doi: 10.1001/archderm.1965.01600160005001
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LYNCH, PETER J.;MIEDLER, LEO J.
doi: 10.1001/archderm.1965.01600160007002
Abstract Erythropoietic protoporphyria was observed in four related persons, and 20 cases from the literature were surveyed. In all cases sunlight was a major precipitating factor. Erythema and edema are early changes in this "solar urticaria" and a late eczematous stage occurs in some cases. Erythropoietic protoporphyrin was ten to 50 times normal levels in patients with signs and symptoms. References 1. Range 588 to 973μgm/100 cc. 2. In their written report Peterka et al are presenting seven cases; only four of these are reviewed here. 3. Reference 6. 4. Kosenow, W., and Treibs, A.: Lichtüberenpfindlichkeit und Porphyrinämie , Z Kinderheilk 73:82-91, 1953.Crossref 5. Magnus, I.A., et al: Erythropoietic Protoporphyria: A New Porphyria Syndrome with Solar Urticaria Due to Protoporphyrinemia , Lancet 2:448-451 ( (Aug 26) ) 1961.Crossref 6. Holti, G.; Magnus, I.A.; and Rimington, C.: Erythropoietic Porphyria in Sisters , Brit J Derm 75:225-234 ( (June) ) 1963.Crossref 7. Redeker, A.G., and Browno, R.S.: Erythropoietic Protoporphyria Presenting as Hydroa Aestivale , Arch Derm 89:104-109 ( (Jan) ) 1964.Crossref 8. Redeker, A.G., Bryan, R.G.: Erythropoietic Protoporphyria , Lancet 1:1449-1450 ( (June 27) ) 1964.Crossref 9. Porter, S.F., and Lowe, V.A.: Congenital Erythropoietic Protoporphyria 1. Case Reports, Clinical Studies, and Porphyrin Analyses in Two Brothers , Blood 22:521-531 ( (Nov) ) 1963. 10. Sweeney, G.D., et al: Erythropoietic Protoporphyria: A Brief Report of the First South African Case , S Afr J Lab Clin Med 9:247-248 ( (Dec) ) 1963. 11. Harber, L.C.; Fleischer, A.S.; and Baer, R.L.: Erythropoietic Protoporphyria and Photohemolysis , JAMA 189:191-194 ( (July 20) ) 1964.Crossref 12. Curwan, V.L., and Pathak, M.A.: Abnormal Porphyrin Metabolism and Polymorphic Photodermatitis , New Eng J Med 27:385-390 ( (Aug 20) ) 1964.Crossref 13. Haeger-Aronsen, B.: Erythropoietic Protoporphyria , Amer J Med 35:450-454 ( (Oct) ) 1963.Crossref 14. Peterka, E.S., et al: Erythropoietic Protoporphyria: I Report of the Clinical and Laboratory Features in Seven New Cases 15. Rimington, C., and Cripps, D.J.: Biochemical and Fluorescence Microscopy Screening Tests for Erythropoietic Protoporphyria , Lancet 1:624-626 ( (March 20) ) 1965.Crossref 16. Wranne, L.: Free Erythrocyte Copro- and Protoporphyrin , Acta Paediat Lat 49( (supp 124) ): 1960. 17. Rimington, C.: Assoc Clin Path Broadsheet (New Series) 36:1961.
PETERKA, EDWARD S.;FUSARO, ROBERT M.;GOLTZ, ROBERT W.
doi: 10.1001/archderm.1965.01600160013003
Abstract Histological and histochemical studies on specimens of skin from four patients with erythropoietic protoporphyria, whose lesions consisted of thickened eczematized plaques on sunlight exposed areas, showed that with hematoxylin and eosin staining large amounts of hyaline material invariably surrounded the blood vessels of the upper corium. Histochemical studies indicated that this material contains an acidic carbohydrate-protein-lipid complex which includes an acid mucopolysaccharide. Skin from a covered area appeared normal clinically and histologically. This material may possibly arise from combination of degradation products of protoporphyrin and components of perivascular connective tissue. When an eruption is present on patients suspected of having erythropoietic protoporphyria, diagnostic help may be obtained by cutaneous biopsy. References 1. California Corporation for Biochemicals, 3625 Medford St., Los Angeles, Calif 90063. 2. Kosenow, W., and Treibs, A.: Lichtüberempfindlichkeit und Porphyrinämie , Z Kinderheilk 73:82-92, 1953.Crossref 3. Magnus, I.A., et al: Erythropoietic Protoporphyria: A New Porphyria Syndrome With Solar Urticaria Due to Protoporphyrinemia , Lancet 2:448-451, 1961.Crossref 4. Redeker, A.G.; Berke, M.; and Levan, N.: Erythropoietic Protoporphyria With Eczema Solare , Arch Derm 86:569-574, 1962.Crossref 5. Porter, F.S., and Lowe, B.A.: Congenital Erythropoietic Protoporphyria. I. Case Reports, Clinical Studies, and Porphyria Analyses in Two Brothers , Blood 22:521, 1963. 6. Langhof, H.; Mueller, R.; and Rietschel, L.: Untersuchungen zur familiaren: protoporphyrinamische Lichturticaria , Arch Klin Exp Derm 212:506-518, 1961.Crossref 7. Peterka, E.S., et al: Erythropoietic Protoporphyria. I. Report of the Clinical and Laboratory Features in Seven New Cases , JAMA , to be published. 8. Fusaro, R.M.: Case Presentations at the Minnesota Dermatologic Society Meeting, University of Minnesota Hospitals, Nov 6, 1964 , Arch Derm , to be published. 9. Fusaro, R.M., and Goltz, R.W.: The Normal Human Eccrine and Apocrine Glands , J Invest Derm 36:79-82, 1961.Crossref 10. McManus, J.F.A.: Carbohydrate Specificity of the Periodic Acid-Schiff Reagent (PAS) Method , Amer J Path 26:690, 1950. 11. Fusaro, R.M., and Goltz, R.W.: A Comparative Study of the Periodic Acid-Schiff and Alcian Blue Stains , J Invest Derm 35:305-307, 1960.Crossref 12. Wolman, M.: Staining of Lipids by the Periodic-Acid-Schiff Reaction , Proc Soc Exp Biol Med 75:583-585, 1950.Crossref 13. Goltz, R.W.; Fusaro, R.M.; and Jarvis, J.K.: The Demonstration of Acid Substances in Normal Skin by Alcian Blue , J Invest Derm 31:183-190, 1958.Crossref 14. Hale, C.N.: Histochemical Demonstration of Acid Polysaccharides in Animal Tissue , Nature 157:802, 1946.Crossref 15. Meyer, K., and Rapport, M.M.: The Mucopolysaccharides of the Ground Substance of Connective Tissue , Science 113:596-599, 1951.Crossref 16. Meyer, K.: The Biological Significance of Hyaluronic Acid and Hyaluronidase , Physiol Rev 27:335-359, 1947. 17. Cripps, D.J.; Senter, G.W.; and Pegum, J.S.: Four Cases of Erythropoietic Protoporphyria Presenting as Light-sensitive Lipoid Proteinosis , Proc Roy Soc Med 57:1095-1096, 1964. 18. Calnan, C.D., and Shuster, S.: Lipoid Proteinosis , Proc Roy Soc Med 55:957-958, 1962.
EPSTEIN, JOHN H.;PINSKI, JAMES B.
doi: 10.1001/archderm.1965.01600160018004
Abstract High serum iron values with marked transferrin saturation were noted in four of 15 patients with porphyria cutanea tarda (PCT). Four others had serum iron and saturation levels near the upper limits of normal. In addition, the presence of hepatic dysfunction and the increased incidence of diabetes in this disease were confirmed. However, a relationship between the characteristic chemical and photocutaneous features of PCT and hemochromatosis could not be substantiated. The mechanisms responsible for the elevated iron values were discussed. The available evidence to date suggests increased absorption rather than reduced utilization as the cause of the abnormal iron findings in PCT. An unexplained but significant tendency to polycythemia was also noted in our series. Two patients had hemoglobin levels greater than 17.5 gm/100cc and six others had values greater than 16 gm/100cc and packed cell volumes higher than 50%, or both. References 1. Unfortunately, liver biopsies were not available for study in the other three patients with high serum iron values. 2. The 77% incidence was noted in a study done at a San Francisco hospital. The hepatic tissue was obtained from 100 unselected autopsy specimens and was not related to any specific diagnosis. 3. Brunsting, L.A.: Observations on Porphyria Cutanea Tarda , Arch Derm 70:551-564, 1954.Crossref 4. Berman, J.: Porphyrie und Zuckerkrankheit: Aufsuchen der Porphyrie bei Zuckerkranken , Z Ges Inn Med 11:186-188, 1956. 5. Berman, J., and Bielicky, T.: Einige aussere Faktoren in der Äetiologie der Porphyria Cutanea Tarda und des Diabetes Mellitus mit besonderer Berücksichtigung der Syphilitischen Infektion und ihrer behandlung , Dermatologica 113:78-87, 1956.Crossref 6. Saunders, S.J.: Iron Metabolism in Symptomatic Porphyria , S Afr J Lab Clin Med 9:277-283, 1963. 7. Kramer, S.: Iron Metabolism in the Porphyrias , S Afr J Lab Clin Med 9:283-287, 1963. 8. Tuffanelli, K.L.: Porphyria Cutanea Tarda Associated With Hemachromatosis , U S Armed Forces Med J 11:120-126, 1960. 9. Langhof, H., and Mildschlag, G.: Aktinischtraumatisch bullöse Porphyrindermatose kombiniert mit beginnender Hamochromatose , Arch Dermat Syph 199:21-32, 1954.Crossref 10. Brugsch, J.: Melanodermie-porphyrie (porphyrie mit melanodermie) , Z Ges Inn Med 11:5-8, 1956. 11. Brugsch, J.; Klaus, D.; and Bienengräber, A.: Ein Weiterer Fall von Melanodermie-Porphyrie mit Leberzirrhose (Porphyrie mit Melanodermie und Leberzirrhose) , Z Ges Inn Med 12:877-881, 1957. 12. Brugsch, J.: Hämochromatose and Melanodermieporphyrie als verschiedene Formen der Hämosynthesestorung bei Pigmentzirrhose und Bronzdiabetes , Z Ges Inn Med 13:411-415, 1958. 13. Lamont, N.M., and Hathorn, M.: Increased Plasma Iron and Liver Pathology in Africans With Porphyria , S Afr Med J 34:279, 1960. 14. Berlin, S.O., and Brante G.: Iron Metabilism in Porphyria and Haemachromatosis , Lancet 2:729, 1962.Crossref 15. Bolgert, M.; Canivet, J.; and LeSourd, M.: La porphyrie cutanée de l'adulte; étude de neuf cas et description , Sem Hop Paris 29:1578-1608 ( (May 14) ) 1953. 16. Bolgert, M., and Canivet, J.: Porphyrie cutanée de l'adulte cliniquement régressive au cours de l'évolution d'une cirrhose terminale à type pigmentaire (presentation de coupe) , Bull Soc Franc Derm Syph 63:373-376, 1956. 17. Boulet, P., et al: Porphyrie cutanée de l'adulte et diabete sucré evolutif , Bull Soc Med Hop Paris 75:653-656, 1959. 18. Burnham, T.K., and Fosnaugh, R.P.: Porphyria, Diabetes, and Their Relationship , Arch Derm 83:717-722, 1961.Crossref 19. Finch, S.C., and Finch, C.A.: Idiopathic Hemochromatosis, an Iron Storage Disease , Medicine 34:381-430, 1955.Crossref 20. Uys, C.J., et al: A Comparative Study of the Autopsy Incidence, Histological Distribution and Relation to Cirrhosis of Liver Siderosis in Three Racial Groups of Cape Town , S Afr J Lab Clin Med 6:1-11, 1960. 21. Rook, A., and Champion, R.H.: Porphyria Cutanea Tarda and Diabetes , Brit Med J 1:860-861, 1960.Crossref 22. Freedman, A.L.: Observations on a Case of Mixed Porphyria With Special Reference to Pathogenesis and Treatment , Ann Intern Med 44:391-406, 1956.Crossref 23. Epstein, J.H., and Redeker, A.G.: Porphyria Cutanea Tarda, A Study of the Effects of Phlebotomy on Porphyrin Metabolism , read before the 85th meeting of the American Dermatological Association, Feb 25-Mar 2, 1965, Boca Raton, Fla . 24. Brehm, G., and Holzmann: Quantitative Bestimmungen der Bluteiweibe speziell des Transferrins und des Haptoglobins, bei der Porphyria cutanea tarda , Klin Wschr 42:283-286, 1964.Crossref 25. Lohsfeldt, F.I.; Labbe, R.F.; and Aldrich, R.A.: Effect of Inosine on Heme Synthesis , JAMA 178:928-929, 1961.Crossref 26. Martin, W.J., and Heck, F.J.: Porphyrins and Porphyria: Review of 81 Cases , Amer J Med 20:239-250, 1956.Crossref 27. DeMatteis, F., and Rimington, C.: Disturbance of Porphyrin Metabolism Caused by Griseofulvin in Mice , Brit J Derm 75:91-104, 1963.Crossref 28. Conrad, M.E.; Berman, A.; and Crosby, W.H.: Iron Kinetics in Laennec's Cirrhosis , Gastroenterology 43:385-390, 1962. 29. MacDonald, R.: Idiopathic Hemochromatosis, Genetic or Acquired? , Arch Intern Med 112:184-190, 1963.Crossref 30. Pechet, G.S., et al: Stainable Tissue Iron, Significance for Hemochromatosis , read before the 53rd Annual Meeting of the International Academy of Pathology, April 1964 . 31. Bothwell, T.H., cited by Kramer, S.: Iron Metabolism in the Porphyrias , S Afr J Lab Clin Med 9:283-287, 1963. 32. Ippen, H.: Allgemein symptome der Späten Hautoporphyrie (porphyria cutanea tarda) als Hinweise für deren Behandlung , Deutsch Med Wschr 86:127, 1961.Crossref 33. Illin, I.I.: The Treatment of Porphyria Cutanea Tarda , Vestn Derm Vener 10:42, 1963.
BLUEFARB, SAMUEL M.;SZANTO, PAUL
doi: 10.1001/archderm.1965.01600160023005
Abstract Recent observations of a fatal case of erythema multiforme associated with acute anuria and acute renal tubular necrosis is described. Involvement of the kidneys in association with erythema multiforme may occur more frequently than is generally realized. This involvement may occur early in the disease and be a major factor in the prognosis. Therefore, a thorough study of the urinary findings should be considered in all cases of erythema multiforme. References 1. Osler, W.: On a Form of Purpura Associated With Articular, Gastrointestinal and Renal Symptoms , New York J Med 48:675 ( (Dec) ) 1888. 2. Von Hebra, F.: On Diseases of the Skin, Including the Exanthemata , C. H. Fagge, (trans.-ed.), London: New Sydenham Society, 1866, vol 1, p 285. 3. Commission on Acute Respiratory Diseases: Association of Pneumonia With Erythema Multiforme Exudativum , Arch Intern Med 78:687, 1946.Crossref 4. Ashby, D.W., and Lazar, T.: Erythema Multiforme , Lancet 1:1091 ( (May 19) ) 1951.Crossref 5. Dresner, E.: Erythema Multiforme Exudativum (Stevens-Johnson Syndrome) , Lancet 2:1036, 1949.Crossref 6. Osler, W.: The Visceral Lesions of the Erythema Group , Brit J Derm 12:227 ( (July) ) 1900. 7. Osler, W.: The Visceral Lesions of Purpura and Allied Conditions , Brit Med J 1:517, 1914.Crossref 8. Gairdner, D.: The Schonlein-Henoch Syndrome (Anaphylactoid Purpura) , Quart J Med 17:95, 1948. 9. Costello, M.J.: Erythema Multiforme Exudativum (Erythema Bullosum Maligns, Pluriorificial Type) , J Invest Derm 8:127 ( (Nov) ) 1947. 10. Robinson, H.M., and McCrumb, F.R.: Comparative Analysis of the Mucocutaneous-olular Syndromes: Review of Eleven Cases and Review of the Literature , Arch Derm Syph 61:539, 1950.Crossref 11. Ustvedt, H.J.: Erythema Exudativum Multiforme , Acta Med Scand 131:32, 1948Crossref 12. and 132:51, 1948. 13. Levitt, L.M., and Burbank, B.: Glomerulonephritis as a Complication of the Schonlein-Henoch Syndrome , New Eng J Med 28:530 ( (March 26) ) 1953.Crossref 14. Bloom, H., and Lovel, T.W.I.: Erythema Multiforme With Renal and Myocardial Injury , Proc Roy Soc Med 57:175 ( (March) ) 1964. 15. Rallison, M.L., et al: Lupus Erythematosus and Stevens-Johnson Syndrome: Occurrence as Reactions to Anticonvulsant Medication , Amer J Dis Child 101:725 ( (June) ) 1961.Crossref 16. Comaish, J.S., and Kerr, D.N.: Erythema Multiforme and Nephritis , Brit Med J 2:84 ( (July 8) ) 1961.Crossref 17. Oliver, J.; MacDowell, M.; and Tracy, A.: Pathogenesis of Acute Renal Failure Associated With Traumatic and Toxic Injury , J Clin Invest 30:1307, 1951.Crossref 18. Bull, G.M.; Joekes, A.M.; and Lowe, K.G.: Renal Function Studies in Acute Tubular Necrosis , Clin Sci 9:379, 1950. 19. Finkenstaedt, J.T., and Merrill, J.P.: Renal Function After Recovery From Acute Renal Failure , New Eng J Med 254:1923, 1956.Crossref
GOLTZ, ROBERT W.;HULT, ANNE-MARIE;GOLDFARB, MACE;GORLIN, ROBERT J.
doi: 10.1001/archderm.1965.01600160029006
Abstract The condition known as cutis laxa has been reviewed and two examples occurring in brothers reported. One of these children died from complications of his disease and came to autopsy. Extensive histologic, ultramicroscopic, histochemical, and biochemical studies on skin and other organs demonstrated a defect of elastic fibers throughout the body. Review of the literature indicates similar widespread involvement in other cases of this disease. Therefore, the title generalized elastolysis is proposed to express, better than does cutis laxa, the extensive distribution in connective tissues of this rare but serious disease. The occurrence of this syndrome in siblings and the evidence of parental consanguinity in several pedigrees strongly suggest an autosomal recessive inheritance. References 1. Goodman, R.M., et al: Pseudoxanthoma Elasticum: A Clinical and Histopathological Study , Medicine 42:297, 1963.Crossref 2. Theopold, W., and Wildhack, R.: Dermatochalasia in Rahmen multipler Abartungen , Monatschr Kinderh 99:213, 1951. 3. Cashman, M.E.: Cutis Laxa , Proc Roy Soc Med 50:719, 1957. 4. Sestak, Z.: Ehlers Danlos Syndrome and Cutis Laxa: An Account of Families in the Oxford Area , Ann Hum Genet 25:313, 1962.Crossref 5. Siegmund. Über das sogennante Oedema lymphangiectaticum. Zentralblatt für allgem , Path path Anat 70:243, 1938. 6. Talbot, F.B.: Metabolism Study of a Case Simulating Premature Senility , Monatschr Kinderh 25:643, 1923. 7. Variot, M., and Caillaux, M.: Peau ridee senile chez une enfant de deux ans: Agenesie du reseau elastique du derme , Bull Soc Med Hop Paris (Nov 21) , p 989, 1919. 8. Vaglio, R.: Uno caso di cutis laxa , Pediatria 31:321, 1923. 9. Raspi, M.: Di un caso di cutis laxa , Riv Clin Pediat 25:648, 1927. 10. Christiaens, L.; Marchand-Alphant., A.; and Fovet, A. Emphysème congenital et cutix laxa , Presse Med 62:1799, 1954. 11. Robinson, H., and Ellis, F.: Cutis Laxa , Arch Derm 77:657, 1958. 12. Bakker, B.J.: Cutis laxa universalis und Lungen-Emphysem , Hautarzt 10:371, 1959. 13. Schreiber, M. and, Tilley, S.: Cutis Laxa , Arch Derm 84:266, 1961.Crossref 14. Touraine, P., and Vissier: Cutis laxa avec Hernie , Sem Hop Paris 23:21, 1947. 15. Marshall, J.; Vogelpoel, L.; and Weber, H. W.: Primary Elastolysis: Report of a Case of Cutis Laxa With Emphysema and a Discussion of some Syndromes Characterized by Elastolysis , S Afr Med J 34:721, 1960. 16. Debre, R., and Mane, J.: "Cutis laxa" avec dystrophie osseuse , Bull Soc Med Hop Paris 53:1038, 1937. 17. Hudelo, Boulanger-Pilet, and Cailliau: Dystrophie cutanée atrophiante par agénésie élastique , Bull Soc Franc Derm Syph 28:496, 1921. 18. Carney, R.G., and Nomland, R.: Acquired Loose Skin (Chalazoderma): Report of a Case , Arch Derm Syph 56:794, 1947.Crossref 19. Goth, A.: Über Chalodermie (Ketly) , Derm Wschr 104:426, 1937. 20. Mracek, F.: " Cutis laxa ," in Handbuch der Hautkrankheiten , Vienna: Alfred Holder, 1902. 21. Rossbach, M.J.: Ein merkwurdiger Fall von griesenhafter Veränderung der allgemeinen Körperdecke bei einem achtzehn jahrigen Jungling , Deutsch Arch Klin Med 36:197, 1884. 22. Kopp, W.: Demonstration zweier Fälle von "Cutis Laxa" (Vatezund Sohn) , Munchen Med Wschr 35:259, 1888. 23. Termine, P.: Contribution a l'étude de l'élastorrhexie systématisée, Thèse de médecine des Hôpitaux de Paris, Paris, Jouer et Cie, 1940. 24. Touraine, A.: l'Elastorrhexie generalisée , Presse Med 49:361, 1961 25. Soc Franc Derm 70:285, 1963 26. Bull Soc Franc Derm Syph 47:255, 1940. 27. Ronchese, F.: Dermatomegaly , Arch Derm 77:666, 1958.Crossref 28. Dubreuilh, W. Un cas de dermatolysis generalisée , Ann Derm 8:529, 1887. 29. Riehl, G.: " Localized, Acquired Dermatochalasis ," 1921, cited by Darier, J., et al: Nouvelle pratique d dermatologie , Paris: Masson Co., 1936, vol 6, p 241. 30. Sequeira, J.H.: A Case of Dermatolysis and Molluscum Fibrosum, With Congenital Morbus Cordis and Kyphosis , Brit J Derm 28:69, 1916.Crossref 31. Banga, I., and Schuler, D.: Contributions to the Structure of Elastin With Special Reference to the Action of Elastase , Acta Physiol Acad Sci Hung 4:13, 1953. 32. Hall, D.A., and Czerkawski, J.W.: The Reaction Between Elastase and Elastic Tissue , Biochem J 80:121, 1961. 33. Hall, D.A.: The Possible Implications of Enzymes of the Elastase Complex in Atherosclerosis , Jour Atheroscler Res 1:173, 1961.Crossref 34. Hall, D.: Elastase, a Bifunctional Enzyme , Arch Biochem Supp 1:239, 1962. 35. Walford, R.L.; Moyer, D.; and Schneider, R.B.: The Structure of Elastin , Arch Path 72:158, 1961. 36. Starcher, B.; Hill, C.H.; and Matrone, G.: Importance of Dietary Copper in Formation of Aortic Elastin , J Nutr 82:318, 1964. 37. Balo, J., and Banga, I.: Elastase and Elastase Inhibitor , Nature 164:491, 1949.Crossref 38. Banga, and Balo, Elastin and Elastase , Nature 171:44, 1953.Crossref 39. Crepaldi, G., et al: Serum Elastase Activity. Method and Value in Normal Subjects , G Geront 11:97, 1963. 40. Schneider, R.B.; Walford, R.L.; and Dignam, W.J.: Serum Elastase Inhibitor Levels in Pregnancy and Under Endocrine Influences , J Appl Physiol 15:992, 1960. 41. Banga, I.: Determination of Elastase and Elastase Inhibitor by Means of Orcein-Elastin , Acta Physiol Acad Sci Hung 24:1, 1963. 42. Carnes, W., et al: Vascular Lesions in Copper Deficient Swine , Fed Proc 20:118, 1961. 43. Shields, G.S., et al: Studies on Copper Metabolism, XXXII, Cardiovascular Lesions in Copper Deficient Swine , Amer J Path 41:603, 1962. 44. Coulson, W.F., et al: Cardiovascular Studies on Copper Deficient Swine , Lab Invest 11:1316, 1962. 45. Smith, E.K.; deAlvarez, R.R.; Forsander, J.: Serum Protein, Lipid and Lipoprotein Fractions in Normal Human Pregnancy , Amer J Obstet Gynec 77:326, 1959. 46. Walford, R.L., and Schneider, R.B.: Serum Elastase Inhibitor: Levels in Animal and Human Sera, Including Selected Disease States , Proc Soc Exp Biol Med 101:31, 1959.Crossref 47. Saxl, H.: Histochemical Studies on the Enzyme Elastomucase and Its Relationship to Atheroma , Int Assoc Geront Trans 122:67, 1957. 48. Scarselli, V., and Repetto, M. Il contenuto in elastina del polmone in funzione dell' eta , G Biochim 8:166, 1959. 49. McKusick, A.: Heritable Disorders of Connective Tissues , St. Louis: C.V. Mosby Company, 1960, p 309. 50. Smith, J.G., Jr., et al: Pseudoxanthoma Elasticum , Arch Derm 86:741, 1962.Crossref 51. Mandel, W., et al: Dissecting Aortic Aneurysm During Pregnancy , New Eng J Med 251:1059, 1954.Crossref 52. Braun-Falco, O.; Rupec, M.; and Lindley, M.J.: Angeborene Dermatochalasis als Leitsymptom eines Symptomenkomplexes , Arch Klin Exp Derm 220:166, 1964.Crossref
doi: 10.1001/archderm.1965.01600160044007
Abstract Thirty-three patients suspected of having squamous cell carcinoma of the skin were studied to evaluate the systemic administration of tetracycline compounds as a screening test for detecting malignancy. The results of this study confirm the affinity of tetracyclines for tumor tissue and indicate that the systemic administration of these compounds is a reliable and reproducible technique for the detection of squamous cell carcinoma of the skin. However, the value of this procedure remains limited since the tumor must be superficially located in the skin in order to demonstrate fluorescence. References 1. Rall, D.P., et al: Appearance and Persistence of Fluorescent Material in Tumor Tissue After Tetracycline Administration , J Nat Cancer Inst 19:79-84 ( (July) ) 1957. 2. Philips, J. W., et al: The Deposition and Retention of Tetracycline in Cancer , Amer J Surg 100:384-388, ( (Sept) ) 1960.Crossref 3. McLeay, J.F.: The Use of Systemic Tetracycline and Ultraviolet in Cancer Detection , Amer J Surg 96:415-419 ( (Sept) ) 1958.Crossref 4. Berk, J.E., and Kantor, S.M.: Demethylchloretetracycline-Induced Fluorescence of Gastric Sediment: Use to Differentiate Benign and Malignant Gastric Lesions , JAMA 179:997-1000, ( (March) 31) 1962.Crossref 5. Rugtveit, A., and Hope, L.: Tetracycline Induced Fluorescence in Gastric Cancer and Benign Ulcers , Gastroenterology 47:32-34 ( (July) ) 1964. 6. Tetracycline Fluorescence of Body Tissues and Tumor Tissues , Nutr Rev 16:244-245 ( (Aug) ) 1958. 7. Vassar, P.S.; Saunders, A.M.; and Culling, C.F.: Tetracycline Fluorescence in Malignant Tumors and Benign Ulcers , Arch Path 69:613-616 ( (June) ) 1960. 8. Lipnik, M.J.: Fluorescent Test for Identification of Skin Malignancy , Sinai Hosp Detroit Bull 10:189-194 ( (Fall) ) 1962. 9. Donsky, H.J., and Mendelson, C.G.: Squamous Cell Carcinoma as a Complication of Hidradenitis Supprativa , Arch Derm 90:488 ( (Nov) ) 1964.Crossref 10. Gougerot, H.; Giraudeau, R.; and Patte, A.: De l'utilite de la lumiere de Wood en dermatologie , Bull Soc Franc Derm Syph 45:345-350 ( (Feb) ) 1938. 11. Margarot, J., and Deveze, P.: La lumiere de Wood en dermatologie , Ann Derm Syph 10:581-608 ( (June) ) 1929. 12. Ronchese, F.; Walker, B.S.; and Young, R.M.: Reddish-Orange Fluoresence of Necrotic Cancerous Surface Under Wood Light , Arch Derm 69:31-42 ( (Jan) ) 1954.Crossref 13. Temime, P.: La fluorescence provoques des eczemas , Ann Derm Syph 80:477-489 ( (Sept) -Oct) 1953. 14. DuBuy, H.G., and Showacre, J.L.: Selective Localization of Tetracycline in Mitochondria of Living Cells , Science 133:196-197 ( (Jan 20) ) 1961.Crossref 15. Grubb, C., and Crabbe, J.G.: Fluorescence Microscopy in Exfoliative Cytology , Brit J Cancer 15:483-448 ( (Sept) ) 1961.Crossref 16. Ackerman, N.B., et al: Aminoacridine Uptake by Experimental Tumors , JAMA 191:103-104 ( (Jan 11) ) 1965.Crossref 17. Burrows, D.: Fluorescent Test for Skin Malignancy , Arch Derm 90:4-11 ( (Oct) ) 1964.Crossref
doi: 10.1001/archderm.1965.01600160049008
This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract The following corrections should be made in the article "Macromolecular Changes in Pigmentary Disorders," by Yutaka Mishima, MD, published in the May 1965 issue of the Archives. Page 519, column 1, the sentence starting on line 20 should read "Subcellular and cytochemical characteristics of nevus cells with reference to their origin are described." In three places in the article the word tyrosine was inadvertently used in place of tyrosinase: On page 519, column 2, under Material and Methods, the sentence starting on line 19 should read "Since the presence of tyrosinase in intradermal nevus. . . ."; on page 536, column 2, line 13 should read "14) of tyrosinase within the albino melanosome" and line 18, "tyrosinase of the albino melanocyte is in an inac-" On page 520, column 2, lines 25 and 26 should be corrected to read "of 30% aqueous solution of glyoxal; 1.906 gm CH3COONa·3H2O; 2.886
doi: 10.1001/archderm.1965.01600160050009
Abstract Cutaneous papillomatosis had been present for 22 years in a 41-year-old woman. After a period of slow advance the process remained stationary. An older sister showed the same condition, and her daughter at age 11 was beginning to develop signs. Occurrence of this rare entity in three members of a family suggests a genetic background to the disorder. References 1. Gougerot, H., and Carteaud, A.: Neue Formen der Papillomatose , Arch Dermat Syph 165:232-267, 1932.Crossref 2. Wise, F., and Sachs, W.: Cutaneous Papillomatosis , Arch Derm Syph 36:475-485, 1937.Crossref 3. Young, A.W.: Cutaneous Papillomatosis; Confluent and Reticulated Variety , Arch Derm 67:594-597, 1953. 4. Mopper, C., and Darnall, T.W.: Nummular and Confluent Papillomatosis , Arch Derm 83:773-776, 1961.Crossref
MICHALOWSKI, ROMAN;RODZIEWICZ, HELENA
doi: 10.1001/archderm.1965.01600160052010
Abstract Erythrasma is not a rare occurrence in elderly women. It was found in 33 or approximately 10% of 328 women 65 to 99 years old. The clinical picture of erythrasma in elderly female patients is frequently subtle and atypical. It is characterized by yellowish-brown or light-brown patches, fairly well limited, with slight scaling and without producing fluorescence. Wood's light was most useful in detecting erythrasma in elderly women because lesions of this disease are frequently invisible or barely visible by daylight or artificial light. If the lesions do not fluoresce they always become considerably darker which then makes them easier to detect. References 1. Polemann, G.: Klinik und Therapie der Pilzkrankheiten , Stuttgart: Georg Thieme Verlag, 1961, pp 229-233. 2. Simons, R.D.G.: Medical Mycology , Nijmegen, Netherlands: Thieme N.V. 1954, pp 146-150.
WINKELMANN, R. K.;BOURLOND, ANDRE
doi: 10.1001/archderm.1965.01600160054011
Abstract A case of symmetric papular and lichenoid dermatitis of the extremities in a child is reported and its similarity to cases of the Gianotti-Crosti syndrome is discussed. The histological picture is compatible with an atypical and focal lichenoid eruption. References 1. Gianotti, F.: Rilievi di una particolare casistica tossinfettiva caratterizzata da eruzione eritemato-infiltrativa desquamativa a focolai, lenticolari, a sede elettiva acroesposta , G Ital Derm 96:678-697 ( (Nov) -Dec) 1955. 2. Crosti, A., and Gianotti, F.: Dermatose éruptive acro-située d'origine probablement virosique , Dermatologica 115:671-677 ( (Nov) ) 1957.Crossref 3. Reich, H.: Das Gianotti-Crosti-Syndrom , Hautarzt 14:315-318 ( (July) ) 1963. 4. Crosti, A., and Gianotti, F.: Ulteriore contributo alla conoscenza dell'acrodermatite papulosa infantile , G Ital Derm 105:477-504 ( (Sept) -Oct) 1964. 5. Duperrat, B., and Puissant: La dermatite éruptive des extrémités chez les enfants , Presse Med 66:1862-1863 ( (Nov 26) ) 1958. 6. Braun-Falco, O., and Rupec, M.: Über das Gianotti-Crosti-Syndrom: Acrodermatitis papulosa eruptiva infantilis , Med Klin 59:210-214 ( (Feb 7) ) 1964. 7. Degos, R.: Dermatologie , Paris: Ernest Flammarion, 1953.
doi: 10.1001/archderm.1965.01600160058012
Abstract An erythematous rash, with macules, papules, and pustules was observed at the time of birth of an otherwise normal Negro infant. The lesions yielded no bacteria and cleared in ten days. References 1. Harris, J., and Schick, B.: Erythema Neonatorum , Amer J Dis Child 92:27, 1956. 2. Keitel, H.G. and Yadov V.: Etiology of Toxic Erythema , Amer J Dis Child 106:306, 1963.Crossref 3. Levy, H., and Bagner, A.B.: The Effect of an Antihistamine Substance (Pyribenzamine) on Erythema Neonatorum , Arch Pediat 68:413, 1951. 4. Levy, H.L., and Cothran, F.: Erythema Toxicum Neonatorum Present at Birth , Amer J Dis Child 103:617, 1962. 5. Luders, D.: Histologic Observations in Erythema Toxicum Neonatorum , Pediatrics 26:219, 1960.
doi: 10.1001/archderm.1965.01600160060013
Abstract Multiple lesions of leukoderma acquisitum centrifugum of Sutton are reported in siblings. The lesions developed at approximately the same age in both children. The case reports are presented to raise the question of an underlying hereditary predisposition corresponding to that believed to exist in vitiligo. References 1. Frank, S.B., and Cohen, H.J.: The Halo Nevus , Arch Derm 89:367-373, 1964.Crossref 2. Feldman, S., and Lashinsky, I.M.: Halo Nevus: Leukoderma Centrifugum Acquisitum (Sutton) ; Leukopigmentary Nevus Arch Derm Syph 34:590, 1936.Crossref 3. Leider, M., and Fisher, A.A.: Fate of Central Nevus in Leukoderma Acquisitum Centrifugum , Arch Derm Syph 60:1160, 1949.Crossref 4. Cornbleet, T.; Bernstein, L.; and Kroll, C.: Observations on Leukoderma Acquisitum Centrifugum , Arch Derm Syph 60:1160, 1949.Crossref 5. Niles, H.D.: Leukoderma Acquisitum Centrifugum , Arch Derm Syph 43:357, 1941.Crossref 6. Butterworth, T., and Strean, L.P.: Clinical Genodermatology Baltimore: Williams & Wilkins Co., p 5, 1962.
RUBIN, ZOLTAN;HYMAN, ARTHUR B.
doi: 10.1001/archderm.1965.01600160062014
Abstract A case of nodulus cutaneus in a smallpox vaccination scar is described. Its occurrence in this site is as far as we know unique. Clinical similarity to malignant melanoma is discussed. The importance of histopathologic examination for the differential diagnosis of these lesions is discussed. References 1. Michelson, H.E.: Nodular Subepidermal Fibrosis , Arch Derm Syph 27:812-820, 1933.Crossref 2. Senear, F.E., and Caro, M.R.: Histiocytoma Cutis , Arch Derm Syph 33:209-226, 1936.Crossref 3. Arnold, L., Jr., and Tilden, I.L.: Histiocytoma Cutis, a Variant of Xanthoma , Arch Derm Syph 47:498-516, 1943.Crossref 4. Rentiers, P.L., and Montgomery, H.: Nodular Subepidermal Fibrosis (Dermatofibroma Versus Histiocytoma) , Arch Derm Syph 59:568-583, 1949.Crossref 5. Gentele, H.: Malignant Fibroblastic Tumors of the Skin , Acta Dermatovener 31 ( (supp 27) ):1-180, 1951. 6. Coste, F.; Piguet, B.; and Hochfeld, M.: Sclerodermiform Dermo-Hypodermatitis, Recurrence Following Vaccination , Bull Soc Franc Derm Syph 55:22-23, 1948. 7. Curth, H.O.; Curth, W.; and Garb, J.: Cutaneous Complications of Mass Vaccination in New York City, 1947 , J Invest Derm 10:197-204, 1948. 8. Curth, H.O.; Curth, W.; and Garb, J.: Cutaneous Complications of Mass Vaccination in New York City, 1947 , J Invest Derm 11:167-188, 1948.Crossref 9. Mali, J.W.H.; Hinsbergh, van W.C.M.; and Hamers, A.: Skin Lesions From Vaccination , Nederl T Geneesk 99:252-257, 1955. 10. Duperrat, B.: Cutaneous Manifestations of Smallpox Vaccinations , Presse Med 63:381-382, 1955. 11. Bureau, Y.; Barrière, H.; and Brunfau, Y.: Skin Disorders Due to Vaccination , Sem Hôp Paris 31:4054-4058, 1955. 12. Lefort, P.: Cutaneous Complications of Anti-Smallpox Vaccination , Bull Med (Paris) 70:265-272, 1956. 13. Bjornberg, A., and Gisslen, H.: Dermatological Complications in Vaccination Against Smallpox , Svensk Lakartidn 59:723-730, 1962. 14. Kompier, A.J.: Some Skin Diseases Caused by Virus , Nederl Milit Geneeskt 15:149-157, 1962. 15. Sarkany, I., and Caron, G.A.: Cutaneous Complications of Smallpox Vaccination , Trans St John Hosp Derm Soc 48:163-170, 1962. 16. Weber, von G., and Riese, W.: Skin Lesions Following Vaccinations , Deutsch Med Wschr 88:1878-1886, 1963.Crossref 17. Gelfarb, M., and Hyman, A.B.: Multiple Noduli Cutanei , Arch Derm 85:89-94, 1962.Crossref 18. Marmelzat, W.L.; Hirsch, P.; and Martel, S.: Malignant Melanomas in Smallpox Vaccination Scars , Arch Derm 83:823, 1964.Crossref
DILLAHA, CALVIN J.;JANSEN, G. THOMAS;HONEYCUTT, W. MAGE;HOLT, GEORGE ANN
doi: 10.1001/archderm.1965.01600160066015
Abstract Actinic keratoses were treated with an ointment containing a 1%, 2.5%, or 5% concentration of 5-fluorouracil. The response with the 5% ointment was comparable to our original studies with 20% 5-fluorouracil ointment. The 1% and 2.5% concentrations were found ineffective. Topical application of 5-fluorouracil labeled with radioactive carbon (14C) in five patients indicated that approximately 6% is absorbed systemically. These data along with repeated hematologic studies suggest that 5-fluorouracil ointment applied to limited skin areas is not absorbed in a degree that would produce general toxicity. We have concluded that 5% 5-fluorouracil ointment applied twice daily can be used as an effective outpatient treatment in the person with numerous actinic keratoses of the face and neck. Prolonged observation will be required to assess the long term results of this treatment. Actinic keratoses on the hands and arms have not responded completely enough to justify this type of treatment. One must avoid applications near the lid margins and mucocutaneous junctions. A phototoxic reaction precluded the ointments use when the patient anticipated prolonged sunlight exposure. References 1. Dillaha, C.J., et al: Selective Cytotoxic Effect of Topical 5-Fluorouracil , Arch Derm 88:247-256 ( (Sept) ) 1963.Crossref 2. Heidelberger, C.: " Nucleic Acid Synthesis and Mechanism of Action of Fluoropyrimidines ," in Harris, R.J.C., (Ed): Biological Approaches to Cancer Chemotherapy; A Symposium held at Louvain, June, 1960 under the auspices of UNESCO and the World Health Organization , New York: Academic Press, 1961, pp 47-58. 3. Nurse, D.S.: Effect of Antimetabolites on Epidermal Structures , Arch Derm 87:258-265 ( (Feb) ) 1963.Crossref 4. Klein, E., et al: Tumors of the Skin: Effects of Local Use of Cytostatic Agents , Skin 1:81-87 ( (April) ) 1962. 5. Chaudhuri, N.K.; Mukherjee, K.L.; Heidelberger, C.: Studies on Fluorinated Pyrimidines: VII. The Degenerative Pathway , Biochem Pharmacol 1:328-341, 1958.Crossref 6. Mukherjee, K.L., and Heidelberger, C.: Studies on Fluorinated Pyrimidines: IX. The Degradation of 5-Fluorouracil-6-C14 , J Bio Chem 235:433-437 ( (Feb) ) 1960. 7. Goldman, L.: The Response of Skin Cancer to Topical Therapy With 5-Fluorouracil , Cancer Chemother Rep 28:49-52 ( (April) ) 1963. 8. Mukherjee, K.L., et al: Studies on Fluorinated Pyrimidines: XVI. Metabolism of 5-Fluorouracil2-C14 and 5-Fluoro-2′-deoxyuridine-2-C14 in Cancer Patients , Cancer Res 23:49-66 ( (Jan) ) 1963. 9. Ansfield, F.J.; Schroeder, J.M.; and Curreri, A.R.: Five Year Clinical Experience With 5-Fluorouracil , JAMA 181:295-299 ( (July 28) ) 1962.Crossref 10. Lemon, H.M., et al: Decreased Intoxication by Fluorouracil When Slowly Administered in Glucose , JAMA 185:1012-1016 ( (Sept 28) ) 1963.Crossref
THOMSEN, KRISTIAN;OSMUNDSEN, POUL E.
doi: 10.1001/archderm.1965.01600160074016
Abstract Thirteen patients with atopic dermatitis were treated orally with guanethidine in daily doses of up to 50 mg for 10 to 30 days. Only six patients experienced a decrease of itching. The delayed blanch reaction did not disappear except in one patient. During early treatment eight patients exhibited marked reddening, edema, and itching of the skin in the face, especially periorbitally. Nine had orthostatic complaints and four had abdominal symptoms. Guanethidine has only a doubtful antipruritic effect in atopic dermatitis in the dosage used. In addition, the delayed blanch reaction after intracutaneous injection of methacholine was studied in 124 dermatological patients and 40 persons without skin diseases. The reaction was found in 15 out of 16 (94%) patients with atopic dermatitis, and in 22% to 30% of patients in other groups. The delayed blanch reaction is characteristic but not specific for atopic dermatitis and the atopic state. References 1. Beck, L., and Brody, M.J.: The Physiology of Vasodilatation , Angiology 12:202-222, 1961.Crossref 2. Burn, J.H.: A New View of Adrenergic Nerve Fibres, Explaining the Action of Reserpine, Bretylium, and Guanethidine , Brit Med J 1:1623-1627, 1961.Crossref 3. Champion, R.H.: Abnormal Vascular Reactions in Atopic Eczema , Brit J Derm 75:12-15, 1963.Crossref 4. Davis, M.J., and Lawler, J.C.: Observations on the Delayed Blanch Phenomenon in Atopic Subjects , J Invest Derm 30:127-131, 1958. 5. Juhlin, L.: Skin Reactions to Iontophoretically Administered Epinephrine and Norepinephrine in Atopic Dermatitis , J Invest Derm 37:201-205, 1961.Crossref 6. Juhlin, L.: Vascular Skin Reactions in Atopic Dermatitis , Acta Dermatovener 42:218-229, 1962. 7. Kalz, F., and Fekete, Z.: Studies on the Mechanism of the White Response and of the Delayed Blanch Phenomenon in Atopic Subjects by Means of Coomassie Blue , J Invest Derm 35:135-140, 1960.Crossref 8. Lobitz, W.C., and Campbell, C.J.: Physiologic Studies in Atopic Dermatitis (Disseminated Neurodermatitis) , Arch Derm Syph 67:575-584, 1953.Crossref 9. Lobitz, W.C.; Heller, M.L.; and Dobson, R.L. Physiologic Studies in Atopic Dermatitis (Disseminated Neurodermatitis) , Arch Derm 75:228-229, 1957.Crossref 10. Maxwell, R.A., et al: Pharmakologie von Guanethidin, einer blutdrucksenkend wirkenden Substanz mit specifischer peripherer Sympaticushemmung , Schweiz Med Wschr 90:109-113, 1960. 11. Möller, H.: On Catechol Amines of the Skin , Acta Dermatovener vol 44, (suppl 55) :1-16, 1964. 12. Rajka, G.: Prurigo Besnier (Atopic Dermatitis) With Special Reference to the Role of Allergic Factors , Acta Dermatovener 40:285-306, 1960. 13. Reed, W.B., and Kierland, R.R.: Vascular Reactions in Chronically Inflamed Skin , Arch Derm 77:181-186, 1958.Crossref 14. Rothman, S., and Bloom, R.E.: The Increased Vasoconstrictor Tendency in Atopic Dermatitis , Arch Belg Derm Syph 13:300-309, 1957. 15. Scott, A.: The Distribution and Behavior of Cutaneous Nerves in Normal and Abnormal Skin , Brit J Derm 70:1-21, 1958.Crossref 16. Scott, A.: Acetylcholine in Normal and Diseased Skin , Brit J Derm 74:317-322, 1962.Crossref 17. Solomon, L.M., and Wentzel, H.E.: Plasma Catecholamines in Atopic Dermatitis , J Invest Derm 41:401-403, 1963.Crossref 18. Solomon, L.M.; Wentzel, H.E.; and Tulsky, E.: The Physiologic Disposition of C14-Norepinephrine in Patients With Atopic Dermatitis and Other Dermatoses , J Invest Derm 43:193, 1964.Crossref 19. Stüttgen, G., and Krause, H.: Zur Bewertung abnormer Hautgefässreaktionen beim endogenen Ekzem und Asthma , Allerg Asthma 3:206-212, 1957. 20. Viglioglia, P.A.: Guanethidine as an Antipruritic , Arch Derm 85:472-475, 1962.Crossref 21. West, J.R.; Johnson, L.A.; and Winkelmann, R.K.: Delayed-Blanch Phenomenon in Atopic Individuals Without Dermatitis , Arch Derm 85:227-228, 1962.Crossref
doi: 10.1001/archderm.1965.01600160078017
Abstract The cutaneous abnormalities of a fully developed example of xeroderma pigmentosum appear to have been at least temporarily ameliorated by the oral administration of methoxsalen over a period of five years. References 1. Lerner, A.B.; Denton, C.R.; and Fitzpatrick, T.B.: Clinical and Experimental Studies With 8-Methoxypsoralen in Vitiligo , J Invest Derm 20:299-314 ( (April) ) 1953. 2. Lerner, A.B.: Potentiation of Suntanning Through Ingestion of 8-Methoxypsoralen , J Invest Derm 25:1 ( (July) ) 1955.Crossref 3. Imbrie, J.D.; Bergeron, L.L.; and Fitzpatrick, T.B.: Follow-Up Study of Effect of Oral Methoxsalen (8-Methoxypsoralen) , Arch Derm 82:617-620 ( (Oct) ) 1960.Crossref 4. Kanof, N.B.: Protection of the Skin Against the Harmful Effects of Sunlight , Arch Derm 74:46-49 ( (July) ) 1956.Crossref 5. Domonkos, A.N.: Xeroderma Pigmentosum: Society Transactions, New York Dermatological Society , Arch Derm 80:500-501 ( (Oct) ) 1959.Crossref 6. Psoralens and Radiant Energy , J Invest Derm 32:131-391, ( (Feb) ) 1959.Crossref
WALDORF, DONALD S.;HAMBRICK, GEORGE W.
doi: 10.1001/archderm.1965.01600160080018
Abstract This report describes a patient with pityriasis rubra pilaris and myasthenia gravis. Hypovitaminosis A was demonstrated repeatedly. The patient had no evidence of underlying collagen disease, endocrine problem, or occult neoplasm. Pharmacological doses of aqueous oral vitamin A ameliorated her dermatosis on two occasions, once on an initial course and a second time after relapse on a control period without therapy. References 1. Pettler, M.F.: Pityriasis Rubra Pilaris With Particular Reference to Vitamin Medication and Dietary Control , Penn Med J 39:864-866, 1936. 2. Brunsting, L.A., and Sheard, C.: Dark Adaptation in Pityriasis Rubra Pilaris , Arch Derm 43:42-59, 1941.Crossref 3. Porter, A.D., and Codding, E.W.: Pityriasis Rubra Pilaris and Vitamin A , Brit J Derm 57:197-200, 1945.Crossref 4. Leitner, Z.A., and Moore, T.: Vitamin A and Skin Disease , Lancet 251:262-265, 1946.Crossref 5. Leitner, Z.A., and Ford, E.B.: Vitamin A and Pityriasis Rubra Pilaris , Brit J Derm 59:407-427, 1947.Crossref 6. Weiner, A.L., and Levin, A.A.: Pityriasis Rubra Pilaris of Familial Type: Experiences in Therapy With Carotene and Vitamin A , Arch Derm 48:288-296, 1943.Crossref 7. Kierland, R.R., and Kulwin, M.H.: Pityriasis Rubra Pilaris: A Clinical Study , Arch Derm 61:925-930, 1950.Crossref 8. Webster, J.R., and Falk, A.B.: Pityriasis Rubra Pilaris: Clinical and Laboratory Observations on Combined Treatment With Corticotropin and Vitamin A , Arch Derm 65:687-700, 1952. 9. Burgoon, C.F., Jr., et al: Effect of Vitamin A on Epithelial Cells of Skin: The Use of Vitamin A in the Treatment of Diseases Characterized by Abnormal Keratinization , Arch Derm 87:63-80, 1963.Crossref 10. Levin, O.L., and Smith, E.B.: Pityriasis Rubra Pilaris: Report of a Case Cured by Thyroid Extract , Arch Derm 3:40-44, 1921.Crossref 11. Becket, P.E.: Pityriasis Rubra Pilaris Associated With Dystrophia Adioposogenitalis , New York J Med 116:372-374, 1922. 12. Bessey, O.A., et al: Determination of Vitamin A and Carotene in Small Quantities of Blood Serum , J Biol Chem 166:177-188, 1946. 13. Rawnsley, H.: Adaptation of Method of Bessey et al for Determination of Serum Vitamin A and Carotene. Personal Communication, 1965. 14. Pillsbury, D.M.; Shelley, W.B.; and Kligman, A.M.: Dermatology , Philadelphia: W. B. Saunders Co., 1956, p 1083. 15. Rothman, S.: Pituitary Basophilism in Juvenile Type of Acanthosis Nigricans , JAMA 156:242-244, 1954.Crossref 16. Curth, H.O., and Aschner, B.M.: Genetic Studies on Acanthosis Nigricans , Arch Derm 79:55-66, 1959.Crossref 17. Harvey, A.M., and Johns, R.: Myasthenia Gravis and the Thymus , Amer J Med 32:1-5, 1962.Crossref 18. Strauss, A.J.L., et al: Immunofluorescence Demonstration of a Muscle Binding Complement-Fixing Serum Globulin in Myasthenia Gravis , Proc Soc Exp Biol Med 105:184-191, 1960.Crossref 19. Lamar, L.M., and Gaethe, G.: Pityriasis Rubra Pilaris , Arch Derm 89:515-522, 1964.Crossref 20. Beer, P.: Studies on the Effect of Vitamin A Acid , Dermatologica 124:192-195, 1962.Crossref 21. Stuttgen, G.: Local Treatment of Keratoses With Vitamin A Acid , Dermatologica 124:65-80, 1962.Crossref
WATT, THOMAS L.;JILLSON, OTIS F.
doi: 10.1001/archderm.1965.01600160084019
Abstract We have recorded the collective experiences of dermatologists at Hitchcock Clinic with patients having pityriasis rubra pilaris, in order to call attention to the possible value of phenoxymethyl penicillin (penicillin V), isonizid, and para-aminosalicylic acid in the treatment of this disease. References 1. Bloom, D.: Discussion of Case Report of Pityriasis Rubra Pilaris presented by Canizares, O. at Manhattan Dermatological Society Meeting , Arch Derm 90:439, 1964. 2. Knudsen, E.A.: Pityriasis Rubra Pilaris in Identical Twins , Brit J Derm 70:27, 1958.Crossref 3. Butterworth, T., and Strean, L.P.: Clinical Genodermatology , Baltimore: The Williams and Wilkins Co., 1962. 4. Lamar, L.M., and Gaethe, G.: Pityriasis Rubra Pilaris , Arch Derm 89:515, 1964.Crossref 5. Kierland, R.R., and Kulwin, M.H.: Pityriasis Rubra Pilaris: A Clinical Study , Arch Derm Syph 61:925, 1950.Crossref 6. Brunsting, L.A., and Sheard, C.: Dark Adaptation in Pityriasis Rubra Pilaris , Arch Derm Syph 43:42, 1941.Crossref 7. Cornbleet, T., and Greenberg, R.: Conversion of Carotene to Vitamin A by Sebaceous Glands , Arch Derm 76:431, 1957.Crossref 8. Burgoon, C.F., Jr., et al: Effect of Vitamin A on Epithelial Cells of Skin , Arch Derm 87:63, 1963.Crossref 9. Webster, J.R., and Falk, A.B.: Pityriasis Rubra Pilaris: Clinical and Laboratory Observations in Combined Treatment With Corticotropin and Vitamin A , Arch Derm Syph 65:685, 1952.Crossref 10. Anthony, T.C.: Brief Clinical Reports of Two Cases of Pityriasis Rubra Pilaris , Aust J Derm 5:185, 1960.Crossref 11. Ashurst, P.J.C.: The Treatment of Pityriasis Rubra Pilaris With Dipasic , Brit J Derm 74:372, 1962.
doi: 10.1001/archderm.1965.01600160087020
Abstract One percent crude coal tar, with and without polysorbate 80, was incorporated into a variety of commercially available cream and ointment bases. The observation was confirmed that mixing 0.5% polysorbate 80 with crude coal tar prior to its addition into the ointments caused the coal tar particles to be evenly dispersed and to be of uniform size. However, when crude coal tar is incorporated into a cream the particles are evenly dispersed without the use of a surfactant. References 1. Pflag, S.C., and Zopf, L.C.: Hydrophilic Forms of Tars , US Armed Forces Med J 2:1177-1181 ( (Aug) ) 1951. 2. Carney, R.G., and Zopf, L.C.: An Improved Coal Tar Ointment Using a Surfactant , A Arch Derm 72:266-271 ( (Sept) ) 1955.Crossref
CATALANO, PHILIP M.;SCHRAGGER, ALAN H.
doi: 10.1001/archderm.1965.01600160089021
Abstract A total of 4.8 million units of benzathine penicillin G, divided into two doses one week apart, is recommended for the treatment of primary, secondary, and latent syphilis. No spinal tap is required in primary or secondary syphilis, in contrast to latent syphilis. The modified "triple-test plan" is used for the separation of the biologic false-positive (BFP) from the syphilitic serologic reactions. References 1. Treatment and Management of Venereal Disease , TB Med 230 , Departments of the Army, the Navy, and the Air Force, (Dec 11) , 1959. 2. Committee on Public Health of the New York Academy of Medicine: Resurgence of Venereal Disease , Bull NY Acad Med 40:802-823, 1964. 3. Moore, M.B.: The Epidemiology of Syphilis , JAMA 186:831-834, 1963.Crossref 4. King, A., and Nicol, C.: Venereal Diseases , Philadelphia: F. A. Davis Co., 1964, pp 13-17, 110, 117-118. 5. Stokes, J.H.; Beerman, H.; and Ingraham, N.R.: Modern Clinical Syphilology , ed 3, Philadelphia: W. B. Saunders Co., 1945, pp 476-649. 6. Syphilis, Modern Diagnosis and Management , Public Health Service Publication No. 743, Public Health Service, US Department of Health, Education and Welfare, 1960. 7. Collart, P.; Borel, L.; and Durel, P.: Significance of Spiral Organisms Found, After Treatment, in Late Human and Experimental Syphilis , Brit J Vener Dis 40:81-89, 1964. 8. Jefferiss, F.J.G.: Tests of Cure in Treated Early and Latent Syphilis , Brit J Vener Dis 39:139-142, 1963. 9. Sablan, R.G., and Best, W.C.: Febrile Response in the Jarisch-Herxheimer Reaction , Arch Derm 90:293-295, 1964.Crossref 10. Carpenter, C.M.; Miller, J.N.; and Boak, R.A.: A "Triple-Test Plan" for the Serologic Diagnosis of Syphilis —a Modern Day Approach , New Eng J Med 263:1016-1018, 1960.Crossref 11. Fiumara, N.J.: Biologic False-Positive Reaction for Syphilis , New Eng J Med 268:402-405, 1963.Crossref 12. Fiumara, N.J.: Reactions for Syphilis , New Eng J Med 268:1197, 1963.Crossref 13. Fiumara, N.J.: The Diagnosis of Syphilis , Tufts Folia Med 7:58-62, 1961. 14. Hunter, E.F.; Deacon, W.E.; and Meyer, P.E.: An Improved FTA Test for Syphilis, the Absorption Procedure (FTA-ABS) , Public Health Rep 79:410-412, 1964.Crossref 15. Deacon, W.E., and Hunter, E.F.: Treponemal Antigens as Related to Identification and Syphilis Serology , Proc Soc Exp Biol Med 110:352-356, 1962.Crossref
WINKELMANN, R. K.;WILHELMJ, C. M.;HORNER, F. A.
doi: 10.1001/archderm.1965.01600160092022
Abstract Dermographism can be produced by modest pressure in the skin of normal persons following the application of tetrahydrofurfuryl nicotinate ointment. This local vascular response to pressure lasts up to 96 hours. It does not follow ultraviolet radiation or other chemically induced erythema. Aspirin will prevent the occurrence of dermographism by blocking tetrahydrofurfuryl nicotinate erythema, but aspirin given after induction of the erythema will not prevent dermographism. This dermographism is not prevented by procaine, atropine, cortisone, diphenhydramine, or 48:80. Histamine is not found in dermal perfusates of the dermographic site. Kinin activity is found in such dermal perfusates but not when the site is occluded by a blood pressure cuff, suggesting that this activity comes from the blood. Perfusion of seven patients who had severe clinical dermographism gave similar results. This study suggests that dermographism, and possibly other forms of physical urticaria, is based on a direct effect of the physical agent on blood vessels and this may be potentiated by chemical agents such as nicotinic acid esters and histamine. References 1. Lewis, T.: The Blood Vessels of the Human Skin and Their Responses , Chicago: Chicago Medical Book Company, 1927. 2. Winkelmann, R.K.: Technique of Dermal Perfusion, unpublished data. 3. Code, C.F., and McIntire, F.C.: " Quantitative Determination of Histamine ," in Methods of Biochemical Analysis , edited by David Glick, New York: Interscience Publishers, Inc., 1956, vol. 3, pp 49-95. 4. Schachter, M.: Polypeptides Which Affect Smooth Muscles and Blood Vessels , New York: Symposium Publications Division, Pergamon Press, 1960. 5. Crismon, J.M., et al: Forearm Blood Flow After Inunction of Rubefacient Substances , J Physiol 145:47P-48P ( (Dec 5) -6) 1959. 6. Crockford, G.W.; Hellon, R.F.; and Heyman, A.: Local Vasomotor Responses to Rubefacients and Ultra-violet Radiation , J Physiol 161:21-29 ( (April) ) 1962. 7. Winkelmann, R.K., and Wilhelmj, C.M., Jr.: Variations of Skin Reaction to Vasodilators: Methacholine (Mecholyl) and Trafuril , J Invest Dermat 41:313-318 ( (Nov) ) 1963.Crossref 8. Spector, W.G., and Willoughby, D.A.: The Demonstration of the Role of Mediators in Turpentine Pleurisy in Rats by Experimental Suppression of the Inflammatory Changes , J Path Bact 77:1-17 ( (Jan) ) 1959.Crossref 9. Zachariae, H.: Skin Histamine in Urticaria: A Spectrofluorometric Assay , Acta Dermatovener 43:214-218, 1963. 10. Shelley, W.B.: Indirect Basophil Degranulation Test for Allergy to Penicillin and Other Drugs , JAMA 184:171-178 ( (April 20) ) 1963.Crossref 11. Fekete, Z., and Kalz, F.: Studies in Capillary Permeability: The Duration and Repair of Experimentally Induced Capillary Damage , Dermatologica 127:289-297, 1962.Crossref 12. Herxheimer, A., and Schachter, M.: Weal and Flare in Human Skin Produced by Histamine and Other Substances , J Physiol 145:34P-35P ( (Dec 5) -6) 1959. 13. Fox, R.H., et al: Bradykinin as a Vasodilator in Man , J Physiol 157:589-602 ( (Aug) ) 1961. 14. Allwood, M.J., and Lewis, G.P.: Bradykinin and Forearm Blood Flow , J Physiol 170:571-581 ( (April) ) 1964. 15. Walzer, A.: Urticaria. III. Experimental Urticaria Factitia , Arch Dermat & Syph 18:868-885 ( (Dec) ) 1928. 16. Calnan, C.D.: Urticarial Reactions , Brit Med J 2:649-655 ( (Sept 12) ) 1964. 17. Beall, G.N.: Urticaria: A Review of Laboratory and Clinical Observations , Medicine 43:131-151 ( (March) ) 1964. 18. Kierland, R.R.: Physical Allergies , Arch Dermat 68:61-68 ( (July) ) 1953. 19. Baer, R.L., and Sulzberger, M.B.: Effect of Pyribenzamine on Dermographism (Urticaria Factitia) , J Invest Dermat 7:201-206 ( (Aug) ) 1946. 20. Rasmussen, K.A.: The Effect of Antihistaminics on Histamine Whealing and on Dermographism: Elucidated by Comparative Electrophoretical Experiments , Acta Dermatovener 29:564-571, 1949. 21. Levi, L., and Meneghini, C.L.: Liberatori di istamina, istaminemia, e mastociti circolanti in alcune dermatosi allergiche , G Ital Derm 100:613-621 ( (Nov) -Dec) 1959. 22. Lorincz, A.L.: Hypersensitivity to Trauma , Amer Pract Digest Treat 7:1314-1317 ( (Aug) ) 1956.
STRAUSS, JOHN S.;POCHI, PETER E.
doi: 10.1001/archderm.1965.01600160099023
Abstract The injection of sebum and comedones into the human skin excites a lymphocytic inflammatory response. The free fatty acids in sebum are chiefly responsible for the observed inflammation. When the inflammation is quite marked, the pilosebaceous follicles undergo rupture, and strands of epithelium grow out to encapsulate the inflammatory mass. Giant cells, which may be present in the inflammatory response, appear to be the result of follicular collapse with the consequent liberation of follicular wall keratin and hair which act as foreign bodies. These histological changes are comparable to those occurring in acne. References 1. Supplied by the late Dr. Stephen Rothman. 2. Strauss, J.S., and Kligman, A.M.: The Pathologic Dynamics of Acne Vulgaris , Arch Derm 82:779-790 ( (Nov) ) 1960.Crossref 3. Lynch, F.W.: Acne Vulgaris: Review of Histlogic Changes Observed in Early Lesions , Arch Derm Syph 42:593-603 ( (Oct) ) 1940.Crossref 4. Strauss, J.S., and Kligman, A.M.: Pathologic Patterns of the Sebaceous Gland , J Invest Derm 30:51-61 ( (Feb) ) 1958. 5. Strauss, J.S., and Kligman, A.M.: Pseudofolliculitis of the Beard , Arch Derm 74:533-542 ( (Nov) ) 1956.Crossref 6. Nicolaides, N., and Wells, G.C.: On the Biogenesis of the Free Fatty Acids in Human Skin Surface Fat , J Invest Derm 29:423-433 ( (Dec) ) 1957Crossref 7. Kirshbaum, J.O., and Kligman, A.M.: The Pathologic Role of Corynebacterium acnes in Acne Vulgaris , Arch Derm 88:832-833 ( (Dec) ) 1963.Crossref 8. Freinkel, R.K., et al: Effect of Oral Tetracycline on the Fatty Acids of Human Sebum, to be published. 9. Smith, M.A.: The Role of Comedones in Acne Vulgaris , Brit J Derm 74:337-338 ( (Aug) -Sept) 1962.Crossref
doi: 10.1001/archderm.1965.01600160113024
Abstract Animals sensitized with 4,5,8-trimethylpsoralen and exposed to longwave ultraviolet light suffered no eye damage. Clinical examination immediately after treatment revealed no change nor did study of histologic sections of the fixed eye. No photoreactive residue was found in the eye using the Daniels technique of testing. References 1. Symposium: Psoralens and Radiant Energy , J Invest Derm 32( (2) ):132-391, 1959. 2. Clark, Janet H.: Photosensitization by 8-Methoxypsoralen , J Invest Derm 37:171, 1961.Crossref 3. Pathak, M.A., and Fitzpatrick, T.B.: Relationship of Molecular Configuration to the Activity of Furocoumarins Which Increase the Cutaneous Responses Following Longwave Ultraviolet Radiation , J Invest Derm 32( (2) ):255, 1959.Crossref 4. Daniels, F., Jr.: A Simple Microbiological Method for Demonstrating Phototoxic Compounds , J Invest Derm 44:259-263, 1965.
EPSTEIN, WILLIAM L.;MAIBACH, HOWARD I.
doi: 10.1001/archderm.1965.01600160118025
Abstract Cell renewal in human epidermis was estimated after intradermal injection of thymidine-H3 in 21 subjects by means of serial biopsies and radioautographs. Results indicated 5% of germinative cells take up thymidine-H3 in 40 minutes. By seven days the number of labeled nuclei more than doubled and most were in the prickle layer. The first cell appeared in the granular layer in 10 to 14 days. After that a steady decline in number of labeled nuclei was observed. Epidermal cell renewal generally required 13 to 18 days. Epidermal cell turnover for man is similar to that reported for mouse and rat. The most important results challenge the older concept that epidermal cells divide and move in an orderly sequence. It now seems that mitosis and migration are random events. References 1. T indicates total turnover time of viable epidermal cells; ie, basal, prickle, and granular cells. BT indicates turnover time of germinative layer. BN/N indicates ratio of total number of germinative cells to total number of viable epidermal cells. 2. BT indicates turnover time of the germinative cell layer. TS indicates DNA synthesizing time. NS/BN indicates fraction of labeled cells to total cells in the germinative layer. 3. Sutton, R.L.: Early Epidermal Neoplasia , Arch Derm Syph 37:738-780, 1948. 4. Hoffman, J.G.: Quantitative Aspects of the Growth of Epidermis , Arch Path 47:37-43, 1949. 5. Pinkus, H.: Personal Communication. (Also cited by Rothberg et al, #4.) 6. Rothberg, S.; Crounse, R.G.; and Lee, J.L.: GlycineC14 Incorporation Into the Proteins of Normal Stratum Corneum and the Abnormal Stratum Corneum of Psoriasis , J Invest Derm 37:497-505, 1961.Crossref 7. Messier, B., and Leblond, C.P.: Preparation of Coated Radioautographs by Dipping Sections in Fluid Emulsion , Proc Soc Exp Biol Med 96:7-10, 1957.Crossref 8. Kopriwa, B.M., and Lebond, C.P.: Improvements in the Coating Technique of Radioautography , J Histochem Cytochem 10:269-284, 1962.Crossref 9. Leblond, C.P.; Greulich, R.C.; and Pereira, J.P.M.: " Relationship of Cell Formation and Cell Migration in the Renewal of Stratified Squamous Epithelia ," in Montagna, W., and Billingham, R.E. (eds.): Advances in Biology of Skin , New York: Pergamon Press, 1964, vol 5, pp 39-67. 10. Ferguson, E.H., and Epstein, W.L.: Clearance of I131 Injected Intralesionally in Patients with Psoriasis , J Invest Derm 37:441-444, 1961.Crossref 11. Downes, A.M.; Sharry, L.F.; and Till, A.R.: The Fate of Intradermal Doses of Labeled Amino Acids in Sheep , Aust J Biol Sci 17:945-959, 1964. 12. Greulich, R.C.: Aspects of Cell Individuality in the Renewal of Stratified Squamous Epithelia , in The Epidermis , Montagna, W., and Lobitz, W.C. (ed.), New York: Academic Press, 1964, pp 117-133. 13. Pilgrim, C., and Maurer, W.: Autoradiographische Bestimmung der DNS-verdopplungszeit verschiedener Zellarten von Maus und Ratte bei doppelmarkierung mit 3H- und 14C-thymidin , Naturwissenschaften 49:544-545, 1962.Crossref 14. Quastler, H., et al: Effect of X-Radiation on DNA Synthesis in Some Squamous Cell Epithelia , Radiol Res 16:561-562, 1962. 15. Defendi, V., and Manson, L.A.: Analysis of the Life-Cycle in Mammalian Cells , Nature 198:359, 1963.Crossref 16. Cameron, I.L., and Greulich, R.C.: Evidence for an Essentially Constant Duration of DNA-Synthesis in Renewing Epithelia of the Adult Mouse , J Cell Biol 18:31-40, 1963.Crossref 17. Cameron, I.L.: Is the Duration of DNA Synthesis in Somatic Cells of Mammals and Birds a Constant? , J Cell Biol 20:185-188, 1964. 18. Quastler, H., and Sherman, F.G.: Cell Population Kinetics in the Intestinal Epithelium of the Mouse , Exp Cell Res 17:420-438, 1959.Crossref 19. Greulich, R.C.: Personal communication to the author, June 1964. 20. Johnson, H.A., et al: A Radioautographic Study of a Human Brain and Glioblastoma Multiforme After the in Vitro Uptake of Tritiated Thymidine , Cancer 13:636-642, 1960.Crossref 21. Kaku, H.; Igarashi, Y.; and Fujita, S.: Cytokinetic Analysis of the Human Skin in Vivo in Normal and Pathologic Conditions: A 3H-Thymidine Autoradiographic Study , Arch Histol Jap 24:457-470, 1964.Crossref 22. Weinstein, G.D., and Van Scott, E.J.: Turnover Time in Normal and Psoriatic Human Epidermis by Autoradiographic Studies , abstracted from the program of the 26th Annual Meeting of the Society for Investigative Dermatology, June 20, 1965 . 23. Epstein, W.L., and Maibach, H.I.: Cell Renewal in Human Epidermis , abstracted, Clin Res 12:226, 1965. 24. Bertalanffy, F.D.: Tritiated Thymidine Versus Colchicine Technique in the Study of Cell Population Cytodynamics , Lab Invest 13:871-886, 1964. 25. Bertalanffy, F.D., and Lau, C.: Cell Renewal , Int Rev Cytol 13:357, 1962. 26. Iversen, O.H., and Bjerknes, R.: Kinetics of Epidermal Reaction to Carcinogens , Acta Path Microbiol Scand , (suppl 165) , 1963. 27. Skjaeggestad, O.: Experimental Epidermal Hyperplasia in Mice, Relation to Carcinogenesis , Acta Path Microbiol Scand , (suppl 169) , 1964. 28. Pinkus, H.: Keratosis Senilis , Amer J Path 29:193-207, 1958. 29. Mercer, E.H.: The Cancer Cell , Brit Med Bull 18:187-192, 1962.
doi: 10.1001/archderm.1965.01600160124026
This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract In the article "Ingram Method of Treating Psoriasis," by Stanley Comaish, MB, published in the July issue of the Archives the following corrections should be made. On page 56, third paragraph under Method the first sentence should read "The anthralin is incorporated into stiff Lassar's paste which must contain 2% salicylic acid." On page 58, left-hand column, the sentence starting on the 23rd line from the top should correctly read "Or, to save jars accumulating, it is equally effective to apply the standard 0.4% paste less frequently, for instance, three times weekly."
doi: 10.1001/archderm.1965.01600160125027
This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
doi: 10.1001/archderm.1965.01600160127028
Abstract Familial Nonallergic Angioneurotic Edema (C'1 Esterase Inhibitor Deficiency). Presented by Dr. K. Frank Austen. A 23-year-old white man is presented from the Massachusetts General Hospital with an intermittent dermatosis of 19 years' duration.Beginning at 4 years of age, the patient has had episodes of localized angioedema of the trunk and extremities, usually associated with severe, crampy abdominal pain and vomiting. Attacks occur regularly at two to four week intervals and can be precipitated by emotion or trauma. The patient's mother and maternal grandmother have the same syndrome.On Nov 30, 1963, there was pitting edema of the neck, face, and lips. On April 25, 1964, there was pitting edema of the right hand to the wrist, with a sharp, erythematous border (Fig 1 and 2).A complete blood count and urine analysis were normal (no eosinophilia); serum C'2 was absent on November 30, and C'1-esterase inhibitor was absent in References 1. Mayer, M.M.: On the Destruction of Erythrocytes and Other Cells by Antibody and Complement , Cancer Res 21:1262-1269 ( (Oct) ) 1961. 2. Austen, K.F., and Cohn, Z.A.: Contribution of Serum and Cellular Factors in Host Defense Reactions: I. Serum Factors in Host Resistance , New Eng J Med 268:994-1000 ( (May) ) 1963.Crossref 3. Rapp, H.J., and Borsos, T.: Complement and Hemolysis , Science 141:738-740 ( (Aug) ) 1963.Crossref 4. Ratnoff, O.D., and Lepow, I.H.: Some Properties of an Esterase Derived From Preparations of the First Component of Complement , J Exp Med 106:327-343, 1957.Crossref 5. Levy, L.R., and Lepow, I.H.: Assay and Properties of Serum Inhibitor of C'1-Esterase , Proc Soc Exp Biol Med 101:608-611 ( (Aug) -Sept) 1959.Crossref 6. Donaldson, V.H., and Evans, R.R.: A Biochemical Abnormality in Hereditary Angioneurotic Edema: Absence of Serum Inhibitor of C'1-Esterase , Amer J Med 34:37-44 ( (July) ) 1963.Crossref 7. Charache, P., et al: Genetic Abnormalities in Hereditary Angioneurotic Edema , J Clin Invest 43:1250 ( (June) ) 1964. 8. Austen, K.F., and Beer, F.: The Measurement of Second Component of Human Complement (C'2hu) by Its Interaction With EAC'lagp, 4gp Cells , J Immun 92:946-957 ( (June) ) 1964.
doi: 10.1001/archderm.1965.01600160141029
This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract Late Cutaneous Syphilis. Presented by Royal M. Montgomery, MD History.— A 28-year-old male stated that he had had a peculiar skin eruption for three months. Examination.— The skin lesions were erythematous crusted circinate plaques. The largest one which was on the abdomen measured 2×3 inches. This was atrophic in the center with a raised circinate border. Another erythematous plaque, approximately 2×2 inches was present on the right side of the neck. This also had a raised border but had some linear nodular areas in the center. There were two crusted areas, each one half inch in diameter, one on the right thumb and the other on the left palm. All lesions had been present for the same length of time, and no admission of any type of prior skin eruption could be elicited. Laboratory Studies.— The dark field examination was negative. The VDRL was positive 1 to 64. Treatment.— The
doi: 10.1001/archderm.1965.01600160142030
This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract Findings on STS in Adults.— A current report from the National Center for Health Statistics, "Findings on the Serologic Test for Syphilis in Adults," is one of a series which describes and evaluates the plan, conduct, and findings of the first cycle of the Health Examination Survey. The report presents serologic findings as related to the demographic variables of age, sex, race, family income, education, place, marital status, and occupation, and compares the information with that obtained in other surveys.The report data were obtained from physical examinations of a nationwide probability sample of persons aged 18 to 79 made during the course of the survey. (from October 1959 through December 1962).In the course of each two-hour examination, a blood specimen was taken for various tests including serologic tests for syphilis (STS). These specimens were sent to the Public Health's Venereal Disease Research Laboratory in Chamblee, Georgia. There a
doi: 10.1001/archderm.1965.01600160144031
Abstract To The Editor: Your recent editorial1 based on a contribution by Katz et al,2 questions the identity of creeping eruption in the United States and the Republic of South Africa. Over 20 years ago de Meillon and Lavoipierre3 reproduced the lesions of creeping eruption with third stage nematode larvae hatched from hookworm eggs contained in dogs' faeces sent to Johannesburg from the Natal coast. They further quoted authority for the statement that the common hookworms of South African dogs are Ancylostoma braziliense and A caninum. This should satisfy you that the infesting agents are identical.Your serious doubt apparently arose from two discrepancies.1. That my untreated larval survivors lived longer than those of Katz et al. This is explained by the fact that I practice in a temperate climate though the majority of my patients acquire their creeping eruption during a holiday at the subtropical Natal References 1. Arch Derm 91:419, 1965.Crossref 2. Katz, R.; Ziegler, J.; and Blank, H.: 420-424. Arch Derm 91:402-404, 1965.Crossref 3. De Meillon, B., and Lavoipierre, M.: S Afr Med J 18:115-116, 1944. 4. Ritchie, E.B., and King, W.C.: J Invest Derm 20:337-341, 1953. 5. Lowenthal, L.J.A.: Aust J Derm 11:171-178, 1954.Crossref