A.M.A. Archives of Dermatology & Syphilology

GARB, JOHN;SIMS, CHARLES F.

1953 A.M.A. Archives of Dermatology & Syphilology

doi: 10.1001/archderm.1953.01540070004001pmid: 13057362

Abstract THE PURPOSE of this investigation was to ascertain whether the response of mycosis fungoides to antimonial therapy corresponded to the degree of reticuloendothelial cell hyperplasia found on histologic examination. Eleven cases were studied. The results of the treatment of the first eight patients with antimonials have been reported.1 The case numbers of the first eight patients in the present report correspond with the order of the case numbers given in the previous publication.2 Case 9 is omitted because the patient refused further treatment due to pain following a few antimony potassium tartrate (tartar emetic) and stibophen (Fuadin) injections. Case 10 is likewise omitted because a drug eruption developed as a result of the antimony therapy and the treatment was discontinued. Three other cases not recorded in the original publication are herewith added and reported as Cases 9,3 10, and 11. Hematoxylin and eosin stains were References 1. Garb, J.: Antimony Preparations in the Treatment of Mycosis Fungoides , J. Invest. Dermat. 13:295 ( (Nov.) ) 1949.Crossref 2. Garb,1 p. 296. 3. Garb, J., and Fisher, S.: Lymphoblastoma Treated with Antimony Lithium Thiomalate (Anthiomaline) , case presented at the Bronx Dermatological Society, New York, April 20, 1950 . 4. Mallory, F.: Pathological Technique , Philadelphia, W. B. Saunders Company, 1938, p. 161. 5. Aschoff, L.: Das reticulo-endotheliale System , Ergebn. inn. Med. Kinderh. 26:1, 1924 6. Jaffee, R. H., in Downey, H., Editor: Handbook of Hematology , New York, Paul B. Hoeber, Inc., 1938, Vol. 2, p. 979. 7. Wintrobe, M. M.: The Reticuloendothelial System , in Tice, F.: Practice of Medicine , Hagerstown, Md., W. F. Prior Company, Inc., 1940, Vol. 6, p. 720. 8. Bailey, F. R.: Bailey's Text-Book of Histology , revised by P. E. Smith and W. M. Copenhaver, Ed. 12, Baltimore, Williams & Wilkins Company, 1948, p. 269. 9. Richter, M. N.: The Reticuloendothelial System, in Pathology , edited by W. A. D. Anderson, St. Louis, C. V. Mosby Company, 1948, p. 1010. 10. Best, C. H., and Taylor, N. B.: The Physiological Basis of Medical Practice: A Text in Applied Physiology , Baltimore, Williams & Wilkins Company, 1950, p. 104. 11. Metchnikoff, E., cited by Best and Taylor.7 12. Best and Taylor,7 p. 105. 13. Urbach, E., and Gottlieb, P. M.: Allergy , New York, Grune & Stratton, Inc., 1943, p. 796 14. Garb,1 p. 305. 15. Ormsby, O. S., and Montgomery, H.: Diseases of the Skin , Ed. 7, Philadelphia, Lea & Febiger, 1948, p. 875. 16. Lever, W. F.: Histopathology of the Skin , Philadelphia, J. B. Lippincott Company, 1949, p. 426. 17. Ormsby and Montgomery,11 p. 875. 18. Fraser, J. F., and Schwartz, H. J.: Neoplastic Disease of the Reticulo-Endothelial System , Arch. Dermat. & Syph. 33:1, and 5 ( (Jan.) ) 1936. 19. Fraser and Schwartz,13 p. 1. 20. Mallory, F. B., and Parker, F., Jr.: Reticulum , Am. J. Path. 3:515 ( (Sept.) ) 1927 21. Lever,11b p. 17. 22. Nageotte, J., and Guyon, L.: Reticulin , Am. J. Path. 6:631 ( (Nov.) ) 1930. 23. Foot, N. C., and Day, H. A.: The Occurrence of Reticulum in Tumors , Am. J. Path. 1:431 ( (July) ) 1925 24. correction 1:681 ( (Nov.) ) 1925 25. Lever,11b p. 17. 26. Szodoray, L.: The Structure of the Junction of the Epidermis and the Corium , Arch. Dermat. & Syph. 23:920 ( (May) ) 1931. 27. Lever,11b p. 17. 28. Fraser, J. F.: The Interpretation of Mycosis Fungoides as a Variety of Lymphosarcoma , Arch. Dermat. & Syph. 11:445 ( (April) ) 1925. 29. Fraser,13 p. 11. 30. Cottini, J. B.: Aspects hématologiques et histopathologiques de trois cas de mycosis fongoide , Ann. dermat. et syph. 8:15 ( (Jan.) ) 1937. 31. Berman, L.: Pathologic Nature of Mycosis Fungoides , Arch. Path. 29:530 ( (April) ) 1940. 32. Berman,23 p. 540. 33. Berger, L., and Vallée, A.: Le mycosis fungoïde: Une réticuloendothéliose de la peau , Presse méd. 38:177 ( (Feb. 5) ) 1930 34. Jaffee,5 p. 1105. 35. Cawley, E. P.; Curtis, A. C., and Leach, J. E.: Is Mycosis Fungoides a Reticuloendothelial Neoplastic Entity? A. M. A. Arch. Dermat. & Syph. 64:255 ( (Sept.) ) 1951. 36. Herzberg, J. J., and Ueberschär, K. H.: Die Mykosis fungoides als neoplastische Erkrankung des erweiterten retikuloendothelialen Systems , Dermat. Wchnschr. 123:316, and 337, 1951. 37. Garb,1 p. 306. 38. Garb, J.: Mycosis Fungoides (Granuloma Fungoides), Tumor Stage, Responding Rapidly to Antimony Preparations: Preliminary Report , J. Invest. Dermat. 10:43 ( (Feb.) ) 1948. 39. Garb,1 p. 304. 40. Berkovsky, M.: Mycosis Fungoides Treated Successfully with Ethylstibamine (Neostibosan) , Arch. Dermat. & Syph. 61:686 ( (April) ) 1950. 41. Henstell, H. H.; Tober, J. N., and Newman, B. A.: The Influence of Nitrogen Mustard on Mycosis Fungoides: Observations Relating Its Effect to Reticulo-Endothelial System , Blood 2:564 ( (Nov.) ) 1947. 42. Jaffee,5 p. 1107. 43. Winer, L. H.: Mycosis Fungoides: Benign and Malignant Reticulum Cell Dysplasia , Arch. Dermat. & Syph. 56:480 ( (Oct.) ) 1947.

SAWICKY, H. H.;DANTO, JULIUS L.;MADDIN, W. STUART

1953 A.M.A. Archives of Dermatology & Syphilology

doi: 10.1001/archderm.1953.01540070020002pmid: 13057363

Abstract IT IS GENERALLY agreed that hormonal influence on the pilosebaceous apparatus is the causative or a contributing factor in the production of acne vulgaris. The androgenic hormones are most commonly incriminated.1 This is based on the observations that (1) acne usually begins at puberty, when there is increased hormonal activity, (2) acne does not develop in eunuchs, (3) the administration of androgens to castrated men and to women with normal skins may produce acne lesions, (4) when the androgens are no longer given to the eunuchs and to women with normal skins the acne lesions disappear. Reports have appeared in the literature showing that the topical application of sex hormones has produced histologic changes in the sebaceous glands of animals.2 Moreover, the therapeutic effectiveness of systemic administrations of various types of estrogenic materials in some cases of acne vulgaris has now been established.3 Recently, reports References 1. Sulzberger, M. B., and Witten, V. H.: Symposium on Diseases of the Skin: Hormones and Acne Vulgaris , M. Clin. North America 35:373-390 ( (March) ) 1951. 2. Barber, H. W.: The Influence of Sex Hormones on the Skin and Pilosebaceous System , in Modern Trends in Dermatology , edited by R. M. B. MacKenna, New York, Paul B. Hoeber, Inc., 1948, Chap. 6, pp. 112-115. 3. Hamilton, J. B.: Male Hormone Substance: A Prime Factor in Acne , J. Clin. Endocrinol. 1:570-592 ( (July) ) 1941.Crossref 4. Reiss, F., and Gellis, S.: Effects Produced on Pilosebaceous System and Adrenals of Rabbit by Inunction of the Sex Hormones , J. Invest. Dermat. 12:159-172 ( (March) ) 1949. 5. Hooker, C. W., and Pfeiffer, C. A.: Effects of Sex Hormones upon Body Growth, Skin, Hair, and Sebaceous Glands in the Rat , Endocrinology 32:69-76 ( (Jan.) ) 1943.Crossref 6. Year Book of Dermatology and Syphilology , edited by M. B. Sulzberger, and R. L. Baer, Chicago, The Year Book Publishers, Inc., 1949, pp. 9-39. 7. Goldzieher, M. A.: Endocrine Pathogenesis and Treatment of Acne Vulgaris , M. Rec. 160:725-727 ( (Dec.) ) 1947. 8. Goeckerman, W. H.: Hormonal Therapy of Acne Vulgaris in the Female: Clinical Attempts at Its Evaluation , Arch. Dermat. & Syph. 61:237-243 ( (Feb.) ) 1950. 9. Sulzberger, M. B., and Wolf, J.: Dermatology: Essentials of Diagnosis and Treatment , Ed. 4, Chicago, The Year Book Publishers, Inc., 1952. 10. Lawrence, C. H., and Werthessen, N. T.: Treatment of Acne with Orally Administered Estrogens , J. Clin. Endocrinol. 2:636-638 ( (Nov.) ) 1942. 11. Shapiro, I.: Estrogens by Local Application in the Treatment of Acne Vulgaris , A. M. A. Arch. Dermat. & Syph. 63:224-227 ( (Feb.) ) 1951. 12. Whitelaw, M. J.: Treatment of Adolescent Acne with Topical Application of Estrogens , J. Clin. Endocrinol. 11:487-491 ( (May) ) 1951. 13. The Premarin cream was supplied by Ayerst, McKenna, & Harrison, Ltd., Dr. John B. Jewell, Medical Director. 14. Siemens, H. W.: Über ein noch nicht beschriebenes Phänomen bei der einseitigen Behandlung von Hautkrankheiten , Hautarzt 2:439-442 ( (Oct.) ) 1951.

RUITER, M.

1953 A.M.A. Archives of Dermatology & Syphilology

doi: 10.1001/archderm.1953.01540070024003pmid: 13057364

Abstract ANGIOKERATOMA corporis diffusum is only rarely described in the usual textbooks. This is not surprising, since only about 20 characteristic cases of angiokeratoma corporis diffusum have been observed since its first description in 1898. However, it would be wrong to consider this skin condition a dermatological curiosity. Investigations during the past few years have shown that in all probability this cutaneous anomaly will have to be considered as a sign of an internal disease unknown so far. It is by no means inconceivable that the rarity of angiokeratoma corporis diffusum (as far as I know, no case has yet been described in America) is due to the fact that remarkably few dermatologists seem to be familiar with this condition. The purpose of this paper is to draw attention once more to the skin disorder concerned. At the same time, a description of the internal anomalies which have recently been References 1. Fabry, J.: Ein Beitrag zur Purpura haemorrhagica nodularis , Arch. Dermat. u. Syph. 43: 1898. 2. Koch, H., cited by Hornbostel, H.; Spier, W., and Koch, H.: Angiokeratoma corporis diffusum universale (Fabry) mit cardio-vaso-renalem Symptomenkomplex als Allgemeinerkrankung , Arztl. Wchnschr. 6:49, 1951. 3. Weicksel, G.: Angiomatosis bzw. Angiokeratosis universalis , Deutsche. med. Wchnschr. 51:898, 1925.Crossref 4. Ruiter, M., and Pompen, A. W. M.: Angiokeratoma corporis diffusum (universale) mit kardiovasorenalem Symptomenkomplex bei 3 Brüdern , Arch. Dermat. u. Syph. 179:165, 1939.Crossref 5. Ruiter, M.: Drie patienten (broers) met angiokeratoma corporis diffusum , Nederl. tijdschr. geneesk. 83:1801, 1939. 6. Ruiter, M.; Pompen, A. W. M., and Wyers, H. J. G.: Über interne und pathologischanatomische Befunde bei Angiokeratoma corporis diffusum (Fabry) , Dermatologica 94:1, 1947.Crossref 7. Pompen, A. W. M.; Ruiter, M., and Wyers, H. J. G.: Angiokeratoma corporis diffusum (universale) Fabry, as a sign of an unknown internal disease: Two autopsy reports , Acta med. scandinav. 128:234, 1947.Crossref 8. Ruiter, M.: Angiokeratoma corporis diffusum (universale) als symptoom van een onbekende en nog niet beschreven inwendige ziekte , Nederl. tijdschr. geneesk. 90:1757, 1946. 9. Scriba, K.: Zur Pathogenese des Angiokeratoma corporis diffusum Fabry mit cardiovasorenalem Symptomenkomplex , Verhandl. deutsch. Gesellsch. Path. 1950, p. 221. 10. Hornbostel, H.; Spier, W., and Koch, H.: Angiokeratoma corporis diffusum universale (Fabry) mit cardio-vaso-renalem Symptomenkomplex als Allgemeinerkrankung , Arztl. Wchnschr. 6:49, 1951. 11. Wertheim: Hämangiome , in Jadassohn, J.: Handbuch der Haut- und Geschlechtskrankheiten , Berlin, Springer-Verlag, 1932, Vol. 2.

SMITH, LESLIE M.;GARRETT, H. D.

1953 A.M.A. Archives of Dermatology & Syphilology

doi: 10.1001/archderm.1953.01540070031004pmid: 13057365

Abstract IN THE last 15 years there has grown up in the arid portions of the American Southwest a colony of patients with various chronic generalized dermatoses, who have migrated from the colder and more humid portions of the country to take advantage of the sunshine and the warm dry air. It is usually difficult to convince these patients that the benefits they receive can be anything but the effect of the sun and dry air, or that rest and a certain amount of adjustment of their emotional difficulties and a lessening of the drive which has become their way of life plays a part in their recovery. They have become a cult of sunworshippers, and many are overdoing the sun treatment to the extent that they are laying a foundation for the future development of keratoses and epitheliomas. Our observation of many of these patients and the history of References 1. Sulzberger, M. B., and Garbe, W.: Nine Cases of Distinctive Exudative Discoid and Lichenoid Chronic Dermatosis , Arch. Dermat. & Syph. 36:247 ( (Aug.) ) 1937. 2. Cannon, A. B.: Allergic Dermatitis Simulating Lymphoblastoma , Arch. Dermat. & Syph. 39:846 ( (May) ) 1939. 3. Sachs, W., and Kirsch, N.: Exudative Discoid and Lichenoid Chronic Dermatosis, (Sulzberger-Garbe): Histopathologic Study , J. Invest. Dermat. 8:215 ( (April) ) 1947. 4. Schneider, E., and Kesten, B.: Polymorphic Prurigo: Psychosomatic Study of 3 Cases , J. Invest. Dermat. 10:205 ( (March) ) 1948. 5. Eidinoff, H.: Effect of Environment on Chronic, Severe and Extensive Itching Dermatoses , J. Invest. Dermat. 14:319 ( (May) ) 1950. 6. Sulzberger, M. B.: The Clinical Significance of Disturbances in Sweat Delivery, Special Lecture , read before the American Academy of Dermatology and Syphilography, Chicago, Dec. 10, 1951 .

FISHMAN, IRVING M.

1953 A.M.A. Archives of Dermatology & Syphilology

doi: 10.1001/archderm.1953.01540070041005pmid: 13057366

Abstract FAVUS is considered a rare mycotic disease in the United States. From time to time reports appear of endemic foci in various parts of the country,1 usually in small numbers and in isolated rural communities where the personal hygiene of the involved patients is rather poor. In these endemic foci, the disease manifests itself primarily as an infection of the scalp, and the hairs become directly involved. Occasionally there is involvement of a nail or two. Sometimes the glabrous skin adjacent to the scalp becomes involved by a direct extension of the process out of the scalp. This report is of an epidemic produced by Trichophyton schoenleini. It occurred entirely on the glabrous skin and was limited to the personnel of a large city hospital in New York.2 In all, 22 persons were involved, and the majority were members of the nursing staff. The first References 1. Barrett, C. C.: Endemic Favus , South M. J. 43:685-689 ( (Aug.) ) 1950.Crossref 2. Dobes, W. L.: Favus: Occurrence in Georgia: Report of 10 Cases , Urol. & Cutan. Rev. 52:729-734 ( (Dec.) ) 1948. 3. Robbins, S. J.: Favus in a Rural Community of New York , Arch. Dermat. & Syph. 58:180-183 ( (Aug.) ) 1948. 4. Eppright, B. R., and McCuistion, C. H.: Endemic Favus in Texas , Arch. Dermat. & Syph. 60:1208-1209 ( (Dec.) ) 1949. 5. Queens General Hospital, Queens, N. Y. 6. Communication with the home school did not confirm the source of the infection, since they had no knoweldge of any such cases either among the student nurses or among any of the hospital patients.

KALDECK, ROBERT

1953 A.M.A. Archives of Dermatology & Syphilology

doi: 10.1001/archderm.1953.01540070047006pmid: 13057367

Abstract PSORIASIS is one of the diseases encountered frequently in the practice of the dermatologist. In the textbooks of dermatology all possible locations and involvements of psoriasis are discussed in detail, except one: psoriasis affecting the eye. Why the dermatologist, who is interested in eye manifestations of syphilis, rosacea, pemphigus, and other diseases, should not be interested in psoriasis of the eye, poses an unanswered question. Is ocular psoriasis so rare or unimportant, or should the diagnosis of this condition be left entirely to the ophthalmologist? Is the ophthalmologist sufficiently aware of the possibility of psoriasis to diagnose it correctly? In the ophthalmological field de Schweinitz,1 in his textbooks, mentioned a number of dermatological conditions affecting the eye, but fails to list psoriasis. Fuchs2 states: In the case of other exanthemata, too, for instance in macular and papular syphilides, in pityriasis, psoriasis, ichthyosis, herpes iris, dematitis herpetiformis, lepra, References 1. de Schweinitz, G. E.: Diseases of the Eye , Ed. 10, Philadelphia, W. B. Saunders Company, 1924. 2. Fuchs, E.: Textbook of Ophthalmology , Philadelphia, J. B. Lippincott Company, 1899. 3. Fox, L. W.: Diseases of the Eye , New York, Appleton-Century-Crofts Company, Inc., 1907. 4. Duke-Elder, W. S.: Textbook of Ophthalmology , St. Louis, C. V. Mosby Company, 1944. Vol. 2. 5. Toth, Z.: Psoriasiseffloreszenz am Lidrand , Klin. Monatsbl. Augenh. 114:562, 1949.

SMITH, C. CONRAD;Simms, Florence;Luszpynsky, Yaroslava

1953 A.M.A. Archives of Dermatology & Syphilology

doi: 10.1001/archderm.1953.01540070053007pmid: 13057368

Abstract RECENTLY the local application of hydrocortisone acetate ointment has been reported to have a favorable effect in a number of dermatoses.1 Because of this the possible percutaneous absorption of hydrocortisone and potential systemic effects were thought worthy of investigation. One of the reasons which had been considered as a hypothetical explanation of the effectiveness of topically applied hydrocortisone in contrast to the ineffectiveness of topically applied cortisone was the possible percutaneous absorption of the former.2 The previously demonstrated apparent lack of absorption of topically applied cortisone in normal subjects fits in with this theory.3 It was also theorized that the apparent beneficial effects of hydrocortisone acetate ointment upon skin lesions located beyond and removed from the actual site of application could possibly be explained on the basis of absorption, with mild systemic effects. It is today well established that a reduction in the circulating eosinophile count References 1. Sulzberger, M. B., and Witten, V. H.: The Effect of Topically Applied Compound F in Selected Dermatoses , J. Invest. Dermat. 19:101, 1952.Crossref 2. Sulzberger, M. B.; Witten, V. H., and Smith, C. C.: Hydrocortisone (Compound F) Acetate Ointment in Dermatological Therapy , J. A. M. A. 151:468, 1953. 3. Goldman, L.; Thompson, R. G., and Trice, E. R.: Cortisone Acetate in Skin Disease: Local Effect in the Skin from Topical Application and Local Injection , A. M. A. Arch. Dermat. & Syph. 65:177, 1952. 4. Sulzberger, M. B.: Some Aspects of ACTH and Cortisone in Dermatology , Tenth International Congress of Dermatology, London, July, 1952 5. Excerpta Med. XIII Dermatology & Venereology 6:364, 1952. 6. Danto, J. L., and Maddin, S.: The Eosinophilic Response in Normal Subjects Following the Inunction of Cortisone Ointment , J. Invest. Dermat. 18:381, 1952. 7. Thorn, G. W., and others: Studies on the Relation of Pituitary-Adrenal Function to Rheumatic Disease , New England J. Med. 1241:529, 1941. 8. Nelson, D. H.; Sandberg, A. A.; Palmer, J. G., and Tyler, F. H.: Blood Levels of 17-Hydroxycorticosteroids Following the Administration of Adrenal Steroids and Their Relation to Levels of Circulating Leukocytes , J. Clin. Invest. 31:843, 1952. 9. Hydrocortone acetate ointment 2.5% was furnished by Merck & Company, Inc.

KIERLAND, ROBERT R.

1953 A.M.A. Archives of Dermatology & Syphilology

doi: 10.1001/archderm.1953.01540070057008pmid: 13057369

Abstract IN PLANNING this presentation I have considered three basic factors: (1) the contributions made by dermatology and dermatologists that are of direct and indirect value to the Armed Forces, (2) the contributions that the Armed Forces and the office of the Secretary of Defense have made to dermatology, and (3) the answer to the question, "What further should be done to make dermatology, dermatologists, and the Armed Forces more mutually advantageous?" Dermatology as a science and dermatologists individually have contributed much to various and broad aspects of military dermatology, especially when it is remembered that prior to World War II dermatology and dermatologists were not recognized as such by the Armed Forces. Throughout the first year of World War II it became clear that dermatologists were a necessity and that cutaneous diseases constituted one of the major causes of hospitalization and disability. In 1944, the total number of References 1. Manual of Dermatology: National Research Council, Division of Medical Sciences , by D. M. Pillsbury, M. B. Sulzberger, and C. S. Livingood, Philadelphia, W. B. Saunders Company, 1942, p. 421. 2. Pillsbury, D. M., and Livingood, C. S.: Experiences in Military Dermatology: Their Interpretation in Plans for Improved General Medical Care , Arch. Dermat. & Syph. 55:441-458 ( (April) ) 1947. 3. Casberg, M. A.: Personal communication to the author. 4. Olansky, S.: Personal communication to the author.

KIERLAND, ROBERT R.

1953 A.M.A. Archives of Dermatology & Syphilology

doi: 10.1001/archderm.1953.01540070064009pmid: 13057370

Abstract GENERALLY speaking, the physical allergies deal with those reactions of hypersensitiveness due to cold, heat, radiant energy, pressure, and mechanical stimuli. I am particularly concerned in this study with those reactions due to heat and cold. However, before going on to my subject I should like to mention that reactions of hypersensitiveness occur occasionally with roentgen, grenz, and radium irradiation, in addition to the rays of the visible spectrum, and it is important to note that certain instances of so-called photosensitivity really are due to the heat of such energy rather than the light per se. If we are to accept the reactions of hypersensitiveness to heat and cold as truly allergic we must use the term broadly and in the sense originally defined by von Pirquet, that is, as an "altered capacity to react." Almost no one, however, agrees with this broad concept, but the feeling persists that the References 1. Rajka, E., and Asboth, A.: Cold Urticaria: Investigations Concerning Its Pathogenesis , Ann. Allergy 9:642-652 ( (Sept.) -Oct.) 1951. 2. Rajka and Asboth.1 3. Rothman, S., in discussion on Rodin, H. H.: Sensitivity to Cold , A. M. A. Arch. Dermat. & Syph. 63:155 ( (Jan.) ) 1951. 4. Urbach, E.; Herrman, M. F., and Gottlieb, P. M.: Cold Allergy and Cold Pathergy , A. M. A. Arch. Dermat. & Syph. 43:366-374 ( (Feb.) ) 1941. 5. Urbach, E., and Gottlieb, P. M.: Allergy , Ed. 2, New York, Grune & Stratton, Inc., 1946, Chap. 17 , pp. 409-434. 6. Melczer, N., and Wlassics, T.: Über die Wärmeüberempfindlichkeit , Arch. Dermat. u. Syph. 176:157-166 ( (Oct.) ) 1937. 7. Rostenberg, A., Jr., in discussion on Rodin, H. H.: Sensitivity to Cold , A. M. A. Arch. Dermat. & Syph. 63:154 ( (Jan.) ) 1951. 8. The 1951 Year Book of Dermatology and Syphilology , edited by M. B. Sulzberger, and R. L. Baer, Chicago, The Year Book Publishers, Inc., 1951, pp. 182-186. 9. Duke, W. W.: Urticaria Caused Specifically by the Action of Physical Agents (Light, Cold, Heat, Freezing, Burns, Mechanical Irritation, and Physical and Mental Exertion) , J. A. M. A. 83:3-8 ( (July 5) ) 1924. 10. Peters, G. A., and Silverman, J. J.: Role of Histamine and Acetylcholine in the Mechanism of Heat Allergy: Report of Studies on a Soldier , Arch. Int. Med. 77:526-543 ( (May) ) 1946. 11. Melczer and Wlassics.2e 12. Peters and Silverman.6 13. Nomland, R.: Cholinogenic Urticaria and Cholinogenic Itching , Arch. Dermat. & Syph. 50:247-249 ( (Oct.) ) 1944. 14. Hopkins, J. G.; Kesten, B. M., and Hazel, O. G.: Urticaria Provoked by Heat or by Psychic Stimuli , Arch. Dermat. & Syph. 38:679-691 ( (Nov.) ) 1938. 15. Grant, R. T.; Pearson, R. S. B., and Comeau, W. J.: Observations on Urticaria Provoked by Emotion, by Exercise and by Warming the Body , Clin. Sc. 2:253-272 ( (July) ) 1936. 16. Sigel, H.: Urticaria Caused by Heat, Exertion and Excitement: Report on 22 Cases Among American Soldiers in Japan , Arch. Dermat. & Syph. 57:204-209 ( (Feb.) ) 1948. 17. Horton, B. T.: Cold Allergy: Report of 2 Cases , Proc. Staff Meet., Mayo Clin. 2:276-278 ( (Nov. 23) ) 1927. 18. Horton, B. T.; Brown, G. E., and Roth, G. M.: Hypersensitiveness to Cold, with Local and Systemic Manifestations of a Histamine-Like Character: Its Amenability to Treatment , J. A. M. A. 107:1263-1269 ( (Oct. 17) ) 1936. 19. Williams, H. L.: The Syndrome of Physical or Intrinsic Allergy of the Head: Myalgia of the Head (Sinus Headache) , Proc. Staff Meet., Mayo Clin. 20:177-183 ( (June 13) ) 1945. 20. Urbach and co-workers.2c,d 21. Rodin, H. H.: Sensitivity to Cold , A. M. A. Arch. Dermat. & Syph. 63:152-154 ( (Jan.) ) 1951. 22. Witherspoon, F. G.; White, C. B.; Bazemore, J. M., and Hailey, H.: Familial Urticaria Due to Cold , A. M. A. Arch. Dermat. & Syph. 58:52-55 ( (July) ) 1948. 23. Kile, R. L., and Rusk, H. A.: A Case of Cold Urticaria with an Unusual Family History , J. A. M. A. 114:1067-1068 ( (March 23) ) 1940. 24. Rasmussen, K. A.: The Effect of Antihistaminics on Histamine Whealing and on Dermographism: Elucidated by Comparative Electrophoretical Experiments , Acta dermat.-venereol. 29:564-571, 1949. 25. Kalz, F.; Bower, C. M., and Prichard, H.: Delayed and Persistent Dermographia , Arch. Dermat. & Syph. 61:772-780 ( (May) ) 1950. 26. Sherman, W. B., and Seebohm, P. M.: Passive Transfer of Cold Urticaria , J. Allergy 21:414-424 ( (Sept.) ) 1950. 27. Williams, H. L.: A Concept of Allergy as Autonomic Dysfunction Suggested as an Improved Working Hypothesis , Tr. Am. Acad. Ophth. 55:123-146 ( (Nov.) -Dec.) 1951.

FOWLE, L. P.;RICE, J. W.

1953 A.M.A. Archives of Dermatology & Syphilology

doi: 10.1001/archderm.1953.01540070072010pmid: 13057371

Abstract NEARLY 100 years have elapsed since Devergie1 described nummular eczema. Since then, nummular eczema has been confused with other disease entities and has been described under such names as orbicular eczema, parasitic eczema, and herpetoid eczema. Devergie was not the first to compare plaques of dermatitis to coins. Rayer,2 in referring to what must have been nummular eczema, stated: "This variety is distinguished by clustered patches of vesicles, the dimensions of which vary from those of a sovereign to those of a two sovereign piece." In Rayer's book there was an illustration showing the radial side of a hand with typical coin-sized plaques of dermatitis. Characteristically, nummular eczema occurs in sharply defined coin-sized vesicular plaques favoring the extensor surfaces of the extremities below the knees and the elbows. The best descriptions of nummular eczema which we have found to date are those by Sulzberger and Wolf3 References 1. Devergie, M. G. A.: Traité pratique des maladies de la peau , Ed. 2, Paris, V. Masson, 1857, p. 233. 2. Rayer, P.: A Theoretical and Practical Treatise on Diseases of the Skin , Philadelphia, Carey & Hart, 1845, p. 114. 3. Sulzberger, M. B., and Wolf, J.: Dermatologic Therapy in General Practice , Ed. 3, Chicago, Year Book Publishers, Inc., 1948. 4. Gross, P.: Nummular Eczema as a Clinical Entity , New York J. Med. 51:2025 ( (Sept. 1) ) 1951. 5. Pillsbury, D. M., and Sternberg, T. H.: Relation of Diet to Cutaneous Infection: Study of Influence of Varying Carbohydrate and Fat Intakes and of Fasting on Experimental Pyogenic Cutaneous Infections in Dogs, with Comparative Determinations of the Glycogen Content of the Skin and Liver , Arch. Dermat. & Syph. 35:893 ( (May) ) 1937. 6. Pollitzer, S. A.: Recurrent Eczematoid Affection of the Hands , J. Cutan. Dis. 30:716 ( (Dec.) ) 1912. 7. Unna, P. G.: Parasitäre Natur des Ekzems , Deutsche Med.-Ztg. 21:809 ( (Aug.) ) 1900. 8. Engman, M. F.: An Infectious Form of an Eczematoid Dermatitis , Am. Med. 4:769 ( (Nov. 15) ) 1902. 9. Lane, C. G.; Rockwood, E. M.; Sawyer, C. S., and Blank, I. H.: Dermatoses of the Hands , J. A. M. A. 128:987 ( (Aug. 4) ) 1945. 10. Storck, H.: Experimentelle Untersuchungen zur Frage der Bedeutung von Mikroben in der Ekzemgenese , Dermatologica 96:177, 1948. 11. Hopkins, H. H., and Burky, E. L.: Cutaneous Autosensitization: Role of Staphylococci in Chronic Eczema of the Hands , Arch. Dermat. & Syph. 49:124 ( (Feb.) ) 1944. 12. Thygeson, P.: Mannitol Fermentation as an Indicator of Conjunctival Pathogenicity of Staphylococci , Arch. Ophth. 20:274 ( (Aug.) ) 1938. 13. Swineford, O., Jr., and Holman, J.: Studies in Bacterial Allergy: Results of 3860 Cutaneous Tests with 34 Crude Polysaccharide or Nucleoprotein Fractions of 14 Different Bacteria , J. Allergy 20:420 ( (Nov.) ) 1949. 14. Coca, A. F.: Familial Nonreaginic Food-Allergy , Springfield, Ill., Charles C Thomas, Publisher, 1943. 15. Kahn, R. L.: Tissue Immunity , Springfield, Ill., Charles C Thomas, Publisher, 1936. 16. Gross, P.: Nummular Eczema: Its Clinical Picture and Successful Therapy , Arch. Dermat. & Syph. 44:1060 ( (Dec.) ) 1941.

JEKEL, LOUIS G.

1953 A.M.A. Archives of Dermatology & Syphilology

doi: 10.1001/archderm.1953.01540070083011pmid: 13057372

Abstract In the hope of stimulating further studies in a more extensive and a more nearly exact manner than is possible to me, I wish to make this short preliminary report on the use of heparin1 in the treatment of psoriasis. Only three cases are included in this report, but these cases were especially interesting because the patients did not respond well to ordinary methods of treatment or else did not tolerate them well. Heparin was merely added to the program in addition to whatever else was being used at the time, when progress was definitely at a standstill and the condition was not satisfactory. Other patients have been treated with this method, with indeterminate results up to now; their cases are not yet ready to be reported. REPORT OF CASES Case 1.—Mrs. J. H. McN., a white woman, aged 64, had had recurrent attacks of contact dermatitis for References 1. Grütz, O., and Burger, M.: Die Psoriasis als Stoffwechsel problem , Klin. Wchnschr. 12:373-379 ( (March 11) ) 1933.Crossref 2. Gross, P., and Kesten, B. M.: The treatment of Psoriasis as a Disturbance of Lipid Metabolism: Further Observations on Lipotropic Therapy Based on a 10-Year Clinical Study , New York J. Med. 50:2683-2686 ( (Nov. 15) ) 1950. 3. Madden, J. F.: Cholesterol Balance and Low Fat Diet in Psoriasis , Arch. Dermat. & Syph. 39:268-277 ( (Feb.) ) 1939. 4. Gofman, J. W.; Lindgren, F. T., and Elliott, H.: Ultracentrifugal Studies of Lipoproteins of Human Serum , J. Biol. Chem. 179:973-979 ( (June) ) 1949. 5. Gofman, J. W.; Lindgren, F. T.; Elliott, H.; Mantz, W.; Hewitt, J.; Strisower, B.; Herring, V., and Lyon, T. P.: The Role of Lipids and Lipoproteins in Atherosclerosis , Science 111:166-171 ( (Feb. 17) ) 1950. 6. Epstein, N. N.; Rosenman, R. H., and Gofman, J. W.: Serum Lipoproteins, and Cholesterol Metabolism in Xanthelasma , A. M. A. Arch. Dermat & Syph. 65:70-81 ( (Jan.) ) 1952. 7. Graham, D. M.; Lyon, T. P.; Gofman, J. W.; Jones, H. B.; Yankley, A.; Simonton, J., and White, S.: Blood Lipids and Human Atherosclerosis: The Influence of Heparin upon Lipoprotein Metabolism , Circulation 4:666-673 ( (Nov.) ) 1951. 8. Stewart, C. D.; Clark, D. E.; Dragstedt, L. R., and Becker, S. W.: The Experimental Use of Lipocaic in the Treatment of Psoriasis: Preliminary Report , J. Invest. Dermat. 2:219-230 ( (Aug.) ) 1939. 9. Epstein, N.: Personal communication to the author.

ROCKWELL, EVELYN

1953 A.M.A. Archives of Dermatology & Syphilology

doi: 10.1001/archderm.1953.01540070085012pmid: 13057373

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract It is not well known that the mite, Dermanyssus gallinae, may infest pigeons. Three cases of dermatitis due to D. gallinae infestation of pigeon are being reported, as this source may be overlooked when tracing the etiology of lichen urticatus suspected to be a reaction to the bites of arthropods. Three white women who share an apartment were seen in May, 1952, with malaise and a pruritic papular eruption on the extremities, neck, and around the waist. History revealed that pigeons roosted outside one window, and many small arthropods were found on the window sill and inside the screen. These were identified as D. gallinae by C. F. Muesebeck and W. C. McDuffie, of the Bureau of Entomology and Plant Quarantine of the United States Department of Agriculture. The mites are especially apt to enter the living quarters after young birds have left the nest. Area control was accomplished in

LIPSCHUTZ, ARTHUR;FITTI, REGINA M.

1953 A.M.A. Archives of Dermatology & Syphilology

doi: 10.1001/archderm.1953.01540070086013pmid: 13057374

Abstract In the summer of 1951, while we were on pediatric service at an affiliate children's hospital and infant home, we were impressed with the prevalence of skin disorders, such as urticaria, impetigo, diaper rash, secondary infection occurring after insect bites, and heat rash among children. It seemed that an agent which would reduced the incidence of these conditions and yet not sensitize or irritate the skin might be of value. A new antibacterial detergent1 was considered to be worthy of clinical investigation. Interest was aroused in this product because of its reported cleansing and antibacterial properties2 and because of the published reports of the antibacterial properties of pHisoHex (Winthrop-Stearns),3 a similar antibacterial synthetic detergent containing 3% of hexachlorophene on a total weight basis, used as surgical "prep" by surgeons and nurses. PURPOSE The purpose of this study was to determine whether a soapless antibacterial cleansing agent References 1. The detergent used in the study was Tod'l, manufactured and supplied by the Centaur-Caldwell Division of Sterling Drugs, Inc. This product is an emulsion composed of a sulfonated ether, petrolatum, and wool fat cholesterols. It contains hexachlorophene, 0.5%, which is a bactericidal synthetic diphenol with the chemical formula bis-(2-hydroxy-3,5,6-trichlorophenyl) methane. 2. Dennis, E. W.: Unpublished data in the files of Sterling-Winthrop Research Institute. 3. Walter, C. W.: The Aseptic Treatment of Wounds , New York, The Macmillan Company, 1948. 4. Fine, J.: The Care of the Surgical Patient , Philadelphia, W. B. Saunders Company, 1949. 5. Thirlby, R. L., and Nesbit, R. M.: Clinical Evaluation of a Bactericidal Detergent for Hand Preparation in Urologic Practice , J. Urol. 62:617 ( (Oct.) ) 1949. 6. Bowers, R. F.: pHisoderm with Hexachlorophene (G-11): Its Integrity as a Surgical Scrub , Am. J. Surg. 78:859 ( (Dec.) ) 1949.Crossref 7. Chisholm, T. C.; Duncan, T. L.; Hufnagel, C. A., and Walter, C. W.: Disinfecting Action of pHisoderm Containing 3 Per Cent Hexachlorophene on the Skin of the Hands , Surgery 28:812 ( (Nov) ) 1950. 8. Freeman, B. S., and Young, T. K., Jr.: Use of a Detergent (pHisoderm®) Combined with Hexachlorophene for Skin Disinfection , Arch. Surg. 61: 1145 ( (Dec.) ) 1950.Crossref 9. Artz, C. P.; Pulaski, E. J., and Shaeffer, J. R.: Clinical Uses of Hexachlorophene , U. S. Armed Forces M. J. 2:819 ( (May) ) 1951. 10. Dull, J. A.; Zintel, H. A.; Ellis, H. L., and Nichols, A.: An Evaluation of pHisoderm G-11 and a Liquid Soap Containing G-11 When Used as the Preoperative Scrub , Surg, Gynec. & Obst. 91:100 ( (July) ) 1950.

LEWIS, GEORGE M.;SCOTT, MICHAEL J.

1953 A.M.A. Archives of Dermatology & Syphilology

doi: 10.1001/archderm.1953.01540070089014

Abstract Striated muscle cell tumors, depending upon the type of cells from which they are derived, are classified as rhabdomyomas and myoblastomas. Rhabdomyomas are tumors derived from mature striated muscle cells, whereas myoblastomas are derived from juvenile muscle cells, or embryonic myoblasts. Abrikossoff,1 in 1926, initially described the latter tumor under the title of myoblastic myoma; it has since been referred to as myoblastoma, granular cell rhabdomyoma, and granular cell myoblastoma. Abrikossoff originally believed that the tumor cells were derived from muscle fibers undergoing changes occurring after injury. Later, he concluded that they arose from embryonal striated muscle cells. Over 200 cases have been described since the original report. Lesions are located most frequently in the upper digestive and respiratory tracts. Cutaneous lesions comprise approximately 20% of the recorded cases, being second in frequency only to lesions of the tongue. Not many of the recorded cases have been published References 1. Abrikossoff, A. I.: Ueber Myome ausgehend von der quergestreiften willkürlichen Muskulatur , Virchows Arch. path. Anat. 260:215, 1926.Crossref 2. Cipollaro, A. C., and Einhorn, M. B.: Granular Cell Myoblastoma: Report of 2 Cases , Arch. Dermat. & Syph. 56:812 ( (Dec.) ) 1947. 3. Kern, A. B.; Kaufman, J. J., and Combes, F. C.: Granular Cell Myoblastoma: Report of Case Simulating Granuloma Inguinale , Arch. Dermat. & Syph. 62:109 ( (July) ) 1950. 4. Morpurgo, B.: Myoblastomi , Arch. sc. med. 59:229 ( (Feb.) ) 1935. 5. Ravich, A.; Stout, A. P., and Ravich, R. A.: Malignant Granular Cell Myoblastoma Involving the Urinary Bladder , Ann. Surg. 121:361 ( (March) ) 1945. 6. Ackerman, L. V., and Phelps, C. R.: Malignant Granular Cell Myoblastoma of the Gluteal Region , Surgery 20:511 ( (Oct.) ) 1946. 7. Powell, E. B.: Granular Cell Myoblastoma , Arch. Path. 42:517 ( (Nov.) ) 1946. 8. Crane, A. R., and Tremblay, R. G.: Myoblastoma (Granular Cell Myoblastoma or Myoblastic Myoma) , Am. J. Path. 21:357 ( (March) ) 1945. 9. Gray, S. H., and Gruenfeld, G. E.: Myoblastoma , Cancer 30:699 ( (Aug.) ) 1937.

FORSEY, R. R.;JACKSON, R.

1953 A.M.A. Archives of Dermatology & Syphilology

doi: 10.1001/archderm.1953.01540070092015pmid: 13057375

Abstract After the report of Schoenbach 1 on the use of stilbamidine in tretatment of blastomycosis, this form of treatment was tried in a case of widespread blastomycosis. The case is being reported, first, to show the efficacy of the drug in this infection and, second, to draw attention to a possible severe toxic reaction to the drug. REPORT OF A CASE Miss B. G., aged 40, was first seen in the outpatient department of the Montreal General Hospital on Aug. 28, 1952, at which time she gave the following history: She had lived all her life in Canada, in rural areas. While she was in high school she had had a bad fall, injuring her head, and six months later alopecia totalis developed. When she was 26 years old, asthma developed after a severe upper respiratory infection; the asthma has persisted to the present. She had pneumonia with pleurisy in References 1. Schoenbach, E. B.; Miller, J. M., and Long, P. H.: The Treatment of Systemic Blastomycosis with Stilbamidine , Ann. Int. Med. 37:31-48 ( (July) ) 1952.Crossref

Webster, James R.;Neuhauser, Irene

1953 A.M.A. Archives of Dermatology & Syphilology

doi: 10.1001/archderm.1953.01540070094016

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract Keratoma Hereditarium Dissipatum Palmare et Plantare with Cutaneous Horn Formation (Brauer) Treated with Lithium Bromide. Presented by (by invitation) Dr. Allan L. Lorincz. Mrs. H. A., a housewife aged 49, came to the University of Chicago Clinics in August, 1952, complaining of painful horny growths on both feet for the past 25 years. Her mother, maternal aunt, four brothers, and three sisters all have had a similar disorder. Some of the mother's grandchildren also have such lesions. Most of the afflicted siblings have, in addition, had "polyneuritis," but details of this are not available. Results of physical examination, except for the skin lesions, were essentially normal, as were results of routine blood cell counts, urinalysis, and chest X-ray. The plantar and palmar skin showed sharply localized hyperkeratotic lesions, many of which were simply small horny papules, but others on the feet were very hard fissured tender horn-like growths, 1 cm.

Schonberg, Irving L.;Haserick, John R.;Stroud, George M.

1953 A.M.A. Archives of Dermatology & Syphilology

doi: 10.1001/archderm.1953.01540070102017

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract Sporotrichosis de Beurmann (Now Healed). Presented by Dr. H. N. Cole; Dr. J. R. Driver, and Dr. H. N. Cole Jr. T. M., a 9-year-old boy, had an eruption on the right side of the neck and face of two weeks' duration. His home is in Green Springs, Ohio, next to a very large dense growth of timber, where there is a great deal of moisture and shade. About May 1, 1952, an eruption, a little sore which became larger, developed, for which he was taken to his family physician, who gave him an ointment to use. The eruption began to get worse; it became swollen and began to ooze on the neck and on the side of the face. He was then given a boric acid wash and penicillin injections, under which treatment the eruption improved somewhat. Later, at the time of the examination, there was a 1-by

Ceder, Elmer T.;Ravits, Harold G.

1953 A.M.A. Archives of Dermatology & Syphilology

doi: 10.1001/archderm.1953.01540070104018

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract Dermatomyositis.—R. Y. a woman, aged 41, had urticaria, edema, erythema, and Raynaud's phenomenon of the hands at the age of 32. At age 35 examination here showed generalized erythema and thick keratinization of soles. A biopsy confirmed the clinical impression of pityriasis rubra pilaris. The same diagnosis had been made elsewhere. An x-ray of the chest showed diffuse miliary infiltrations. Multiple guinea-pig inoculations gave negative results. During the next year and a half atrophy of the shoulder muscles with generalized erythema and desquamation developed. Muscle biopsy revealed dermatomyositis. Skin biopsy revealed "atypical lichen planus." X-ray of the hands showed acrosclerosis, with calcinosis in the fingers. An esophageal x-ray showed a negative picture. Analysis of 24-hour urine specimens revealed preformed creatinine, 340 mg., and creatine, 167 mg. Six months later (March, 1949) she exhibited marked skin changes of the poikiloderma type. At this time her preformed creatinine was 583

1953 A.M.A. Archives of Dermatology & Syphilology

doi: 10.1001/archderm.1953.01540070114019

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract ANNOUNCEMENTS Course in Occupational Skin Problems.—A course of instruction in Occupational Skin Problems will be presented jointly by the Division of Occupational Health of the Public Health Service, the Department of Dermatology and Syphilology of the University of Cincinnati, and the Department of Preventive Medicine and Industrial Health, during the week of Oct. 12-16, 1953. The object of the course is to give physicians a greater understanding of cutaneous problems of occupational origin. The program will be divided into three daily sessions, consisting of morning lectures and clinical demonstrations, afternoon field instruction in industrial plants, and evening panel discussions. The didactic presentations will include a review of the anatomy, physiology, and chemistry of the skin. Consideration will be given to the etiology, clinical appearance, diagnosis, and treatment of occupational dermatoses. This will be supplemented by discussions of specific measures of prevention and control. The evening sessions, in panel form,

1953 A.M.A. Archives of Dermatology & Syphilology

doi: 10.1001/archderm.1953.01540070115020