Case Reports in Oncological Medicine

Myoteri, Despoina;Dellaportas, Dionysios;Ayiomamitis, Georgios;Strigklis, Konstantinos;Kouroumpas, Efstratios;Zizi-Sermpetzoglou, Adamantia

2019 Case Reports in Oncological Medicine

doi: 10.1155/2019/5605401pmid: 31205794

Nikolaidi, Adamantia;Konstantopoulou, Irene;Pistalmantzian, Nikolaos;Fostira, Florentia;Yannoukakos, Drakoulis;Athanasiadis, Ilias

2019 Case Reports in Oncological Medicine

doi: 10.1155/2019/9357924pmid: 31223512

We report a case of a 58-year-old female with ovarian cancer. The patient presented with ascites, and the biopsies revealed a low-grade adenocarcinoma, either a serous papillary ovarian cancer with peritoneal implants or a primary peritoneal carcinoma. She received neoadjuvant chemotherapy and after 5 cycles achieved partial response, and then, she underwent a total hysterectomy/bilateral salpingo-oophorectomy. The patient underwent germline gene-panel testing for the detection of mutations in cancer predisposing genes. A truncating mutation in the Fanconi anemia complementation group M (FANCM) gene was detected in heterozygosity, namely, p.Arg658Ter (c.1972C>T, rs368728266). The patient’s family history is unremarkable, with no reported cases of breast or ovarian cancer, a fact that can be attributed to the significant lower penetrance of FANCM mutations.

Koti, Krishna Amulya;Backianathan, Selvamani;Sebastian, Patricia;Matthew, Leni G.;Raam, Mithun;Masih, Dipti

2019 Case Reports in Oncological Medicine

doi: 10.1155/2019/2870302pmid: 31218087

The stomach is a very unusual site of metastasis. Published reports on metastatic lesion in the stomach is generally limited to single case reports and case series. Gastric metastasis in an Ewing’s sarcoma is extremely rare and has been reported in English literature but once to our knowledge. We present a case report of Ewing’s sarcoma of the right proximal femur metastasizing to the stomach. A young female treated for Ewing’s sarcoma of the femur in 2012 presented with gastric metastasis after four years of disease-free interval. She was treated with irinotecan-based chemotherapy followed by total gastrectomy with esophagojejunal anastomosis and radiation therapy. At one-year follow-up, she was disease free.

ELJack, Ammar;El Abdallah, Mohamad;Al-Banaa, Kadhim;Chaudhry, Kashif;Musa, Faisal

2019 Case Reports in Oncological Medicine

doi: 10.1155/2019/3740547pmid: 31236296

<i>Introduction</i>. Tumor lysis syndrome (TLS) is a metabolic derangement that results from rapid destruction of cells. It happens frequently in cancers receiving chemotherapy, particularly hematological malignancies. It can lead to death in severe cases. Tumor lysis syndrome that leads to acute renal failure requiring dialysis and/or ICU admission can be associated with a higher rate of complications and mortality. <i>Case Report</i>. We present a 24-year-old male patient with Burkitt&#x2019;s lymphoma. After receiving one cycle therapy, he developed severe kidney injury from TLS. We initiated renal replacement therapy soon after his admission to the ICU, with marked response to therapy. This led to early discharge from the ICU. <i>Conclusion</i>. Early initiation of renal replacement therapy after TLS-AKI can improve the severity of AKI and hasten recovery and prevent complications. This can lead to earlier discharge from the hospital and better outcomes.

Elktaibi, Abderrahim;Rharrassi, Issam;Hammoune, Nabil;Darouassi, Youssef;Hanine, Mohammed Amine;Ammar, Haddou

2019 Case Reports in Oncological Medicine

doi: 10.1155/2019/9468194pmid: 31192018

Laryngeal chondrosarcoma is a rare laryngeal tumor that most frequently originates from the cricoid cartilage. The majority of lesions are low grade and the distinction from benign chondromas must be made. We present a case of a laryngeal chondrosarcoma arising from the cricoid cartilage in a 75-year-old Arab man who presented with hoarseness, dysphonia, and dyspnea. Endoscopic and radiological examinations showed a mass of the wall of his larynx with displaced structures, airway obstruction, and destruction of the cartilage. The patient underwent total laryngectomy. Histological examination supported the diagnosis of low-grade chondrosarcoma. Five months later, the radiological and clinical findings showed no evidence of recurrence or metastases. Laryngeal chondrosarcomas remain a rare disease of unknown etiology, with slow and insidious symptoms. The treatment is surgical, given the importance of preserving the larynx to patients&#x2019; quality of life. The prognosis is favorable and metastases rarely occur.