Archives of Dermatology and Syphilology

STOKES, JOHN H.;SCHOCH, ARTHUR G.;IRELAND, FRANKLIN A.

1931 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1931.03880230003001

Abstract The material for this study includes a survey of 2,439 patients with syphilis, of whom 913 had early infections in the primary or secondary stage. In this series, 56 patients were discovered who presented various forms of cutaneous and mucosal relapse. These have been considered and reported on separately.1 In the series were also 4 cases of possible reinfection, 2 from departmental and 2 from private records, and 2 additional private cases which illustrate certain problems that arise in the attempt to differentiate clinically between what Balzer,2 Hecht,3 Bernard4 and, recently Lortat-Jacob, Roberti and Poumeau-Delille5 called pseudoreinfection and true reinfection. As pseudoreinfection is essentially relapse, we were impressed with the differential significance of this problem, and from a review of the literature, our study of relapse and the 6 illustrative cases mentioned offer a critique of the problem of clinical differentiation of reinfection from the References 1. Stokes, J. H.; Besancon, J. H., and Schoch, A. G.: Infectious Recurrence and Mucocutaneous Relapse in Syphilis: Diagnosis, Public Health Significance and Relation to Treatment , J. A. M. A. 96:344 ( (Jan. 31) ) 1931.Crossref 2. Quoted by Bernard, R.: Bruxelles-méd. 7:72 ( (Nov. 7) ); 3. 105 (Nov. 21) 1926. 4. Hecht, H.: Die kombinierte Abortivbehandlung der Syphilis , Arch. f. Dermat. u. Syph. 126:327, 1919.Crossref 5. Bernard, R.: Réinfection syphilitique; pseudoréinfection-superfection , Bruxelles-méd. 7:72 ( (Nov. 7) ); 6. 105 (Nov. 21) 1926. 7. Lortat-Jacob, L.; Roberti, J., and Poumeau-Delille: Les réinoculations syphilitiques , Ann. de dermat. et syph. 1:2 ( (Jan.) ) 1930. 8. Halley, C. R. L., and Wasserman, H.: Second Infection in Syphilis , Arch. Int. Med. 41:843 ( (June) ) 1928.Crossref 9. White, C. F.: Reinfection in Syphilis: With Observations on Twenty-Eight Cases , Brit. M. J. 2:509 ( (Oct. 20) ) 1917.Crossref 10. Driver, J. R.: Reinfection in Syphilis , J. A. M. A. 83:1728 ( (Nov. 29) ) 1924.Crossref 11. Moore, J. E., and Kemp, J. E.: The Treatment of Early Syphilis: Clinical Results in 402 Patients , Bull. Johns Hopkins Hosp. 39:16 ( (July) ) 1926; 12. The Treatment of Early Syphilis: The Wassermann Reaction in Treated Early Syphilis , Moore Bull. Johns Hopkins Hosp. 39:36 ( (July) ) 1926. 13. Chesney, A. M.: Immunity in Syphilis , Baltimore, Williams & Wilkins Company, 1927. 14. Harrison, L. W.: Review of Experimental Research in Syphilis and Its Possible Application to Man , Brit. J. Ven. Dis. 5:173 ( (July) ) 1929. 15. Neisser, A. L.: Arb. a. d. k. Gsndhtsamte. 37:1, 1911. 16. Kolle, W.: Ueber der Schutzwirkung der Antisyphilitika (Arsenderwati, Queksilber und Wismut) gegenüber der experimentellen Syphilisinfektion , Deutsche med. Wchnschr. 50:1074 ( (Aug. 8) ) 1924.Crossref 17. Frei, W., quoted by Harrison, L. W.: Brit. J. Ven. Dis. 5:173 ( (July) ) 1929. 18. Prigge, R.: Immunity Results of Experimental Investigation of Syphilis , Therap. d. Gegenw. 70:385 ( (Sept.) ); 19. 447 (Oct.) 1929 20. abstr., Ven. Dis. Inform. 2:75 ( (Jan. 20) ) 1930. 21. Chesney, A. M., and Kemp, J. E.: Experimental Observations on the "Cure" of Syphilis in the Rabbit with Arsphenamine , J. Exper. Med. 39:553, 1924;Crossref 22. Studies in Experimental Syphilis: III. Further Observations on the Possibility of the Cure of Syphilis in the Rabbit with Arsphenamine , Chesney J. Exper. Med. 42:17, 1925.Crossref 23. Voegtlin, C., and Dyer, H. A.: Reinoculation as a Criterion of Cure of Experimental Syphilis, with Reference to Arsphenamine, Neoarsphenamine, and Sulpharsphenamine , Pub. Health Rep. 40:2511, 1925.Crossref 24. Uhlenhuth, P., and Grossmann, H.: Zur Frage der Immunität bei Syphilis mit besonderer Berücksichtigung experimenteller Untersuchungen am Kaninchen , Ztschr. f. Immunitätsforsch. u. exper. Therap. 55:380, 1928. 25. Manteufel, P., and Richter, A.: Beiträge zur experimentellen Syphilisforschung , Deutsche med. Wchnschr. 52:2113, 1926.Crossref 26. Worms, W.: Erscheinungslos verlaufende experimentelle Syphilisinfektion beim Kaninchen und Affen , Deutsche med. Wchnschr. 52:785, 1926.Crossref 27. Brown, H. W., and Pearce, L.: Superinfection Experiments with Treponema Pallidum , Proc. Soc. Exper. Biol. & Med. 18:255, 1921. 28. Kolle, W., and Schlossberger, H.: Die Persistenz der Syphilisspirochäte im Mäusen während langer Zeiträume , Deutsche med. Wchnschr. 54:129 ( (Jan. 27) ) 1928. 29. Brown, H. W., and Pearce, L.: Superinfection in Experimental Syphilis Following the Administration of Subcurative Doses of Arsphenamine or Neoarsphenamine , J. Exper. Med. 30:553 ( (May 1) ) 1921. 30. Warthin, A. S.: Lesions of Latent Syphilis , Brit. M. J. 2:236 ( (Aug. 10) ) 1929. 31. Adachi, Y.: On Experimental Reinoculation of Syphilis in Rabbits: II. Reinoculation Experiment in Syphilitic Rabbits; "Superinfection," Acta dermat. 4:393, 1925. 32. Kolle, W.: Die Bedeutung der experimentellen symptomlosen Syphilisinfektion für die Erforschung der Lues—Epidemiologie und Pathologie , Centralbl. f. Bakteriol. (Abt. 1) 106:134, 1928. 33. Breinl, F., and Wagner, R.: Untersuchungen über Immunität bei experimenteller Kaninchensyphilis , Ztschr. f. Immunitätsforsch. u. exper. Therap. 60:23, 1929. 34. Stokes, John H.: Modern Clinical Syphilology , Philadelphia, W. B. Saunders Company, 1927. 35. Hell, F.: Reinduratio, Reinfectio, Superinfectio und chancriform Papeln bei Lues , Arch. f. Dermat. u. Syph. 124:443, 1917. 36. Nielsen, L.: Papulo-erosiv Syphilitide im Mund und Schlund mit Nächweissung von Spirochaeta pallida ungefähr neun Jahre nach Infektion , Monatschr. f. prak. Dermat. 48:53, 1909. 37. Lacapère: Apropos d'une reinfection syphilitique: Le séro-réaction positive est le fonction du terrain de la graine , Bull. Soc. franç. de dermat. et syph. 20:391, 1909. 38. Hudelo and Rabut: Récidives, secondaires et accidents chancriformes chez les syphilitiques traités , Presse méd. 32:740 ( (Sept. 10) ) 1924. 39. Gennerich, W. A.: Die bisherigen Erfolge die Salvarsan Behandlung im Marinelazarett zu Wik , München. med. Wchnschr. 61:513 ( (March 10) ) 1914. 40. Cassar, A.: Un cas de pseudo-réinfection syphilitique , Ann. de dermat. et syph. 6:376, 1916. 41. Hecht, H.: Ein Beitrag zur Reinfiktio syphilitica , Dermat. Ztschr. 28:193, 1919. 42. Stokes (footnote 28, p. 570). 43. Stokes (footnote 28, pp. 532 and 579). 44. Stokes (footnote 28, p. 764). 45. Stokes (footnote 28, p. 561). 46. Stokes, John H.: A Spurious Chancre , Arch. Dermat. & Syph. 3:295 ( (March) ) 1921.

HORRALL, O. H.;WAKERLIN, G. EARLE

1931 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1931.03880230030002

Abstract In the first article1 we drew the following conclusions: The Kahn test is negative in 95 per cent of nonsyphilitic rabbits and the Wassermann in 100 per cent. The Kahn and Wassermann reactions are parallel with the intensity of the syphilitic involvement. Kahn and Wassermann reactions are negative in latent experimental syphilis in rabbits. Treatment that modifies the course of experimental syphilis also modifies the Kahn and Wassermann reactions. The Kahn reaction is more sensitive than the Wassermann, as evidenced by its tendency to become positive earlier and remain positive longer. The Kahn test is somewhat more desirable than the Wassermann for use in the study and the treatment of experimental syphilis in rabbits. METHOD The technic and interpretation of the quantitative Kahn test were exactly the same as those employed in the previous work,1 and the same person performed the tests. Virtually the same technic was used References 1. Wakerlin, G. E., and Horrall, O. H.: Experimental Syphilis in Rabbits: I. An Experimental Study of the Kahn and Wassermann Reactions , Arch. Dermat. & Syph. 18:539 ( (Oct.) ) 1928.

de MELLO, LOPO

1931 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1931.03880230037003

Abstract Scabies has been a well known disease for many years. As far back as the twelfth century, the Arabian author, Avenzoar, remarked that the "itch" was caused by a small animalcule, but seven centuries elapsed before its cause was actually demonstrated. About the middle of the sixteenth century, an English physician, Thomas Monfet, again called attention to a small animalcule as the cause of scabies. In 1685, Bonomi, in collaboration with Cestoni, reported the finding of the acarus in the vesicles, calling it Sarcoptes scabiei, and drew attention to an antiparasitic treatment with sulphur, vitriol, etc., both by baths and by ointments. The treatment continued to be the same, but the causative agent was apparently forgotten—no mention of it was again made until 1812—and even doubted by some illustrious dermatologists, such as Allibert and Biett. About this time, Gales, a pharmacist at the St. Louis Hospital in Paris, reported positive References 1. Milian: Treatment of Scabies , Brasil-med. 2:304 ( (Nov. 17) ) 1923. 2. Moullard, P.: Thèse de Paris , Presse méd. , (September) , 1927.

WINER, LOUIS H.

1931 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1931.03880230040004

Abstract Amyloidosis of the internal organs has been thoroughly studied by internists and pathologists for many years, but only in recent times has this degenerative change been recognized in the skin. In 1905, Pospelow1 discussed the condition in his textbook. In 1909 Schilder2 examined the skin of fourteen patients who at postmortem examination showed general amyloidosis. In seven of the specimens he was able to demonstrate amyloid, even though the skin was normal clinically. Amyloid is a morphologic, homogeneous, structureless substance, which has peculiar characteristic staining qualities. Methyl violet stains amyloid a metachromatic bright red. Iodine produces a dark brown, and the addition of sulphuric acid changes the brown to a dirty green. The van Gieson method gives a clear yellow. In examining for amyloid one should test with several stains before making a definite diagnosis, because every example of amyloid possesses a different staining intensity, probably owing to References 1. Pospelow, A.: Lehrbuch die Hautkrankheiten , Moscow, 1905. 2. Schilder, Paul: Ueber die amyloide Entartung der Haut , Frankfurt. Ztschr. f. Path. 3:782, 1909. 3. Königstein, H.: Arch. f. Dermat. u. Syph. 148:330. 1925.Crossref 4. Bennhold, H.: Kongress d. deutsch. Gesellsch. f. inn. Med. , 1922, p. 313. 5. Guttmann, C.: Dermat. Ztschr. 28:65, 1923.Crossref 6. Königstein, H.: Wien. klin. Wchnschr. 14:157, 1921. 7. Juliusberg, F.: Zur Kenntnis der Amyloidosis der Haut , Dermat. Ztschr. 29:3, 1923. 8. Freudenthal, F.: Zentralbl. f. Haut und Geschlechtskr. 20:26, 1926 9. 27: 469, 1928 10. 29:100, 608 and 768, 1928. 11. Maschkilleisson and Sirkin: Acta dermat.-venereol. , 1928, no. (10) , p. 1079. 12. Truffi, G.: Gior. ital. di. dermat. e sifil. 70:1, 1929. 13. Jukeliss: Acta dermat.-venereol. , 1929, no. (6) , p. 663. 14. Kreibich, C.: Arch. f. Dermat. u. Syph. 116:385, 1913.Crossref 15. Lindwurm: Ztschr. f. rationelle Med. 14:257, 1862. 16. Kennedy, D.: Arch. f. Dermat. u. Syph. 136:245, 1921.Crossref 17. Hoffmann, E.: Arch. f. Dermat. u. Syph. 146:89, 1924Crossref 18. Deutsch. Dermat. Gesellsch, 1923. 19. This case was presented and discussed by Professor Oppenheim at the Wiener Dermatological Gesellschaft, March, 1930. 20. Maschkilleisson: Acta dermat.-venereol. 11:77, 1930.

GOODMAN, HERMAN

1931 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1931.03880230048005

Abstract The impression has been gaining credence that ringworm infection of the skin has been increasing within the past few years. The increase may now be actual, or cases of tinea may now be diagnosed that in the past were not considered to be due to fungi. It has been interesting to compile the statistics reported from the New York Skin and Cancer Hospital, and their wider publication may be justified. Tinea was eighth or ninth in the order of incidence of the most common diseases of the skin from 1913 to 1927, inclusive, which was taken in five-year periods, as explained in my previous compilation.1 Epidermophytosis, ringworm of the feet and hands, was almost exactly equivalent to the number of cases of acne for 1928 and 1929. Routine examinations disclosed some clinical phase of ringworm of the toes in approximately half of the people of postadolescent age in the References 1. Statistics of the Ten Most Common Skin Diseases , Arch. Dermat. & Syph. 20:186 ( (Aug.) ) 1929.

RUTLEDGE, WINSTON U.

1931 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1931.03880230050006

Abstract Following Schamberg's introduction of gold sodium thiosulphate in the treatment for lupus erythematosus, several reports appeared on the use of this and similar compounds. For three years these drugs have been widely employed, and it now seems that an attempt to appraise their value in the light of a longer experience would be worth while. The use of gold compounds in the treatment of patients with lupus erythematosus dates from 1913, when Reute1 first reported the use of gold potassium cyanide in a case lupus erythematosus. From that time until almost ten years later, little was written on this type of therapy, although in 1917 Adolf Feldt2 had prepared a new gold compound, 4-amino-2-aurothiophenol carbonic acid, and had been using it with considerable success in the treatment for various types of systemic tuberculosis. In 1921, Kohrs3 reported a case of lupus erythematosus with cure by this drug, References 1. Reute: Deutsche med. Wchnschr. 39:1727. 1913.Crossref 2. Feldt: Berl. klin. Wchnschr. 54:1111, 1917 3. Therap. Monatsh. 32:241, 1918 4. München. med. Wchnschr. 67:1500, 1920. 5. Kohrs: Dermat. Wchnschr. 73:181, 1921. 6. Martenstein, H.: Klin. Wchnschr. 1:2235, 1922.Crossref 7. Rickmann, L.: München. med. Wchnschr. 71:1609 ( (Nov. 14) ) 1924. 8. Throne, Clark, Van Dyke and Meyers: New York State J. Med. 27:1064, 1927. 9. Schamberg, J. F., and Wright, C. S.: Use of Gold and Sodium Thiosulphate in Treatment of Lupus Erythematosus , Arch. Dermat. & Syph. 15:119 ( (Feb.) ) 1927. 10. Görl, L., and Voigt, L.: München. med. Wchnschr. 73:1360, 1926. 11. Stuhl, K.: Deutsche med. Wchnschr. 50:207 ( (Feb. 15) ) 1924.

KLAUDER, JOSEPH V.;Rule, Anna M.;Madden, Bernard

1931 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1931.03880230060007

Abstract The mechanism of immunity from syphilis is not clearly understood. From the evidence it appears to be more cellular than humoral. Comprehensive summaries of studies of the immunity to syphilis have been published by Neisser,1 Levaditi,2 Bruck3 and Zinsser4 and more recently by Chesney5 and Harrison.6 A detailed review is not necessary here. A brief summary and a review of recent pertinent experimentations only are given. Attempts to produce active immunity to syphilis in man or in the lower animals by injecting filtrates of syphilitic tissue, killed and living syphilitic virus and cultures of Spirochaeta pallida have generally been unsuccessful. Attempts at passive immunization with the serum of immune persons or the serum of animals either infected with syphilis or treated with dead cultures of Spirochaeta pallida have also proved fruitless. Comparable to Neisser's studies of passive immunization against syphilis, Bruck7 gave syphilitic References 1. Neisser, A.: Bericht über die in 1905-1909 ausgeführten Arbeiten zur Erforschung der Syphilis , Arb. a. d. k. Gsndtsamte. 37:1, 1911. 2. Levaditi, C.: De l'immunité acquise dans la syphilis , Ztschr. f. Immunitätsforsch. u. exper. Therap. 2:277, 1910. 3. Bruck, C., in Kolle and Wassermann: Handbuch der Pathogenmikroorganismen , Jena, Gustav Fischer, 1913, vol. 7. 4. Zinsser, H.: Infection and Resistance , ed. 3, New York, The Macmillan Company, 1923. 5. Chesney, A.: Immunity in Syphilis , Baltimore, Williams & Wilkins Company, 1927. 6. Harrison, L. W.: Review of Experimental Research in Syphilis and Its Possible Application to Man , Brit. J. Ven. Dis. 5:173 ( (July) ) 1929. 7. Bruck, C.: Beitrag zur Frage einer Serum Therapie bei Syphilis , Klin. Wchnschr. 7:71, 1928.Crossref 8. Mulzer, P.: Zur Serumbehandlung der Syphilis , Klin. Wchnschr. 5:1920, 1926.Crossref 9. Worms, W.: Beiträge zur experimentellen Syphilisforschung , Deutsche med. Wchnschr. 53:959, 1927.Crossref 10. Jáureguy, F., and Lancelotti, L.: Résumé des recherches experimentales sur la syphilis , Bull. Acad. de méd., Paris 92:1295, 1924. 11. Manteufel, P.; Richter, A., and Worms, W.: Beiträge zur experimentellen Syphilisforschung: Das Syphilisheilserum von Dr. Query (Paris) , Deutsche med. Wchnschr. 53:435, 1927.Crossref 12. Zinsser, H.; Hopkins, J. G., and McBurney, M. J.: Studies on Treponema Pallidum and Syphilis , J. Exper. Med. 24:561, 1916.Crossref 13. Eberson, F.: Immunity Studies in Experimental Syphilis , Arch. Dermat. & Syph. 4:490 ( (June) ) 1921. 14. Manteufel, P.: Richter, A., and Worms, W.: Beiträge zur experimentellen Syphilisforschung , Arb. a. d. Reichsgsndhtsamte. 57:297, 1926. 15. Kolmer, J., and Rule, A.: The Spirocheticidal Activity of the Human Syphilitic Serum and the Immunologic Significance of the Wassermann Reaction , Arch. Dermat. & Syph. 20:90 ( (July) ) 1929. 16. Cohn, A.: Ueber Schutzstoffe bei der experimentellen Syphilis , Klin. Wchnschr. 19:886, 1929. 17. Hauptmann, A., and Gallinek, A.: Zur Frage der Schutzstoffe bei Syphi lis , Klin. Wchnschr. 8:1485, 1929. 18. Suranyi, L.: Ueber die Bedeutung der Lipoide für die Biologie und Immunitätslehre , Ztschr. f. Immunitätsforsch. u. exper. Therap. 53:74, 1927. 19. Landsteiner, K., and Simms, S.: Production of Heterogenetic Antibodies with Mixtures of the Binding Part of the Antigen and Protein , J. Exper. Med. 38:127, 1923. 20. Jermoljewa, S.: Ueber Antigeneigenschaften der Lipoide , Ztschr. f. Immunitätsforsch. u. exper. Therap. 57:102, 1928. 21. Much, H.: Ueber Lipoide , Hippokrates 1:1, 1929. 22. Schumacher, J.: Ueber den chemischen Aufbau der Spirochaeta pallida , Dermat. Wchnschr. 79: 1457, 1494 and 1514, 1924. 23. Bergel, S.: Further Communications on the Biology and Staining of the Syphilis Spirochete , Klin. Wchnschr. 8:1218, 1929. 24. Rosen, I., and Krasnow, F.: Cholesterol Studies in Syphilis , Arch. Dermat. & Syph. 20:75 ( (July) ) 1929. 25. Sachs, H.; Klopstock, A., and Weil, A. J.: Die Enstehung der syphilitischen Blutveränderung , Deutsche med. Wchnschr. 51:589, 1925. 26. Sachs, H., and Klopstock, A.: Deutsche med. Wchnschr. 52:650, 1926 27. 53:394, 1927. 28. Torii, F.: Ueber den Mechanismus der Entstehung von den syphilitischen Blutveränderungen , Jap. J. Dermat. & Urol. 28:43, 1928. 29. Henning, L.: Gelingt es bei Meerschweinchen mit Gemischen aus alkoholischen Extrakten arteigener Organe und Schweineserum positive Seroreaktionen, sowie anaphylaktische Lipoid-Antikörper zu erzeugen? Ztschr. f. Immunitätsforsch. u. exper. Therap. 55:19, 1928. 30. Brandt, R.; Guth, H., and Müller, R.: Zur Erzeugung der positiven Wassermann Reaction durch kombinierte Injektion von Lipoiden und Schweineserum , Klin. Wchnschr. 5:68, 1926. 31. Klopstock, F.: Ueber die Blutveränderung in Syphilis , Klin. Wchnschr. 7:1896, 1928. 32. Bergel, S.: Die Syphilis im Lichte neurer experimentellbiologischer und immuntherapeutischer Untersuchungen , Jena, Gustav Fischer, 1925. 33. Bergel, S.: Die Heilbarkeit der erworbenen Syphilis und die Frage der Immunität , Beihefte z. Med. Klin. (Hft. (6) ) 25:115, 1929. 34. Kolmer, J. A.: Serum Diagnosis by Complement-Fixation with Special Reference to Syphilis: The Principles, Technique and Clinical Applications , Philadelphia, Lea & Febiger, 1928, p. 347. 35. Graetz: Beiträge zur allgemeinen und speziellen Pathologie der experimentellen Kaninchen-Syphilis , Virchows Arch. f. path. Anat. 254:382, 1925. 36. Förtig, H.: Experimentelle Beiträge zur Frage der Erzeugung der syphilitischen Blutveränderung am Menschen und Kaninchen , Ztschr. f. Immunitätsforsch. u. exper. Therap. 52:328, 1927. 37. Hecht, H., and Schubert, I.: Ueber das Zustandekommen der syphilitischen Blutveränderungen , Deutsche med. Wchnschr. 52:2151, 1925. 38. Martin, H.: Experimentelle Untersuchungen am Menschen über das Zustandekommen der syphilitischen Serumveränderungen , Dermat. Ztschr. 46:176, 1926. 39. Frei, W., and Grünmandel, S.: Gelingt es beim Menschen mit Gemischen aus alkoholischem Plazenta-Extrakt und Serum eine positive Wassermannsche Reaktion zu erzeugen? Ztschr. f. Immunitätsforsch. u. exper. Therap. 51:517, 1927.

CLAWSON, B. J.;ALLEN, P. K.

1931 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1931.03880230070008

Abstract The therapy described in this paper was suggested by a series of experiments carried out in studying the results of treatment with vaccine in animals made hypersensitive to streptococci in an attempt to find a basis for vaccine therapy in acute rheumatic fever. These animals were made hypersensitive (allergic) by subcutaneous injection into one area of agar at 45 C. heavily seeded with streptococci. This method of producing and maintaining an allergic state had been demonstrated by Swift.1 In from twelve to eighteen days after the initial sensitizing dose, the animals were given subcutaneous injections by the method previously used in producing experimental rheumatoid subcutaneous nodules.2 Into ten places on the right side of the back of each animal was injected subcutaneously 11/100 of a standard amount of streptococci and into ten places on the left side,1/1,000 of the amount. In a former series of experiments with increasing References 1. Swift, H. F.: Reaction of Rabbits to Nonhemolytic Streptococci , J. Exper. Med. 49:615, 1929.Crossref 2. Clawson, B. J.: Experimental Streptococcic Inflammation in Normal, Immune and Hypersensitive Animals , Arch. Path. 9:1142 ( (June) ) 1930. 3. Michelson, H. E., and Allen, P. K.: Acne Conglobata , Arch. Dermat. & Syph. 23:49 ( (Jan.) ) 1931.

GOODMAN, HERMAN;BURR, MARJORIE

1931 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1931.03880230077009

Abstract Juvenile acrodynia is found in many parts of the world, and has frequently been reported from sections of the United States other than New York City. To date there is but one report of a patient with juvenile acrodynia from this city. The wide publication of a first report usually brings a train of reports of other cases not previously recognized. We believe that there must be many other cases unrecognized and undiagnosed. Since the symptoms are distinctive, there need be no excuse for failure to detect acrodynia. Once seen, the disease leaves an indelible impression on the observer. Acrodynia, Swift's disease, Feer's disease, pink disease, erythredema and dermatopolyneuritis are a few of the names that have been applied to the disease. Juvenile acrodynia, while perhaps fairly common, has been widely recognized as a distinct entity only within the last fifteen years. Evers1 of India, in 1880, described what References 1. Evers: Indian M. Gaz. , (Aug. 2) , 1880 (not available). 2. Swift, H.: Lancet 1:611, 1918. 3. Clubbe, C. F., cited by Wood (reference 4). 4. Wood, A. J.: M. J. Australia 1:145 ( (Feb. 19) ) 1921 5. abstr., Lancet 1:811 ( (April 23) ) 1921. 6. Thursfield, J. H., and Patterson, D. H.: Proc. Roy. Soc. Med. (Sect. Dis. Child.) 15:53, 1922. 7. Bilderback, J. B.: Northwest Med. 19:263 ( (Oct.) ) 1920. 8. Weston, William: Arch. Pediat. 37:513 ( (Sept.) ) 1920. 9. Wyckoff, C. W.: Juvenile Acrodynia , Am. J. Dis. Child. 37:88 ( (Jan.) ) 1929. 10. Smith, C. H.: Tuberculin Skin Reactions . Am. J. Dis. Child. 38:1137 ( (Dec.) ) 1929. 11. Kernoban, J. W., and Kennedy, R. L. J.: Acrodynia (So-Called): Study of Pathology , Am. J. Dis. Child. 36:341 ( (Aug.) ) 1928.Crossref 12. Helmick, A. G.: Arch. Pediat. 44:405 ( (July) ) 1927. 13. McClendon, S. J.: Yeast and Irradiated Ergosterol in the Treatment of Acrodynia , J. A. M. A. 93:455 ( (Aug. 10) ) 1929.Crossref 14. Perlman, H. H.: M. J. & Rec. 130:370 ( (Oct. 2) ) 1929. 15. Craig, R. A.: Arch. Pediat. 44:581, 1927. 16. Zahorsky, J.: Pink Disease Treated with Yeast , Am. J. Dis. Child. 37:449 ( (Feb.) ) 1929. 17. Byfield, A. H.: A Polyneuritic Syndrome Resembling Pellagra-Acrodynia (?) Seen in Very Young Children , Am. J. Dis. Child. 20:347 ( (Nov.) ) 1920. 18. Vipond, A. E.: Arch. Pediat. 39:699 ( (Nov. 19) ) 1922. 19. Blood, Wilke S.: Personal communication.

CORNBLEET, THEODORE;MONTGOMERY, B. E.

1931 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1931.03880230084010

Abstract It is an obvious fact that the surface of the skin has remarkable powers for freeing itself of the constant and ubiquitous organic contaminations by which it is beset. Just how it accomplishes this task and how efficient it really is, remains unknown. These studies were undertaken to help solve these two problems. Although the broad outlines of these experiments and the ultimate goals to be achieved were conceived before anything was done, no attempt was made to follow a rigid program in the work. Some of the experiments being performed simultaneously were unrelated, except in their broader features, because the subjects were the material that happened to be available in the clinic at the time. It was felt that in the beginning it would be well to obtain as many facts as possible and to utilize these later by relating them in the hope that thereby some fundamental conclusions

SZODORAY, LEWIS

1931 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1931.03880230096011

Abstract The view of histologists concerning the structure of the junction of the epidermis and the corium has undergone essential changes with time, especially since precise knowledge of the so-called argyrophil lattice fibrils or argyrophil reticulum was obtained. As is well known, investigation was first made of the behavior and structure of the basement membrane described by Todd and Bowman. By employing the newest methods, histologists succeeded in demonstrating the finest elements of the basal layer and of the connective tissue of the papillae. Herxheimer1 changed his former belief in the existence of some membrane, emphasizing its origin from the connective tissue; at the same time he pointed out that fine fibrils proceed from the basement membrane into the basal layer and that the basal cells also have fibrils reaching the membrane. As is now well known, this connection is reciprocal. As early as 1895, Nékám2 called attention to References 1. Herxheimer: Ueber die epidermidale Basalmembran , Dermat. Ztschr. 23: 129, 1916.Crossref 2. Nékám: Quelques considérations sur la disposition et la fonction des fibres élastiques de la peau , Ann. de dermat. et syph. 26:109, 1895. 3. Homma: Gitterfasern in normaler menschlicher Haut , Wien. klin. Wchnschr. 35:149, 1922. 4. Welti: Ueber die morphologischen Beziehungen zwischen Epidermis und subepithelialem Stratum . Arch. f. Dermat. u. Syph. 146:497, 1929.Crossref 5. Tryb: Ueber eine seltene Erkankung der Haut . Arch. f. Dermat. u. Syph. 143:428, 1923.Crossref 6. Kogoj: Ueber die Art der Verbindung zwischen Epidermis und Kutis , Dermat. Ztschr. 39:203, 1923.Crossref

BELOTE, GEORGE H.

1931 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1931.03880230102012

Abstract Up to 1924, only 15 cases of human tularemia had been described. Since that time more than 800 cases have been reported in the literature, and one cannot escape the conviction that the disease is widespread at present. Cases have been reported from every state in the Union, except the New England states, Delaware and Washington, as well as from Japan and Russia. Under these conditions, cases varying from the typical are likely to occur from time to time. An unusual case of well proved human tularemia forms the basis for this report. For a complete bibliography and an exposition on the various phases of tularemia, reference should be made to the excellent book by Simpson,1 published in 1929. REPORT OF CASE A. K., a farmer, aged 67, whose home was in northern Michigan, presented himself at the clinic on June 3, 1930, complaining of an ulcer on the References 1. Simpson, W. M.: Tularemia , New York, Paul B. Hoeber, Inc., 1929. 2. Netherton, E. W.: Tularemia with Reference to Its Cutaneous Manifestations , Arch. Dermat. & Syph. 16:170 ( (Aug.) ) 1927. 3. Miller, H. E., and Taussig, L. R.: Tularemia . Arch. Dermat. & Syph. 19:378 ( (March) ) 1929.

ROSENTHAL, SOL ROY

1931 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1931.03880230110013

Abstract It was thought for a long time that diseases of the skin predisposed to nephritis. This was explained by a suppression of the function of the skin that resulted in nitrogenous retention and albuminuria. Partial varnishing of the skin of man, however, failed to produce albuminuria (d'Edenhurzen and Lomikowsky1 and Senator2). Thibierge3 (1885), on the strength of these and other experimental studies, in addition to his own clinical material, reasoned that the same noxa that caused nephritis might also cause the manifestations of the skin. Jadassohn4 observed that, although albuminuria accompanied certain lesions of the skin, it did not necessarily denote nephritis, for in many instances the albuminuria disappeared with the dermatitis. The explanation then offered, and the one now accepted, for the lesions of the skin occurring with true nephritis was that the nephritis was primary and the dermatitis secondary, the latter resulting from a References 1. Thibierge, G.: Ann. de dermat. et syph. 6:511, 1885. 2. Senator, H.: Wie wirkt Firnissen auf die Haut des Menschen? Virchows Arch. f. path. Anat. 70:182, 1877.Crossref 3. Thibierge, G.: Dermatoses et Albuminurie , Ann. de dermat. et syph. 6:511, 1885. 4. Jadassohn, J.: Hautkrankheiten bei Stoffwechsel-Anomalien , Internationaler Dermatologen-Kongress, Berlin, 1904. 5. Merk, L.: Dermatoses Albuminuricae , Arch. f. Dermat. u. Syph. 43:469, 1898.Crossref 6. Block, H.: Beziehungen zwischen Hautkrankheiten und Stoffwechsel , Ergebn. d. inn. Med. u. Kinderh. 2:521, 1908. 7. Chiari, H.: Ueber einen Fall von urämischer Dermatitis , Prag. med. Wchnschr. 36:30, 1905. 8. Walthard, B.: Zur Lehre der urämischen Hautveränderungen , Frankfurt. Ztschr. f. Path. 32:8, 1925. 9. Gruber, G. B.: Ueber die Pathologie der urämischen Hauterkrankungen , Deutsches Arch. f. klin. Med. 121:242, 1916-1917. 10. Rössle, R.: Urämische Dermatitis , Virchows Arch. f. path. Anat. 271:304, 1929.Crossref 11. Thursfield, H.: Hautkrankheiten bei Brightscher Krankheit , Frankfurt. Ztschr. f. Path. 32:12, 1925. 12. Huet, J.: Erythema papulatum uraemicum, Nederl. tijdschr. v. geneesk., 1870 and 1872 13. abstr., Ann. de dermat. et syph. 6:511, 1885. 14. Bruzelius, A.: On Erythema Uraemicum , Ann. de dermat. et syph. 6:511, 1885. 15. Gans, O.: Hauterkrankungen bei Urämie , Berlin, Julius Springer, 1925, vol. 1, p. 155. 16. Fox, C.: Hemorrhagic Erythema in Bright's Disease , Lancet , (June) , 1899 17. abstr., Wchnschr. f. prakt. dermat. 30:181, 1900. 18. Marchand, F., in Marchand and Krehl: Handbuch der allgemeine Pathologie , Leipzig, 1915, vol. 2, p. 297. 19. Kaulen, G.: Ueber Hautblutungen bei Urämie , Monatschr. f. Kinderh. 22:599, 1922. 20. Dalche, P., and Claude, H.: Ulcerations hemorragiques de la peau et des muqueuses dans l'urémie , Bull. et mém. Soc. méd. d. hôp. de Paris 20:75. 1903. 21. Pfaundler, M., and von Seht, L.: Zur Systematik der Blutungsübel im Kindesalter , Ztschr. f. Kinderh. 19:225, 1919.Crossref 22. Oestreicher, A.: Ueber den Nachweis des Harnstoffes in den Geweben. mittelst Xanthydrol , Virchows Arch. f. path. Anat. 257:614, 1925.Crossref 23. Further studies in regard to the pathogenesis of pseudomembranous colitis are being carried out. 24. Gryns, G.: Osmotische Druck und Ionenlehre , Arch. f. d. ges. Physiol. 63:86, 1896.Crossref 25. Marshall, E. K., and Davis, D. M.: Urea: Its Distribution in and Elimination from the Body , J. Biol. Chem. 18:53, 1914. 26. Hewlett, A. W.; Gilbert, Q. O., and Wickett, A. D.: The Toxic Effects of Urea on Normal Men , Arch. Int. Med. 18:636 ( (Nov.) ) 1916.Crossref 27. Tileston and Comfort: High Non-Protein Nitrogen in Acute Intestinal Obstruction , in Wells, H. G.: Chemical Pathology , Philadelphia, W. B. Saunders Company, 1925, p. 611. 28. Strauss, H.: Ueber Urämie , Berl. klin. Wchnschr. 52:368, 1915. 29. Kendall, E. C.: Experimental Hyperthyroidism , J. A. M. A. 69:612 ( (Aug. 25) ) 1917.Crossref 30. Wells, H. G.: Chemical Pathology , Philadelphia, W. B. Saunders Company, 1925, p. 602.

HOOKEY, JOHN A.

1931 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1931.03880230122014

Abstract This study of keratoma senilis (senile keratosis) and verruca senilis (seborrheic keratosis) was undertaken because a definite, clearcut picture of the lesions could not be obtained from a review of the literature on the subject. I have attempted to show that the existing confusion with regard to these common lesions need not exist, that it is important to distinguish one lesion from the other, and that the lesions differ with respect to etiology, clinical and pathologic characteristics and prognosis. CLINICAL CHARACTERISTICS Keratoma senilis, when fully developed, presents a typical appearance. The lesions appear as sharply circumscribed, flat, elevated or verrucous, brownish, keratotic, scaling patches. They are usually situated on the face, hands and forearms, although they occur elsewhere on the body. Men are affected more often than women, as a rule after middle age and often in association with the changes of senile atrophy. The lesions begin as small, sharply References 1. Barthélemy, M.: Des verrues séborrhéiques ou verrues plates de la vieillesse , Ann. de dermat. et syph. 12:535, 1881. 2. Handford, quoted by Pollitzer (footnote 4). 3. Neumann, quoted by Pollitzer (footnote 4). 4. Pollitzer, S.: The Seborrhoeic Wart , Brit. J. Dermat. 2:199 ( (July) ) 1890. 5. Unna, P. G.: Hard and Mixed Nevi; Naevi Seborrheica , in Histopathology of Diseases of the Skin , New York, The Macmillan Company, 1896, pp. 1140 and 1164. 6. Dubreuilh, W.: Des hyperkératoses circonscrites , Ann. de dermat. et syph. 27:1158, 1896. 7. Hartzell, M. B.: Some Precancerous Affections of the Skin, More Particularly Precancerous Keratoses , J. Cutan. Dis. 21:393 ( (Sept.) ) 1903. 8. Schuchart, quoted by Hartzell (footnote 7). 9. Dubreuilh, W. A.: Verrue senile , in La pratique dermatologique , Paris, Masson et Cie, 1904, vol. 4, p. 828. 10. Hyde, J. N.: Keratosis Senilis; Verruca Senilis Vel Plana , in Diseases of the Skin , Philadelphia, Lea & Febiger, 1909, pp. 457 and 483. 11. Hartzell, M. B.: Keratoma Senilis; Verruca Senilis , in Diseases of the Skin , Philadelphia, J. B. Lippincott & Company, 1914, pp. 472 and 500. 12. Ormsby, O. S.: Keratosis Senilis; Verruca Senilis , in Diseases of the Skin , Philadelphia, Lea & Febiger, 1927, pp. 474 and 504. 13. DuBois, C.: Étude histologique d'un lentigo , Ann. de dermat. et syph. 45:385, 1914-1915. 14. Montgomery, D. W.: The Anatomy of a Patch of Seborrhoeic Keratosis , J. Cutan. Dis. 32:6 ( (Jan.) ) 1914 15. A Contribution to the Treatment of Senile Patches , Philadelphia M. J. 1:211 ( (Jan. 29) ) 1898. 16. Williams, C. M.: Malignant Degeneration in Benign Dermatoses , Arch. Dermat. & Syph. 2:168 ( (Aug.) ) 1920. 17. Sutton, R. L.: The Symptomatology and Treatment of Seborrheic Keratoses , J. A. M. A. 64:403 ( (Jan. 30) ) 1915. 18. MacKee, G. M., and Lewis, G. M.: Precancerous Dermatoses , Atlantic M. J. 31:371 ( (March) ) 1927. 19. Sequeira, J. H.: Verruca Plana Senilis, "Seborrhoic" Wart; Keratosis Senilis , in Diseases of the Skin , ed. 3, Philadelphia, P. Blakiston's Son & Company, 1919, pp. 523 and 524. 20. Darier, J., and Pollitzer, S.: Flat Senile Warts (Verruca Plana Senilis); Keratosis Senilis , in a Textbook of Dermatology , Philadelphia, Lea & Febiger, 1920, pp. 208-209. 21. Highman, W. J.: Seborrhoeal Keratomas , in Dermatology , New York, The Macmillan Company, 1921, p. 333. 22. Darier, J.: Verrues planes senilis , in Précis de dermatologie , ed. 4, Paris, Masson et Cie, 1928, p. 263. 23. Freudenthal, Walter: Verruca senilis und Keratoma senilis , Arch. f. Dermat. u. Syph. 152:505, 1926 24. Rumpfhautepitheliom nebst Bemerkungen über die Verruca senilis und das Keratoma senilis , Freudenthal Arch. f. Dermat. u. Syph. 158:539, 1929. 25. Gans, Oscar: Keratoma senilis; Verruca senilis, Histologie der Hautkrankheiten , Berlin, Julius Springer, 1928, vol. 2. pp. 374 and 377. 26. Eller, J. J., and Ryan, V. J.: Senile Keratosis and Seborrheic Keratosis, unpublished data. 27. Darier, J.: Note sur la dyskératose, en particulier dans la "maladie de Paget," Bull. Soc. franç. de dermat. et syph. 32:1 ( (Jan. 18) ) 1925 28. Dyskératose folliculaire , in Précis de dermatologie , ed. 4, Paris, Masson et Cie, 1928, p. 263. 29. Bloch, B.: Ueber benigne, nicht naevoide Melanoepithelioma der Haut nebst Bemerkungen über das Wesen und die Genese der Dendritenzellen , Arch. f. Dermat. u. Syph. 153:20, 1927. 30. Becker, S. W.: Cutaneous Melanoma , Arch. Dermat. & Syph. 21:818 ( (May) ) 1930. 31. Michael, J. C., and Seale, E. R.: Dermatosis Papulosa Nigra , Arch. Dermat. & Syph. 20:629 ( (Nov.) ) 1929 32. 21:295 (May) 1930. 33. Johnson, C. E., and Harvey, S. C.: Granuloma Senilis , Arch. Dermat. & Syph. 21:566 ( (April) ) 1930. 34. Kreibich, C.: Granuloma Senile , Arch. f. Dermat. u. Syph. 153:807, 1927. 35. Engman, M. F.: Precancerous Conditions of the Skin , J. Lab. & Clin. Med. 1:31, 1915. 36. McCoy, J. N.: Solar Keratoses and Cutaneous Cancer , Arch. Dermat. & Syph. 1:175 ( (Feb.) ) 1920. 37. Montgomery, D. W.: Unusual Exposure to Light Followed by Seborrheic Keratosis , J. A. M. A. 60:709 ( (Jan. 4) ) 1913.Crossref 38. Dubreuilh, W.: Epithéliomatose d'origine solaire , Ann. de dermat. et syph. 38:387, 1907. 39. Darier, J.: Keratoma senilis , in Précis de dermatologie , ed. 4, Paris, Masson et Cie, 1928, p. 992. 40. Dawson, J. W.: Melanomata, Their Morphology and Histogenesis: Study of Cell Origins and Transformations with Critical Discussion on Aspects of Tumour, Growth and Clinical Review , Edinburgh M. J. 32:501 ( (Oct.) ) 1925. 41. Bowen, J. T.: Precancerous Dermatoses: A Study of Two Cases of Chronic Atypical Epithelial Proliferation , J. Cutan. Dis. 30:241 ( (May) ) 1912. 42. Heimann, W. J.: Precancerous Dermatoses , J. Cancer Research 1:343 ( (July) ) 1916. 43. Drake, J. A., and Whitfield, Arthur: Paget's Disease of the Vulva , Brit. J. Dermat. 41:177 ( (May) ) 1929.Crossref 44. Fraser, J. F.: Bowen's Disease and Paget's Disease of the Nipple: Their Relation to Dyskeratosis , Arch. Dermat. & Syph. 18:809 ( (Dec.) ) 1928. 45. Kogoj, F.: La dyskératose , Ann. de dermat. et syph. 8:351, 1927. 46. Montgomery, Hamilton: Superficial Epitheliomatosis , Arch. Dermat. & Syph. 20:339 ( (Sept.) ) 1929. 47. Bowen, J. T.: Precancerous Dermatoses: A Sixth Case of a Type Recently Described , J. Cutan. Dis. 33:787 ( (Dec.) ) 1915. 48. Darier, J.: La dermatose précancéreuse de Bowen dyskératose lenticulaire et en disques , Ann. de dermat. et syph. 45:449, 1914-1915. 49. Montgomery, Hamilton: Basal Squamous Cell Epithelioma , Arch. Dermat. & Syph. 18:50 ( (July) ) 1928. 50. Broders, A. C.: The Grading of Carcinoma , Minnesota Med. 8:726 ( (Dec.) ) 1925.

1931 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1931.03880230135015

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract SECTION ON DERMATOLOGY, AMERICAN MEDICAL ASSOCIATION Members of the Section on Dermatology of the American Medical Association are invited to be guests of the Philadelphia Dermatological Society at a Luncheon to be given on Wednesday, June 10, at 12: 30 p. m., at the University Club, 16th and Locust Streets, Philadelphia.

1931 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1931.03880230136016

Abstract Of course the first thing an editor likes to get is a record of good original work; the next thing, is a paper that is well written and in readable form. One of the things that make an editor love an author is a paper that indicates a sense of responsibility for authorship; that he has taken the trouble to plan and develop it in logical sequence, and that he knows that good manners in writing require attention to spelling, grammar and punctuation. The writer who takes it for granted that the editor realizes that he can spell, punctuate and write grammatical English and so does not take the trouble to do so may have a fine indifference, but he has not specialized in knowledge of human nature. Editors are apt to be irritable, like other people, and to feel that it is not their place to labor over the References 1. The American Medical Association is glad to supply labels for this purpose on request.

1931 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1931.03880230138017

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract In the article by Dr. E. William Abramowitz in the April issue (Arch. Derm. & Syph.23:644, 1931) the following errors occurred: Page 651—13th line, "boric acid" should read "benzoic acid." Page 661—In the last formula, near the bottom of the page, "National Formulary" following Lotio Alba should read "Pharmaceutical Recipe Book." Page 669—The formula appearing about the middle of the page should begin: Page 673—Lines 10 and 11. should read 3 per cent salicylic acid, 5 per cent benzoic acid in one hundred parts of petrolatum.

Rattner, Herbert

1931 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1931.03880230139019

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.

Engman, Martin F.;Weiss, Richard S.

1931 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1931.03880230160020

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract Dermatitis Due to Phenolphthalein. Presented by Dr. Joseph Grindon. A young man, first seen about three weeks previous to presentation presented some dry, brownish patches next to the mouth and on the chin. There were also similar darker patches on the back of the neck and near the right elbow. There were a few pink patches on the left forearm that had developed more recently. When the patient was presented, these patches had faded, except those near the right elbow. The itching had ceased. The patient had been using "Feen-a-mint" occasionally for one year until three weeks previous to presentation. DISCUSSION Dr. S. T. Millard, Topeka, Kan.: Did the young man say that the itching had been very intense?Dr. J. Grindon: Yes, sometimes there was severe itching that he attributed to "hives." Neurotic Dermatitis. Presented by Dr. E. E. Brown. A woman, aged 36, a housewife, complained of severe

Fraser, J. Frank;Kingsbury, Jerome

1931 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1931.03880230162021

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract Lymphangitis and Sycosis of the Upper Lip. Presented by Dr. Howard Fox. H. J. H., was first presented for this condition on April 22, 1930. Dr. Binford Throne suggested that vaccines be injected intradermally into the lesions. This was carried out, and a vaccine similar to that used by Dr. Throne was given twice a week for one month, with slight temporary benefit after the first two or three injections. From this course of treatment no permanent benefit was obtained. The patient was then given autogenous vaccines subcutaneously for one month, which did not give relief. Ulcer of the Hand and Foot. Presented by Dr. Howard Fox. H. J. H. had previously been presented on Oct. 28, 1930, as having a case for diagnosis. Histologic examination of lesions on the hands and feet showed prickle cell epithelioma. A Case for Diagnosis (Lymphogranuloma?). Presented by Dr. Eugene F. Traub. In I.

Finnerud, Clark W.

1931 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1931.03880230171022

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract Pemphigus or Leukoplakia? Presented by Dr. E. A. Oliver. A white man, aged 43, was first seen on April 21, 1930. On either side of the mouth on the buccal mucosa opposite the last molar teeth there were two patches the size of a quarter. These were much inflamed and irritated, and covered with a grayish pellicle. On the mucous membrane of the lower lip there was another superficial area. Examination also revealed an erythematous scarlatiniform eruption on the chest and the abdomen, which was evidently caused by an injection of neoarsphenamine given by another physician several days previously. The Wassermann test of the blood and the examination for Vincent's organisms gave negative results.Since April 21, he had been under constant observation. The lesions had been painted with silver nitrate and mild silver protein, and recently he had been using a sodium perborate paste. He did not improve under

Parkhurst, H. J.;Driver, J. R.

1931 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1931.03880230181023

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract Lichen Planus. Presented by Dr. R. E. Barney. Mrs. I. R., aged 41, had been under treatment for a latent syphilitic infection since September, 1925. Since 1922, she had noticed an asymptomatic eruption on the wrists and dorsa of the hands. It had first appeared during the course of what seemed to be a dermatitis caused by arsphenamine, while she had been under the care of another physician.On the dorsa of the hands, flexures of the wrists and to lesser extent on the flexor surfaces of the forearms, there was an eruption consisting of purplish-gray lesions varying in size from that of a pinhead to that of a small pea. Some of the lesions were distinctly papular, angular, flat-topped, shiny and umbilicated, and occasionally adherent scales were present. Some of the lesions were atrophic.One of the atrophic lesions showed the following histologic picture: The epidermis was thin, and

Turnacliff, D. D.;Gager, Edward C.

1931 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1931.03880230184024

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract Granuloma Annulare. Presented by Dr. C. D. Freeman. Miss S. presented lesions that began one year before presentation on the right elbow as deep-seated infiltrations of the skin. Her past history was unimportant. At the time of presentation there were lesions on both arms and on the right thigh. The nodules were not crescentic or circinate, but were more or less irregularly arranged, and involution had taken place in some of the lesions. The biopsy specimen showed a decided cellular infiltration with lymphocytes, polymorphonuclear leukocytes and proliferative connective tissue cells in the subpapular layer. Necrosis was present in the center of some of the infiltrated areas.The patient's father and mother died of tuberculosis, the mother having contracted it from the father. Her brothers and sisters were well. DISCUSSION Dr. C. D. Freeman: When I first saw the case I thought that the condition was sarcoid, but a diagnosis of

1931 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1931.03880230190025

1931 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1931.03880230193026

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.