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AbstractThe analysis of human genomes has revealed an unexpectedly large variability among individuals of a population. This variation occurs via numerous different mechanisms and on many different scales, ranging from single nucleotide changes to the loss or gain of lengths of DNA encompassing...
AbstractThe development of programmable nucleases in the past two decades has enabled scientists to generate specific mutations to the genomes of many different organisms and tissues. Programmable nucleases including meganucleases, zinc finger nucleases (ZFNs), transcription activator like...
AbstractTrypanosomes are protozoans causing African trypanosomiasis, a neglected tropical disease in Africa affecting humans and animals. Control methods have focused on the use of drugs which have adverse effects and vector control methods which have proved to be ecologically unsustainable....
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