Archives of Dermatology and Syphilology

PARDO-CASTELLO, V.

1932 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1932.01450020811001

Abstract In June, 1923, I reported before the Forty-Sixth Annual Meeting of the American Dermatological Association1 the observations on thirty-six cases of a skin condition which I called, after Jeanselme's original name, achromia parasitaria. The disease has been observed since then with fair frequency in Cuba, and it has been the subject of much discussion at the meetings of the Cuban Dermatological Society where the parasitic nature of the ash-white spots was doubted, until I succeeded in demonstrating the presence of mycelial threads in the deep part of the corneous layer. In the United States little attention has been given to this subject aside from the efforts of Prof. Howard Fox to cultivate fungi from the scales of similar lesions. The general attitude in America has been one of doubt about the real parasitic nature of this condition, and the common impression seems to be that it is a partial References 1. Pardo-Castello, V., and Dominguez, M.: Achromia Parasitaria , Arch. Dermat. & Syph. 9:82 ( (Jan.) ) 1924. 2. Kistiakowsky, E. W.: Pityriasis Versicolor and Ultraviolet Rays: Achroma Cutis Postparasitaria , Arch. Dermat. & Syph. 15:695 ( (June) ) 1927. 3. Gougerot; Joyeux and others: Achromies "parasitaires" ou mieux epidermomycosis achromiantes , Bull. Soc. franç. dermat. et syph. 36:1028 ( (Nov.) ) 1929. 4. Gougerot; Joyeux and Arnaudet: Un cas d' achromie parasitaire nord africain , Bull. Soc. franç. de dermat. et syph. 37:110 ( (Jan.) ) 1930. 5. Kistiakowsky, E. W.: L'achromie qui apparaît sous l'action des rayons ultra-violet du soleil sur le pityriasis versicolor, est-elle parasitaire ou post-parasitaire? Ann. de dermat. et de syph. 1:1264 ( (Dec.) ) 1930. 6. Artom, M.: Contributo allo studio della pityriasis, versicolor acromizzante , Gior. ital. di dermat. e sif. 71:1945 ( (Dec.) ) 1930. 7. Mantarro, G.: Epidermomicosis acromizzante da hemispora stellata , Gior. ital. di dermat. e sif. 72:131 ( (Feb.) ) 1931. 8. Castellani, A.: Fungi and Fungous Diseases , Arch. Dermat. & Syph. 17: 215 ( (Feb.) ) 1928.

RIDDELL, HON. WILLIAM RENWICK

1932 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1932.01450020816002

Abstract Simon Nicolas Henri Linguet was one of the most extraordinary men of a very extraordinary period. Born in 1736 at Rheims, educated in Paris, well skilled in mathematics and a fine linguist, he became a soldier, a lawyer and a satirist. His life being in danger, he fled to England, but not receiving the attention he expected, he went to Brussels and then back to France. In the troublous times of the last two decades of the eighteenth century, driven by the enmity provoked by his satire, he resided alternately in France, England, the Netherlands and Austria; finally in the Terror he was condemned to death and went bravely to the guillotine, June 27, 1794. His writings are very numerous, chiefly legal, historical and philosophical, and practically all more or less satirical, the satire not being very bitter as a rule. One of his lesser works not mentioned in the References 1. Riddell: Hieronymus Fracastorius , Toronto, 1928, pp. 8 and 16 2. Jacques de Bethencourt first gave the name venereal disease (morbus venereus) in his New Penitential Lent , Paris, 1527. 3. Dr. Pangloss (from the Greek "pas [pasa, pan]" meaning all and "glosse," meaning tongue), one of Voltaire's best known characters. He appears in "Candide" as the incurably optimistic philosopher with whom the favorite maxim was ever : "Everything is for the best in this best of all possible worlds." He was the tutor of Candide. Candide lived in Westphalia in the Chateau of Baron Thunderthentronck. 4. The theory accepted with practical universality in the Middle Ages was that there were four humors in the body: (1) Blood, (2) Bile, (3) Phlegm and (4) Melanchole or Black Bile. On the proper mixture of these and their regular flow depended the health of the body; an excess of one or more was injurious as was any interruption of them. Our "good humor," "bad humor," "temperament," "distemper," "sanguine," "phlegmatic," "bilious," "melancholy," etc., are relics of the terminology of this theory, the connotation now being, of course, quite different. 5. What is meant is that the current theory made the medicines without life, operating by mechanical or chemical means and not living creatures. 6. Jean Baptiste Tavernier (1605-1689), born in Paris, was a French traveler to Turkey, Persia, central Asia and the East Indies; his Travels were published in 1676 to 1679. 7. Melinde, or Melinda, is a town in British East Africa; it was successively an Arabian, Portuguese and Zanzibar trading-post. It is about 200 miles south of the equator. Nothing is known at the present time of the extraordinary influence of its women noted by Tavernier, and one is at liberty to be skeptical about it. 8. Job 2:3, ashes; 2:7, boils; 2:8, potsherd; 10:10, curdled; 4:8, reaping fruit of iniquity. 9. It will be seen later in the text that the origin of perruques (wigs) is traced to the baldness of Francis I of France, caused by syphilis. 10. The invasion of Italy by Charles VIII of France began in 1494; he conquered Naples, but retired precipitately in the face of the league of the Pope and the Emperor. He died in 1498 when he was preparing for another invasion (Riddell: Hieronymus Fracastorius, p. 16). 11. Baas, J. H.: Outlines of History of Medicine and the Medical Profession , translated by H. E. Handerson, New York, 1889, p. 229 12. Baas: Outlines of History of Medicine and the Medical Profession 1889, pp. 226 and 230 13. "Aethiops mineral" is defined by an old writer thus: "A Medicine made by Imbodying equal parts of running Quicksilver and Flower of Brimstone and then Deflagrating or Burning off the Mixture in a Crucible." 14. A "Dragée" is a sort of sugarplum or sweetmeat in the center of which is a drug, and it is intended for the more ready taking of the medicine. Keyser's Dragées were a quack medicine having some vogue at the time for the cure of syphilis; they were composed of acetate of mercury, manna, starch, mucilage and gum tragacanth.

RAIZISS, GEORGE W.;SEVERAC, M.

1932 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1932.01450020825003

Abstract In a recent article1 dealing with 3-acetyl-amino-4-hydroxyphenyl-1-arsonic acid, generally known as acetarsone or stovarsol, we expressed the view that the problem of the toxicity of this compound requires reconsideration, since we found lower values for the toxicity of acetarsone than those heretofore obtained by other workers in this field. Soon after the discovery of the antisyphilitic action of this preparation, conflicting reports regarding its toxicity appeared in the literature. When, in 1922, Levaditi, Navarro-Martin and Fournier2 first recommended acetarsone (stovarsol) for use in the treatment for syphilis, they stated that the lethal dose of the drug, when given to the rabbit by mouth, is 0.6 Gm. per kilogram of body weight, but that a dose of from 0.3 to 0.4 Gm. is easily tolerated by the animals, some rabbits having tolerated well even 0.7 Gm. of stovarsol per kilogram. When, however, the toxicity of the References 1. Raiziss, G. W.; Severac, M., and Moetsch, J. C.: Toxicity of Acetarsone (Stovarsol) , J. Chemotherapy 7:1 ( (April) ) 1930. 2. Levaditi, C.; Navarro-Martin, A., and Fournier, L.: Recherches sur l'action curative et préventive de stovarsol administré par la voie digestive dans la syphilis , Ann. Inst. Pasteur 36:729, 1922. 3. Collier, W. A., and Evers, E.: Untersuchungen über die Heil- und Schutz-Wirkung des Stovarsol , Dermat. Ztschr. 44:1 ( (May) ) 1925.Crossref 4. Schlossberger, H., quoted by Collier and Evers (footnote 3). 5. Worms, W.: Weitere experimentelle Untersuchungen zur Stovarsolfrage , Deutsche med. Wchnschr. 51:428 ( (March 13) ) 1925.Crossref 6. Poole, A. K.: A Note on the Prophylactic and Therapeutic Activity of the Sodium Salt of Stovarsol , Bull. Johns Hopkins Hosp. 38:242 ( (March) ) 1926. 7. Anderson, H. H., and Leake, C. D.: Toxicity of Stovarsol , Proc. Soc. Exper. Biol. & Med. 27:267 ( (Jan.) ) 1930. 8. These figures were obtained with exceptionally good samples. The average maximum tolerated dose is 0.8 Gm. 9. Fourneau, E.: Sur l'emploi de l'acide oxy-aminophenylarsinique , Ann. Inst. Pasteur 35:571, 1921. 10. Navarro-Martin, A.: Sur l'emploi de l'aminophenolarsenate de soude (189) dans le traitement de trypanosomiasis , Ann Inst. Pasteur 36:38, 1922. 11. Fourneau, Navarro-Martin and Trefouel : Les dérivés de l'acide phenylarsinique dans le traitement de trypanosomiasis et de spirilloses expérimentales , Ann. Inst. Pasteur 37:581 ( (June) ) 1923. 12. Raiziss and Severac: Standardization of the Trypanocidal Test and of the Trypanocidal Value of Arsphenamine , Arch. Dermat. & Syph. 18:263 ( (Aug.) ) 1928. 13. Fischl, V.: Die Ergebnisse experimenteller Prüfung der Oxyacetamino-Phenylarsinsäure , Klin. Wchnschr. 8:1414, 1929. 14. Raiziss, G. W., and Gavron, J. L.: A Study of the Colloidal Properties of Arsphenamine and Allied Products , J. Pharmacol. & Exper. Therap. 20:163 ( (Oct.) ) 1922. 15. Raiziss and Severac: Chemotherapeutic Studies Concerning the Penetration of Organic Compounds of Arsenic into the Cerebrospinal System , Arch. Dermat. & Syph. 22:1031 ( (Dec.) ) 1930. 16. Sézary, A., and Barbé, A.: Résultats cliniques et biologiques de la stovarsolthérapise dans 125 cas de paralysie générale , Presse méd. 37:1 ( (Jan. 2) ) 1929: 17. abstr., J. Chemotherapy 6:15 ( (April) ) 1929. 18. Horster, H.: Tierexperimentelle Untersuchungen über die Wirksamkeit von Spirozid gegenüber der luetischen Infektion des Zentralnervensystems , Med Klin. 27:511 ( (April 2) ) 1931.

SCHOLTZ, MOSES

1932 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1932.01450020838004

Abstract Trichophytid as a clinical conception was first introduced in 1908 by Jadassohn,1 who described lichen-like lesions on the trunk in patients with trichophytic kerion lesions on the scalp. These were associated with systemic symptoms and with a positive reaction to trichophytin. Later Bloch2 confirmed and elaborated this conception on an immunologic basis by reproducing the condition experimentally by injections of trichophytin. He also described other types of lesions, such as scarlatinoid. erythema multiforme, nodular and pustular. Several other observers, among them Brash, reported similar lesions and supplied more immunologic evidence. Sutter3 demonstrated fungi in lymphatic glands, and Bruusgaard4 found fungi in the sections of small veins. All these studies, however, were made in cases of deep trichophytosis, mostly of kerion type. In 1911 Sabouraud5 for the first time isolated epidermophyton fungus from the superficial eczematoid vesicular and scaly intertriginous lesions of the toes. References 1. Jadassohn, J.: Klin. Wchnschr. , 1918, p. 489. 2. Bloch, Bruno: Ann. de dermat. et syph. 2:1, 1921. 3. Sutter: Arch. f. Dermat. u. Syph. 127:735, 1919.Crossref 4. Bruusgaard, E.: Brit. J. Dermat. 34:150 ( (May) ) 1922.Crossref 5. Sabouraud, R.: Ann. de dermat. et syph. 1:289, 1910. 6. Wolff, Kauffman: Dermat. Ztschr. 20:385, 1914.Crossref 7. Ormsby, O. S., and Mitchell, J. H.: Ringworm of Hands and Feet , J. A. M. A. 67:711 ( (Sept. 2) ) 1916.Crossref 8. Darier, J.: Lancet 2:578, 1919; 9. Précis de dermatologie , Paris, Masson & Cie, 1927. 10. White, Charles, and Greenwood. A. M.: Epidermophytosis , Tr. Sect. Dermat. & Syph., A. M. A. , 1921, p. 181. 11. Williams, Charles: Dermatophytid Complicating Tursa Cruris , Arch. Dermat. & Syph. 22:636 ( (Oct.) ) 1930: 12. Tinea Barbae Involving Upper Lips and Accompanied by Dermatophytid , Williams Arch. Dermat. & Syph. 23:213 ( (Feb.) ) 1931. 13. Jadassohn, W., and Peck, S.: Epidermophytosis of the Feet and Epidermophytids of the Hands , Arch. Dermat. & Syph. 22:40 ( (July) ) 1930; 14. Arch. f. Dermat. u. Syph. 158:16, 1929. 15. Sicoli, A.: Ann. de dermat. et syph. 5:69, 1924. 16. Jadassohn J.: Importance of Immune Biologic Processes in Morphology of Skin Lesions , Arch. Dermat. & Syph. 21:355 ( (March) ) 1930. 17. Arnold: Arch. f. Dermat. u. Syph. 136:225, 1923. 18. Sloimovici, M. A., and Ullmo, A.: Ann. de dermat. et syph. 8:554, 1927. 19. Ravaut: Presse méd. 36:1443 ( (Nov. 14) ) 1928. 20. Alexander, A.: Dermat. Ztschr. 50:185, 1927. 21. Raika: Arch. f. Dermat. u. Syph. 143:205, 1928. 22. Keller, P.: Dermat. Ztschr. 49:33, 1926. 23. Karrenberg, C. L.: Inquiries into the Present State of Epidermophytids in Europe . Tr. Sect. Dermat. & Syph., A. M. A. , 1927, p. 179. 24. Ormsby: Treatise of the Diseases of the Skin , Philadelphia, Lea & Febiger, 1921. 25. Sutton: Diseases of the Skin , St. Louis, C. V. Mosby Company, 1926. 26. Lehmann, C. F.: Acute Vesicular Eruptions of Hands and Feet , Arch. Dermat. & Syph. 21:449 ( (March) ) 1930. 27. Kenery, L.: Dermat. Wchnschr. 43:1577, 1930.

WEISS, EDWARD

1932 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1932.01450020849005

Abstract REPORT OF A CASE Mrs. F. S., a Jewess, aged 39, was first seen in August, 1925, when she complained of hives of seven weeks' duration. The family history was negative for allergic disturbances. The past history revealed no serious illness. The menses were normal. The patient had never been pregnant. She had suffered from constipation as long as she could remember. She had been nervous for three months owing to domestic difficulties, which, however, had been satisfactorily settled. General physical examination and examination of the urine and stools gave negative results. The blood count, blood sugar and blood urea nitrogen were normal. A dental x-ray film demonstrated an abscess of one tooth, which was extracted. Gynecologic examination revealed a fibroid tumor of the uterus, to which no great attention was paid at the time. A complete series of food tests (scratch method) was made, with no definite results. References 1. Horton, B. T., and Brown. S. E.: Am. J. M. Sc. 178:191, 1929.Crossref 2. Blackford, L. M.: Cold Urticaria and Histamine Allergy; Report of a Case , J. A. M. A. 96:525 ( (Feb. 14) ) 1931.Crossref 3. Weiss, E.: J. Allergy, to be published.

LEVIN, OSCAR L.;SILVERS, SEYMOUR H.

1932 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1932.01450020851006

Abstract During the past few years, laboratory research in the physiology and chemistry of the skin has yielded important results. The close alliance between physiologic chemistry and clinical dermatology has been demonstrated, and it is probable that more knowledge of this alliance will have great influence in bringing about an understanding of various skin conditions that are now, for the most part, incomprehensible. Investigators have been especially interested in the reaction and secretions of the skin in health and disease. It has been shown that an altered reaction affects the skin as a medium and may favor the growth and multiplication of saprophytic and pathogenic organisms. The result is naturally injurious and may even be accompanied by changes in the morphology of the skin cells. But it is difficult and at times impossible to determine when the changes in the reaction of the skin or skin surface are primary, causing References 1. Michaelis, L., and Kramstyk, A.: Die Wasserstoffionenkonzentration der Gewebssäfte , Biol. Zentralbl. 62:180, 1914. 2. Schade, H.; Neukirch, P., and Halpert, A.: Ueber lokale Acidose des Gewebes und die Methodik ihrer intravitalen Messung , Ztschr. f. d. ges. exper. Med. 24:11, 1921.Crossref 3. Unna, P. G., and Golodetz, L.: Zur Chemie der Haut: VI. Hautreagenzien , Monatsh. f. prakt. Dermat. 50:451, 1910. 4. Rothman, S.: Die aktuelle Reaktion der Haut , in Jadassohn : Handbuch der Haut- und Geschlechtskrankheiten , Berlin, Julius Springer, 1929, vol. 1, p. 325. 5. Schmidtmann, M.: Ueber die intracelluläre Wasserstoffionenkonzentration unter physiologischen und einigen pathologischen Bedingungen , Ztschr. f. d. ges. exper. Med. 45:714, 1925.Crossref 6. Yamasaki, Y.: Ueber die Fermente der Haut , Biochem. Ztschr. 147:203, 1924. 7. Hayashi, Hirokichi: Experimentelle Studien über die Empfindlichkeit der Haut gegen äussere Reize , Jap. J. M. Sc. Tr. Sect. XIII, Dermat. 1:95, 1927; 8. Zentralbl. f. Haut- u. Geschlechtskr. 34:682, 1930. 9. Meineri, P. A.: Il pH di estratti di cute eczematosa e psoriasica , Dermosifilografo 5:73, 1930; 10. Zentralbl. f. Haut- u. Geschlechtskr. 34:682, 1930. 11. Crosti, A.: Ricerche su alcune proprietà fisico-chimiche del sangue e degli essudati cutanei in dermatosi , Gior. ital. di dermat. c sif. 70:1063, 1929; 12. Zentralbl. f. Haut- u. Geschlechtskr. 34:682, 1930. 13. Bazett, H. C., and McGlone, B.: The Effect of Temperature on the Acidity of the Skin , J. Physiol. 64:393, 1928. 14. Liechti, A.: Ueber Reaktionsänderungen im Röntgenstrahlen Gewebe , Klin. Wchnschr. 4:1911, 1926.Crossref 15. Kaplansky, S., and Soloweitschik, S.: Ueber die Wirkung ultravioletter und Röntgenstrahlen auf die aktuelle Reaktion der Haut , Ztschr. f. d. ges. exper. Med. 55:111, 1927.Crossref 16. Gans, O.: Ueber die biologische Wirkung und die Angriffspunkte dei Röntgenstrahlen , Arch. f. Dermat. u. Syph. 155:64, 1928.Crossref 17. Memmesheimer, A.: Die H-ion Konzentration der Hautoberfläche , Klin. Wchnschr. 3:2102, 1924.Crossref 18. Keller, P.: Die biologischen Grundlagen für die elektrischen Potentiale der Haut , Arch. f. Dermat. u. Syph. 160:136, 1930.Crossref 19. Sharlit, H., and Scheer, M.: The Hydrogen-Ion Concentration of the Surface of the Healthy Intact Skin . Arch. Dermat. & Syph. 7:592 ( (May) ) 1923. 20. Lloyd, Arnold; Gustafson, C. J.; Hull, T. G.; Montgomery, B. E., and Singer, Charlotte: The Self-Disinfecting Power of the Skin as a Defense Against Microbic Invasion , Am. J. Hyg. 11:345, 1930. 21. Talbert, G. A.: Effect of Work and Heat on the Hydrogen-Ion Concentration of the Sweat , Am. J. Physiol. 50:433, 1919; 22. Further Studies on the Hydrogen-Ion Concentration of Human Sweat , Talbert Am. J. Physiol. 61:493, 1922. 23. Schade, H., and Marchionini, A.: Der Sauremantel der Haut , Klin. Wchnschr. 7:12, 1928;Crossref 24. Zur physikalischen Chemie der Hautoberfläche , Arch. f. Dermat. u. Syph. 154:690, 1928.Crossref 25. Marchionini, A.: Physikalisch-Chemische Untersuchungen über ekkrinen und apokrinen Schweiss , Schweiz. med. Wchnschr. 58:1055, 1928; 26. Untersuchungen über die Wasserstoffionenkonzentration der Haut , Arch. f. Dermat. u. Syph. 158:290, 1929.Crossref 27. Brill, E.: Ueber den Säuregehalt des menschlichen Schweisses bei Haut-Kranken und Hautgesunden , Arch. f. Dermat. u. Syph. 156:488, 1928.Crossref 28. Scholtz, W.: Ueber Säure Behandlungen von Hautkrankheiten , Klin. Wchnschr. 9:1670, 1930.Crossref 29. Lustig, B., and Perutz, A.: Ueber ein einfaches Verfahren zur Bestimmung der Wasserstoffionenkonzentration der normalen menschlichen Haut-Oberfläche , Arch. f. Dermat. u. Syph. 162:129, 1930.Crossref 30. Perutz, A., and Lustig, B.: Ueber die Wasserstoffionenkonzentration der Hautoberfläche und ihre Regulation bei Dermatosen , Arch. f. Dermat. u. Syph. 163:18, 1931.Crossref

SCHOCH, ARTHUR G.

1932 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1932.01450020861007

Abstract Wright1 was probably the first to use calcium therapy in dermatology thirty-five years ago in the treatment for urticaria. Since then calcium therapy has been widely used in the treatment for urticaria, eczema and dermatitis. There seems to be fairly general agreement that calcium therapy is of distinct value in the treatment for certain dermatoses. Nearly all of the favorable results reported are based on clinical evidence. Attempts to demonstrate the mode of action of calcium in animals, as well as attempts to show calcium deficiencies in patients with urticaria and dermatitis, have, for the most part, been unsuccessful. The futility of seeking a relation between minor fluctuations of serum calcium values and inflammations of the skin in patients has been demonstrated by Klauder and Brown,2 Schamberg and Brown,3 Brown and Greenbaum,4 Nathan and Stern5 and others. In the studies of Luithlen,6 References 1. Wright, A. E.: Notes on Two Cases of Urticaria Treated by the Administration of Calcium Chloride , Brit. J. Dermat. 8:82, 1896.Crossref 2. Klauder, J. V., and Brown, Herman: Experimental Studies in Eczema: I. Study of the Sensitivity of the Skin of Rabbits to Chemical Irritants under Experimentally Induced Conditions , Arch. Dermat. & Syph. 11:283 ( (March) ) 1925; 3. II. A Correlation of the Chemistry with the Irritability of the Skin of Animals under Normal and under Experimentally Induced Conditions , Klauder Arch. Dermat. & Syph. 15:1 ( (Jan.) ) 1927; 4. III. The Rate of the Sympathetic Nervous System and Calcium-Potassium Ratio in Altering Cutaneous Irritability in the Rabbit , Klauder Arch. Dermat. & Syph. 19:52 ( (Jan.) ) 1929; 5. IV. A Correlation of Potassium-Calcium Ratio in the Serum and in the Skin of Rabbits with the Irritability of the Skin , Klauder Arch. Dermat. & Syph. 20:326 ( (Sept.) ) 1929; 6. V. Studies of the Potassium, Total and Diffusible Calcium Ratios in Blood of Patients with Diseases of the Skin , Klauder Arch. Dermat. & Syph. 22:877 ( (Nov.) ) 1930. 7. Schamberg, J. F., and Brown, Herman: A Study of Inorganic Salts in the Blood in Psoriasis and Certain Other Dermatoses , Arch. Dermat. & Syph. 9:368 ( (March) ) 1924. 8. Brown, Herman; and Greenbaum, S. S.: Blood Calcium Distribution in Urticaria , Brit. J. Dermat. 42:183 ( (April) ) 1930. 9. Nathan, E., and Stern, F.: Ueber Kalium und Calciumschwankungen im Blutserum bie Dermatosen ; Arch. f. Dermat. u. Syph. 156:446, 1928. 10. Luithlen, F.: Tierversuch über Hautreaction , Wien. klin. Wchnschr. 24: 703, 1911. 11. Januschke, H.: Ueber Entzündungshemmund , Wien. klin. Wchnschr. 26: 869, 1913. 12. Cantarow, A., and Gordon, B.: The Effect of Parathyroid Extract on Certain Factors Underlying the Production of Edema , Arch. Int. Med. 42:939 ( (Dec.) ) 1928. 13. Jones, J. H.: Rapaport, M., and Hodes, H. L.: The Source of Excess Calcium in Hypercalcemia Induced by Irradiated Ergosterol , J. Biol. Chem. 89:647 ( (Dec.) ) 1930. 14. Clark, E. P., and Collip, J. B.: A Modification of the Serum Calcium Method of Tisdall , J. Biol. Chem. 63:461, 1925. 15. Mead Johnson & Company supplied the irradiated viosterol used in this study.

KING, ALLEN D.

1932 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1932.01450020866008

Abstract There are features of certain dermatoses which indicate that local alterations of cutaneous circulation may be concerned in their etiology. This paper contains the investigative study of the cutaneous circulation in three of these conditions, namely, epidermophytosis of the feet, alopecia areata and scleroderma. The work is based on the urticarial reaction of the skin to histamine applied intradermally, and the results are compared with those obtained from one hundred normal control cases. The histamine wheal was first reported by Eppinger1 in 1913. It was studied further by Sollmann and Pilcher2 in 1917. Dale and Richards3 made an extensive investigation of the pharmacologic action of histamine, and concluded that it caused dilatation of the capillaries by decreasing the tone of these vessels. Lewis4 very ingeniously has shown that the normal skin gives a constant reaction to histamine, characterized by the formation of a central wheal References 1. Eppinger, H.: Wien. med. Wchnschr. 23:1414, 1913. 2. Sollmann and Pilcher: J. Pharmacol. & Exper. Therap. 9:309 ( (March) ) 1917. 3. Dale and Richards: J. Physiol. 52:110 ( (July) ) 1918. 4. Lewis, T.: Blood Vessels of Human Skin and Their Responses , London, Shaw & Sons, Ltd., 1927. 5. Harris, K. E.: Heart 14:161 ( (Dec.) ) 1927. 6. Jones. T. D.: Heart 14:339 ( (March) ) 1929. 7. Starr, I., Jr.: Change in the Reaction of the Skin to Histamine , J. A. M. A. 90:2092 ( (June 30) ) 1928; 8. Am. J. M. Sc. 180:149 ( (Aug.) ) 1930. 9. Caldwell, J. M., and Mayo, J. G.: Cutaneous Reactions to Histamine , Arch. Int. Med. 47:403 ( (March) ) 1931. 10. Rondelli, U.: Minerva med. 8:850 ( (Dec. 8) ) 1928. 11. Roxburgh, A. C.: Brit. J. Dermat. 41:351 ( (Oct.) ) 1929.

WILLIAMS, CHARLES M.;CARPENTER, CEDRIC C.

1932 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1932.01450020873009

Abstract The active principle of the pathogenic fungi in the skin was first isolated by Scholtz1 in 1918. Until recently the use of this extract has been limited to those who had the necessary facilities for its preparation, but since 1929, it has been obtainable from commercial laboratories. The purpose of this paper is to study, by means of the intradermal skin test, the accuracy of the product in the diagnosis of dermatomycoses of the glabrous skin. False positive reactions of the skin are obtained in a high percentage of patients tested with extract contaminated by bacteria. Doctors Goodman and Litterer first demonstrated such results in the pathological laboratory of the Stuyvesant Square Hospital, and the fact has been fully confirmed in this series of cases. In most pseudopositive reactions, the skin responds with a marked local reaction, consisting of a large erythematous area surrounded by References 1. Scholtz, W.: Ueber die diagnostische und therapeutische Anwendung des Trichophytin Hochst , München. med. Wchnschr. 65:509, 1918. 2. Darier, J.: Précis de dermatologie , Paris, Masson & Cie, 1928, p. 732. 3. MacKee, G. M., and Lewis, G. M.: Keratolysis Exfoliativa and the Mosaic Fungus , Arch. Dermat. & Syph. 23:445 ( (March) ) 1931. 4. von Graffenried, C. R.: Dermat. Wchnschr. 6:361 ( (May 25) ) 1918. 5. Peck, S. M.: Epidermophytosis of the Feet and Epidermophytids of the Hands , Arch. Dermat. & Syph. 22:43 ( (July) ) 1930. (Reported on chart.) 6. Sulzberger, M. B., and Kerr, P. S.: Hypersensitiveness of Urticarial Type with Circulating Antibodies and Passive Transference , J. Allergy 2:11 ( (Nov.) ) 1930. 7. Wise, F., and Sulzberger, M. B.: Urticaria and Hay Fever Due to Trichophytin , J. A. M. A. 95:1504 ( (Nov. 14) ) 1930. 8. Ramirez, M. A.: Sensitization Case , M. J. & Rec. 132:382 ( (Oct. 15) ) 1930. 9. Peck (footnote 5, p. 74). 10. Goodman, H.: Tinea: The Second Most Prevalent Disease of the Skin , Arch. Dermat. & Syph. 23:873 ( (May) ) 1931. 11. Van Dyck, L. S.; Kingsbury, J.; Throne, B., and Myers, C. N.: Use of Trichophytin as a Diagnostic and Therapeutic Agent in Mycotic Infections of the Skin , New York State J. Med. 31:611, 1931.

GILMAN, ROBERT L.;WEIDMAN, FRED D.

1932 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1932.01450020878010

Abstract The fact that during pregnancy a hormone is eliminated in the urine naturally prompts thoughts to other secretions such as the saliva, sweat glands, etc. The last named are such remarkably efficient agents in preventing the elimination of certain body products and drugs1 that the opportunity must not be lost when presented to inquire whether this extends also to hormones, particularly since the presence or absence of this hormone has been made so unequivocal of late and been so whole-heartedly accepted as a diagnostic test for pregnancy. TECHNIC Perspiration was collected in a rubber sheet from six colored women, all in the eighth to ninth month of pregnancy, by means of the electric light cabinet. A vulvar pad was applied to prevent possible contamination of materials by urine. Abundance of water was urged on the subjects, but no drugs were administered. As 100 cc. of perspiration suffices for a References 1. Schaffer, H. W.: Studies of Perspiration: I. Bismuth , Arch. Dermat. & Syph. 22:624 ( (June) ) 1930. 2. Friedman, M. H., and Lapham, M. E.: Simple Rapid Procedure for the Laboratory Diagnosis of Early Pregnancies , Am. J. Obst. & Gynec. 21:405 ( (March) ) 1931.

MADDEN, JOHN F.

1932 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1932.01450020880011

Abstract Acute disseminated lupus erythematosus may be defined as an exanthematous acute disease that is characterized by the development of an erysipelas-like facial erythema and profound constitutional symptoms. In its course signs appear that have enough similarity to those of discoid lupus erythematosus to relate the syndrome definitely to the latter condition. HISTORY The disease was first described by Kaposi1 in 1872. He observed a series of patients who had fever and severe toxic symptoms associated with cutaneous lesions that resembled those of erysipelas, and accordingly called the disease erysipelas perstans faceii. After prolonged observation he discovered that in some cases signs of chronic lupus erythematosus developed, and also that the reverse was true. He therefore definitely established the relationship of the two rather diverse dermatoses. In the next twenty-five years many keen observers reported cases that confirmed Kaposi's observations. Prominent among these were Hardaway,2 Hallopeau, References 1. Kaposi, M.: Neure Beiträge zur Kenntniss des Lupus Erythematosus , Arch. f. Dermat. u. Syph. 4:36, 1872.Crossref 2. Hardaway: J. Cutan. Dis. 7:447, 1889; 3. 10:268, 1892. 4. Hallopeau: Wickham's Paris Letter , Brit. J. Dermat. 4:123, 1892.Crossref 5. Koch: Arch. f. Dermat. u. Syph. 37:39, 1896.Crossref 6. Cavafy: Brit. J. Dermat. 9:328, 1897. 7. Boeck: Brit. J. Dermat. , vol. 10, (Sept.) , 1898; 8. Boeck Brit. J. Dermat. 10, (Oct.) , 1898; 9. Arch. f. Dermat. u. Syph. 42:71, 1898;Crossref 10. Tr. Fourth Internat. Dermat. Cong. , Paris, 1900, p. 188. 11. Sequeira, J. H., and Balean, H.: Lupus Erythematosus, a Clinical Study of Seventy-One Cases , Brit. J. Dermat. 14:366, 1902.Crossref 12. Pernet, George: Le lupus erythémateux aigu d' emblée, Thèse de Paris, 1908. 13. Ehrmann, S., and Falkenstein, F.: Ueber Lupus erythematodes , Arch. f. Dermat. u. Syph. 141:408, 1922.Crossref 14. Brown, G. A.: New York M. J. 106:931 ( (Nov. 17) ) 1917. 15. Goeckerman, W. H.: Lupus Erythematosus as a Systemic Disease . J. A. M. A. 80:542 ( (Feb. 24) ) 1923.Crossref 16. Keefer. C. S., and Felty, A. R.: Acute Disseminate Lupus Erythematosus: Report of Three Fatal Cases . Bull. Johns Hopkins Hosp. 35:294 ( (Sept.) ) 1924. 17. Scholtz, M.: Lupus Erythematosus Acutus Disseminatus Hemorrhagicus , Arch. Dermat. & Syph. 6:466 ( (Oct.) ) 1922. 18. Veiel, F.: Lupus erythematodes acutus , in Jadassohn, J.: Handbuch der Haut- und Geschlechtskrankheiten , Berlin, Julius Springer, 1931, vol. 10, pt. (1) , p. 705. 19. Sibley, W. K., and Wynn, W. H.: Fatal Case of Lupus Erythematosus Disseminatus , Brit. J. Dermat. 35:323 ( (Aug.) -Sept.) 1923. 20. Gibson, F.: Fatal Case of Lupus Erythematosus, with Postmortem , Brit. J. Dermat. 37:232, 1925. 21. Low; Logan and Rutherford: A Fatal Case of Lupus Erythematosus with Autopsy , Brit. J. Dermat. 32:253, 1920. 22. Seminario, C., and Pessano, J.: Acute Lupus Erythematosus: Four Cases , Semana méd. 2:721 ( (Sept. 4) ) 1930. 23. Lewandowsky, F.: Die Tuberkulose der Haut , Berlin, Julius Springer, 1916. 24. Reitmann, K., and von Zumbusch, L.: Beitrag zur Pathologie des Lupus erythematodes acutus (disseminatus) , Arch. f. Dermat. u. Syph. 99:147, 1910. 25. Gennerich, Wilhelm: Ueber die Aetiologie des Lupus erythematodes , Arch. f. Dermat. u. Syph. 135:184, 1921. 26. Grütz, O.: Beiträge zur Klinik und Histologie des Lupus erythematodes acutus , Arch. f. Dermat. u. Syph. 147:524, 1924. 27. Sundt, H.: A Case of Lupus Erythematosus with Acute Exacerbation and the Appearance of Erysipelas and Phlegmon Capitis Followed by Death, with Negative Postmortem Findings as Regards Tuberculosis , Brit. J. Dermat. 38:273, 1926. 28. Wail, S. S.: Pathogenesis and Pathologic Anatomy of Acute Lupus Erythematosus , Arch. f. Dermat. u. Syph. 161:43, 1930.Crossref 29. Bloch, B., and Ramel, E.: Lupus Erythematodes and Tuberculosis , Schweiz. med. Wchnschr. 32:723, 1924. 30. Brooke, H. G.: Lupus Erythematosus and Tuberculosis , Brit. J. Dermat. 7:73, 1895.Crossref 31. Roberts, L.: Acute Lupus Erythematosus (aigu d' emblée) , Brit. J. Dermat. 33:167, 1911. 32. Gardiner, F.: Lupus Erythematosus , Edinburgh M. J. 30:233, 1923. 33. Stokes, J. H.: Diagnosis of Disseminate Erythematous Lupus , M. Clin. North America 10:290 ( (Sept.) ) 1926. 34. Stümpke, G.: Zur Aetiologie des Lupus erythematodes , Dermat. Wchnschr. 82:289, 1926. 35. Ravogli, A.: Lupus Erythematosus Diffusus Unfortunately Treated with Tuberculin . J. Cutan. Dis. 33:266, 1915. 36. Kren, O., and Löwenstein, E.: Zur Pathogenese der Tuberkulide , Dermat. Wchnschr. 92:594 ( (April 18) ) 1931. 37. Pulay, E.: Stoffwechselpathologie und Hautkrankheiten , Dermat. Wchnschr. 73:1217, 1921. 38. Calmette, A., and Valtis, T.: Filtrable Elements of Tuberculosis Virus , Ztschr. f. Tuberk. 58:402 ( (Nov.) ) 1930. 39. von Zumbusch, L.: Zur Aetiologie des Lupus erythematodes , Arch. f. Dermat. u. Syph. 149:136, 1925.Crossref

MONASH, SAMUEL

1932 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1932.01450020902012

Abstract I have found no record of a systematic study of pigmentation of the nails in the Negro. Heller,1 in his comprehensive work on the nails, referred principally to communications on this subject by Ochs2 and Templeton.3 Ochs' patient was a Negress, 37 years old, who had on all the finger-nails parallel, pigmented. longitudinal stripes, which were present from birth. Templeton3 described a pigmented longitudinal stripe occurring on the nail of the fourth finger of the left hand in a Negress of 28. It had been noticed first as a dark spot near the root of the nail nine years before, and had gradually extended out toward the free edge, increasing somewhat in width in the last two years. The pigment was shown to be in all probability melanin, and Templeton considered the pigmented stripe a nevus. He stressed the rarity of the condition, for which reason References 1. Heller, J.: Krankheiten der Nagel , Berlin. Julius Springer. 1927. 2. Ochs, B. F.: J. Cutan. Dis. 32:238, 1914. 3. Templeton, H. J.: Pigmented Stripe in the Nail , Arch. Dermat. & Syph. 14:533 ( (Nov.) ) 1926. 4. Todd, T. W., and van Gorder, L.: Am. J. Phys. Anthropol. 4:244, 1921. 5. Barnes, I.: Human Biol. 1:321, 1929.

TAUSSIG, LAURENCE

1932 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1932.01450020908013

Abstract The symptom complex that was first designated poikiloderma atrophicans vasculare by Jacobi in 19071 is an unusual condition. A number of cases have been presented at various dermatological meetings in this country and in Europe. In nearly every instance a controversy developed as to whether the condition was entitled to a special classification or whether it was simply an unusual form of one of the more common skin conditions. The rarity of the disease and its controversial status induced me to report a typical and well developed case. The patient was shown at the meeting of the San Francisco Dermatological Society on Oct. 10, 1930, and the diagnosis was concurred in by those present. REPORT OF A CASE History.—D. McG., a boatman, aged 53, entered the Marine Hospital at San Francisco for treatment for an ulcerated area that had developed on the inner surface of References 1. Jacobi, E.: Fall für Diagnose (Poikilodermia atrophicans vascularis) , Verhandl. d. deutsch. dermat Gesellsch., IX Kongress, Bern, 1906 , 9:321, 1907. 2. Lane, John E.: Poikiloderma Atrophicans Vasculare , Arch. Dermat. & Syph. 4:563 ( (Nov.) ) 1921. 3. Lane, John E.: Poikiloderma Atrophicans Vasculare , Arch. Dermat. & Syph. 8:373 ( (Sept.) ) 1923. 4. Petges, G., and Petges, A.: Poïkilodermatomyosite dans la jeunesse et l'enfance , Ann. de dermat. et syph. 1:441, 1930. 5. Civatte, A.: Poikilodermie reticulée pigmentaire du visage et du cou , Ann. de dermat. et syph. 4:605, 1923. 6. Jacobi, E.: Poikilodermia atrophicans vascularis , Ikonographia Dermatologica , 1908, no. (3) , p. 95. 7. Petges and Cléjat: Sclérose atrophique de la peau et myosite généralisée , Ann. de dermat. et syph. 7:550, 1906. 8. Rottmann, H. G.: Ueber Poikilodermia atrophicans vascularis (Jacobi) mit bemerkenswerter Nebenbefunden , Arch. f. Dermat. u. Syph. 153:747, 1927. 9. Jaffé, Kaete: Zwei Fälle von Sklero-Poikilodermie , Arch. f. Dermat. u. Syph. 159:257, 1930.

FRIED, S. M.;ORLOV, S. S.

1932 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1932.01450020919014

Abstract The morphologic identity of Spirochaeta pallida and Spirochaeta cuniculi and the resemblance between the processes caused by these micro-organisms, respectively, in the animal body cast a shadow of doubt, at the very beginning, on the value of the results obtained from the study of experimental syphilis in the rabbit. More than that, they have led Arzt and Kerl, Klarendon and Simon and others to the belief that the existence of a spontaneous spirochetosis in the rabbit makes this animal altogether useless for the study of experimental syphilis. However, the majority of investigators (Jacobstahl, Kolle, Mulzer, Uhlenhuth and others), basing their results on comparative studies of spontaneous spirochetosis and of experimental syphilis, have expressed the opinion that in spite of the morphologic resemblances of both strains, the contrast of the diseases that they cause respectively is rather sharp, and the margin of error in their discrimination is practically nil.

COMBES, FRANK C.

1932 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1932.01450020932015

Abstract The annular macular syphilid, or the neurosyphilid of Unna, is one of the rarer manifestations of syphilis, and, oddly, one that is alluded to in only a few of the textbooks on dermatologic practice. The first case to be presented before a dermatologic society in this country was by Howard Fox1 in 1917. The case herein presented agreed in its various manifestations with those previously described, but showed also some unusual lesions of the genitals. Insufficient treatment for early syphilis is responsible for the reappearance of secondary cutaneous symptoms. These relapsing roseolas may recur several times during the first few years of the disease. Harttung2 mentioned one patient, treated with mercury, in whom the syphilid recurred five times in three years, disappearing after each recurrence. Fournier3 reported a case in which a relapse occurred eight times in four years. The purpose of this communication is to References 1. Fox, Howard: The Annular Macular Syphilide, or So-Called Neurosyphilide , J. Cutan. Dis. 25:215 ( (April) ) 1917. 2. Harttung: Beitrag zur Kenntnis der wiederkehrenden makulösen Syphilide , Arch. f. Dermat. u. Syph. 43:307, 1898.Crossref 3. Fournier, A.: Roséoles syphilitiques à récidives multiples , Ann. de dermat. et syph. 7:1141, 1896. 4. Mauriac, C.: Leçons sur les maladies vénériennes , Paris, J. B. Baillière et fils, 1883, p. 523. 5. Jullien, L.: Traité pratique des maladies vénériennes , Paris, J. B. Baillière et fils, 1899, p. 701. 6. Souplet, M.: Sur un cas d'érythème circiné tertiaire , Ann. de dermat. et syph. 3:1151, 1892. 7. Brauman, J.: De l'érythème circiné tertiaire, Annales de la syphilis, Thèse de Paris, 1891. 8. Leistikow, L.: Zur Therapie der Neurosyphilid , Monatsh. f. prakt. Dermat. 18:177, 1894. 9. Neilsen, L.: Circinäre syphilitische Erythema (Neurosyphilide-Unna) , Monatsh. f. prakt. Dermat. 22:500, 1896. 10. von Zeissl, M.: Roseolarecidiv 29 Jahre nach der Infection; 3 Fälle von Mastdarmsyphilis , Wien. med. Presse 34:82, 1893. 11. Taylor, R. S.: A Practical Treatise on Genito-Urinary and Venereal Diseases , ed. 3, New York, Lea Bros. & Company, 1904, p. 542. 12. Shillitoe, A.: A Case of Circinate Erythematous Syphilide , Proc. Roy. Soc. Med. (Sect. Dermat.) 1:21, 1907-1908. 13. Abraham, P. S., and Davis, IL, in Power and Murphy: A System of Syphilis , New York, Oxford University Press, 1910, vol. 5, p. 38. 14. Rothwell, J. J.: Annular Macular Syphilis , J. Cutan. Dis. 36:395 ( (July) ) 1918. 15. Stokes, J. H.: Modern Clinical Syphilology , Philadelphia, 1927, p. 472. 16. Buschke, A., in Riecke: Lehrbuch der Haut- und Geschlechtskrankheiten , Jena, Gustav Fischer, 1914, p. 658. 17. Fox, G. H.: J. Cutan. Dis. 21:234 ( (April) ) 1913. 18. Fournier, A., in discussion of Souplet (footnote 6). 19. Unna, P.: Neurosyphilides et neuroléprides , J. d. mal. cutan. et syph. , (August) -September, 1889, vol. 1. 20. Wickham: Correspondence , Monatsh. f. prakt. Dermat. 5:464, 1891. 21. Freund, E.: Gior. ital. di dermat. e sif. 66:1248 ( (Aug.) ) 1925. 22. Unna, P.: Histopathology of the Diseases of the Skin , translated by Norman Walker, Edinburgh, W. F. Clay, 1896, p. 124. 23. Hardy, A.: Maladies de la peau , Paris, A. Delahaye, 1858, p. 154. 24. Quinquard, in discussion of Souplet (footnote 6). 25. Vidal, in discussion of Souplet (footnote 6). 26. Bazin, A. P. E.: Leçons théoriques et cliniques sur la syphilis et les syphilides , Paris, A. Delahaye, 1866, p. 282. 27. Bassereau: Traité des affections de la peau symptomatiques de la syphilis . Paris, J. B. Baillière et fils, 1852.

BECKER, S. WILLIAM;PAUTRIER, L. M.;WORINGER, F.

1932 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1932.01450020941016

Abstract Neroderma pigmentosum is a well known condition, concerning which an extensive literature has accumulated. In recent years, the cases have been studied from the functional standpoint, as regards both cutaneous hypersensitiveness and pigmentary disturbance. Martenstein1 studied a patient, and found hypersensitiveness to ultraviolet, alpha and roentgen rays. No sensitivity was elicited to infrared and visible rays or to chemical irritants. In a second patient, Martenstein and Bobowitsch2 found hypersensitiveness to all types of rays. Juon3 found hypersensitiveness to ultraviolet and roentgen rays. That the pigmentation is merely a secondary phenomenon is suggested by the case reported by Audry.4 A man, aged 24, with an inoperable carcinoma of the lower lip, was seen. The skin presented the marked changes found in xeroderma pigmentosum, namely, atrophy and telangiectasia. The condition had been present since infancy. The hair was brown. No pigment, crust or verrucae were seen. References 1. Martenstein, H.: Experimentelle Untersuchungen über Strahlungempfindlichkeit bei Neroderma pigmentosum , Arch. f. Dermat. u. Syph. 147:499, 1924.Crossref 2. Martenstein, H., and Bobowitsch: Ueber Strahlenempfindlichkeit bei Xeroderma pigmentosum (Untersuchungen an einem weiteren Fall) , Arch. f. Dermat. u. Syph. 150:165, 1926.Crossref 3. Juon, M.: Beitrag zu den experimentellen Untersuchungen über Strahlenempfindlichkeit bei Xeroderma pigmentosum , Arch. f. Dermat. u. Syph. 156:367, 1928.Crossref 4. Audry, C.: Sur un cas de xeroderma pigmentosum sans pigmentation , Ann. de dermat. et syph. 8:199, 1907. 5. Bertaccini, G.: Xeroderma pigmentoso, richerche, cliniche esperimentali , Gior. ital. di dermat. e sif. 68:1152, 1927; 6. Nuovo osservazioni sopra un caso di xeroderma pigmentoso , Bertaccini Gior. ital. di dermat. e sif. 70:3, 1929.

TULIPAN, LOUIS

1932 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1932.01450020951017

Abstract Since the advent of the patch test in determining cutaneous susceptibility to external irritants, many substances have been added to the list of proved causes of dermatitis. An examination of the literature1 concerning dermatoses from external irritants revealed no mention of cinnamon as a possible cause. The following case is presented as a dermatitis due to cinnamon. REPORT OF A CASE E. G., a white man, aged 33, was seen with an eruption on the hands. He had been a baker for nineteen years and had had an eruption on his hands only once before, seven years prior to examination, which had healed spontaneously after three weeks. His duties consisted in preparing the dough and icing for pies and cakes, as well as their final baking. Four days before the onset of the eruption, he had changed his position, although his duties were the same. On examination, about References 1. White, R. Prosser: The Dermatergoses or Occupational Affections of the Skin , New York, Paul B. Hoeber, Inc., 1929. 2. Weber, L.: A List of Cutaneous Irritants , Arch. Dermat. & Syph. 21:757 ( (May) ) 1930. 3. List of Irritating Plants in the United States , Compiled by Bureau of Plant Industry. Department of Agriculture, (March) , 1923. 4. White, C. J.: Boston M. J., 1897, p. 78; quoted by White, R. P. (footnote 1). 5. Wood, A. G.: Food Analysis . New York, McGraw-Hill Book Company, Inc., 1915, p. 34.

Rattner, Herbert

1932 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1932.01450020954018

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.

1932 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1932.01450020970019

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.

Ebert, Michael H.

1932 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1932.01450020971020

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract MultipleBenignEpithelioma of the Scalp. Presented by Dr. A. W. Stillians. An American woman of Polish descent, aged 42, first noticed growths on the scalp eighteen years before presentation. Since then they had slowly increased in number and size. Within the last few years they had appeared in small numbers on the trunk; later many small papules had appeared on the face. There was slight tenderness at times, which increased after injury to the tumors. Intense roentgenotherapy had been given over the left frontal region, leaving a large scar with a small central ulcer, still open, although the last irradiation had been given in May, 1931. The top of the scalp was thickly covered with more or less pedunculated tumors, red because of telangiectases on their surfaces, ranging in size from a few millimeters to over 2 cm. in diameter and elevated as much as 1.5 cm. Some of

Van Studdiford, M. T.

1932 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1932.01450020979021

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract HerpesZoster: Pyoderma, Acute. Presented by Dr. T. A. Maxwell, New Orleans. P. S., a white woman, aged 50, stated that for the two weeks before presentation she had suffered from pain in the thigh and sacrum. This was followed by a vesiculopustular eruption grouped in a linear strip over the left thigh and extending to the upper third part of the leg. DISCUSSION Dr.Oliver S. Ormsby, Chicago: The patient had lesions that resembled herpes zoster on one side. There is a point I wish to emphasize about zoster that I have found to be of diagnostic value. True herpes zoster always has, in the early stages, an associated glandular involvement which is an important corroborative symptom. For example, when there is a localized herpetic eruption not typical of zoster situated on the foot, leg or elsewhere, if an accompanying painful gland is found, it would aid

Rosenthal, Theodore;Silver, Henry

1932 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1932.01450020993022

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract Lymphoblastoma (AleukemiLeukemia). Presented by Dr. S. Feldman. A. T., a white man, aged 57, with an irrelevant personal history, about six weeks before presentation, noticed small reddish masses on his chest and back. Four weeks later a sore throat, with difficulty in swallowing, developed and he became gradually weaker. On examination there were bluish nodules, ranging in size from that of a penny to that of a half dollar, that were movable with the skin. Examination of the blood showed: white blood cells, 2,400; red blood cells, 1,800,000; hemoglobin, 30 per cent; polymorphonuclears, 24 per cent, and lymphocytes, 76 per cent. There were several abnormal forms, including lymphoblasts. The biopsy revealed round cell infiltration of the middle and lower layers of the corium and subcutis. The cells were uniform in size and shape and were packed closely with very few fibers between. The cells approached closely the type

Maloney, E. R.;Fraser, J. F.

1932 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1932.01450020997023

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract A Case for Diagnosis (LichenPlanus). Presented by Dr.John E. Lane. J. A., a man, aged 33, presented a generalized, slightly scaly erythroderma of two months' duration. A few clear pea-sized vesicles had appeared occasionally. The inguinal, axillary and cervical glands were moderately enlarged. The blood count was normal, and the Wassermann reaction was negative. There was some lichenification but no papules typical of lichen planus. DISCUSSION Dr. E. F. Traub: The patient presented definite lichenified papules on the penis, and scattered throughout the entire eruption there seemed to be characteristic lichen-like papules. Owing to the scratching, this condition might be interpreted as lichenification, but some of the papules seemed to be entirely independent of the lines of cleavage of the skin; a distinct violaceous color with the suggestion of milky striation was also present. I should think that lichen planus would have to be ruled out. Dr. W.

1932 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1932.01450021009025

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract This book is really not a treatise on the fundamentals of dermatology but a synopsis of dermatology, and is a good example of this sort of manual. It gives accurately, but in bare outline, the pictures of cutaneous diseases, and its usefulness, like all such manuals, must be chiefly in diagnosis. One cannot get an intelligent picture of any cutaneous disease from so brief a description, and such a book must be supplemented by a larger work to which the puzzled reader may refer after he thinks he has located the disease in which he is at the moment interested. Schalek has done his job well, but the question must be raised as to the value of such brief synopses, except perhaps in cramming for an examination.

1932 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1932.01450021009024

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract This is an excellent work by a pediatrician on the subject of infantile eczema and allied dermatoses. The first section of 50 pages is devoted to clinical considerations, with case reports and photographic illustrations of intertriginous dermatitis, seborrheic dermatitis, psoriatic dermatitis, erythroderma, erythroderma desquamativa of Leiner and the various clinical types of eczema. These dermatoses are lucidly presented and differentiated in an original manner, and the subjects of crusta lactea, erythroderma desquamativa of Leiner and neurodermatitis are particularly well discussed. In the next section of 120 pages on pathogenesis, more than 50 pages are devoted to the consideration of infantile eczema as an allergic phenomenon, with alimentary allergy predominant, and the important antigens are discussed. Eczema is also considered at times a vasomotor reflex neurosis activated by local external irritation, and at times as the exhibition of a diathesis, a nutritional disturbance or a metabolic disorder. The tendency

1932 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1932.01450021010026

1932 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1932.01450021013027

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.