952;66:710-716.Crossref 8. Brownstein MH, Helwig EB: Spread of tumors to the skin . Arch Dermatol 1973;107:80-86.Crossref

Safer, Leslie F.;Lang, Pearon G.;Demetree, John W.;Jones, Henry E.

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020063031

Abstract Tinea faciei is an uncommon dermatophyte infection that involves the face. It is a protean entity that is capable of mimicking several other dermatoses, eg, chronic discoid lupus erythematosus (LE), systemic LE, polymorphous light eruption, and contact dermatitis.1 There are 11 cases of tinea faciei simulating chronic discoid LE reported in the literature. Most of these have been caused by Trichophyton rubrum.1-4 In each case the lesions resolved after appropriate antifungal therapy. A patient with tinea corporis who also had tinea faciei coexistent with active chronic discoid LE of the face. Report of a Case A 21-year-old woman complained of a pruritic, scaling rash on her thighs that gradually progressed during a two-year period to involve the gluteal, inguinal, axillary, and inframammary regions. Approximately nine months before seeking medical attention, she noted involvement of her malar regions. There were no other associated dermatologic complaints, and her medical history References 1. Gilgor RS, Tindall JP, Elson M: Lupus erythematosus-like tinea of the face (tinea faciale) . JAMA 1971;215:2091-2094.Crossref 2. Howell JB, Wilson JW, Caro MR: Tinea capitis caused by Trichophyton tonsurans (sulfureum or crateriform) . Arch Dermatol 1952;65:194-205.Crossref 3. Shanon J, Raubitschek F: Tinea faciei simulating chronic discoid lupus erythematosus . Arch Dermatol 1960;82:268-271.Crossref 4. Pravda DJ, Pugliese MM: Tinea faciei . Arch Dermatol 1978;114:250-252.Crossref 5. McEachin BL: Tinea faciale and lupus erythematosus . JAMA 1971;21:828.Crossref 6. Alarcon-Segovia D, Worthington JW, Ward LE, et al: Lupus diathesis and the hydralazine syndrome . N Engl J Med 1965;272:462-466.Crossref

Peltier, Frank A.;Pursley, Terry V.;Apisarnthanarax, Prapand;Raimer, Sharon S.

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020065032

Abstract Hodgkin's disease (HD) may exhibit cutaneous manifestations in about 25% of the cases. Nonspecific involvement including pruritus and prurigo, eczematous eruptions, exfoliative dermatitis, pigmentation, alopecia, and ichthyosis is most commonly seen. Specific papular, nodular, and ulcerative skin lesions are also seen, but much less frequently. A patient had an unusual eczematoid dermatitis that showed the histologic features of palisading necrobiotic granuloma associated with HD. To our knowledge, this is the first case of this manifestation reported in the literature. Report of a Case A 68-year-old man was referred to us in June 1979 with increasing malaise, anorexia, arthralgias, and a pruritic dermatitis that had spread from the legs to the upper parts of the trunk and arms during the previous eight months. He had a medical history of psoriasis of the feet, toenails, and fingernails, chronic obstructive pulmonary disease, and hypertension. His medications included prednisone and a thiazide diuretic.Initial References 1. Blaylock WK, Moon JH: Hodgkin's disease , in Demis DJ, Dobson RL, McGuire J, et al (eds): Clinical Dermatology . New York, Harper & Row Publishers Inc, 1979, chap 20-28. 2. Sacks EL, Donaldson SS, Gordon J, et al: Epithelioid granulomas associated with Hodgkin's disease . Cancer 1978;41:562-567.Crossref 3. Brinker H: Epithelioid cell granulomas in Hodgkin's disease . Acta Pathol Microbiol Scand A 1970;78:19-32. 4. Harman RRM: Hodgkin's disease, seminoma of testicle and widespread granuloma annulare . Br J Dermatol 1977;97( (suppl 15) ):50-51.Crossref

Lupton, George P.;Goette, Detlef K.

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020066033

Abstract The dermal infiltrate of lichen planus histologically is characterized by a preponderance of lymphocytes; plasma cells, if present, are usually sparse in number. We describe herein a patient whose lesions of lichen planus contained numerous plasma cells in the dermal infiltrate. Report of a Case A 56-year-old woman was examined for a characteristic eruption of lichen planus of four years' duration. She was also studied for a protein-losing enteropathy of undetermined cause. She had a history of Raynaud's phenomenon since the age of 28 years. She had not taken any medications that could be implicated as a cause of her eruption.On physical examination, the patient's buccal mucosa and lips contained leukokeratotic reticulated lesions. Her upper and lower extremities showed multiple polyangular violaceous plaques with Wickham's striae. The patient had anonychia of both great toenails and the second right toenail and pterygium formation of both thumbnails.Abnormal laboratory findings included References 1. Lever WF, Schaumburg-Lever G: Histopathology of the Skin , ed 5. Philadelphia, JB Lippincott Co, 1975, pp 147-148. 2. McCarthy L: Histopathology of Skin Diseases . St Louis, CV Mosby Co, 1931, p 212. 3. Ackerman AB: Histologic Diagnosis of Inflammatory Skin Disease . Philadelphia, Lea & Febiger, 1978, pp 204-210. 4. Montgomery H: Dermatopathology . New York, Harper & Row Publishers Inc, 1967, vol 1, p 286. 5. Pinkus H, Mehregan AH: A Guide to Dermatohistopathology , ed 2. New York, Appleton-Century-Crofts, 1976, p 143. 6. Okun MR, Edelstein LM: Gross and Microscopic Pathology of the Skin . Boston, Dermatopathology Foundation Press, 1976, vol 1, p 338.

Weston, William L.

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020068034

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract This is the second edition of a text by the world's foremost authorities in immunofluorescence microscopy of the skin. The book is up-to-date in every section and presents the latest information. The chapters of the book are somewhat uneven in their writing, as is to be expected from a text by many authors. Some chapters are not concise. For example, chapter 6 (on the nature of autoimmunity) is presented in a menadering form and is extraordinarily difficult to follow. New terminology is introduced but not well explained. A new unifying concept of autoimmunity may not be appropriate to this text and, if included, should be concise and easy to comprehend. In contrast, there is a concise, easily read section on antibody methods. The section on bullous diseases and connective-tissue diseases is also well written, understandable, and provides a good up-to-date review of immunofluorescence and immunopathologic findings in patients with those

Beerman, Herman

1981 Archives of Dermatology

doi: 10.1001/archderm.1981.01650020068035

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract If readers expect this book to be merely another of the review spate of primers or atlases on sexually transmitted diseases, they will be disappointed. This is not a brief digest of the salient features of these diseases, profusely illustrated, but rather a scholarly account of the ever increasing varieties of diseases transmitted through sexual contact. In fact, one of the drawbacks of this book, for those who are unfamiliar with the characteristics of these diseases, is the lack of illustrations. On the other hand, the authors have written it "primarily for those who are actively engaged in the increasingly demanding clinical practice of venereology and who, by so doing in the United Kingdom at least, now tend to undertake so large a part of the primary care of adolescents and young adults." The contents of the book include a 43-page introduction. Never in one place have I found such