Engineering biomaterials to tailor the microenvironment for macrophage–endothelium interactionsGuan, Ya; Racioppi, Luigi; Gerecht, Sharon
2023 Nature Reviews Materials
doi: 10.1038/s41578-023-00591-9
Macrophages and endothelial cells (ECs) have essential roles in physiological and pathological conditions by regulating inflammation, vascularization and tissue remodelling. Although the interactions between macrophages and ECs in tissue homeostasis and disease progression have been extensively studied in the past few decades, the role of the extracellular matrix in this intercellular process is less known. Here, we review the current knowledge on how microenvironmental cues, biophysical and biochemical, dictate macrophage–endothelium crosstalk in the pathology of different diseases. We summarize studies using biomaterials as extracellular matrix with tenable properties to manipulate macrophage–EC fate to regulate innate and adaptive immunity, angiogenesis and regeneration. Finally, we discuss the potential and challenges of developing novel therapeutic strategies to tailor macrophage–EC niches to restore homeostasis in various diseases.
Lightwave electronics in condensed matterBorsch, Markus; Meierhofer, Manuel; Huber, Rupert; Kira, Mackillo
2023 Nature Reviews Materials
doi: 10.1038/s41578-023-00592-8
Key properties of quantum materials stem from dynamic interaction chains that connect stable electronic quasiparticles through short-lived coherences, which are difficult to control at their natural time and length scales. Lightwave electronics sculpts the quantum flow of electrons and coherences faster than an oscillation cycle of light by using intense optical-carrier waves as fast biasing fields, which can access multi-electron interaction chains. In this Review, we summarize the key functionalities and the latest advances in lightwave electronics for both fundamental and technological explorations. For example, lightwave-driven ballistic electron transport through dynamically changing band structures has already led to the demonstration of phenomena such as high-harmonic emission and dynamic Bloch oscillations. Lightwave electronic control could also seamlessly convert quantum states between light and matter to create quantum chips that simultaneously exploit electronics for efficient interactions and optics for speed or long coherence lifetimes. Additionally, we present an outlook towards applications of lightwave electronics including quasiparticle colliders to explore quantum phenomena; all-optical band-structure reconstruction in ambient conditions; attoclocks to measure the interaction dynamics of diverse quantum phenomena; ultrafast electron videography to watch electronic reactions unfold; efficient light sources to create compact integration; and petahertz electronics to speed up traditional semiconductor electronics.