Archives of Dermatology and Syphilology

ENGMAN, MARTIN F.;EBERSON, FREDERICK

1921 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1921.02350160002001

Abstract To give a clear idea of the meaning of latency, we must point to a few biologic facts in relation to the invasive stage of syphilis. After a given infection, when the virus is deposited on an abraded surface, the organisms begin to proliferate and are wafted quickly into the general circulation, as has been actually demonstrated by Brown and Pearce1 and one of us.2 The organisms continue to increase at the site of the lesion and probably within the body until the period of multiple systemic localization occurs. When the spirochetes are planted in the tissues and organs of the body, colonies are formed and through their growth and life cycle induce certain biochemical changes which may be exhibited in all organs; and, no matter where located, seem to stimulate the same cellular reaction. They arrive by way of the blood stream in these various organs and References 1. Brown, Wade H., and Pearce, Louise: A Note on the Dissemination of Spirochaeta Pallida from the Primary Focus of Infection , Arch. Dermat. & Syph. 2:470 ( (Oct.) ) 1920. 2. Eberson, F.: The Dissemination of Spirochaeta Pallida in Experimental Syphilis , Arch. Dermat. & Syph. 3:111 ( (Feb.) ) 1921. 3. Personal communication. 4. Engman, M. F.: The Pathogenesis of Placental Syphilis: A Preliminary Report , J. A. M. A. 58:1415 ( (May 11) ) 1912. 5. Levaditi: Ztschr. f. Immunitätsforsch. Ref. 2:277, 1910. 6. J. Exper. Med. 32:473, 1920. 7. McNeill, H. L.: Syphilis in the Southern Negro , J. A. M. A. 67:1001 ( (Sept. 30) ) 1916. 8. Day and McNitt: Am. J. Syph. 3:595, 1919. 9. Warthin: Am. J. M. Sc. 152:508, 1916. 10. Waller: Prag. Vierteljahrschr. f. prakt. Heilkunde 29:112, 1851 11. Waller Prag. Vierteljahrschr. f. prakt. Heilkunde 31:51, 1851. 12. Canstatts Jahresber. f. d. ges. Med. 4:336, 1856. 13. Lindwurm and Schulze: Würzburger med. Ztschr. 3:143, 1862. 14. Flügge: Deutsch. med. Wchnschr. 31:1755, 1905. 15. Noeggerath and Stähelin: München. med. Wchnschr. 52:1481, 1905. 16. Raubitschek: Wien. klin. Wchnschr. 18:752, 1905. 17. Sobernheim and Tomasczewski: München. med. Wchnschr. 52:1857, 1905. 18. Wolters: Med. Klin. 1:963, 1905. 19. Zabolotny: Zentralbl. f. Bakteriol. Ref. 38:13, 1905. 20. Elliot and Wile: J. Cutan. Dis. 34:645, 1916. 21. Uhlenhuth and Mulzer: Berl. klin. Wchnschr. 49:153, 1912. 22. Frühwald: Wien. klin. Wchnschr. 25:584, 1912. 23. Jeans: Am. J. Syph. 3:114 ( (Jan.) ) 1919. 24. Baisch: München. med. Wchnschr. 56:1929, 1906. 25. Reasoner, M. A.: Early Death from Cerebral Syphilis, with Successful Rabbit Inoculation , J. A. M. A. 66:1917 ( (June 17) ) 1916.Crossref 26. Buschke and Fischer: Compt. rend. Soc. de biol. 58:845, 1905 27. Berl. klin. Wchnschr. , 1906, No. (13) , p. 383. 28. Dohi and Tanaka: Quoted by Metschnikoff, System of Syphilis 1:61, 1914. 29. Nichols, H. J., and Hough, W. H.: Demonstration of Spirochaeta Pallida in the Cerebrospinal Fluid . J. A. M. A. 60:108 ( (Jan. 11) ) 1913.Crossref 30. Reasoner, M. A.: Some Phases of Experimental Syphilis , J. A. M. A. 67:1799 ( (Dec. 16) ) 1916.Crossref 31. Hochsinger: Cited by Mott, System of Syphilis , 1914, Ed. 11, p. 418. 32. Finger and Londsteiner: Arch. f. Dermat. u. Syph. 81-82:152, 1906Crossref 33. 81-82:147, 1906. 34. Warthin: Am. J. Syph. 2:425, 1918. 35. Uhlenhuth and Mulzer: Centralbl. f. Bakteriol., Part 2, Orig. 64:165, 1912. 36. Neisser and Hoffmann: Arb. a. d. k. Gesndhtsamte 37:72. 1911. 37. Uhlenhuth and Mulzer: Berl. klin. Wchnschr. 50:2031, 1913. 38. Corzan: J. Nerv. & Ment. Dis. 49:282, 1919.

WILE, UDO J.

1921 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1921.02350160027002

Abstract With the exception of syphilis of the rectum, syphilis of the intestine may be said to be a rare entity, at least from the clinical stand-point. The condition is recognized frequently, however, in syphilis of the new-born, and we are principally indebted to pathologic reports for literature on cases of true intestinal syphilis in the acquired form of the disease. The bedside recognition of the condition, which today perhaps is facilitated by the serologic examination, was a few years ago well-nigh impossible. A few cases recognized intra vitam are from time to time seen in surgical clinics in which the patients are operated on for various abdominal conditions simulated by syphilis. Thus, for example, intestinal obstruction, perforation, peritonitis, tuberculosis and carcinoma are conditions for which operation is occasionally resorted to, and in which syphilitic conditions of the bowel, both small and large, are occasionally encountered. Neumann,1 while stating that References 1. Neumann: Nothnagel , Spez. Path. u. Therap., Hölder, Wien . 23:405, 1899. 2. Fraenkel: Ueber tertiare Darmsyphilis , München. med. Wchnschr. 48: 1262, 1901 3. Zur Lehrer von der Acquirirten Magendarmsyphilis , Virchow's Arch. 155:507, 1899Crossref 4. Friedreich: Zur Chirurgischen Pathologie von Netz. u. Mesenterium , Arch. f. klin. Chir. 61:998, 1900 5. Oberndorfer: Ueber die viscerale Form der congenitalen Syphilis mit specieller Berücksichtigungen des Magen-Darmcanals , Virch. Arch. 159:179, 1900.Crossref 6. Reach: Cited by Goto, p. 208. 7. Brunner: Syphilis des Darms , Deutsch. Chir. 46E:333, 1907. 8. Horwitz: Four Cases of Secondary Syphilis Complicated with Chronic Appendicitis , Ann. Surg. 27:74, 1898. 9. Rieder, Zur Kenntnis der Specifisch Darmerkrankungen bei Acquirirte Syphilis , Hamburger Jahrbuch , No. (1) . 10. Vantini: Cited by Brunner. 11. Trinkler: Mitt. a. d. Grenzgeb. d. Med. und Chir. 10:727 12. Chirurgische Kongress, 1904, p. 149 13. Brunner; Sigmoidio-Rectostomy, Langenbeck's Arch. 58: 334, 1899. 14. Kummel: Cited by Brunner. 15. Gross: Cited by Brunner. 16. Guttmann: Multiple Dunndarmgeschwure hochstwahrscheinlich Syphilitischer Natur , Ztschr. f. klin. Med. 50:404, 1903. 17. Hueter: Ueber Darmlues , München. med. Wchnschr. 53:284, 1906. 18. Blackmore, A.: A Case of Syphilitic Ulceration of the Intestine , Lancet 2:615, 1885.Crossref 19. Fischer: Syphilis of the Stomach and Intestines, with Report of Cases , Monograph read at meeting of the Medical Association of Georgia, 1915 . 20. Elder: Acute Intestinal Obstruction Caused by Syphilitic Ulceration in the Ileum . Brit. M. J. 1:1068, 1904.Crossref 21. Rosenfeld: Die Syphilitische Dunndarmstenose , Berl. klin. Wchnschr. 39:No. (307) , 1902. 22. Solms: Kasuistische Beitrage zur Pathologie der Magen und Darmkrankheiten , Arch. f. Verdauunzskr. 17:174, 1911.Crossref 23. Goto: Beiträge zur Erworbenen Syphilis der Ileocaecalgegend , Arch. f. Deutsch. Chir. 97:207, 1912. 24. Riedel: Ileus un Folge von etwas aufsergewöhnlichen Strangbildungen, Verwachsungen und Achsendrehungen, sowie von Darmsyphilis , Mitt. a. d. Grenzgeb. d. Med. u. Chir. 2:483, 1897. 25. Friedreich: Zur Chirurgischen Pathologie von Netz. u. Mesenterium , Langenbeck's Arch. 61:998, 1900. 26. Fournier and Lereboullet: Diarrhées Syphilitiques Tertiaire , Gaz. hebd. de méd. , N. S. 5:637, 1900. 27. Ringel: Syphilitische Darmstenose , Deutsch. med. Wchnschr. 25:11, 1899.Crossref 28. Weiss: Die Syph. Erkrankungen des Darms. , Centralbl. f. d. Grenzgeb. d. Med. u. Chir. 5:577 and 625, 1902.

KLAUDER, JOSEPH VICTOR;GREENBAUM, SIGMUND S.

1921 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1921.02350160032003

Abstract Creeping eruption, or larva migrans, first described by Lee in 1874, is a relatively rare disease in this country. There are only thirteen references in the literature to the disease occurring in the United States. These cases were reported by Van Harlingen,1 Stelwagon,2 Hamburger,3 Shelmire,4 Hutchins,5 Moorhead,6 Gosman,7 Haase,8 Kirby-Smith,9 Knowles,10 Gaskill,11 Whitehouse12 and by Fox.13 In many of these reported cases the disease was contracted in the southern part of the United States. A number of cases of larva migrans have been reported as occurring in various countries, particularly in Russia, in which the disease is most common; it is also common in the Shetland Islands and in Norway. According to Lee, it is common among Arabian children, whose mothers burn the part with a hot wire. Extensive studies of this disease have been made, notably References 1. Van Harlingen, A.: Report of Three Cases of Creeping Larvae in the Human Skin , Am. J. Med. Sc. 124:436-441, 1902.Crossref 2. Stelwagon, H. W.: A Case of Creeping Eruption , J. Cutan. Dis. 21:502-504, 1903. 3. A Second Case of Creeping Eruption , Stelwagon A Case of Creeping Eruption 22:359-362, 1904. 4. Hamburger, L. P.: Creeping Eruption: Its Relations to Myiasis , J. Cutan. Dis. 22:217-227, 1904. 5. Shelmire, J. B.: Creeping Eruption; Report of a Case , J. Cutan. Dis. 23:257-260, 1905. 6. Hutchins, M. B.: Report of Two Cases of Larva Migrans, with Special Reference to the Treatment , J. Cutan. Dis. 34:270-271, 1906 7. Another Case of Hyponomoderma (Larva Migrans) Demonstrating the Immediate Curative Effect of Chloroform Injected in Situ , Hutchins J. Cutan. Dis. 36:521-522, 1908. 8. Moorhead, J. D.: Creeping Disease , Texas Med. News 15:167-170, 1906. 9. Gosman, G. H. R.: Two Cases of Creeping Eruption , J. A. M. A. 54: 38-39 ( (Jan. 1) ) 1910.Crossref 10. Haase, M.: A Case of Larva Migrans , J. Cutan. Dis. 28:393-394, 1910. 11. Kirby-Smith, J. L.: Extensive Creeping Eruption , New York M. J. 101: 506-507, 1915. 12. Knowles, F. C.: Creeping Eruption (Larva Migrans) of the Skin , J. A. M. A. 66:172-177 ( (Jan. 15) ) 1916.Crossref 13. Gaskill, H. K.: Larva Migrans , Trans. Phila. Dermat. Soc., J. Cutan. Dis. 35:105, 1917. 14. Whitehouse: Larva Migrans , Trans. N. Y. Dermat. Soc., J. Cutan. Dis. 35:187, 1917. 15. Fox, H.: Larva Migrans , N. Y. Dermat. Trans., J. Cutan. Dis. 35:608, 1917. 16. Sokolow, J. L.: Ueber ein Wurmchen, welches in der epidermoidalen Schicht der menschlichen Haut Gange bildet , Wratsch. 1895, No. (52) , p. 1456 17. abstr. in Arch. f. Dermat. u. Syph. 38:153, 1897. 18. Samson-Himmelsbjerna, C. V.: Ein Hautmaulwurf , Arch. f. Dermat. u. Syph. 41:367-372, 1897.Crossref 19. Wosstrikow, P. E., and Bogrow, S. L.: Zuraetiologie der "Creeping Disease," Arch. f. Dermat. u. Syph. 90:323-331, 1908.Crossref 20. Lenglet, E., and Delaunay, P.: Un cas de Larva Migrans Ann. de dermat. et syph. 4:107-112, 1904. 21. Rille and Riecke: Handbuch der Hautkrankheiten , Mracek 4:178, 1939. 22. Darier, J.: Cas de Creeping Disease (Larva Migrans) Contracte a Paris , Ann. de dermat. et syph. 6:113-120, 1920. 23. Crocker, H. R: Larva Migrans , Diseases of the Skin , Ed. 2, p. 926. 24. Lee, R.: Creeping Eruption . Trans. London Clinical Soc. 8:44, 1875 25. Lee Creeping Eruption Trans. London Clinical Soc. 17:74, 1884. 26. Kaposi: Wien. med. Wchnschr. 31:1370, 1881 27. 32:248, 1882 28. Schmidt: Mith. des Vereines der Aerzte in Steiermark 31:48, 1900.

MCNAIR, JAMES B.

1921 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1921.02350160038004

Abstract DEFINITION Rhus dermatitis caused by Rhus diversiloba and Rhus toxicodendron is an irritation of the skin caused, in the case of Rhus toxicodendron, by Pfaff's toxicodendrol and in the case of Rhus diversiloba by lobinol, a nonvolatile substance containing a polyhydrophenol with unsaturated side chains.1 These toxic substances may or may not have the same chemical composition. ETIOLOGY I have shown in preceding papers2 that the active principle lobinol is neither bacterial nor volatile, and that poisoning occurs from actual contact with the resinous sap of the plant. This contact, however, may result through an intermediary agent, which carries the sap, such as particles of soot in smoke, clothing, cordwood, croquet balls and shoes. AVENUES CF INFECTION A suitable channel must be present so that the pathogenic lobinol may enter the body and produce its specific disease. Such avenues of infection are the cutaneous surfaces, the respiratory, alimentary References 1. McNair, James B.: J. Am. Chem. Soc. 43:159 ( (Jan.) ) 1921.Crossref 2. McNair, James B.: J. Infect. Dis. 19:419, 1916Crossref 3. J. Am. Chem. Soc. 43: 159 ( (Jan.) ) 1921.Crossref 4. Busey: Am. J. M. Sc. 17:436, 1873Crossref 5. Kalm, P.: Travels Into North America , Ed. 2 1:53, 60 to 64 and 139 6. 2:20, 1772. 7. Horsfield: Abst. Med. Repts. 2:186, 1805. 8. Schwalbe, C.: München. med. Wchnschr. 49:1616, 1902 9. Med. Rec. 63: 855, 1903. 10. Thudichum, C. L.: The Alkaloidal Clinic 10:829, 1903. 11. Hadden, A.: Med. Rev. of Rev. 12:764, 1906. 12. Ward, Ralph F.: New York M. J. 88:1224 ( (Dec. 26) ) 1908. 13. Lindley, J. S.: Am. J. Dermat. & Gen.-Urin. Dis. 12:342, 1908. 14. Von Adelung. E.: Arch. Int. Med. 11:148, 1913 15. Interstate M. J. 20:139, 1913 16. Proc. Soc. Exper. Biol. & Med. 10:61, 1912-1913. 17. McNair, James B.: J. Infect. Dis. 20:485, 1917. 18. Overton and Meyer. Hypothesis , Jahresb. f. wissenschaftl. Botanik 34: 669, 1900 19. Arch. f. exper. Path. u. Pharmakol. 42:109, 1899. 20. Robertson: Biol. Chem. 4:1, 1908. 21. Articles on this subject by Bardeen may be found in Johns Hopkins Hosp. Repts. 7: 1898 22. Wells: Articles on this subject by Bardeen may be found in Johns Hopkins Hosp. Repts. 18987., p. 562. 23. McNair, James B.: J. Infect. Dis. 19:419, 1916.Crossref 24. Pfaff. Franz: J. Exper. Med. 2:181, 1897.Crossref 25. Fontana, Felix: Treatise on the Venom of the Viper; on the American Poisons , etc., Trans. by J. Skinner, Ed. 2, 2:181, 1795. 26. Van Mons, J. B.: Actes la société de médecine, chirurgie et pharmacie 1: Pt. (2) , p. 13, 1797. 27. Horsfield, Thomas: In C. Caldwell's "Medical Theses," 1805, p. 113; Inaugural Dissertation on Rhus, Univ. of Pa., 1798. 28. Dakin, R.: Am. J. M. Sc. 4:98, 1829.Crossref 29. White, J. C.: New York M. J. 17:225, 1873 30. Boston M. & S. J. 93: 265, 1875. 31. Park, R.: Arch. Dermat. 5:227, 1879. 32. Cundell-Juler: The Cincinnati Lancet and Clinic , N. S. 11:73, 1883. 33. Morrow, P. A.: Drug Eruptions, 1887, p. 167. 34. Conner, J. J.: Am. J. Dermat. & Gen.-Urin. Dis. 11:368, 1907. 35. Bigelow, J.: American Medical Botany 1:96, 1817 36. 3:20, 1820 37. Blackwood, W. R. D.: Some Thoughts on Rhus Poisoning , Philadelphia Med. Times 10:618, 1880. 38. Burgess, T. J. W.: Canad. J. M. Sc. 5:327, 1880 39. Pharmacol. J. 11:858, 1881. 40. Prichard, A. W.: Bristol Med.-Chir. J. 9:22, 1891. 41. Dunmire, G. B.: Philadelphia Med. Times 12:636, 1881-1882. 42. Farquhar, C.: Univ. Med. Mag. 1:640, 1888-1889. 43. Boston M. & S. J., 1897. 44. Payne, G. F.: Am. Pharmaceutical Assn. Proc. 42:135, 1894. 45. Treille, G.: Marseille Med. 41:149 and 161, 1904. 46. Seabrook, H. H.: New York M. J. 54:51, 1891. 47. Beringer, G. M.: Am. J. Pharmacy 68:18, 1896. 48. Stirling, E. C.: An Eruption of the Skin Caused by the Poison Ivy , Australasian M. Gaz. 33:355, 1913. 49. Frost, J.: London Med. & Physical J. 55:116, 1826. 50. Hunt, J. H.: Brooklyn M. J. 11:392, 1897. 51. Maisch, J. M.: Am. Pharmaceutical Assn. Proc. 13:166, 1865. 52. Planchon, L.: Accidentis causes par le contact du Rhus toxicodendron , Montpellier Med. , Ser. 2 9:61, 219, 1887. 53. Cantrell, J. A.: Med. News 59:484, 1891. 54. Kunz, R. E.: Med. Tribune 5:111, 1883. 55. Walker, J. B.: Med. News 59:556, 1891. 56. Balch, A. W.: J. A. M. A. 46:819, 1906. 57. Von Adelung, Edw.: Arch. Int. Med. , 11:148, 1913 58. Interstate M. J. 20: 139, 1913 59. Proc. Soc. Exper. Biol. & Med. 10:61, 1912-1913. 60. Bogue, E. E.: Garden and Forest, 1894. 61. Parrish, J.: New Jersey Med. Reporter 4:55, 1851. 62. Nicholson, F.: Brit. M. J. 1:530, 1899. 63. Hurlbut, E. T. M.: California Homeopath 7:235, 1869.

FOX, GEORGE HENRY

1921 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1921.02350160059005

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract Many physicians, who in school and college have devoted years to laborious study of Latin and Greek, have allowed their knowledge of these languages to become too rusty for practical use. They recognize a few Greek words as old friends, though not always at first glance, and many Latin words are quite familiar. They omit most of the Latin quotations which they encounter in reading, and they are often unable to translate phrases even in common use. There are some who, like the writer, have at times felt a laudable desire to brush up their linguistic knowledge and have struggled again with the Latin grammar or the Greek Testament, but most of us have soon concluded that more pleasure might be obtained from some other amusement. For all who wish to refresh or add to their presumably meager knowledge of these languages, the surest and most attractive means of accomplishing

WEISS, RICHARD S.

1921 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1921.02350160068006

Abstract The summer of 1920 was noteworthy for the large number of cases of epidermophyton infection observed in both clinical and private practice. Moreover, many of the cases were of such severity as to produce disability. The epidemiology of the disease has never, to my knowledge, been worked out, and I cannot suggest any reason for this increase in the number and severity of the cases. The disability caused by the cases of severe foot disease led me to try several drugs in the hope of shortening the course of the disease, and, as a result of this investigation, I can strongly recommend the application of a saturated solution of picric acid in water. I have not been able to find any reference to the use of picric acid in epidermophyton infection, hence this report. The type of case in which this solution appears to be of great service is the

KILDUFFE, ROBERT A.

1921 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1921.02350160070007

Abstract Since the introduction of the Wassermann test as a serologic method of diagnosis in syphilis in 1906, the reaction has been the subject of extensive and intensive study, particularly as concerns its mechanism and the standardization of its technic. The fact that we are still in doubt as to an exact and definite understanding of the mechanism whereby the reaction occurs; that the exact nature of the body whose presence in syphilitic serum gives rise to the reaction is still a matter of uncertainty; and, above all, the clear and evident necessity for a thorough understanding of the principles of the test, in so far as they are known, and of the many niceties of technic which must be mastered and understood before one is competent to perform and interpret the test—all these have given an added impetus to numerous attempts to simplify the reaction and render it available to References 1. McDonagh: Brit. J. Dermat. 28:114 ( (April) -June) 1916.Crossref 2. Galli-Valerio: Cor.-B1. f. schweiz. Aertze 49:1978 ( (Dec. 25) ) 1919. 3. Wolffenstein: Berl. med. Wchnschr. 56:1110 ( (Nov. 24) ) 1919. 4. Wodtke: München. med. Wchnschr. 67:399 ( (April 2) ) 1920. 5. Baumgartel: München. med. Wchnschr. 67:402 ( (April 2) ) 1920. 6. Dekenga and Platenga: Nederl. Tijdschr. v. Geneesk. 1:1631 ( (May 8) ) 1920. 7. Messerschmidt: Deutsch. med. Wchnschr. 46:150 ( (Feb. 5) ) 1920.Crossref

1921 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1921.02350160075008

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract In an abstract of Stokes and Bushman's article, "A Clinical Study of Wassermann-Fast Syphilis, with Special Reference to Prognosis and Treatment," which appeared in the February number of the Archives, on page 177, line 1, "66 per cent." should have been 6.6 per cent.

1921 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1921.02350160076009

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract Dr. George Henry Fox, who has given us so many thoughtful suggestions as to diction and vocabulary in dermatologic writings, has contributed to this issue of the Archives an interesting article on "Dermatological Etymology." He emphasizes the interest and instructive value of this subject. It is to be hoped that his suggestions will stimulate others to follow at least a little way along this path of profitable study; for, as Dr. Fox says, "It enlarges one's vocabulary; it renders more accurate the appreciation of the meaning of words, and it tends to precision in the use of them." And no one who reads medical literature can fail to note the need for improvement in all these respects, as well as in many other matters of style. It is a sad fact that the style of medical articles is notoriously loose; this is the result partly of inexperience in writing, partly

1921 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1921.02350160078010

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.

Azúa,

1921 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1921.02350160100011

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract SILVER SALVARSAN IN THE TREATMENT OF SYPHILIS. Drs. Covisa and Bejarano. We have treated forty patients, including patients with primary, secondary and tertiary syphilis and neurosyphilis. Besides its action on the Wassermann test, silver arsphenamin causes these three remarkable effects on primary syphilis: (1) quick disappearance of the chancrous induration, (2) disappearance of spirochetes with 10 cg. of the drug, (3) quicker clearing of local adenopathies. In secondary and tertiary cases silver arsphenamin acts energetically and quickly in surprisingly small doses.The action of this drug on the Wassermann test has been discussed by German authors. As representative of the results obtained by us, we may mention two cases of serum positive primary syphilis and four cases of secondary syphilis. In the first two cases the Wassermann test became negative with 70 cg. and 40 cg. of silver arsphenamin, respectively. In the secondary cases the reaction became negative with doses

Quinn, William A.

1921 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1921.02350160102012

Abstract IDIOPATHIC MULTIPLE HEMORRHAGIC SARCOMA. Presented by Drs. Ormsby and Mitchell. A man, aged 56 years, presented a disorder which began two years previously, following bites by gnats. The evolution of the lesions could not be outlined by the patient.At the time of presentation the disorder was situated chiefly on the legs and feet which were swollen; the skin was hard and the seat of solid edema. Many nodules, varying in size between that of a pea and that of a small coin, were distributed over these areas. The nodules exhibited various shades of brown chiefly, but some were bluish-red. Two lesions were present on the buttocks, one on the glans penis, and there was a scar following excision of one of the lesions on the finger. The circulation of both legs exhibited a retiform appearance. DISCUSSION Dr. Wile thought it was a case of the Kaposi type of sarcoma, References 1. Transactoins of the Chicago Dermatological Society , Arch. Dermat. & Syph. 1:476 ( (April) ) 1920.

Winfield, James M.

1921 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1921.02350160108013

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract TUBERCULOSIS CUTIS ASSOCIATED WITH RECURRENT LYMPHANGITIS. Presented by Dr. Howard Fox. S. R., a man aged 37, born in Austria, a butcher, had nothing in his family or personal history to suggest tuberculosis. His parents and eight brothers and sisters were living and apparently well. He had been married fifteen years and had six healthy children. With the exception of "three attacks of erysipelas" occurring within one month, eight years ago, he had always been well and "never seen a doctor in his life." As a result of the attack of erysipelas the nose, upper lip and adjacent portion of the cheeks had remained slightly swollen and red. The present eruption appeared suddenly without any preceding trauma or other known cause two and a half years ago. The upper lip became decidedly red and swollen, and an open sore appeared on the left side of the lip below the nostril.

Fox, Howard

1921 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1921.02350160118014

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract PAGET'S DISEASE OF THE NIPPLE. Presented by Dr. Williams. Mrs. A. W., aged 45 years, was born in the United States and had always lived here. About three years ago she noticed a little blood under the skin over the right areola of the breast. The blood oozed out and has flowed intermittently with admixture of pus ever since. She presented a round lesion on the right breast about an inch in diameter, with a fairly sharp marginated border and erythematous eroded surface. The nipple was entirely retracted. There was no adenopathy of the axillae and only a slight infiltration of the skin lesion. There were no definite nodules in the breast. The patient had nursed both her children; the youngest one was about 19 years old. She still menstruated. DISCUSSION Dr. Pollitzer said there was no question about the diagnosis or about the treatment—operation at the earliest possible moment.

Freeman, C. D.

1921 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1921.02350160130015

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract Regular Meeting, Feb. 2, 1921 EPIDERMOPHYTOSIS, KERATOTIC TYPE. Presented by Dr. Irvine. A woman, aged 64, presented a few months ago a thickened keratotic condition on the palms and soles. On the legs over the tibiae there were a few vesicles. The vesicles promptly disappeared under treatment with Whitfield's ointment. The keratotic condition resisted Whitfield's ointment but responded to a 40 per cent. salicylic acid plaster. CASE FOR DIAGNOSIS. Presented by Dr. Freeman. A man, aged 28, presented an extensive eruption over the body. The condition began two years ago. The patient had been treated elsewhere for syphilis. DISCUSSION Dr. Michelson stated that the predominating lesions were telangiectatic, and that the disease was not pityriasis lichenoides chronica or Majocchi's disease.Dr. Butler stated that at first glance the disease bore a striking resemblance to Brocq's disease, but this would not explain the new vessel formation. He considered that it was

1921 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1921.02350160133016

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables. Abstract Chatterji has collected information regarding the protean manifestations of syphilis from many authorities, and has amplified it from his own practice. His experience taught him that the manifestations which the disease undergoes in the tropics provide a great field for research. He believes that it is generally admitted that in the tropics (he speaks for India), syphilis manifests itself more in the lesions of the skin, mucous membranes, and in ulcers (tropical ulcers) than in typical tertiary lesions or parasyphilitic conditions. It has been suggested that various skin lesions, described under the name of tropical phagedenia or tropical ulcer, are really manifestations of syphilis. It is generally accepted that tertiary ulceration in the tropics assumes a malignancy which is not so common in cold climates. Many of the tropical conditions are of protozoal origin, for example, yaws, gangosa, and dermal leishmaniasis (oriental sore), and as such they may give positive

1921 Archives of Dermatology and Syphilology

doi: 10.1001/archderm.1921.02350160134017

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.