Archives of Dermatology

Burrows, William M.;Stoughton, Richard B.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630260003001

Abstract • Ten healthy human volunteers were exposed to a primary sensitizing dose of 1 mg dinitrochlorobenzene (DNCB) by an open topical technique within an area that had been pretreated with a potent topical glucocorticosteroid compound. Quantitative elicitation testing was performed on the opposite side by an open patch test technique two weeks after the sensitizing application. One (10%) of the ten subjects became sensitized. A matched control group of ten subjects was similarly sensitized without steroid treatment. Eight (80%) of the ten became sensitized. One month later, five of the eight test subjects in whom sensitization had been prevented were retested in an identical fashion without steroid pretreatment, to determine if any degree of tolerance had been induced. All five subjects became sensitized. Topical glucocorticosteroids inhibited the development of sensitization to topically applied DNCB. Tolerance was not induced by this single process. (Arch Dermatol 112:175-178, 1976) References 1. Claman HN: Corticosteroids and lymphoid cells . New Engl J Med 287:388-397, 1972.Crossref 2. Balow JE, Rosenthal AS: Glucocorticoid suppression of macrophage migration inhibitory factor . J Exp Med 137:1031-1041, 1973.Crossref 3. Weston WL, Claman HN, Kruegar GG: Site of action of cortisol in cellular immunity . J Immunol 110:880-883, 1973. 4. Zurier RB, Weissman G: Antiimmunologic and antiinflammatory effects of steroid therapy . Med Clin North Am 57:1295-1307, 1973. 5. deSousa M, Fachet J: The cellular basis of the mechanism of action of cortisone acetate on contact sensitivity to oxazolone in the mouse . Clin Exp Immunol 10:673-684, 1972. 6. Boss PS, Jolley WB, Ainsworth GJ: Mechanisms of action of topically applied triamcinolone acetonide in prolonging skin allograft and survival time . Transplantation 15:17-21, 1973.Crossref 7. North RJ: The action of cortisone acetate on cell-mediated immunity to infection . J Exp Med 134:1485-1500, 1971.Crossref 8. Cohen IR, Stavy L, Feldman M: Glucocorticoids and cellular immunity in vitro . J Exp Med 132:1055-1070, 1970.Crossref 9. Stavy L, Cohen IR, Feldman M: Stimulation of rat lymphocyte proliferation of hydrocortisone during the induction of cell-mediated immunity in vitro . Transplantation 17:173-179, 1974.Crossref 10. MacKenzie AW, Stoughton RB: Method for comparing percutaneous absorption of steroid . Arch Dermatol 86:608-610, 1962.Crossref 11. Vickers CFH: Stratum corneum reservoir for drugs , in Montagna W, Stoughton RB, Variscott E (eds): Pharmacology and the Skin . New York, Appleton-Century-Crofts Inc, 1972, pp 177-189. 12. Chase MW, Macher E: The fate of antigen in induction of delayed allergic responses , in Montagna W and Billingham R (eds): Immunology and the Skin . New York, Appleton-Century Crofts Inc, 1969, pp 63-93. 13. Pearson MN, Raffel S: Macrophage-digested antigen as inducer of delayed hypersensitivity . J Exp Med 133:494-505, 1971.Crossref 14. Asherson GL, Allison AC, Zembala M: Production of delayed hypersensitivity by antigen associated with peritoneal exudate cells and the effect of pretreatment with Freund's complete adjuvant . Immunology 22:465-473, 1972. 15. Tanioku K: The role of macrophages in the development of contact sensitivity . Acta Derm Venereol ( (Suppl) )73:187-188, 1973. 16. Baumgarten A, Geczy AF: Induction of delayed hypersensitivity by dinitrophenylated lymphocytes . Immunology 19:205-217, 1970. 17. Nakagawa S, Beki H, Taniokv K: The distribution of 2, 4-dinitrophenyl groups in guinea pig skin following surface application of 2, 4-dinitrochlorobenzene: An immunofluorescent study . J Invest Dermatol 57:269-277, 1971.Crossref 18. McFarlin DE, Balfour B: Contact sensitivity in the pig . Immunology 25:995-1009, 1973.

Hubler, Winthrope R.;Clabaugh, West

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630260007002

Abstract • Norwegian scabies is an ectoparasitic infestation by Sarcoptes scabiei, characterized by hyperkeratotic lesions of the hands, feet, ears, and scalp, which contain many mites. An epidemic of Norwegian scabies involved 22 patients in a 25-patient ward of mentally and physically handicapped persons (mostly mongoloids). The pathogenesis of the prolific mite population is unclear, but either a specific immunologic deficit or the inability to effectively eliminate the mites by scratching is a plausible possibility. (Arch Dermatol 112:179-181, 1976) References 1. Calnan CD: Crusted scabies . Br J Dermatol 62:71-78, 1950.Crossref 2. Sweitzer SE, Winer LH: Norwegian scabies . Arch Dermatol Syphilol 43:678-681, 1941.Crossref 3. Maguire HC Jr, Kligman AM: Norwegian scabies . Arch Dermatol 82:62-64, 1960.Crossref 4. Schiff BL, Ronchese F: Norwegian scabies . Arch Dermatol 89:236-238, 1964.Crossref 5. Kurtin SB, Leider M: Norwegian scabies: Report and lessons of a case . New Engl J Med 278:1099-1100, 1968.Crossref 6. Burks JW Jr, Jung RC, George WM: Norwegian scabies . Arch Dermatol 74:131-140, 1956.Crossref 7. Haydon JR Jr, Caplan RM: Epidemic scabies . Arch Dermatol 103:168-173, 1971.Crossref 8. Kocsard E: Scabies keratotica . Cutis 3:41-45, 1967. 9. Mellanby K: Scabies . Middlesex, England, EW Classey Ltd, 1972. 10. Prakken JR, van Vloten TJ: Allergy in scabies: Positive intracutaneous tests with antigen from scabies norvegica: Passive transfer of antibodies. (Prausnitz-Küstner) . Dermatologica 99:124-131, 1949.Crossref 11. Ingram JT: Ward epidemic from Norwegian scabies . Br J Dermatol 63:311-317, 1951.Crossref

Resh, William;Stoughton, Richard B.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630260010003

Abstract • Topical antibiotics were used on patients with acne vulgaris. Corynebacterium acnes organisms from open comedones were quantitated during treatment, and the progress of the disease was evaluated. Clindamycin lotion completely suppressed the growth of C acnes organisms, whereas erythromycin and tetracycline did not depress the C acnes counts. Taken as a group, these antibiotics gave a substantial improvement of the disease on the treated side as compared with paired untreated sides of the face and back. (Arch Dermatol 112:182-184, 1976) References 1. Unna PG: The Histopathology of the Diseases of the Skin . N Walker (trans), New York, MacMillan Company, 1896. 2. Marples MJ: The Ecology of the Human Skin . Springfield, Ill, Charles C Thomas, Publisher, 1965. 3. Shehadeh NH, Kligman AM: The bacteriology of acne . Arch Dermatol 88:829-831, 1963.Crossref 4. Reisner RM, Silver DZ, Puhvel M, et al: Lipolytic activity of Corynebacterium acnes . J Invest Dermatol 51:190-196, 1968.Crossref 5. Kirschbaum JO, Kligman AM: The pathogenic role of Corynebacterium acnes in acne vulgaris . Arch Dermatol 88:832-833, 1963.Crossref 6. Izumi AK, Marples R, Kligman AM: Bacteriology of acne comedones . Arch Dermatol 102:397-399, 1970.Crossref 7. Marshall JH, Kelsey JC: A standard culture medium for general bacteriology . J Hyg 58:367-372, 1960.Crossref 8. Fulton JE, Pablo G: Topical antibiotic therapy for acne: Study of the family of erythromycins . Arch Dermatol 110:83-86, 1974.Crossref

Penneys, Neal S.;Eaglstein, William H.;Frost, Philip

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630260013004

Abstract • Fourteen of 15 patients with pemphigus have responded successfully to systemically administered gold therapy for up to four years. Eight of the 15 (56%) are in remission, requiring no therapy (mean, 21 months). The remaining seven patients are receiving maintenance systemic gold therapy. Only one instance of toxicity was seen during maintenance therapy. The high remission rate associated with gold therapy and the infrequent side-effects during maintenance therapy suggest that systemically given gold therapy may be the treatment of choice for the management of pemphigus, following initial therapy with corticosteroids when necessary. (Arch Dermatol 112:185-187, 1976) References 1. Ryan JG: Pemphigus: A 20-year survey of experience with 70 cases . Arch Dermatol 104:14-20, 1971.Crossref 2. Krain LS: Pemphigus: Epidemiologic and survival characteristics of 59 patients, 1955-1973 . Arch Dermatol 110:862-865, 1974.Crossref 3. Lever WF, Goldberg HS: Treatment of pemphigus vulgaris with methotrexate . Arch Dermatol 100:70-78, 1969.Crossref 4. Roenigk HH, Deodhar S: Pemphigus treatment with azathioprine: Clinical and immunologic correlation . Arch Dermatol 107:353-357, 1973.Crossref 5. McKelvey EM, Hasegawa J: Cyclophosphamide and pemphigus vulgaris . Arch Dermatol 103:198-200, 1971.Crossref 6. Penneys NS, Eaglstein WH, Indgin S, et al: Gold sodium thiomalate treatment of pemphigus . Arch Dermatol 108:56-60, 1973.Crossref 7. Freyberg RH: Gold therapy in rheumatoid arthritis , in Hollander JL, McGarty DJ (eds): Arthritis and Allied Conditions . Philadelphia, Lea & Febiger, 1972, p 470. 8. Keenan J, Thompson JB, Chamberlain MA, et al: Prolonged corticotrophic action of a synthetic substituted 1-18ACTH . Br Med J 3:742-743, 1971.Crossref 9. Soler-Bechara J, Rammerer WD, Rogdoff B, et al: Maintenance gold therapy for rheumatoid arthritis—Analysis of effectiveness in 167 patients , abstracted. Arthritis Rheum 8:469-470, 1965. 10. Persellin RH, Hess EV, Ziff M: Effect of a gold salt on the immune response . Arthritis Rheum 10:99-105, 1967.Crossref 11. Penneys NS, Ziboh V, Gottlieb NL, et al: Inhibition of prostaglandin synthesis and human epidermal enzymes by aurothiomalate in vitro: Possible actions of gold in pemphigus . J Invest Dermatol 63:356-361, 1974.Crossref 12. Gottlieb NL, Smith PM, Penneys NS, et al: Gold concentrations in hair, nail, and skin during chrysotherapy . Arthritis Rheum 17:56-62, 1974.Crossref 13. Gottlieb NL, Smith PM, Smith EM: Tissue gold concentrations in a rheumatoid arthritic receiving chrysotherapy . Arthritis Rheum 15:16-22, 1972.Crossref

Espy, Paul D.;Jolly, Henry W.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630260017005

Abstract • Norwegian scabies is rare yet distinctive. The majority of reported cases have been in patients with a relatively small group of diseases, including Down syndrome and lepromatous leprosy. A case occurred in a patient on long-term immunosuppressive therapy following a kidney transplant. Altered host factors appear to be the prime determinants in the pathogenesis of the disease. (Arch Dermatol 112:193-196, 1976) References 1. Wilkinson DS: Norwegian (crusted) scabies . Br J Dermatol 65:31, 1953. 2. Kocsard E, et al: Scabies crustosa (scabies Norvegica) in Mongols . Aust J Dermatol 5:235-240, 1959.Crossref 3. Maguire HC Jr, Kligman AM: Norwegian scabies . Arch Dermatol 82:62-64, 1960.Crossref 4. Hyman D: Psoriatic-like lesions in Norwegian scabies . Cutis 11:336, 1973. 5. Anderson NP, Stout M: Norwegian scabies . Arch Dermatol Syph 42:499-500, 1940. 6. Bedi BMS: Norwegian scabies (a clinical study) . Indian J Dermatol 17:76-78, 1972. 7. Short B, Derrick EH: A remarkable case of scabies . Med J Aust 1:621, 1948. 8. Anderson I: Norwegian scabies . Br Med J 2:25, 1952.Crossref 9. Dostrovsky A, et al: Scabies Norvegica and lymphatic leukemia . Dermatologica 113:26-34, 1956.Crossref 10. Tanaka T, Usuba M: Scabies Norvegica associated with leukemia cutis . Tohoku J Exp Med 72:35-41, 1960.Crossref 11. Herridge CF: Norwegian scabies (crusted scabies) . Br Med J 1:239-240, 1963.Crossref 12. Logan JC, et al: Norwegian scabies and lymphatic leukemia . Br J Dermatol 79:303-305, 1967.Crossref 13. Walshe MM: Norwegian scabies . West Indian Med J 16:57-61, 1967. 14. Macmillan AL: Unusual features of scabies associated with topical fluorinated steroids . Br J Dermatol 87:496-497, 1972.Crossref 15. Paterson WD, et al: Norwegian scabies during immunosuppressive therapy . Br Med J 4:211-212, 1973.Crossref 16. Norwegian scabies during immunosuppressive therapy . Br Med J 4:485-486, 1973. 17. Evans DI: Norwegian scabies and monocytic leukemia . Br Med J 4:613, 1973.Crossref 18. Ingram JT: Ward epidemic from Norwegian scabies . Br J Dermatol 63:311-317, 1951.Crossref 19. Burks JW, et al: Norwegian scabies . Arch Dermatol 74:131-140, 1956.Crossref 20. George WM: Norwegian scabies . Arch Dermatol 78:320-324, 1958.Crossref 21. Johnson CG, Mellanby K: Parasitology of human scabies . Parasitology 34:285-290, 1942.Crossref 22. Hessler R: An extreme case of parasitism . Am Naturalist 27:346-352, 1893.Crossref 23. Pirila V, et al: Scabies Norvegica . Arch Derm Venereol 47:267-268, 1967. 24. Haydon JR Jr, Caplan RM: Epidemic scabies . Arch Dermatol 103:168-173, 1971.Crossref 25. Mellanby K: Scabies . London, Oxford University Press, 1943. 26. Mellanby K: The development of symptoms, parasitic infection and immunity in human scabies . Parasitology 35:197-206, 1944.Crossref 27. Heilesen B: Acarus scabiei and scabies . Acta Derm Venereol 26( (suppl 14) ):1-370, 1946. 28. Summons J: A case of Norwegian scabies . Aust J Dermatol 8:44-47, 1965.Crossref 29. Prakken JR, Van Vloten TJ: Allergy in scabies . Dermatologica 99:124-131, 1949.Crossref 30. Kurtin SB, Leider M: Norwegian scabies: Report and lessons of a case . N Engl J Med 278:1099-1100, 1968.Crossref 31. Marples MJ: Ecology of Human Skin . Springfield, Ill, Charles C Thomas Publisher, 1965, pp 324-325.

Rau, Robert C.;Dubin, Howard V.;Taylor, William B.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630260021006

Abstract • Oriental sore (acute cutaneous leishmaniasis) is usually a self-limited infection of the skin caused by the protozoan Leishmania tropica. This disease is endemic to the Mediterranean, Asia, Africa, and the Middle East, and is seen in this country among travellers and immigrants. We found four cases at the University of Michigan and diagnosed and treated the disorder. Some of the treatments currently recommended for this disease are potentially toxic, and none have been proved to be of real value. Uncomplicated, acute cutaneous leishmaniasis (L tropica) may best be managed by withholding treatment and observing the patient. (Arch Dermatol 112:197-201, 1976) References 1. Hambrick GW, Even-Paz Z: Cutaneous leishmaniasis encountered in Philadelphia . JAMA 198:101-105, 1966.Crossref 2. Hart M, et al: Late cutaneous leishmaniasis . Arch Dermatol 99:455-458, 1969.Crossref 3. Szymanski FJ: Cutaneous leishmaniasis . Arch Dermatol 85:550-551, 1962.Crossref 4. Tilley RF: Cutaneous leishmaniasis . Arch Dermatol 90:240, 1964. 5. Newman BA, Promerantz LM: Disseminated cutaneous leishmaniasis (tropica) . Arch Dermatol 98:105-106, 1968.Crossref 6. Palitz LL: Diagnosis: Cutaneous leishmaniasis (treated with dihydrostreptomycin) . Arch Dermatol 80:102, 1959.Crossref 7. Farah FS, Malak JA: Cutaneous leishmaniasis . Arch Dermatol 103:467-474, 1971.Crossref 8. Harman RRM: Parasitic worms and protozoa , in Rook A: Textbook of Dermatology . Oxford, England, Blackwell Scientific Publications, 1972. 9. Bray RS, Lainso R: The immunology and serology of leishmaniasis . Trans R Soc Trop Med Hyg 59:535-544, 1965.Crossref 10. Kurban AK: Cutaneous leishmaniasis . Leb Med J 18:381-386, 1965. 11. Harvey SC: Heavy metals , in Goodman L, Gilman A: The Pharmacological Basis of Therapeutics . London, The Macmillian Co, 1970. 12. Plorde JJ, Bennett IL: Leishmaniasis , in Wintrobe MM, et al: Harrison's Principles of Internal Medicine . New York, McGraw-Hill Book Co Inc, 1970. 13. Walton BC, et al: American cutaneous leishmaniasis . JAMA 228:1256-1258, 1974.Crossref 14. Long PI: Cutaneous leishmaniasis treated with metronidazole . JAMA 223:1378-1379, 1973.Crossref 15. Turk JL, Bryceson ADM: Immunological phenomena in leprosy and related disease . Adv Immunol 13:209-266, 1971. 16. Bryceson ADM: Diffuse cutaneous leishmaniasis in Ethiopia . Trans R Soc Trop Med Hyg 63:708-737, 1969.Crossref

Drake, Thomas E.;Maibach, Howard I.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630260026007

Abstract • A patient had acute stomatitis and dermatitis due to a popular toothpaste containing cinnamon oil flavor. Cinnamon cassia oil is known as a topical sensitizer and was demonstrated to be the offending allergen. Cinnamic aldehyde and related chemicals are used widely, so that patients having cinnamon allergy may be exposed to many sources. There is difficulty in diagnosing allergic contact stomatitis. (Arch Dermatol 112:202-203, 1976) References 1. Wilkinson D, Fregert S, et al: Terminology of contact dermatitis . Acta Derm Venereol 50:287, 1970. 2. Hjorth N: Eczematous allergy to balsam, allied perfumes and flavouring agents , Acta Derm Venereol 41 ( (suppl) ):46, 1961. 3. Hjorth N, Jervoe P: Allergisk Kontaktstomatitis og Kontaktdermatitis Fremdkalt af Smogstoffen i Tandpasta . Tandlaegebladet 71:937-942, 1967. 4. Loveman AB: Stomatitis venenata: Report of a case of sensitivity of mucous membranes and the skin to oil of anise . Arch Dermatol 37:70-81, 1938. 5. Papa CM, Shelley WB: Menthol hypersensitivity: Diagnostic basophil response in a patient with chronic urticaria, flushing and headache . JAMA 189:546, 1964.Crossref 6. Laubach J, Malkinson FD, Ringrose E: Chelitis caused by cinnamon oil (cassia) in toothpaste , JAMA 152:404, 1953.Crossref 7. Collins F, Mitchell JC: Aroma chemicals: Reference sources for perfume and flavour ingredients . Contact Dermatitis , to be published. 8. Bonnevie P: Some experience of war-time industrial dermatoses . Acta Derm Venereol . 28:231, 1948. 9. Millard LG, Contact sensitivity to toothpaste . Br Med J 1:676, 1973.Crossref 10. Kirton W, Wilkinson DS: Contact sensitivity to toothpaste . Br Med J 2:115-116, 1973.Crossref 11. Millard LG: Acute contact sensitivity to a new toothpaste . J Dentist 1:168-170, 1973.Crossref 12. Magnusson B, Kirton V, Wilkinson D: Toothpaste contact dermatitis . Contact Dermatitis , to be published.

Zimmerman, Michael R.;Clark, Wallace H.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630260028008

Abstract • Examination of the mummy of an Egyptian who died in 892 BC ± 53 years showed the skin to be well preserved, with inguinal subcorneal vesicles of the type seen in subcorneal pustular dermatosis. This condition apparently antedates by almost three millenia its description as a clinicopathological entity by Sneddon and Wilkinson in 1956. (Arch Dermatol 112:204-205, 1976) References 1. Sneddon IB, Wilkinson DS: Subcorneal pustular dermatosis . Br J Dermatol 68:385-394, 1956.Crossref 2. Budge EAW: The Mummy , ed 2. New York, Collier Books, 1972. 3. Ruffer MA: Studies in the Paleopathology of Egypt . Chicago, University of Chicago Press, 1921. 4. Zimmerman MR: Histological examination of experimentally mummified tissues . Am J Phys Anthropol 37:271-280, 1972.Crossref 5. Lever WF: Histopathology of the Skin , ed 4. Philadelphia, JB Lippincott Co, 1967, pp 129-131. 6. Giacometti L, Chiarelli B: The skin of Egyptian mummies: A study in survival . Arch Dermatol 97:712-713, 1968.Crossref 7. Post PW, Daniels F Jr: Histological and histochemical examination of American Indian scalps, mummies, and a shrunken head . Am J Phys Anthropol 30:269-294, 1969.Crossref 8. Ruffer MA, Ferguson AR: An eruption resembling that of variola in the skin of a mummy of the 20th Dynasty (1200-1100 B.C.) . J Pathol Bacteriol 15:1-2, 1911.Crossref 9. Smith GE: The Royal Mummies . Cairo, Musée de Caire, 1912. 10. Wilder HH: The restoration of dried tissues, with special reference to human remains . Am Anthropol 6:1-17, 1904.Crossref 11. Wells C: Pseudopathology , in Brothwell D, Sandison AT (eds): Diseases in Antiquity . Springfield, Ill, Charles C Thomas Publishers, 1967.

Greer, Kenneth E.;Bishop, Gregory F.;Ober, William C.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630260030009

Abstract • A 52-year-old patient was admitted to the hospital for evaluation of hypertension. He had two skin lesions, one on the forehead and one in the postauricular area, which had been present since birth. The forehead lesion was a nevus sebaceous and the postauricular lesion was a syringocystadenoma papilliferum. Except for a few patients with widespread nevus sebaceous and syringocystadenoma papilliferum associated with neurologic abnormalities, most of the previously reported patients with these nevi have had solitary lesions of one or the other. An association of nevus sebaceous and syringocystadenoma papilliferum in the same lesion is not uncommon. Despite bleeding and crusting in one of the lesions and despite informing the patient that a malignant neoplasm may develop in these nevi, he refused excision of either of the lesions. (Arch Dermatol 112:206-208, 1976) References 1. Jancar S: Nevus syringocystadenomatosus papilliferum with skull and brain lesions, hemiparesis, epilepsy and mental retardation . Br J Dermatol 82:402-405, 1970.Crossref 2. Feuerstein RC, Mims LC: Linear nevus sebaceous with convulsions and mental retardation . Am J Dis Child 104:675-679, 1962. 3. Wilson-Jones E, Heyl T: Nevus sebaceus . Br J Dermatol 82:99-117, 1970.Crossref 4. Mehregan AH, Pinkus H: Life history of organoid nevi . Arch Dermatol 91:574-588, 1965.Crossref 5. Helwig EB, Hackney VC: Syringadenoma papilliferum . Arch Dermatol 71:361-372, 1955.Crossref 6. Hashimoto K, Lever W: Appendage Tumors of the Skin . Springfield, Ill, Charles C Thomas Publisher, 1968, p 46. 7. Constant E, Davis DG: The premalignant nature of the sebaceous nevus of Jadassohn . Plast Reconstr Surg 50:257-259, 1972.Crossref

Mohs, Frederic E.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630260033010

Abstract • Complete microscopical control of the excision of cancer of the skin is achieved by removing tissues layer by layer and examining the undersurface of each layer by means of frozen sections. If the cancer is extensive and complicated or if it is of a type readily spread over an excisional surface, the tissues are fixed in situ with zinc chloride prior to excision (chemosurgery, fixed tissue technique). If the cancer is not too extensive or complicated, the tissues are excised in the fresh, unfixed state (chemosurgery, fresh tissue technique). Both techniques are highly reliable; for example, in two consecutive series of basal cell carcinomas treated chemosurgically, the five-year rate of cure was 99.3% for the 9,351 lesions removed by the fixed tissue technique and 97% for the 127 lesions removed by the fresh tissue technique. (Arch Dermatol 112:211-215, 1976) References 1. Mohs FE: Chemosurgery in Cancer, Gangrene and Infections . Springfield, Ill, Charles C Thomas Publisher, 1956. 2. Mohs FE, Guyer MF: Pre-excisional fixation of tissues in the treatment of cancer in rats . Cancer Res 1:49-51, 1941. 3. Mohs FE: Chemosurgery: A microscopically controlled method of cancer excision . Arch Surg 42:279-295, 1941.Crossref 4. Mohs FE: The chemosurgical method for the microscopically controlled excision of external cancer with reference to eyelid . Trans Am Acad Ophthalmol Otolaryngol 62:355-356, 1958. 5. Mohs FE: Chemosurgery for facial neoplasms . Arch Otolaryngol 95:62-67, 1972.Crossref 6. Tromovitch TA, Stegeman SJ: Microscopically controlled excision of skin tumors: Chemosurgery (Mohs): Fresh tissue technique . Arch Dermatol 110:231-232, 1974.Crossref 7. Mohs FE: Chemosurgical treatment of melanoma: A microscopically controlled method of excision . Arch Dermatol Syphilol 62:269-279, 1950.Crossref 8. Mohs FE: Prevention and treatment of skin cancer . Wis Med J 73:85-92, 1974.