Archives of Dermatology

Parrish, John A.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250007001

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract Psoralens have been used for decades to stimulate repigmentation in cases of vitiligo. Recently, there has been considerable interest in the treatment of psoriasis with orally administered psoralens and subsequent exposure to longwave ultraviolet light (UVA, 320 to 400 nm). The relationship between the responses of these skin diseases to psoralen therapy and the striking erythemogenic and melanogenic effects of photoactive psoralens on normal skin is unknown. No relationship has yet been established between any of these cutaneous effects and the known formation of photoadducts of thymine and psoralen, nor between cutaneous effects of psoralen therapy and the transiently decreased DNA synthesis that occurs when psoralentreated cells are exposed to UVA. Double-blind acute toxicity studies performed on human volunteers and studies of large numbers of vitiligo cases have disproved the early concerns about the possible hepatotoxicity of psoralens. Repeated exposure to high doses of UVA is carcinogenic to certain laboratory

Cohen, Haim A.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250009002

Abstract † Patients suffering from contact dermatitis caused by chromium sensitivity showed positive reactions to intradermal tests with chromium and cobalt chlorides. Patch tests to cobalt in unaffected and in healed eczematous skin areas gave negative results. A large number of chromiumsensitive patients also showed a positive intradermal test reaction to cobalt bound to human serum albumin and a negative reaction to cobalt bound to rabbit liver glycogen. It has been suggested that these positive reactions to cobalt are secondary sensitivities to cobalt, caused by cobalt-denaturated human serum albumin that is so similar to the denaturated product of chromium cations that the competent cells cannot distinguish between them. (Arch Dermatol 112:37-39, 1976) References 1. Baer RL: Multiple eczematous sensitivities . JAMA 170:1041-1045, 1959.Crossref 2. Cohen HA: Experimental production of circulating antibodies to chromium . J Invest Dermatol 38:13-29, 1962. 3. Mali JWH, van Kotten JW, van Neer FCJ: Some aspects of the behaviour of chromium compounds in the skin . J Invest Dermatol 41:111-122, 1963.Crossref 4. Cohen HA: Tuberculin-type sensitivity to trivalent chromium . Isr J Med Sci 1:79-83, 1965. 5. Gell PGH, Benacerraf B: Studies on hypersensitivity: IV. The relationship between contact and delayed sensitivity: A study on the specificity of cellular immune reactions . J Exp Med 113:571-585, 1961.Crossref 6. Gell PGH, Silverstein AM: Delayed hypersensitivity to hapten-protein conjugates: I. The effect of carrier protein and site of attachment to hapten . J Exp Med 115:1037-1051, 1962.Crossref 7. Cohen HA: Carrier specificity of tuberculintype reaction to trivalent chromium . Arch Dermatol 93:34-40, 1966.Crossref 8. Geiser JD, Jeanneret JP, Delacretaz J: Eczema due to cement and sensitization to cobalt . Dermatologica 121:1-7, 1960.Crossref 9. Rostenberg A Jr, Perkins AJ: Nickel and cobalt dermatitis . J Allergy 22:466-474, 1951.Crossref 10. Welch H, Rostenberg A Jr: Hypersensitivity of the tuberculin-type to crystalline penicillin sodium . JAMA 126:10-12, 1944.Crossref 11. Rostenberg A Jr, Welch H: A study of the types of hypersensitivity induced by penicillin . J Med Sci 210:158-167, 1945.Crossref 12. Epstein S, Pinkus H, Hanson D: Penicillin dermatitis based on tuberculin-type sensitivity: Report of a case with remarks on experimental sensitization to penicillin . Ann Allergy 4:186-195, 1946. 13. Epstein S: Dermal contact dermatitis sensitivity to rivanol and gentian violet . Dermatologica 117:287-296, 1958.Crossref 14. Epstein S: Contact dermatitis from neomycin due to dermal delayed (tuberculin-type) sensitivity: Report of 10 cases . Dermatologica 113:191-201, 1956.Crossref 15. Baer RL, Lipkin C, Kanof NB, et al: Changing patterns of sensitivity to common contact allergens . Arch Dermatol 89:3-8, 1964.Crossref 16. Jandl JH, Simmons RL: The agglutination and sensitization of red cells by metallic cations: Interactions between multivalent metals and the red-cell membrane . Br J Dermatol 3:19-38, 1958. 17. Sulzberger MB, Rostenberg A Jr: Acquired specific supersensitivity (allergy) to simple chemicals: IV. A method of experimental sensitization, and demonstration of increased susceptibility in individuals with eczematous dermatitis of contact type . J Immunol 36:17-27, 1939.

Sorensen, Gregory W.;Jones, Henry E.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250012003

Abstract † Delayed hypersensitivity (DH) to seven common antigens was examined in 38 men with chronic dermatophyte infections and in 20 controls. A similar percentage of the infected and the control groups reacted to four antigens. In addition to showing a low frequency of DH to trichophytin, the infected group also showed a significant reduction in their reactions to intradermal mumps skin test antigen and to a Rhus oleoresin patch test. Two members (5%) of the infected group were anergic to all tests. Patients with chronic dermatophytosis appear to have a relatively specific defect in DH to trichophytin, but their cell-mediated responses to other antigens may also be somewhat decreased. The subjects studied did not appear to suffer excessive morbidity from infectious diseases, other than dermatophytosis. (Arch Dermatol 112:40-42, 1976) References 1. Hildick-Smith G, Blank H, Sarkany I: Fungus Diseases and Their Treatment . Boston, Little Brown & Co, 1964, pp 42-52. 2. Jones HE, Reinhardt JH, Rinaldi MG: Immunologic susceptibility to chronic dermatophytosis . Arch Dermatol 110:213-220, 1974.Crossref 3. Jones HE, Reinhardt JH, Rinaldi MG: A clinical, mycological, and immunological survey for dermatophytosis . Arch Dermatol 108:61-65, 1973.Crossref 4. Jones HE, Reinhardt JH, Rinaldi MG: Model dermatophytosis in naturally infected subjects . Arch Dermatol 110:369-374, 1974.Crossref 5. Fudenberg H, Good RA, Goodman HC, et al: Primary immunodeficiencies: Report of a World Health Organization Committee . Pediatrics 47:927-946, 1971. 6. Bean SF, South MA: Cutaneous manifestations of immunogenetic deficiency disorders . J Invest Dermatol 60:503-508, 1973.Crossref 7. Jones HE, Lewis CW, McMarlin SL: Allergic contact sensitivity in atopic dermatitis . Arch Dermatol 107:217-222, 1973.Crossref 8. Hanifin JM, Ray LF, Lobitz WC Jr: Immunological reactivity in dermatophytosis . Br J Dermatol 90:1-8, 1974.Crossref 9. Kirkpatrick CH, Rich RR, Bennett JE: Chronic mucocutaneous candidiasis: Model-building in cellular immunity . Ann Intern Med 74:955-978, 1971.Crossref 10. Lamb D, Pilney F, Kelly WD, et al: A comparative study of the incidence of anergy in patients with carcinoma, leukemia, Hodgkin's disease and other lymphomas . J Immunol 89:555-558, 1962. 11. Young RC, Corder MP, Berard CW, et al: Immune alterations in Hodgkin's disease: Effect of delayed hypersensitivity and lymphocyte transformation on course and survival . Arch Intern Med 131:446-454, 1973.Crossref

Rodriguez, Jose;Ackerman, A. Bernard

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250015004

Abstract † Nine cases of cutaneous xanthogranuloma in adults are reported. These lesions were histologically indistinguishable from the xanthogranulomas in infants and children (juvenile xanthogranuloma), and, like those in the young, they were not associated with abnormalities of serum lipids. Unlike juvenile xanthogranuloma, however, in our small sample there was no concomitant involvement of the eye in adult xanthogranuloma. (Arch Dermatol 112:43-44, 1976) References 1. Helwig E, Hackney VC: Juvenile xanthogranuloma . Am J Pathol 30:625-626, 1954. 2. Adamson HF: Congenital xanthoma multiplex . Br J Dermatol 17:222, 1905. 3. McDonagh JER: A contribution to our knowledge of the naevoxanthoendothelioma . Br J Dermatol 24:85, 1912.Crossref 4. Gartmann H, Tritsch H: Hein-und grobknotiges Naevoxanthoendotheliom . Dermatologica 215:409-421, 1963. 5. Gronzalez-Cruzi F, Campbell RJ: Juvenile xanthogranuloma: Ultrastructural study . Arch Pathol 89:65-72, 1970. 6. Esterly N, Sahihi T, Medenica M: Juvenile xanthogranuloma . Arch Dermatol 105:99-102, 1972.Crossref 7. Blank H, Eglick P, Beerman H: Nevoxanthoendothelioma with ocular involvement . Pediatrics 4:349-354, 1949. 8. Sanders TE: Intraocular juvenile xanthogranuloma . Am J Ophthalmol 54:455-462, 1962. 9. Zimmerman L: Ocular lesions of juvenile xanthogranuloma . Trans Am Acad Ophthalmol Otolaryngol 69:412-441, 1965. 10. Llottsfeldt F, Good R: Juvenile xanthogranuloma with pulmonary lesions . Pediatrics 33:233-238, 1964. 11. Webster SB, Reister SC, Harman LE Jr: Juvenile xanthogranuloma with extracutaneous lesions . Arch Dermatol 92:71-76, 1966.Crossref 12. Newell GB, Stone OJ, Mullins JF: Juvenile xanthogranuloma and neurofibromatosis . Arch Dermatol 107:262, 1973.Crossref 13. Sibulkin D, Olichney JJ: Juvenile xanthogranuloma in a patient with Niemann-Pick disease . Arch Dermatol 108:829-831, 1973.Crossref

Jablonska, Stefania;Chorzelski, Tadeusz P.;Beutner, Ernst H.;Maciejowska, Ewa;Rzęsa, Genowefa

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250017005

Abstract • Nine patients had clinical and histological features suggestive of both dermatitis herpetiformis (DH) and bullous pemphigoid (BP). Five patients responded to treatment with sulfapyridine or sulfones: in two the response was inconsistent, and the disease was controlled by combined treatment with prednisone; in one patient, there was no response to sulfapyridine or sulfones. Immunofluorescence studies showed IgA deposits in a linear homogeneous pattern at the basement membrane zone in all patients, and IgG was present in five. No circulating anti-basement membrane antibodies were detected by repeated immunofluorescence examinations. The authors conclude that the occasional overlapping of BP and DH should not lead to dropping the distinction between the two entities. For overlap cases that cannot be classified as BP or DH, the term "intermediate or mixed form of DH and BP" seems to be most suitable. (Arch Dermatol 112:45-48, 1976) References 1. Lever WF: Pemphigus . Medicine 32:1-123, 1953.Crossref 2. Lever WF: Pemphigus and Pemphigoid , Springfield, Ill, Charles C. Thomas Publisher, 1965. 3. Rook A, Waddington E: Pemphigus and pemphigoid . Br J Dermatol 65:425-431, 1953.Crossref 4. Piérard J, Whimster I: The histological diagnosis of dermatitis herpetiformis, bullous pemphigoid and erythema multiforme . Br J Dermatol 73:253-266, 1961.Crossref 5. Rupee M, Kint A, Braun-Falco 0: Zur Frage der Histopathologie der peribullösen Veränderungen bei Dermatitis herpetiformis Duhring und ihrer Differentialdiagnose . Z Haut Geschlechtskr 34:121, 1963. 6. Van der Meer JB: Granular deposits of immunoglobulins in the skin of patients with dermatitis herpetiformis: An immunofluorescent study . Br J Dermatol 81:493-503, 1969.Crossref 7. Van der Meer JB: Dermatitis herpetiformis: A specific immunopathological entity?, thesis. Utrecht University, Utrecht, the Netherlands, 1972. 8. Beutner EH, Chorzelski TP, Jordon RE: Autosensitization in Pemphigus and Bullous Pemphigoid . Springfield, Ill, Charles C Thomas Publishers, 1970. 9. Jablonska S: Immunopathology of bullous disease . Ann Clin Res 2:7-12, 1970. 10. Chorzelski TP, Beutner EH, Jablonska S, et al: Immunofluorescence studies in the diagnosis of dermatitis herpetiformis and its differentiation from bullous pemphigoid . J Invest Dermatol 56:373-380, 1971.Crossref 11. Beutner EH, Chorzelski TP, Bean SF, et al (eds): Immunopathology of The Skin: Labeled Antibody Studies . Stroudsburg, Pa, Dowden, Hutchinson & Ross, 1973. 12. Beutner EH, Jordon RE: Demonstration of skin antibodies in sera of pemphigus vulgaris patients by indirect immunofluorescent staining . Proc Soc Exp Biol Med 117:505-510, 1964.Crossref 13. Jordon RE, Beutner EH, Witebsky E, et al: Basement zone antibodies in bullous pemphigoid . JAMA 200:751-756, 1967.Crossref 14. Chorzelski TP, Jablonska S: Immunopathologische Untersuchungen bei der Duhringschen Krankheit und Pemphigoid . Dermatol Wochenschr 153:558-563, 1967. 15. Chorzelski TP, Jablonska S, Blaszczyk M, et al: Autoantibodies in pemphigoid . Dermatologica 136:325-334, 1968.Crossref 16. Beutner EH, Jordon RE, Chorzelski TP: Immunopathology of pemphigus and bullous pemphigoid . J Invest Dermatol 51:63-80, 1968.Crossref 17. Marks J, Shuster S, Watson AJ: Small-bowel changes in dermatitis herpetiformis . Lancet 2:1280-1282, 1966.Crossref 18. Marks R, Whittle MW, Beard RJ, et al: Small-bowel abnormalities in dermatitis herpetiformis . Br Med J 1:552-555, 1968.Crossref 19. Marks J, Shuster S: Dermatitis herpetiformis: The role of gluten . Arch Dermatol 101:452-457, 1970.Crossref 20. Fraser NG, Murray D, Alexander JOD: Structure and function of the small intestine in dermatitis herpetiformis . Br J Dermatol 79:509-518, 1967.Crossref 21. Fry L, Keir P, McMinn RHM, et al: Small intestinal structure and function and haematological changes in dermatitis herpetiformis . Lancet 2:729-733, 1967.Crossref 22. Jablonska S, Chorzelski T: Kann das histologische Bild die Grundlage zur Differenzierung des Morbus Duhring mit dem Pemphigoid und Erythema multiforme darstellen? Dermatol Wochenschr 146:590-603, 1962. 23. Winkelmann RK, Roth HL: Dermatitis herpetiformis with acantholysis or pemphigus with response to sulphonamides: Report of two cases . Arch Dermatol 82:385-390, 1960.Crossref 24. De Mento FJ, Grover RW: Acantholytic herpetiform dermatitis . Arch Dermatol 107:883-887, 1973.Crossref 25. Honeyman JF, Honeyman A, Lobitz WC, et al: The enigma of bullous pemphigoid and dermatitis herpetiformis . Arch Dermatol 106:22-25, 1973.Crossref 26. Thivolet J, Beyvin AJ, Perrat HV, et al: Autoimmunité au cours de la maladie de Duhring-Brocq . Bull Soc Fr Dermatol Syphiligr 76:463-467, 1969. 27. Thivolet J, Beyvin AJ: Immunologie de la forme pemphigoide de la maladie de Duhring-Brocq . Bull Soc Fr Dermatol Syphiligr 78:369, 1971. 28. Seah PP, Fry L, Stewart JS, et al: Immunoglobulins in the skin in dermatitis herpetiformis and coeliac disease . Lancet 1:611-614, 1972.Crossref 29. Fry L, Seah PP: Dermatitis herpetiformis , in Fry L, Seah PP (eds): Immunological Aspects of Skin Diseases . New York, John Wiley & Sons, 1974, p 22. 30. Heid E, Maleville J, Roveri D, et al: Intérét de la diète iodée dans la maladie de Duhring-Brocq: Ses incidences sur le test thérapeutique sulfones-sulfamides . Bull Soc Fr Dermatol Syphiligr 80:10-12, 1973.

Waller, Jack D.;Greenberg, Joseph H.;Lewis, Charles W.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250021006

Abstract • Three cases of hereditary hemorrhagic telangiectasia (HHT) with cerebrovascular malformation are presented. Previous reports of HHT have given little attention to its association with cerebrovascular malformation, despite frequent neurological symptoms in patients with HHT. Eleven other cases of HHT with neuropathologic or radiographic evidence of cerebrovascular malformation have been reported in the literature. We think that this association may be more frequent than previously suspected. The subtlety of the symptoms in HHT is stressed, and it is suggested that patients with cerebrovascular malformation be examined carefully for HHT, and vice versa. (Arch Dermatol 112:49-52, 1976) References 1. Babington BG: Hereditary epistaxis . Lancet 2:362, 1865. 2. Legg JW: A case of haemophilia complicated with multiple naevi . Lancet 2:865, 1876. 3. Rendu H: Epistaxis répétées chez un sujet porteur de petits angiomes cutanés et muqueux . Bull Soc Med Hop Paris 13:731-733, 1896. 4. Osler W: On a family form of recurring epistaxis, associated with multiple telangiectases of the skin and mucous membranes . Bull Johns Hopkins Hosp 12:333-337, 1901. 5. Parkes-Weber F: Developmental telangiectatic haemorrhage and so-called "Telangiectasia"—familial and non-familial . Br J Child Dis 21:198, 1924. 6. Rodes CB: Cavernous hemangiomas of lung with secondary polycythemia . JAMA 110:1914-1915, 1938.Crossref 7. Chandler D: Pulmonary and cerebral arteriovenous fistula with Osler's disease . Arch Intern Med 116:277-282, 1965.Crossref 8. Trell E, Johansson BW, Linell F, et al: Familial pulmonary hypertension and multiple abnormalities of large systemic arteries in Osler's disease . Am J Med 53:50-63, 1972.Crossref 9. Courville CB: Encephalic lesions in hereditary hemorrhagic telangiectasis (Rendu-Osler-Weber disease): Report of a case with the disclosure of microscopic telangiectasis in the leptomeninges . Bull Los Angeles Neurol Soc 22:28-35, 1957. 10. Garland HG, Anning ST: Hereditary haemorrhagic telangiectasia: A genetic and bibliographical study . Br J Dermatol 62:289-310, 1950.Crossref 11. Hodgson CH, Burchell HB, Good AC, et al: Hereditary hemorrhagic telangiectasia and pulmonary arteriovenous fistula: Survey of a large family . N Engl J Med 261:625-636, 1959.Crossref 12. Taveras JM, Wood EH: Diagnostic Neuroradiology . Baltimore, Williams & Wilkins Co, 1964. 13. Toole JF, Patel AN: Cerebrovascular Disorders . New York, McGraw-Hill Book Co Inc, 1967. 14. Boczko ML: Neurological implications of hereditary hemorrhagic telangiectasis . J Nerv Ment Dis 139:525-536, 1964.Crossref 15. LeRoux BT: Pulmonary arteriovenous fistulae . Q J Med 28:1-19, 1959. 16. Snyder LH, Doan CA: Studies in human inheritance: Is the homozygous form of multiple telangiectasia lethal? J Lab Clin Med 29:1211-1216, 1944. 17. Ytrehus Ø: Hereditary hemorrhagic telangiectasis and cirrhosis of liver . Nord Med 38:730-733, 1948. 18. Brinkmann E: Über Oslersche Krankheit . Folia Haematol 70:119-129, 1950. 19. Bird RM, Jaques WE: Vascular lesion of hereditary hemorrhagic telangiectasia . N Engl J Med 260:597-599, 1959.Crossref 20. Zelman S: Liver fibrosis in hereditary hemorrhagic telangiectasia: Fibrosis of diffuse insular character . Arch Pathol 74:66-72, 1962. 21. Sochocky S: Arteriovenous fistula of the lung . J Lancet 82:12-17, 1962. 22. Quickel KE Jr, Whaley RJ: Subarachnoid hemorrhage in a patient with hereditary hemorrhagic telangiectasia . Neurology 17:716-719, 1967.Crossref 23. Reagan TJ, Bloom WH: The brain in hereditary hemorrhagic telangiectasia . Stroke 2:361-368, 1971.Crossref 24. Bean WB: Congenital and hereditary lesions and birthmarks , in Vascular Spiders and Related Lesions of the Skin . Springfield, Ill, Charles C Thomas Publisher, 1958, pp 132-157.

Dantzig, Paul I.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250025007

Abstract • Sixty patients with severe pustular and cystic acne were treated for prolonged periods with clindamycin (150 mg to 300 mg daily). The average duration of therapy was five months, with 18 patients being treated for more than six months. Only two (3.4%) patients developed mild diarrhea, which was rapidly reversible on discontinuance of the drug. No other adverse reactions were observed. These data suggest that long-term, low-dose clindamycin therapy may be safe for severe pustular or cystic acne. (Arch Dermatol 112:53-54, 1976) References 1. Wansker BA: Antibiotics and pustulocystic acne: A long-term double-blind evaluation . Arch Dermatol 84:96-98, 1961.Crossref 2. Hicks JH: Demethylchlortetracycline: A double-blind study in the treatment of acne with attention to side effects noted . South Med J 55:357-360, 1962.Crossref 3. Stewart WD, Maddin S, Nelson AJ, et al: Therapeutic agents in acne vulgaris: I. Tetracycline . Can Med Assoc J 89:1096-1097, 1963. 4. Knox JM, Owens DW: Demethylchlortetracycline in the treatment of acne vulgaris . South Med J 58:1056-1060, 1965.Crossref 5. Savin RC, Turner MC: Antibiotics and the placebo reaction in acne . JAMA 196:365-367, 1966.Crossref 6. Witkowski JA, Simons HM: Objective evaluation of demethyl-chlortetracycline hydrochloride in the treatment of acne . JAMA 196:397-400, 1966.Crossref 7. Moss HV: Acne vulgaris: Treatment with three newer antibiotics . Cutis 10:375-376, 1972. 8. Hall JH, Tindall SP, Callaway JL, et al: The use of lincomycin in dermatology . South Med J 61:1287-1294, 1968.Crossref 9. Strauss JS: Acne vulgaris , in Fitzpatrick TB, et al (eds): Dermatology in General Medicine . New York, McGraw-Hill Book Co Inc, 1970, pp 358-367. 10. Cunliffe WJ, et al: The effect of clindamycin in acne: A clinical and laboratory investigation . Br J Dermatol 87:37-41, 1972.Crossref 11. Smith EB, et al: Antibiotic treatment for acne . Tex Med 67:90-93, 1971. 12. Cohen IE, et al: Clindamycin-associated colitis . JAMA 223:1379-1380, 1973.Crossref 13. Shemkin PM, Link RJ: Pseudomembranous colitis. A consideration in the barium enema differential diagnosis of acute generalized ulcerative colitis . Br J Rad 46:437-439, 1973.Crossref 14. Tedesco FJ, Stanley RJ, Alpers DH: Diagnostic features of clindamycin-associated pseudomembranous colitis , N Engl J Med 290:841-843, 1974.Crossref 15. Tedesco FJ, Barton RW, Alpers DH: Clindamycin-associated colitis: A prospective study . Ann Intern Med 81:429-433, 1974.Crossref 16. Pillsbury DM: A Manual of Dermatology . Philadelphia, WB Saunders Co, 1971, pp 172-174. 17. Wolfe MS: Clindamycin-associated colitis . JAMA 229:266-267, 1974.Crossref 18. Wilkinson SP: Clindamycin and colitis . Lancet 1:415, 1974.Crossref 19. Wells RF: Clindamycin-associated colitis . Ann Intern Med 81:547-548, 1974.Crossref

Wright, Robert C.;Franco, Robert S.;Denton, M. Drue;Blaney, Donald J.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250027008

Abstract • An unusual, nodulocystic form of scleromyxedema (lichen myxedematosus) developed in a 48-year-old man with a six-year history of psoriasis. The scleromyxedema responded to intermittent therapy with melphalan and prednisone. Dermabrasion smoothed and softened the skin and increased the mobility of the perioral skin. Two months after remission of the skin lesions, psoriasis recurred. (Arch Dermatol 112:63-66, 1976) References 1. Rudner EJ, Mehregan A, Pinkus H: Scleromyxedema: A variant of Lichen Myxedematosus . Arch Dermatol 93:3-12, 1966.Crossref 2. Lai a Fat RF, Suurmond D, Rádl J, et al: Scleromyxedema (lichen myxedematosus) associated with a paraprotein, IgG 1 of type kappa . Br J Dermatol 88:107-116, 1973.Crossref 3. Perry HO, Montgomery H, Stickney JM: Further observations on lichen myxedematosus . Ann Intern Med 53:955-969, 1960.Crossref 4. Hardmeier T, Vogel A: Elektronenmikroskopische Befunde beim Skleromyxödem Arndt-Gottron . Arch Klin Exp Dermatol 237:722-736, 1970.Crossref 5. Dalton JE, Allen J, Bechtel HB, et al: A study of a case of lichen myxedematosus (papular mucinosis) . Arch Dermatol 81:422-426, 1960.Crossref 6. Donald GF, Hensley WJ, McGovern VJ: Lichen myxedematosus (papular mucinosus): A brief review of the literature and report of a case which failed to respond to ACTH and cortisone . Aust J Dermatol 2:28-34, 1953.Crossref 7. Feldman P, Shapiro L, Pick AI, et al: Scleromyxedema: a dramatic response to melphalan . Arch Dermatol 99:51-56, 1969.Crossref 8. Boas NF: Methods for the determination of hexosamines in tissue . J Biol Chem 204:553, 1953. 9. Scott JE: Aliphatic ammonium salts in the assay of acidic polysaccharides from tissue , in Glick D (ed): Methods of Biochemical Analysis . New York, Interscience Publishers Inc, 1960, vol 8, pp 145-197. 10. Svennerholm L: Quantitative estimation of sialic acids: II. A colorimetric resorcinol-hydrochloric acid method . Biochim Biophys Acta 24:604-611, 1957.Crossref 11. Montgomery H, Underwood LJ: Lichen myxedematosus (differentiation from cutaneous myxedemas or mucoid states) . J Invest Dermatol 20:213-236, 1953. 12. Dalton JE, Seidell MA: Studies on lichen myxedematosus (papular mucinosis) . Arch Dermatol Syphilol 67:194-209, 1953.Crossref 13. Gersh I, Catchpole HR: The organization of ground substance and basement membrane and its significance in tissue injury, disease and growth . Am J Anat 85:457-522, 1949.Crossref 14. Fleischmajer R, Blumenkrantz N: Fractionation of glycosaminoglycans from psoriatic skin . J Invest Dermatol 55:274-276, 1970.Crossref 15. Hollman EPMJ, Mier PD, VanDeStaak WJBM, et al: Cutaneous acid mucopolysaccharides in some dermatoses . Br J Dermatol 85:421-423, 1971.Crossref 16. Epstein WL: Immunologic factors in psoriasis , in Farber EM (ed): Psoriasis: Proceedings of the International Symposium, Stanford University, 1971 . Stanford, Calif, Stanford University Press, 1971, pp 297-303. 17. Rimbaud P, Meynadier J, Clot J, et al: Le phenomene des rosettes rhumatoides dans le psoriasis . Bull Soc Fr Dermatol Syphiligr 80:136-137, 1973. 18. Osserman EF, Isobe T: Plasma cell dyscrasias: General considerations , in Williams WJ (ed): Hematology . New York, McGraw-Hill Inc, 1972, pp 950-956. 19. Cairns RJ: Metabolic and nutritional disorders , in Rook A (ed): Textbook of Dermatology . Oxford, England, Blackwell Scientific Publications Ltd, 1972, vol 2, pp 1849-1850. 20. Freinkel RK, Freinkel N: Dermatologic manifestations of endocrine disorders , in Fitzpatrick TB (ed): Dermatology in General Medicine . New York, McGraw-Hill Book Co Inc, 1971, pp 1442-1443. 21. Domonkos AN: Andrews' Diseases of the Skin . Philadelphia, WB Saunders Co, 1971, pp 195-197. 22. Braverman IM: Skin Signs of Systemic Disease . Philadelphia, WB Saunders Co, 1970, pp 134-136.

Hill, Thomas G.;Crawford, John N.;Rogers, Charles C.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250031009

Abstract • Radiation therapy led to local resolution of a case of lichen myxedematosus, which, to our knowledge, is the first reported successful treatment of the disease by radiation therapy. Radiation therapy is only the second therapeutic modality that is effective in the treatment of lichen myxedematosus. We propose specific criteria for the diagnosis of lichen myxedematosus to facilitate future studies into the nature of this disease. (Arch Dermatol 112:67-69, 1976) References 1. Dubreuilh W: Fibromes miliaries follicularies: Sclerodermis consecutive . Arch Dermatol Syph 7:569-570, 1906. 2. Gottron HA: Skleromyxodem (eine eigenartige Erscheinangys form von Myxothesaurodermis) . Arch Derm Syph Berlin 199:71-91, 1954.Crossref 3. Fowlkes RW, Blaylock WK, Mullinax F: Immunologic studies in lichen myxedematosus . Arch Dermatol 95:370-374, 1967.Crossref 4. Perry HO, Montgomery H, Stickney JM: Further observations on lichen myxedematosus . Ann Intern Med 53:955-969, 1960.Crossref 5. Verhov JL: Scleromyxoedema: A variant of lichen myxedematosus . Br J Dermatol 81:873, 1969. 6. Wigley JEM, Rees DL, Symmers WSTC: Lichen myxedematosus . Br J Dermatol 69:408-410, 1957.Crossref 7. Montgomery H, Underwood LJ: Lichen myxedematosus: Differentiation from cutaneous myxedemas or mucoid states . J Invest Dermatol 20:213-236, 1953. 8. Dalton JE, Seidell MA: Studies on lichen myxedematosus: Papular mucinosis . Arch Dermatol Syph 67:194-209, 1953.Crossref 9. Feldman P, Shapiro L, Pick AI, et al: Scleromyxedema: A dramatic response to melphalan . Arch Dermatol 99:51-56, 1969.Crossref 10. Degos R: Anomalies globuliniques dans les mucinoses cutances . Bull Soc Fr Dermatol Syphiligr 77:579-591, 1970. 11. Traenkle HL: X-ray induced skin cancer in man , in Urbach F (ed): National Cancer Institute Monograph 10 , 1967, pp 423-432. 12. Court-Brown WM, Doll R: Mortality from cancer and other causes after radiotherapy for ankylosing spondylitis . Br Med J 2:1327-1332, 1965.Crossref 13. Sauders TS, Montgomery H: Chronic roentgen and radium dermatitis . JAMA 100:23-28, 1938.Crossref 14. Crawley EP, Lupton CH, Wheeler CE, et al: Examination of normal and myxedematosus skin . Arch Dermatol 76:537-544, 1957.Crossref 15. McCarthy JY, Osserman E, Lombardo PC, et al: An abnormal serum globulin in lichen myxedematosus . Arch Dermatol 89:446-450, 1964.Crossref 16. Lawrence DA, Tye MJ, Liss M: Chemical analysis of the basic immunoglobulin in papular mucinosis . Immunochemistry 9:41-49, 1972.Crossref 17. Wells JV, Fudenberg HH, Epstein WL: Idiotypic determinants on the monoclonal immunoglobulins associated with papular mucinosis . J Immunol 108:977-983, 1972. 18. Lai A Fat RFM, Suurmond D, Rádl J, et al: Scleromyxoedema (lichen myxedematosus) associated with a paraprotein, IgG 1 of type kappa . Br J Dermatol 88:107-116, 1973.Crossref 19. Piper W, Hardmeier T, Schäfer E: Das Skleromyxödem Arndt-Gottron: Eine paraproteinämische Erkrankung . Schweiz Med Wochenschr 97:829-838, 1967. 20. Fudenberg HH, Epstein WL, Shuster J, et al: Diagnostic paraprotein in papular mucinosis . Bibl Haematol 29:318-321, 1968. 21. Shapiro CM, Fretzin D, Morris S: Papular mucinosis . JAMA 214:2052-2054, 1970.Crossref

Comaish, J. S.;Felix, R. H.;McGrath, H.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250034010

Abstract • A patient with tuberculous meningitis developed a pellagra-like skin eruption after treatment with isoniazid. Administration of the drug was continued, and a topical preparation of niacinamide (nicotinamide) was applied to one half of the face and the back of one hand. The areas treated responded rapidly, and subsequently all affected areas of the patient were treated, with almost complete resolution of the rash. At the same time, there was noticeable improvement in the patient's depression and apathy. We suggest that all of these changes could be due to percutaneous absorption of niacinamide. (Arch Dermatol 112:70-72, 1976) References 1. McConnell RB, Cheatham HD: Acute pellagra during isoniazid therapy . Lancet 2:959-960, 1952.Crossref 2. Harrison RJ, Feiwel M: Pellagra caused by isoniazid . Br Med J 2:852-854, 1956.Crossref 3. Dihorenzo PA: Pellagra-like syndrome associated with isoniazid therapy . Acta Derm Venereal 47:318-322, 1967. 4. Cohen LK, George W, Smith R: Isoniazidinduced acne and pellagra: Occurrence in slow inactivators of isoniazid . Arch Dermatol 109:377-381, 1974.Crossref 5. Rook A, Wilkinson DS, Ebling FJG: Text-book of Dermatology , ed 2. Oxford, England, Blackwell Scientific Publications, 1972. 6. Bereston ES: Reaction to antituberculous drugs . J Invest Dermatol 33:427-439, 1959.Crossref 7. Cronin E, Stoughton RB: Percutaneous absorption of nicotinic acid and ethyl nicotinate in human skin . Nature 195:1103-1104, 1962.Crossref 8. Stoughton RB, Clendinning WE, Kruse D: Percutaneous absorption of nicotinic acid and derivatives . J Invest Dermatol 35:337-341, 1960.Crossref 9. Parker R: Clinical observations of four cases of pellagra . Transactions of the National Association for the Study of Pellagra , Columbia, SC, 1909, vol 1, p 237. 10. Smith SG, Smith DI, Callaway JL: Dysfunction of the sebaceous gland associated with pellagra . J Invest Dermatol 4:23-42, 1941.Crossref 11. Wiener K: Skin Manifestations of Internal Disorders (Dermadromes) . St. Louis, CV Mosby Co, 1947, p 500. 12. Press M, Hartop PJ, Prottey C: Correction of essential fatty acid deficiency in man by the continuous application of sunflower seed oil . Lancet 1:597-598, 1974.Crossref