Archives of Dermatology

Parrish, John A.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250007001

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract Psoralens have been used for decades to stimulate repigmentation in cases of vitiligo. Recently, there has been considerable interest in the treatment of psoriasis with orally administered psoralens and subsequent exposure to longwave ultraviolet light (UVA, 320 to 400 nm). The relationship between the responses of these skin diseases to psoralen therapy and the striking erythemogenic and melanogenic effects of photoactive psoralens on normal skin is unknown. No relationship has yet been established between any of these cutaneous effects and the known formation of photoadducts of thymine and psoralen, nor between cutaneous effects of psoralen therapy and the transiently decreased DNA synthesis that occurs when psoralentreated cells are exposed to UVA. Double-blind acute toxicity studies performed on human volunteers and studies of large numbers of vitiligo cases have disproved the early concerns about the possible hepatotoxicity of psoralens. Repeated exposure to high doses of UVA is carcinogenic to certain laboratory

Cohen, Haim A.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250009002

Abstract † Patients suffering from contact dermatitis caused by chromium sensitivity showed positive reactions to intradermal tests with chromium and cobalt chlorides. Patch tests to cobalt in unaffected and in healed eczematous skin areas gave negative results. A large number of chromiumsensitive patients also showed a positive intradermal test reaction to cobalt bound to human serum albumin and a negative reaction to cobalt bound to rabbit liver glycogen. It has been suggested that these positive reactions to cobalt are secondary sensitivities to cobalt, caused by cobalt-denaturated human serum albumin that is so similar to the denaturated product of chromium cations that the competent cells cannot distinguish between them. (Arch Dermatol 112:37-39, 1976) References 1. Baer RL: Multiple eczematous sensitivities . JAMA 170:1041-1045, 1959.Crossref 2. Cohen HA: Experimental production of circulating antibodies to chromium . J Invest Dermatol 38:13-29, 1962. 3. Mali JWH, van Kotten JW, van Neer FCJ: Some aspects of the behaviour of chromium compounds in the skin . J Invest Dermatol 41:111-122, 1963.Crossref 4. Cohen HA: Tuberculin-type sensitivity to trivalent chromium . Isr J Med Sci 1:79-83, 1965. 5. Gell PGH, Benacerraf B: Studies on hypersensitivity: IV. The relationship between contact and delayed sensitivity: A study on the specificity of cellular immune reactions . J Exp Med 113:571-585, 1961.Crossref 6. Gell PGH, Silverstein AM: Delayed hypersensitivity to hapten-protein conjugates: I. The effect of carrier protein and site of attachment to hapten . J Exp Med 115:1037-1051, 1962.Crossref 7. Cohen HA: Carrier specificity of tuberculintype reaction to trivalent chromium . Arch Dermatol 93:34-40, 1966.Crossref 8. Geiser JD, Jeanneret JP, Delacretaz J: Eczema due to cement and sensitization to cobalt . Dermatologica 121:1-7, 1960.Crossref 9. Rostenberg A Jr, Perkins AJ: Nickel and cobalt dermatitis . J Allergy 22:466-474, 1951.Crossref 10. Welch H, Rostenberg A Jr: Hypersensitivity of the tuberculin-type to crystalline penicillin sodium . JAMA 126:10-12, 1944.Crossref 11. Rostenberg A Jr, Welch H: A study of the types of hypersensitivity induced by penicillin . J Med Sci 210:158-167, 1945.Crossref 12. Epstein S, Pinkus H, Hanson D: Penicillin dermatitis based on tuberculin-type sensitivity: Report of a case with remarks on experimental sensitization to penicillin . Ann Allergy 4:186-195, 1946. 13. Epstein S: Dermal contact dermatitis sensitivity to rivanol and gentian violet . Dermatologica 117:287-296, 1958.Crossref 14. Epstein S: Contact dermatitis from neomycin due to dermal delayed (tuberculin-type) sensitivity: Report of 10 cases . Dermatologica 113:191-201, 1956.Crossref 15. Baer RL, Lipkin C, Kanof NB, et al: Changing patterns of sensitivity to common contact allergens . Arch Dermatol 89:3-8, 1964.Crossref 16. Jandl JH, Simmons RL: The agglutination and sensitization of red cells by metallic cations: Interactions between multivalent metals and the red-cell membrane . Br J Dermatol 3:19-38, 1958. 17. Sulzberger MB, Rostenberg A Jr: Acquired specific supersensitivity (allergy) to simple chemicals: IV. A method of experimental sensitization, and demonstration of increased susceptibility in individuals with eczematous dermatitis of contact type . J Immunol 36:17-27, 1939.

Sorensen, Gregory W.;Jones, Henry E.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250012003

Abstract † Delayed hypersensitivity (DH) to seven common antigens was examined in 38 men with chronic dermatophyte infections and in 20 controls. A similar percentage of the infected and the control groups reacted to four antigens. In addition to showing a low frequency of DH to trichophytin, the infected group also showed a significant reduction in their reactions to intradermal mumps skin test antigen and to a Rhus oleoresin patch test. Two members (5%) of the infected group were anergic to all tests. Patients with chronic dermatophytosis appear to have a relatively specific defect in DH to trichophytin, but their cell-mediated responses to other antigens may also be somewhat decreased. The subjects studied did not appear to suffer excessive morbidity from infectious diseases, other than dermatophytosis. (Arch Dermatol 112:40-42, 1976) References 1. Hildick-Smith G, Blank H, Sarkany I: Fungus Diseases and Their Treatment . Boston, Little Brown & Co, 1964, pp 42-52. 2. Jones HE, Reinhardt JH, Rinaldi MG: Immunologic susceptibility to chronic dermatophytosis . Arch Dermatol 110:213-220, 1974.Crossref 3. Jones HE, Reinhardt JH, Rinaldi MG: A clinical, mycological, and immunological survey for dermatophytosis . Arch Dermatol 108:61-65, 1973.Crossref 4. Jones HE, Reinhardt JH, Rinaldi MG: Model dermatophytosis in naturally infected subjects . Arch Dermatol 110:369-374, 1974.Crossref 5. Fudenberg H, Good RA, Goodman HC, et al: Primary immunodeficiencies: Report of a World Health Organization Committee . Pediatrics 47:927-946, 1971. 6. Bean SF, South MA: Cutaneous manifestations of immunogenetic deficiency disorders . J Invest Dermatol 60:503-508, 1973.Crossref 7. Jones HE, Lewis CW, McMarlin SL: Allergic contact sensitivity in atopic dermatitis . Arch Dermatol 107:217-222, 1973.Crossref 8. Hanifin JM, Ray LF, Lobitz WC Jr: Immunological reactivity in dermatophytosis . Br J Dermatol 90:1-8, 1974.Crossref 9. Kirkpatrick CH, Rich RR, Bennett JE: Chronic mucocutaneous candidiasis: Model-building in cellular immunity . Ann Intern Med 74:955-978, 1971.Crossref 10. Lamb D, Pilney F, Kelly WD, et al: A comparative study of the incidence of anergy in patients with carcinoma, leukemia, Hodgkin's disease and other lymphomas . J Immunol 89:555-558, 1962. 11. Young RC, Corder MP, Berard CW, et al: Immune alterations in Hodgkin's disease: Effect of delayed hypersensitivity and lymphocyte transformation on course and survival . Arch Intern Med 131:446-454, 1973.Crossref

Rodriguez, Jose;Ackerman, A. Bernard

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250015004

Abstract † Nine cases of cutaneous xanthogranuloma in adults are reported. These lesions were histologically indistinguishable from the xanthogranulomas in infants and children (juvenile xanthogranuloma), and, like those in the young, they were not associated with abnormalities of serum lipids. Unlike juvenile xanthogranuloma, however, in our small sample there was no concomitant involvement of the eye in adult xanthogranuloma. (Arch Dermatol 112:43-44, 1976) References 1. Helwig E, Hackney VC: Juvenile xanthogranuloma . Am J Pathol 30:625-626, 1954. 2. Adamson HF: Congenital xanthoma multiplex . Br J Dermatol 17:222, 1905. 3. McDonagh JER: A contribution to our knowledge of the naevoxanthoendothelioma . Br J Dermatol 24:85, 1912.Crossref 4. Gartmann H, Tritsch H: Hein-und grobknotiges Naevoxanthoendotheliom . Dermatologica 215:409-421, 1963. 5. Gronzalez-Cruzi F, Campbell RJ: Juvenile xanthogranuloma: Ultrastructural study . Arch Pathol 89:65-72, 1970. 6. Esterly N, Sahihi T, Medenica M: Juvenile xanthogranuloma . Arch Dermatol 105:99-102, 1972.Crossref 7. Blank H, Eglick P, Beerman H: Nevoxanthoendothelioma with ocular involvement . Pediatrics 4:349-354, 1949. 8. Sanders TE: Intraocular juvenile xanthogranuloma . Am J Ophthalmol 54:455-462, 1962. 9. Zimmerman L: Ocular lesions of juvenile xanthogranuloma . Trans Am Acad Ophthalmol Otolaryngol 69:412-441, 1965. 10. Llottsfeldt F, Good R: Juvenile xanthogranuloma with pulmonary lesions . Pediatrics 33:233-238, 1964. 11. Webster SB, Reister SC, Harman LE Jr: Juvenile xanthogranuloma with extracutaneous lesions . Arch Dermatol 92:71-76, 1966.Crossref 12. Newell GB, Stone OJ, Mullins JF: Juvenile xanthogranuloma and neurofibromatosis . Arch Dermatol 107:262, 1973.Crossref 13. Sibulkin D, Olichney JJ: Juvenile xanthogranuloma in a patient with Niemann-Pick disease . Arch Dermatol 108:829-831, 1973.Crossref

Jablonska, Stefania;Chorzelski, Tadeusz P.;Beutner, Ernst H.;Maciejowska, Ewa;Rzęsa, Genowefa

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250017005

Abstract • Nine patients had clinical and histological features suggestive of both dermatitis herpetiformis (DH) and bullous pemphigoid (BP). Five patients responded to treatment with sulfapyridine or sulfones: in two the response was inconsistent, and the disease was controlled by combined treatment with prednisone; in one patient, there was no response to sulfapyridine or sulfones. Immunofluorescence studies showed IgA deposits in a linear homogeneous pattern at the basement membrane zone in all patients, and IgG was present in five. No circulating anti-basement membrane antibodies were detected by repeated immunofluorescence examinations. The authors conclude that the occasional overlapping of BP and DH should not lead to dropping the distinction between the two entities. For overlap cases that cannot be classified as BP or DH, the term "intermediate or mixed form of DH and BP" seems to be most suitable. (Arch Dermatol 112:45-48, 1976) References 1. Lever WF: Pemphigus . Medicine 32:1-123, 1953.Crossref 2. Lever WF: Pemphigus and Pemphigoid , Springfield, Ill, Charles C. Thomas Publisher, 1965. 3. Rook A, Waddington E: Pemphigus and pemphigoid . Br J Dermatol 65:425-431, 1953.Crossref 4. Piérard J, Whimster I: The histological diagnosis of dermatitis herpetiformis, bullous pemphigoid and erythema multiforme . Br J Dermatol 73:253-266, 1961.Crossref 5. Rupee M, Kint A, Braun-Falco 0: Zur Frage der Histopathologie der peribullösen Veränderungen bei Dermatitis herpetiformis Duhring und ihrer Differentialdiagnose . Z Haut Geschlechtskr 34:121, 1963. 6. Van der Meer JB: Granular deposits of immunoglobulins in the skin of patients with dermatitis herpetiformis: An immunofluorescent study . Br J Dermatol 81:493-503, 1969.Crossref 7. Van der Meer JB: Dermatitis herpetiformis: A specific immunopathological entity?, thesis. Utrecht University, Utrecht, the Netherlands, 1972. 8. Beutner EH, Chorzelski TP, Jordon RE: Autosensitization in Pemphigus and Bullous Pemphigoid . Springfield, Ill, Charles C Thomas Publishers, 1970. 9. Jablonska S: Immunopathology of bullous disease . Ann Clin Res 2:7-12, 1970. 10. Chorzelski TP, Beutner EH, Jablonska S, et al: Immunofluorescence studies in the diagnosis of dermatitis herpetiformis and its differentiation from bullous pemphigoid . J Invest Dermatol 56:373-380, 1971.Crossref 11. Beutner EH, Chorzelski TP, Bean SF, et al (eds): Immunopathology of The Skin: Labeled Antibody Studies . Stroudsburg, Pa, Dowden, Hutchinson & Ross, 1973. 12. Beutner EH, Jordon RE: Demonstration of skin antibodies in sera of pemphigus vulgaris patients by indirect immunofluorescent staining . Proc Soc Exp Biol Med 117:505-510, 1964.Crossref 13. Jordon RE, Beutner EH, Witebsky E, et al: Basement zone antibodies in bullous pemphigoid . JAMA 200:751-756, 1967.Crossref 14. Chorzelski TP, Jablonska S: Immunopathologische Untersuchungen bei der Duhringschen Krankheit und Pemphigoid . Dermatol Wochenschr 153:558-563, 1967. 15. Chorzelski TP, Jablonska S, Blaszczyk M, et al: Autoantibodies in pemphigoid . Dermatologica 136:325-334, 1968.Crossref 16. Beutner EH, Jordon RE, Chorzelski TP: Immunopathology of pemphigus and bullous pemphigoid . J Invest Dermatol 51:63-80, 1968.Crossref 17. Marks J, Shuster S, Watson AJ: Small-bowel changes in dermatitis herpetiformis . Lancet 2:1280-1282, 1966.Crossref 18. Marks R, Whittle MW, Beard RJ, et al: Small-bowel abnormalities in dermatitis herpetiformis . Br Med J 1:552-555, 1968.Crossref 19. Marks J, Shuster S: Dermatitis herpetiformis: The role of gluten . Arch Dermatol 101:452-457, 1970.Crossref 20. Fraser NG, Murray D, Alexander JOD: Structure and function of the small intestine in dermatitis herpetiformis . Br J Dermatol 79:509-518, 1967.Crossref 21. Fry L, Keir P, McMinn RHM, et al: Small intestinal structure and function and haematological changes in dermatitis herpetiformis . Lancet 2:729-733, 1967.Crossref 22. Jablonska S, Chorzelski T: Kann das histologische Bild die Grundlage zur Differenzierung des Morbus Duhring mit dem Pemphigoid und Erythema multiforme darstellen? Dermatol Wochenschr 146:590-603, 1962. 23. Winkelmann RK, Roth HL: Dermatitis herpetiformis with acantholysis or pemphigus with response to sulphonamides: Report of two cases . Arch Dermatol 82:385-390, 1960.Crossref 24. De Mento FJ, Grover RW: Acantholytic herpetiform dermatitis . Arch Dermatol 107:883-887, 1973.Crossref 25. Honeyman JF, Honeyman A, Lobitz WC, et al: The enigma of bullous pemphigoid and dermatitis herpetiformis . Arch Dermatol 106:22-25, 1973.Crossref 26. Thivolet J, Beyvin AJ, Perrat HV, et al: Autoimmunité au cours de la maladie de Duhring-Brocq . Bull Soc Fr Dermatol Syphiligr 76:463-467, 1969. 27. Thivolet J, Beyvin AJ: Immunologie de la forme pemphigoide de la maladie de Duhring-Brocq . Bull Soc Fr Dermatol Syphiligr 78:369, 1971. 28. Seah PP, Fry L, Stewart JS, et al: Immunoglobulins in the skin in dermatitis herpetiformis and coeliac disease . Lancet 1:611-614, 1972.Crossref 29. Fry L, Seah PP: Dermatitis herpetiformis , in Fry L, Seah PP (eds): Immunological Aspects of Skin Diseases . New York, John Wiley & Sons, 1974, p 22. 30. Heid E, Maleville J, Roveri D, et al: Intérét de la diète iodée dans la maladie de Duhring-Brocq: Ses incidences sur le test thérapeutique sulfones-sulfamides . Bull Soc Fr Dermatol Syphiligr 80:10-12, 1973.

Waller, Jack D.;Greenberg, Joseph H.;Lewis, Charles W.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250021006

Abstract • Three cases of hereditary hemorrhagic telangiectasia (HHT) with cerebrovascular malformation are presented. Previous reports of HHT have given little attention to its association with cerebrovascular malformation, despite frequent neurological symptoms in patients with HHT. Eleven other cases of HHT with neuropathologic or radiographic evidence of cerebrovascular malformation have been reported in the literature. We think that this association may be more frequent than previously suspected. The subtlety of the symptoms in HHT is stressed, and it is suggested that patients with cerebrovascular malformation be examined carefully for HHT, and vice versa. (Arch Dermatol 112:49-52, 1976) References 1. Babington BG: Hereditary epistaxis . Lancet 2:362, 1865. 2. Legg JW: A case of haemophilia complicated with multiple naevi . Lancet 2:865, 1876. 3. Rendu H: Epistaxis répétées chez un sujet porteur de petits angiomes cutanés et muqueux . Bull Soc Med Hop Paris 13:731-733, 1896. 4. Osler W: On a family form of recurring epistaxis, associated with multiple telangiectases of the skin and mucous membranes . Bull Johns Hopkins Hosp 12:333-337, 1901. 5. Parkes-Weber F: Developmental telangiectatic haemorrhage and so-called "Telangiectasia"—familial and non-familial . Br J Child Dis 21:198, 1924. 6. Rodes CB: Cavernous hemangiomas of lung with secondary polycythemia . JAMA 110:1914-1915, 1938.Crossref 7. Chandler D: Pulmonary and cerebral arteriovenous fistula with Osler's disease . Arch Intern Med 116:277-282, 1965.Crossref 8. Trell E, Johansson BW, Linell F, et al: Familial pulmonary hypertension and multiple abnormalities of large systemic arteries in Osler's disease . Am J Med 53:50-63, 1972.Crossref 9. Courville CB: Encephalic lesions in hereditary hemorrhagic telangiectasis (Rendu-Osler-Weber disease): Report of a case with the disclosure of microscopic telangiectasis in the leptomeninges . Bull Los Angeles Neurol Soc 22:28-35, 1957. 10. Garland HG, Anning ST: Hereditary haemorrhagic telangiectasia: A genetic and bibliographical study . Br J Dermatol 62:289-310, 1950.Crossref 11. Hodgson CH, Burchell HB, Good AC, et al: Hereditary hemorrhagic telangiectasia and pulmonary arteriovenous fistula: Survey of a large family . N Engl J Med 261:625-636, 1959.Crossref 12. Taveras JM, Wood EH: Diagnostic Neuroradiology . Baltimore, Williams & Wilkins Co, 1964. 13. Toole JF, Patel AN: Cerebrovascular Disorders . New York, McGraw-Hill Book Co Inc, 1967. 14. Boczko ML: Neurological implications of hereditary hemorrhagic telangiectasis . J Nerv Ment Dis 139:525-536, 1964.Crossref 15. LeRoux BT: Pulmonary arteriovenous fistulae . Q J Med 28:1-19, 1959. 16. Snyder LH, Doan CA: Studies in human inheritance: Is the homozygous form of multiple telangiectasia lethal? J Lab Clin Med 29:1211-1216, 1944. 17. Ytrehus Ø: Hereditary hemorrhagic telangiectasis and cirrhosis of liver . Nord Med 38:730-733, 1948. 18. Brinkmann E: Über Oslersche Krankheit . Folia Haematol 70:119-129, 1950. 19. Bird RM, Jaques WE: Vascular lesion of hereditary hemorrhagic telangiectasia . N Engl J Med 260:597-599, 1959.Crossref 20. Zelman S: Liver fibrosis in hereditary hemorrhagic telangiectasia: Fibrosis of diffuse insular character . Arch Pathol 74:66-72, 1962. 21. Sochocky S: Arteriovenous fistula of the lung . J Lancet 82:12-17, 1962. 22. Quickel KE Jr, Whaley RJ: Subarachnoid hemorrhage in a patient with hereditary hemorrhagic telangiectasia . Neurology 17:716-719, 1967.Crossref 23. Reagan TJ, Bloom WH: The brain in hereditary hemorrhagic telangiectasia . Stroke 2:361-368, 1971.Crossref 24. Bean WB: Congenital and hereditary lesions and birthmarks , in Vascular Spiders and Related Lesions of the Skin . Springfield, Ill, Charles C Thomas Publisher, 1958, pp 132-157.

Dantzig, Paul I.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250025007

Abstract • Sixty patients with severe pustular and cystic acne were treated for prolonged periods with clindamycin (150 mg to 300 mg daily). The average duration of therapy was five months, with 18 patients being treated for more than six months. Only two (3.4%) patients developed mild diarrhea, which was rapidly reversible on discontinuance of the drug. No other adverse reactions were observed. These data suggest that long-term, low-dose clindamycin therapy may be safe for severe pustular or cystic acne. (Arch Dermatol 112:53-54, 1976) References 1. Wansker BA: Antibiotics and pustulocystic acne: A long-term double-blind evaluation . Arch Dermatol 84:96-98, 1961.Crossref 2. Hicks JH: Demethylchlortetracycline: A double-blind study in the treatment of acne with attention to side effects noted . South Med J 55:357-360, 1962.Crossref 3. Stewart WD, Maddin S, Nelson AJ, et al: Therapeutic agents in acne vulgaris: I. Tetracycline . Can Med Assoc J 89:1096-1097, 1963. 4. Knox JM, Owens DW: Demethylchlortetracycline in the treatment of acne vulgaris . South Med J 58:1056-1060, 1965.Crossref 5. Savin RC, Turner MC: Antibiotics and the placebo reaction in acne . JAMA 196:365-367, 1966.Crossref 6. Witkowski JA, Simons HM: Objective evaluation of demethyl-chlortetracycline hydrochloride in the treatment of acne . JAMA 196:397-400, 1966.Crossref 7. Moss HV: Acne vulgaris: Treatment with three newer antibiotics . Cutis 10:375-376, 1972. 8. Hall JH, Tindall SP, Callaway JL, et al: The use of lincomycin in dermatology . South Med J 61:1287-1294, 1968.Crossref 9. Strauss JS: Acne vulgaris , in Fitzpatrick TB, et al (eds): Dermatology in General Medicine . New York, McGraw-Hill Book Co Inc, 1970, pp 358-367. 10. Cunliffe WJ, et al: The effect of clindamycin in acne: A clinical and laboratory investigation . Br J Dermatol 87:37-41, 1972.Crossref 11. Smith EB, et al: Antibiotic treatment for acne . Tex Med 67:90-93, 1971. 12. Cohen IE, et al: Clindamycin-associated colitis . JAMA 223:1379-1380, 1973.Crossref 13. Shemkin PM, Link RJ: Pseudomembranous colitis. A consideration in the barium enema differential diagnosis of acute generalized ulcerative colitis . Br J Rad 46:437-439, 1973.Crossref 14. Tedesco FJ, Stanley RJ, Alpers DH: Diagnostic features of clindamycin-associated pseudomembranous colitis , N Engl J Med 290:841-843, 1974.Crossref 15. Tedesco FJ, Barton RW, Alpers DH: Clindamycin-associated colitis: A prospective study . Ann Intern Med 81:429-433, 1974.Crossref 16. Pillsbury DM: A Manual of Dermatology . Philadelphia, WB Saunders Co, 1971, pp 172-174. 17. Wolfe MS: Clindamycin-associated colitis . JAMA 229:266-267, 1974.Crossref 18. Wilkinson SP: Clindamycin and colitis . Lancet 1:415, 1974.Crossref 19. Wells RF: Clindamycin-associated colitis . Ann Intern Med 81:547-548, 1974.Crossref

Wright, Robert C.;Franco, Robert S.;Denton, M. Drue;Blaney, Donald J.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250027008

Abstract • An unusual, nodulocystic form of scleromyxedema (lichen myxedematosus) developed in a 48-year-old man with a six-year history of psoriasis. The scleromyxedema responded to intermittent therapy with melphalan and prednisone. Dermabrasion smoothed and softened the skin and increased the mobility of the perioral skin. Two months after remission of the skin lesions, psoriasis recurred. (Arch Dermatol 112:63-66, 1976) References 1. Rudner EJ, Mehregan A, Pinkus H: Scleromyxedema: A variant of Lichen Myxedematosus . Arch Dermatol 93:3-12, 1966.Crossref 2. Lai a Fat RF, Suurmond D, Rádl J, et al: Scleromyxedema (lichen myxedematosus) associated with a paraprotein, IgG 1 of type kappa . Br J Dermatol 88:107-116, 1973.Crossref 3. Perry HO, Montgomery H, Stickney JM: Further observations on lichen myxedematosus . Ann Intern Med 53:955-969, 1960.Crossref 4. Hardmeier T, Vogel A: Elektronenmikroskopische Befunde beim Skleromyxödem Arndt-Gottron . Arch Klin Exp Dermatol 237:722-736, 1970.Crossref 5. Dalton JE, Allen J, Bechtel HB, et al: A study of a case of lichen myxedematosus (papular mucinosis) . Arch Dermatol 81:422-426, 1960.Crossref 6. Donald GF, Hensley WJ, McGovern VJ: Lichen myxedematosus (papular mucinosus): A brief review of the literature and report of a case which failed to respond to ACTH and cortisone . Aust J Dermatol 2:28-34, 1953.Crossref 7. Feldman P, Shapiro L, Pick AI, et al: Scleromyxedema: a dramatic response to melphalan . Arch Dermatol 99:51-56, 1969.Crossref 8. Boas NF: Methods for the determination of hexosamines in tissue . J Biol Chem 204:553, 1953. 9. Scott JE: Aliphatic ammonium salts in the assay of acidic polysaccharides from tissue , in Glick D (ed): Methods of Biochemical Analysis . New York, Interscience Publishers Inc, 1960, vol 8, pp 145-197. 10. Svennerholm L: Quantitative estimation of sialic acids: II. A colorimetric resorcinol-hydrochloric acid method . Biochim Biophys Acta 24:604-611, 1957.Crossref 11. Montgomery H, Underwood LJ: Lichen myxedematosus (differentiation from cutaneous myxedemas or mucoid states) . J Invest Dermatol 20:213-236, 1953. 12. Dalton JE, Seidell MA: Studies on lichen myxedematosus (papular mucinosis) . Arch Dermatol Syphilol 67:194-209, 1953.Crossref 13. Gersh I, Catchpole HR: The organization of ground substance and basement membrane and its significance in tissue injury, disease and growth . Am J Anat 85:457-522, 1949.Crossref 14. Fleischmajer R, Blumenkrantz N: Fractionation of glycosaminoglycans from psoriatic skin . J Invest Dermatol 55:274-276, 1970.Crossref 15. Hollman EPMJ, Mier PD, VanDeStaak WJBM, et al: Cutaneous acid mucopolysaccharides in some dermatoses . Br J Dermatol 85:421-423, 1971.Crossref 16. Epstein WL: Immunologic factors in psoriasis , in Farber EM (ed): Psoriasis: Proceedings of the International Symposium, Stanford University, 1971 . Stanford, Calif, Stanford University Press, 1971, pp 297-303. 17. Rimbaud P, Meynadier J, Clot J, et al: Le phenomene des rosettes rhumatoides dans le psoriasis . Bull Soc Fr Dermatol Syphiligr 80:136-137, 1973. 18. Osserman EF, Isobe T: Plasma cell dyscrasias: General considerations , in Williams WJ (ed): Hematology . New York, McGraw-Hill Inc, 1972, pp 950-956. 19. Cairns RJ: Metabolic and nutritional disorders , in Rook A (ed): Textbook of Dermatology . Oxford, England, Blackwell Scientific Publications Ltd, 1972, vol 2, pp 1849-1850. 20. Freinkel RK, Freinkel N: Dermatologic manifestations of endocrine disorders , in Fitzpatrick TB (ed): Dermatology in General Medicine . New York, McGraw-Hill Book Co Inc, 1971, pp 1442-1443. 21. Domonkos AN: Andrews' Diseases of the Skin . Philadelphia, WB Saunders Co, 1971, pp 195-197. 22. Braverman IM: Skin Signs of Systemic Disease . Philadelphia, WB Saunders Co, 1970, pp 134-136.

Hill, Thomas G.;Crawford, John N.;Rogers, Charles C.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250031009

Abstract • Radiation therapy led to local resolution of a case of lichen myxedematosus, which, to our knowledge, is the first reported successful treatment of the disease by radiation therapy. Radiation therapy is only the second therapeutic modality that is effective in the treatment of lichen myxedematosus. We propose specific criteria for the diagnosis of lichen myxedematosus to facilitate future studies into the nature of this disease. (Arch Dermatol 112:67-69, 1976) References 1. Dubreuilh W: Fibromes miliaries follicularies: Sclerodermis consecutive . Arch Dermatol Syph 7:569-570, 1906. 2. Gottron HA: Skleromyxodem (eine eigenartige Erscheinangys form von Myxothesaurodermis) . Arch Derm Syph Berlin 199:71-91, 1954.Crossref 3. Fowlkes RW, Blaylock WK, Mullinax F: Immunologic studies in lichen myxedematosus . Arch Dermatol 95:370-374, 1967.Crossref 4. Perry HO, Montgomery H, Stickney JM: Further observations on lichen myxedematosus . Ann Intern Med 53:955-969, 1960.Crossref 5. Verhov JL: Scleromyxoedema: A variant of lichen myxedematosus . Br J Dermatol 81:873, 1969. 6. Wigley JEM, Rees DL, Symmers WSTC: Lichen myxedematosus . Br J Dermatol 69:408-410, 1957.Crossref 7. Montgomery H, Underwood LJ: Lichen myxedematosus: Differentiation from cutaneous myxedemas or mucoid states . J Invest Dermatol 20:213-236, 1953. 8. Dalton JE, Seidell MA: Studies on lichen myxedematosus: Papular mucinosis . Arch Dermatol Syph 67:194-209, 1953.Crossref 9. Feldman P, Shapiro L, Pick AI, et al: Scleromyxedema: A dramatic response to melphalan . Arch Dermatol 99:51-56, 1969.Crossref 10. Degos R: Anomalies globuliniques dans les mucinoses cutances . Bull Soc Fr Dermatol Syphiligr 77:579-591, 1970. 11. Traenkle HL: X-ray induced skin cancer in man , in Urbach F (ed): National Cancer Institute Monograph 10 , 1967, pp 423-432. 12. Court-Brown WM, Doll R: Mortality from cancer and other causes after radiotherapy for ankylosing spondylitis . Br Med J 2:1327-1332, 1965.Crossref 13. Sauders TS, Montgomery H: Chronic roentgen and radium dermatitis . JAMA 100:23-28, 1938.Crossref 14. Crawley EP, Lupton CH, Wheeler CE, et al: Examination of normal and myxedematosus skin . Arch Dermatol 76:537-544, 1957.Crossref 15. McCarthy JY, Osserman E, Lombardo PC, et al: An abnormal serum globulin in lichen myxedematosus . Arch Dermatol 89:446-450, 1964.Crossref 16. Lawrence DA, Tye MJ, Liss M: Chemical analysis of the basic immunoglobulin in papular mucinosis . Immunochemistry 9:41-49, 1972.Crossref 17. Wells JV, Fudenberg HH, Epstein WL: Idiotypic determinants on the monoclonal immunoglobulins associated with papular mucinosis . J Immunol 108:977-983, 1972. 18. Lai A Fat RFM, Suurmond D, Rádl J, et al: Scleromyxoedema (lichen myxedematosus) associated with a paraprotein, IgG 1 of type kappa . Br J Dermatol 88:107-116, 1973.Crossref 19. Piper W, Hardmeier T, Schäfer E: Das Skleromyxödem Arndt-Gottron: Eine paraproteinämische Erkrankung . Schweiz Med Wochenschr 97:829-838, 1967. 20. Fudenberg HH, Epstein WL, Shuster J, et al: Diagnostic paraprotein in papular mucinosis . Bibl Haematol 29:318-321, 1968. 21. Shapiro CM, Fretzin D, Morris S: Papular mucinosis . JAMA 214:2052-2054, 1970.Crossref

Comaish, J. S.;Felix, R. H.;McGrath, H.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250034010

Abstract • A patient with tuberculous meningitis developed a pellagra-like skin eruption after treatment with isoniazid. Administration of the drug was continued, and a topical preparation of niacinamide (nicotinamide) was applied to one half of the face and the back of one hand. The areas treated responded rapidly, and subsequently all affected areas of the patient were treated, with almost complete resolution of the rash. At the same time, there was noticeable improvement in the patient's depression and apathy. We suggest that all of these changes could be due to percutaneous absorption of niacinamide. (Arch Dermatol 112:70-72, 1976) References 1. McConnell RB, Cheatham HD: Acute pellagra during isoniazid therapy . Lancet 2:959-960, 1952.Crossref 2. Harrison RJ, Feiwel M: Pellagra caused by isoniazid . Br Med J 2:852-854, 1956.Crossref 3. Dihorenzo PA: Pellagra-like syndrome associated with isoniazid therapy . Acta Derm Venereal 47:318-322, 1967. 4. Cohen LK, George W, Smith R: Isoniazidinduced acne and pellagra: Occurrence in slow inactivators of isoniazid . Arch Dermatol 109:377-381, 1974.Crossref 5. Rook A, Wilkinson DS, Ebling FJG: Text-book of Dermatology , ed 2. Oxford, England, Blackwell Scientific Publications, 1972. 6. Bereston ES: Reaction to antituberculous drugs . J Invest Dermatol 33:427-439, 1959.Crossref 7. Cronin E, Stoughton RB: Percutaneous absorption of nicotinic acid and ethyl nicotinate in human skin . Nature 195:1103-1104, 1962.Crossref 8. Stoughton RB, Clendinning WE, Kruse D: Percutaneous absorption of nicotinic acid and derivatives . J Invest Dermatol 35:337-341, 1960.Crossref 9. Parker R: Clinical observations of four cases of pellagra . Transactions of the National Association for the Study of Pellagra , Columbia, SC, 1909, vol 1, p 237. 10. Smith SG, Smith DI, Callaway JL: Dysfunction of the sebaceous gland associated with pellagra . J Invest Dermatol 4:23-42, 1941.Crossref 11. Wiener K: Skin Manifestations of Internal Disorders (Dermadromes) . St. Louis, CV Mosby Co, 1947, p 500. 12. Press M, Hartop PJ, Prottey C: Correction of essential fatty acid deficiency in man by the continuous application of sunflower seed oil . Lancet 1:597-598, 1974.Crossref

Anolik, Mitchell A.;Rudolph, Robert I.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250037011

Abstract • A patient who had recently had a renal transplant was on a maintenance regimen of azathioprine and prednisone. She developed a florid, scaling, papular eruption clinically identical to Darier disease. Biopsy specimens and skin scrapings, however, showed a scabietic infestation. We believe that this highly atypical presentation, which had several features found in Norwegian scabies, was due to a muted inflammatory response that permitted a great proliferation of the mites. (Arch Dermatol 112:73-74, 1976) References 1. Orkin M: Resurgence of scabies . JAMA 217:593-597, 1971.Crossref 2. Haydon JR Jr, Caplan RM: Epidemic scabies . Arch Dermatol 103:168-173, 1971.Crossref 3. Shrank AB, Alexander SL: Scabies: Another epidemic? Br Med J 1:669-671, 1967.Crossref 4. Marples MJ: The Ecology of the Human Skin . Springfield, Ill, Charles C Thomas Publisher, 1965, pp 314-333. 5. Bean SF: Bullous scabies . JAMA 230:878, 1974.Crossref 6. Brown WH: Some clinical manifestations of endogenous sensitization eruptions following local infection or injury . Br J Dermatol 51:197-207, 1939.Crossref 7. MacMillan AL: Unusual features of scabies associated with topical fluorinated steroids . Br J Dermatol 87:496-497, 1972.Crossref 8. Mellanby K: The development of symptoms, parasitic infection and immunity in human scabies . Parasitology 35:197-206, 1944.Crossref 9. Koranda FC, Dehmel EM, Kahn G, et al: Cutaneous complications in immunosuppressed renal homograft recipients . JAMA 229:419-424, 1974.Crossref 10. Park RK, Goltz RW, Carey TB: Unusual cutaneous infections associated with immunosuppressive therapy . Arch Dermatol 95:345-350, 1967.Crossref 11. Haim S, Friedman-Birnbaum R, Better OS, et al: Skin complications of immunosuppressed patients: Follow-up of kidney recipients . Br J Dermatol 89:169-173, 1973.Crossref 12. Ingram JT: Ward epidemic from Norwegian scabies . Br J Dermatol 63:311-317, 1951.Crossref 13. Kurtin SB, Leider M: Norwegian scabies: Report and lessons of a case . N Engl J Med 278:1099-1100, 1968.Crossref 14. Hancock BW, Ward AM: Serum immunoglobulin in scabies . Jn Invest Dermatol 63:482-484, 1974.Crossref 15. Warburton MA: Sarcoptic scabies in man and animals: A critical survey of our present knowledge regarding the acari concerned . Parasitology 12;265-300, 1920.Crossref 16. Burks JW Jr, Jung R, George WM: Norwegian scabies . Arch Dermatol 74:131-140, 1956.Crossref 17. Swanson MA, Schwartz RS: Immunosuppressive therapy: The relation between clinical response and immunologic competence . N Engl J Med 277:163-170, 1967.Crossref 18. Ebling FJ, Rook A: Disorders in keratinization , in Rook A, Wilkinson DS, Ebling FJG (eds): Textbook in Dermatology . Philadelphia, FA Davis Co, 1972, pp 1169-1171. 19. Frost P: Darier-White disease , in Fitzpatrick TB, Arndt KA, Clark WH Jr, et al (eds): Dermatology in General Medicine . New York, McGraw-Hill Book Co Inc, 1971, pp 266-271.

Fellner, Michael J.;Katz, James M.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250039012

Abstract • A 78-year-old woman with Parkinson disease developed tense bullous lesions on the chest, arms, and in the groin that were diagnosed as bullous pemphigoid. Histologic examination, as well as immunofluorescence tests, confirmed this diagnosis. The possibility of a drug-induced disease was considered because she was taking seven different medications. Furosemide (Lasix) was suspected primarily. Complete clearing occurred with prednisone therapy, but readministration of furosemide resulted in bulla formation. (Arch Dermatol 112:75-77, 1976) References 1. Bean SF, Good RA, Windhorst DB: Bullous pemphigoid in an 11-year-old boy . Arch Dermatol 102:205-208, 1970.Crossref 2. Chorelski TP, Maciejowski E, Tablonska S, et al: Coexistence of pemphigus and bullous pemphigoid . Arch Dermatol 109:849-853, 1974.Crossref 3. Cram DL, Griffith MR, Fukuyama K: Pemphigus-like antibodies in cicatricial pemphigoid . Arch Dermatol 109:235-238, 1974.Crossref 4. Barranco VP: Mixed bullous disease . Arch Dermatol 110:221-224, 1974.Crossref 5. Fincher DF, Dupree E, Bean SF: Bullous pemphigoid in childhood: Immunofluorescent studies . Arch Dermatol 103:88-90, 1971.Crossref 6. Bart BJ, Bean SF: Bullous pemphigoid following the topical use of fluorouracil . Arch Dermatol 102:457-460, 1970.Crossref 7. Gibson TP, Blue P: Erythema multiforme and furosemide therapy . JAMA 212:160, 1970.Crossref 8. Ebringer A, Adam WR, Parkin JD: Bullous hemorrhagic eruption associated with furosemide . Med J Aust 1:768-771, 1969. 9. Roberts-Thompson IC, Whittingham S, Young-Chaiyud U, et al: Aging, immune response, and mortality . Lancet 2:368-370, 1974.Crossref 10. Klaus MV, Fellner MJ: Penicilloyl-specific serum antibodies in man: Analysis in 592 individuals from the newborn to old age . J Gerontol 28:312-316, 1973.Crossref

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250041013

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract In the article, "Milker's Nodules: Pathogenesis, Tissue Culture, Electron Microscopy, and Calf Inoculation," published in the October Archives (111:1307-1311, 1975), two errors occurred. The sentence beginning at the bottom of page 1307 and continuing on page 1308 should have read "A 10% W/V suspension of tissue collected from nodules on the patient's fingers and hands was made in medium 199 supplemented with 0.5% bovine serum albumin." On page 1311, the last line in column 2, should have read "stored at —70 C for several months," not 90 C.

Keczkes, K.;Barker, D. J.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250042014

Abstract • A 60-year-old woman with a threeyear history of an acquired hepatic cutaneous porphyria was discovered to have a porphyrin-producing malignant hepatoma. An attempt was made to treat her with fluorouracil perfused through a hepatic artery catheter. It did not produce shrinkage of the tumor, but the patient remains alive and ambulant a year after the infusion, although her skin lesions (scarring, bulla formation, and hyperpigmentation) on the fingers, back of hands, and face persist and she continues to excrete abnormally high quantities of porphyrin in her feces. (Arch Dermatol 112:78-82, 1976) References 1. Hamminga H: Lichtdermatose, onder het beeld van hidroa vacciniformia, op grond van intestinale gezwelvorming (porphyrinurie) . Ned Tijdschr Geneeskd 95:696-700, 1951. 2. Tio TH, Leijnse B, Jarrett A, et al: Acquired porphyria from a liver tumour . Clin Sci 16:517-527, 1957. 3. Berman J, Braun A, Volek V: Jaterni biopsie a jeji klinicke hodnoceni u porphyria cutanea tarda . Acta Univ Carol Med 8:589-595, 1959. 4. Von Klotz H, Klotz L: Frischauf H, et al: Eisenkinetik bei Porphyria Cutanea Tarda . Dermatologica 137:97-106, 1968.Crossref 5. Denk R, Holzman H: Paraneoplastische Porphyria Cutanea Tarda . Med Welt 25:1446-1447, 1969. 6. Thompson RPH, Nicholson DC, Farnan T, et al: Cutaneous porphyria due to a malignant primary hepatoma . Gastroenterology 59:779-783, 1970. 7. Rimbaud P, Maynadier J, Guilhou JJ: La porphyrie cutanée tardive: A propos de deux observations associées a un cancer hepatique . Sem Hop Paris 49:719-725, 1973. 8. Rimington C: Quantitative Determination of Porphobilinogen and Porphyrins in Urine and Faeces , broadsheet 21. Association of Clinical Pathologists, 1958. 9. Rimington C, Cripps DJ: Biochemical and fluorescence-microscopy screening-tests for erythropoietic protoporphyria . Lancet 1:624-626, 1965.Crossref 10. Brunsting LA: Observations on porphyria cutanea tarda . Arch Dermatol 70:551-564, 1954.Crossref 11. Braun A, Berman J: Pathological anatomy in porphyria cutanea tarda . Acta Univ Carol Med 8:597-605, 1959. 12. Berman J, Braun A: Incidence of hepatoma in porphyria cutanea tarda . Rev Czech Med 8:290-295, 1962. 13. Kordac V: Frequency of occurrence of hepatocellular carcinoma in patients with porphyria cutanea tarda in long term follow up . Neoplasma 19:135-138, 1972. 14. Goldberg A, Rimington C: Diseases of Porphyrin Metabolism . Springfield, Ill, Charles C Thomas Publisher, 1962. 15. Rimington C: Patterns of porphyrin excretion and their interpretation . S Afr J Lab Clin Med 9:255-261, 1963. 16. Wells GC, Rimington C: Studies on a case of porphyria cutanea tarda . Br J Dermatol 65:338-351, 1953. 17. Waldenstrom J: The porphyrias as inborn errors of metabolism . Am J Med 22:758-773, 1957.Crossref

Fritsch, William C.;Maharry, Randall R.;Clabaugh, West A.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250047015

Abstract • A hemorrhagic reaction of unknown cause can occur approximately five weeks after superficial dermabrasion of tattoos. This reaction may lead to alarm in the patient and possibly to increased scarring in the area treated. Intralesional corticosteroid injections have sped resolution. It is wise to forewarn patients of this potential complicaton of tattoo dermabrasion. (Arch Dermatol 112:83-85, 1976) References 1. Epstein E: Dermabrasion , in Epstein E (ed): Skin Surgery , ed 3. Springfield, Ill, Charles C Thomas Publisher, 1970, pp 378-398. 2. Burks JW Jr: Wire Brush Surgery . Springfield, Ill, Charles C Thomas Publisher, 1956. 3. March CH: Dermabrasion . Am Fam Physician 1:68-74, 1970. 4. Baker TJ, Gordon HL: Chemical face peeling and dermabrasion . Surg Clin North Am 51:387-401, 1971. 5. Johnson HM: Headaches and risks of dermabrasion . Arch Dermatol 81:26-33, 1960.Crossref 6. Boo-Chai K, Mutou Y: Complications after dermabrasion in Asians . Plast Reconstr Surg 27:413-418, 1961.Crossref

Kitano, Yukio

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250050016

Abstract • A boy had multiple large tumors on the scalp, whitish nodules on the nape and both sides of the neck, hypertrophic gingiva, and severe flexural contractures of hip and knee joints. The histopathologic structure of the tumor was characteristic of juvenile hyalin fibromatosis. The tumor cells were embedded in an amorphous eosinophilic ground substance. X-ray films revealed numerous osteolytic and osteoclastic lesions that are important findings in the study of this disease. (Arch Dermatol 112:86-88, 1976) References 1. Kitano Y, Horiki M, Aoki T, et al: Two cases of juvenile hyalin fibromatosis . Arch Dermatol 106:877-883, 1972.Crossref 2. Murray J: On three peculiar cases of molluscum fibrosum in children . Med Chir Trans 38:235-253, 1873. 3. Whitfield A, Robinson AH: A further report on the remarkable series of cases of molluscum fibrosum in children . Med Chir Trans 86:293-301, 1903. 4. Puretić S, Puretić B, Fiser-Herman M, et al: A unique form of mesenchymal dysplasia . Br J Dermatol 74:8-19, 1962.Crossref 5. Ishikawa H, Hori Y: Systematisierte Hyalinose in Zusammenhang mit Epidermolysis bullosa polydystrophica und Hyalinosis cutis et mucosae . Arch Klin Exp Dermatol 218:30-51, 1964.Crossref 6. Drescher E, Wyke S, Markiewicz C, et al: Juvenile fibromatosis in siblings (Fibromatosis hyalinica multiplex juvenilis) . J Pediatr Surg 2:427-430, 1967.Crossref 7. Enjoji M, Kato S, Kamikozuru K, et al: Juvenile fibromatosis of the scalp in siblings . Acta Medica Univ Kagoshima 10( (suppl) ):145-151, 1968. 8. Gutiérrez G, et al: Fibromatosis hialinica múltiple juvenil. A propósito de un caso . Med Cutan 7:283-286, 1973. 9. Puretić S, Puretić B: Clinical and histopathological observations on systemic familial mesenchymosis , Proceedings of the 13th International Congress of Pediatrics . Vienna, Verlag der Wiener Medizinischen Akademie, 1971, vol 5, pp 373-381.

Canizares, Orlando

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250053017

Abstract This is a report of my observations of the present dermatologic conditions in India. It is based on voluminous notes taken during a visit, at my own initiative and expense, in February 1975. During that time, I visited seven cities and a dozen teaching institutions and had many conversations with leading dermatologists. My purpose is to give a comprehensive view of the problems faced by our Indian colleagues in the universities and in private practice. This report shows some interesting variations in the patterns of skin diseases observed in India as compared with those encountered in Western countries. It also shows that the problems faced by teachers and researchers are the same all over the World. However, they are much more pressing in a developing and overcrowded country. It is hoped that, through a better understanding of the problems, needs, and aspirations of colleagues in India, Western dermatologists will become

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250059018

Abstract National Program Conference Takes Up Resource Attraction The subject under discussion was "resource attraction for dermatology"—with equal time given to consideration of human resources and of the monetary resources needed for growth and development of the specialty.Some 70 participants were called together by the American Academy of Dermatology's National Program for Dermatology as part of a continuing program of "idea exchange" discussions—designed to zero in on problems facing the specialty of dermatology and to reach conclusions that can provide guidance to the groups represented at the conference.The idea exchange discussion taking up resource attraction convened at the Marylhurst Education Center near Portland, Ore., late in August. In addition to participants active in affairs of the American Academy of Dermatology, the Dermatology Foundation, the American Dermatological Association, the Society of Investigative Dermatology, the Association of Professors of Dermatology, and the American Board of Dermatology, invitees also included representatives from

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250062019

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract Foundation for International Dermatologic Education.— In this issue of Archives, there is an article that describes the plight of dermatologists in India. The article also states that the most pressing deficiencies in the dermatologic structure in India could be corrected. Since that article was submitted, the Foundation for International Dermatologic Education has awarded a short-term fellowship to an Indian dermatologist so that he may study dermatopathology in the United States. Many other projects are planned.The Foundation for International Dermatologic Education is engaged in a fund-raising campaign to assist dermatologic education in developing countries. Annual membership is $30 (tax deductible). Send contributions to Coleman Jacobson, MD, Treasurer, 3707 Gaston Ave, Dallas, TX 75240. AMA Section on Dermatology.— The Section on Dermatology of the American Medical Association will meet in Dallas, June 26-30, 1976. An interesting and informative program is being planned for symposia devoted to the sexually transmitted diseases, advances

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250063020

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.

Epstein, Ervin

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250064021

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.

Handler, Harvey L.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250065023

Abstract To the Editor.— In the book Human Sexual Inadequacy, Masters and Johnson discuss the prevention of premature ejaculation.1 This is performed by a "squeeze technique" on the head of the penis prior to the sensation of impending ejaculation. The following is a report of an adverse effect of this technique. Report of a Case.— A 27-year-old man had had dark spots on the head of his penis for one day. Examination showed a nonblanching, flat, petechial eruption localized entirely to the glans penis. There were no other clinical abnormalities. Results of the following laboratory studies were within normal limits: complete blood cell count, platelet count, plasma prothrombin time, erythrocyte sedimentation rate, and urinalysis. The patient takes no medications. Questioning disclosed that he had vigorously squeezed the head of his penis during intercourse the previous day. He subsequently felt pain in the head of the penis; the next morning, he References 1. Masters WH, Johnson VE: Human Sexual Inadequacy , ed 1. New York, New American Library Inc, 1970, pp 101-105. 2. Stein JJ, Martin DC: Priapism . Urology 3:8-14, 1974.Crossref

Burdick, K. H.;Baughman, R.;Bagatell, F. K.;Casper, P. J.;Leibsohn, E.;Shanahan, D. F.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250065022pmid: 1108801

Abstract To the Editor.— Naproxen (d-2-[6′-methoxy-2′-naphthyl]propionic acid) is a nonsteroidal, anti-inflammatory drug currently undergoing clinical evaluation in the United States. The compound has demonstrable efficacy in the management of arthritis.1,2 In the course of these investigations, we received a number of isolated reports of improvement in the skin of psoriatic patients who were being treated with naproxen for their arthritis. Further, in the active "underground" of psoriatic patients, reports of the favorable effect of this drug have been circulated, and a number of patients are purchasing this drug in Mexico and Canada, where it has been marketed for some time. In view of this situation, it seemed advisable to conduct a carefully controlled double blind study to test the efficacy of this drug in the treatment of psoriasis. Materials and Methods.— Adult patients with stable, chronic psoriasis volunteered to participate in the study after being informed as to the nature References 1. Naproxen: Proceedings of an international medical symposium . Scand J Rheumatol , (suppl 2) , pp 1-181, 1973. 2. Naproxen: Proceedings of an international medical symposium held in conjunction with the Sixth Pan American Congress on Rheumatic Diseases . J Clin Pharmacol 15:305-384, 1975.Crossref

Mackie, Bruce S.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250066026pmid: 1247289

Abstract To the Editor.— With reference to plasma cell cheilitis,1 I would like to suggest the possibility that the lesion reported by Baughman et al was a form of fixed drug eruption. It was noted that the patient had been treated with chlorothiazide and indomethacin, both of which can cause fixed eruptions.I would like to point out that somewhat similar, but ulcerated, lesions on the center of the lower lip have been reported in elderly patients as being caused by drugs.2 These lesions show substantial plasma cell infiltration, and I have seen one case that was caused by indomethacin. I regard such lesions as a form of fixed drug eruption, and I believe that the reason these lesions ulcerate in patients in Sydney is the advanced solar degeneration that always accompanies them. The patient reported by Baughman et al appeared to have little solar degeneration, and the lesion References 1. Baughman RD, Berger P, Pringle WM: Plasma cell cheilitis . Arch Dermatol 110:725-726, 1974.Crossref 2. Mackie BS: Drug-induced ulcer of the lip . Br J Dermatol 79:106-110, 1967.Crossref

Pedro, Steven D.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250066024

Abstract To the Editor.— The recent cooperative study "Uses for Immunofluorescence Tests of Skin and Sera"1 stated that the speckled nuclear immunofluorescence pattern may be associated with mixed connective tissue (MCT) disease, as described by Sharp et al.2 However, Dr Burnham, emphasizing strict attention to nuclear immunofluorescence morphological features, has demonstrated that the nuclear speckles found in MCT disease actually correspond to his nuclear immunofluorescence pattern of threads and fine threads.3 These patterns probably represent the ribonuclease-resistant extractable nuclear antigen antibody of Sharp et al.2,4,5 Dr Burnham has reported the prognostic importance of nuclear immunofluorescence patterns in lupus erythematosus. He described the thready pattern as being the only particulate pattern not in his good prognostic group, with a 33% incidence of renal involvement.5 The reported incidence of renal involvement in MCT disease is extremely low.1 Can Dr Burnham comment on the low degree of renal involvement References 1. Uses for immunofluorescence tests of skin and sera: Utilization of immunofluorescence in the diagnosis of bullous diseases, lupus erythematosus, and certain other dermatoses, Cooperative Study . Arch Dermatol 111:371-381, 1975.Crossref 2. Sharp GC, Irvin WS, Tan EM, et al: Mixed connective tissue disease: An apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA) . Am J Med 52:148-159, 1972.Crossref 3. Burnham TK, Banks PW: Antinuclear antibodies: I. Patterns of nuclear immunofluorescence . J Invest Dermatol 62:526-534, 1974.Crossref 4. Burnham TK: Editorial comments , in Melkerson FD, Pearson RN (eds): Year Book of Dermatology . Chicago, Year Book Medical Publishers Inc, 1974, pp 257-258. 5. Burnham TK: Antinuclear antibodies: II. The prognostic significance of nuclear immunofluorescent patterns in lupus erythematosus . Arch Dermatol 111:203-207, 1975.Crossref

Burnham, Thomas K.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250066025

Abstract In Reply.— The key to the questions asked by Dr Pedro is that he has misquoted and consequently misinterpreted our statements concerning the relationship between threads and fine threads1-3 and the two separate antibodies to extractable nuclear antigen (ENA) of Sharp et al.4 A serum exchange with Gordon C. Sharp, MD, showed that the pattern he reported as speckles4 (also referred to as such in the cooperative study on immunofluorescence tests5) could in fact be separated morphologically into two patterns, threads and fine threads.1 We suggested that these two patterns might represent the two antibodies reported to be reactive with ENA.1 Specifically, we suggested that the fine threads might possibly represent the antibody to ribonucleasesensitive ENA, seen in patients with mixed connective tissue (MCT) disease,4 while the threads may be produced by the antibody to ribonuclease-resistant ENA,6 found in patients with systemic lupus erythematosus References 1. Burnham TK, Bank PW: Antinuclear antibodies: I. Patterns of nuclear immunofluorescence . J Invest Dermatol 62:526-534, 1974.Crossref 2. Burnham TK: Editorial comments , in Melkerson FD, Pearson RW (eds): Year Book of Dermatology . Chicago, Year Book Medical Publishers Inc, 1974, pp 257-258. 3. Burnham TK: Antinuclear antibodies: II. The prognostic significance of nuclear immunofluorescent patterns in lupus erythematosus . Arch Dermatol 111:203-207, 1975.Crossref 4. Sharp GC, Irvin WS, Tan EM, et al: Mixed connective tissue disease: An apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA) . Am J Med 52:148-159, 1972.Crossref 5. Uses for immunofluorescence tests of skin and sera: Utilization of immunofluorescence in the diagnosis of bullous diseases, lupus erythematosus, and certain other dermatoses, Cooperative Study . Arch Dermatol 111:371-381, 1975.Crossref 6. Burnham TK: Antinuclear antibodies: Significance of nuclear staining patterns , in Beutner EH, Chorzelski TP, Bean SF, et al (eds): Immunopathology of the Skin: Labeled Antibody Studies . Stroudsburg, Pa, Dowden, Hutchinson & Ross Inc, 1973, pp 379-392.

Hoke, Axel W.

1976 Archives of Dermatology

doi: 10.1001/archderm.1976.01630250066027

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract To the Editor.— Recently, we saw a young woman with an unusually severe and prolonged reaction to liquid nitrogen therapy for a small wart on her leg. Further investigation disclosed previously undiagnosed cold urticaria. Although this patient had no systemic problems, with the far more vigorous cryosurgical techniques now popular for treatment of neoplasms, the possibility of inducing histamine shock in such a patient should be seriously considered.