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Signal Transduction and Targeted Therapy

Subject Areas: Cancer Research
Publisher: Nature Publishing Group UK - Springer Journals
SJR: 53

Open Access

Journal Article

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases

Qian, Lu; Zhu, Yanli; Deng, Chao; Liang, Zhenxing; Chen, Junmin; Chen, Ying; Wang, Xue; Liu, Yanqing; Tian, Ye; Yang, Yang

2024 Signal Transduction and Targeted Therapy

doi:10.1038/s41392-024-01756-w pmid:38424050

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s), consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related coactivator (PRC), was discovered more than a quarter-century ago. PGC-1s are essential coordinators of many vital cellular events,...
Open Access

Journal Article

Metabolic memory: mechanisms and diseases

Dong, Hao; Sun, Yuezhang; Nie, Lulingxiao; Cui, Aimin; Zhao, Pengfei; Leung, Wai Keung; Wang, Qi

2024 Signal Transduction and Targeted Therapy

doi:10.1038/s41392-024-01755-x pmid:38413567

Metabolic diseases and their complications impose health and economic burdens worldwide. Evidence from past experimental studies and clinical trials suggests our body may have the ability to remember the past metabolic environment, such as hyperglycemia or hyperlipidemia, thus leading to chronic...
Open Access

Journal Article

Resilience conferred by APOE-R136S: a defense bestowed by nature to combat Alzheimer’s disease

Xiao, Bin; Kuruvilla, Joshua; Tan, Eng-King

2024 Signal Transduction and Targeted Therapy

doi:10.1038/s41392-024-01775-7 pmid:38424046
Open Access

Journal Article

Navigating Epstein–Barr virus autoimmunity: role of NK cells and T cells in multiple sclerosis

Xie, Chu; Sun, Cong; Zeng, Mu-Sheng

2024 Signal Transduction and Targeted Therapy

doi:10.1038/s41392-024-01774-8 pmid:38424043
Open Access

Journal Article

Tet methylcytosine dioxygenase 2 (TET2) deficiency elicits EGFR-TKI (tyrosine kinase inhibitors) resistance in non-small cell lung cancer

Zhang, Jian; Zhao, Kejia; Zhou, Wenjing; Kang, Ran; Wei, Shiyou; Shu, Yueli; Yu, Cheng; Ku, Yin; Mao, Yonghong; Luo, Hao; Yang, Juqin; Mei, Jiandong; Pu, Qiang; Deng, Senyi; Zha, Zhengyu; Yuan, Gang; Shen, Shensi; Chen, Yaohui; Liu, Lunxu

2024 Signal Transduction and Targeted Therapy

doi:10.1038/s41392-024-01778-4 pmid:38461173

Despite epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) have shown remarkable efficacy in patients with EGFR-mutant non-small cell lung cancer (NSCLC), acquired resistance inevitably develops, limiting clinical efficacy. We found that TET2 was poly-ubiquitinated by E3...
Open Access

Journal Article

Correction: c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses

Wang, Xu-Yan; Wei, Yuan; Hu, Bo; Liao, Yuan; Wang, Xiaodong; Wan, Wen-Hua; Huang, Chun-Xiang; Mahabati, Mahepali; Liu, Zheng-Yu; Qu, Jing-Rui; Chen, Xiao-Dan; Chen, Dong-Ping; Kuang, Dong-Ming; Wang, Xue-Hao; Chen, Yun

2024 Signal Transduction and Targeted Therapy

doi:10.1038/s41392-024-01783-7 pmid:38519471
Open Access

Journal Article

Suppression of ITPKB degradation by Trim25 confers TMZ resistance in glioblastoma through ROS homeostasis

Yan, Yuanliang; Zhou, Shangjun; Chen, Xi; Yi, Qiaoli; Feng, Songshan; Zhao, Zijin; Liu, Yuanhong; Liang, Qiuju; Xu, Zhijie; Li, Zhi; Sun, Lunquan

2024 Signal Transduction and Targeted Therapy

doi:10.1038/s41392-024-01763-x pmid:38438346

Temozolomide (TMZ) represents a standard-of-care chemotherapeutic agent in glioblastoma (GBM). However, the development of drug resistance constitutes a significant hurdle in the treatment of malignant glioma. Although specific innovative approaches, such as immunotherapy, have shown favorable...
Open Access

Journal Article

Elevated Kallistatin promotes the occurrence and progression of non-alcoholic fatty liver disease

Fang, Zhenzhen; Shen, Gang; Wang, Yina; Hong, Fuyan; Tang, Xiumei; Zeng, Yongcheng; Zhang, Ting; Liu, Huanyi; Li, Yanmei; Wang, Jinhong; Zhang, Jing; Gao, Anton; Qi, Weiwei; Yang, Xia; Zhou, Ti; Gao, Guoquan

2024 Signal Transduction and Targeted Therapy

doi:10.1038/s41392-024-01781-9 pmid:38472195

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, and the development of non-alcoholic steatohepatitis (NASH) might cause irreversible hepatic damage. Hyperlipidemia (HLP) is the leading risk factor for NAFLD. This study aims to illuminate the causative...
Open Access

Journal Article

First-line camrelizumab (a PD-1 inhibitor) plus apatinib (an VEGFR-2 inhibitor) and chemotherapy for advanced gastric cancer (SPACE): a phase 1 study

Chen, Xiaofeng; Xu, Hao; Chen, Xiaobing; Xu, Tongpeng; Tian, Yitong; Wang, Deqiang; Guo, Fen; Wang, Kangxin; Jin, Guangfu; Li, Xiao; Wang, Rong; Li, Fengyuan; Ding, Yongbin; Tang, Jie; Fang, Yueyu; Zhao, Jing; Liu, Liang; Ma, Ling; Meng, Lijuan; Hou, Zhiguo; Zheng, Rongrong; Liu, Yang; Guan, Ni; Zhang, Bei; Tong, Shuang; Chen, Shiqing; Li, Xing; Shu, Yongqian

2024 Signal Transduction and Targeted Therapy

doi:10.1038/s41392-024-01773-9 pmid:38528050

Patients with advanced gastric cancer typically face a grim prognosis. This phase 1a (dose escalation) and phase 1b (dose expansion) study investigated safety and efficacy of first-line camrelizumab plus apatinib and chemotherapy for advanced gastric or gastroesophageal junction adenocarcinoma....
Open Access

Journal Article

Precise genome-editing in human diseases: mechanisms, strategies and applications

Zheng, Yanjiang; Li, Yifei; Zhou, Kaiyu; Li, Tiange; VanDusen, Nathan J.; Hua, Yimin

2024 Signal Transduction and Targeted Therapy

doi:10.1038/s41392-024-01750-2 pmid:38409199

Precise genome-editing platforms are versatile tools for generating specific, site-directed DNA insertions, deletions, and substitutions. The continuous enhancement of these tools has led to a revolution in the life sciences, which promises to deliver novel therapies for genetic disease. Precise...

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