Disorders of Sexual Development: Current Status and Progress in the Diagnostic ApproachGarcía-Acero, Mary; Moreno, Olga; Suárez, Fernando; Rojas, Adriana
2020 Current Urology
doi: 10.1159/000499274pmid: 31998049
Disorders of sexual development (DSD) are conditions with an atypical chromosomal, gonadal or phenotypic sex, which leads to differences in the development of the urogenital tract and different clinical phenotypes. Some genes have been implicated in the sex development during gonadal and functional differentiation where the maintenance of the somatic sex of the gonad as either male or female is achieved by suppression of the alternate route. The diagnosis of DSD requires a structured approach, involving a multidisciplinary team and different molecular techniques. We discuss the dimorphic genes and the specific pathways involved in gonadal differentiation, as well as new techniques for genetic analysis and their diagnostic value including epigenetic mechanisms, expanding the evidence in the diagnostic approach of individuals with DSD to increase knowledge of the etiology.
A Systematic Review of the World of Validated Suprapubic Catheter Insertion Simulation Trainers: From ‘Head-Blocks' to ‘Lunch Boxes'Nonde, James; Laher, Abdullah Ebrahim; McDowall, Jared; Adam, Ahmed
2020 Current Urology
doi: 10.1159/000499273pmid: 31998050
Purpose: Various suprapubic catheter insertion simulators have been described to aid in the training of this fundamental skill. The purpose of this review was to evaluate and critically appraise all validated simulators. Methods: The PubMed, Web of Science, Cochrane Library, Scopus, British Medical Journal and the Embase databases were searched (March 2018), by using key search terms “suprapubic trainer”, “suprapubic model”, “suprapubic simulation” and “suprapubic simulator”. Results: A total of 196 articles were identified; 117 unrelated, 53 animal studies and 20 duplications. Only 6 articles met the inclusion criteria for this review. The median number of participants per study was 30.5. Material costs ranged from 1.71 to 60 dollars per model. Only 2 studies incorporated the use of ultrasound. Conclusion: Despite validated suprapubic catheter insertion models being a specially needed learning resource, only few have been described-mostly for not resourceful environments. There exists a general lack of guidelines on model validation processes. There is a need to develop, appropriately validate and integrate models into training curriculum.
Recent Updates on Mesenchymal Stem Cell Based Therapy for Acute Renal FailureMissoum, Asmaa
2020 Current Urology
doi: 10.1159/000499272pmid: 31998051
Acute kidney injury, formerly known as acute renal failure, is a pathological condition in which ischemia or toxic damage contributes to the loss of renal proximal tubule epithelial cells. Pathophysiological events such as oxidative stress, mitochondrial dysfunction, and direct renal tubular epithelial cells toxicity are responsible for the progression of the disease. This devastating decline in renal function affects mostly patients in the intensive care units and requires costly and invasive treatments such as dialysis and organ transplant. Fortunately, recent therapies such as the use of mesenchymal stem cells (MSCs) were proven to be effective in ameliorating renal failure via paracrine and immunomodulatory mechanisms. These fibroblast-like adult stem cells that differentiate multilineagely can be isolated from dental pulps, umbilical cords, amniotic fluids, adipose tissues, and bone marrows. Depending on their sources, the therapeutical application of each MSC type has its own capacities, advantages, and drawbacks. The review discusses and compares the latest research studies on the use of different MSCs sources to treat renal failure. Concerns about the future clinical application of MSCs such as homing, toxicity, and the risk of immune rejection are also highlighted.
‘Prostate Cancer' Information on the Internet: Fact or Fiction?Moolla, Yusuf; Adam, Ahmed; Perera, Marlon; Lawrentschuk, Nathan
2020 Current Urology
doi: 10.1159/000499271pmid: 31998052
Background/Aims: In today's information era, patients often seek information regarding health using the internet. We assessed reliability and validity of internet information regarding ‘prostate cancer'. Methods: Search term ‘prostate cancer' used on Google website (June 2017). Critical analysis was performed on first 100 hits using JAMA benchmarks, DISCERN score, Health on the Net. Results: 33 500 000 hits returned. Top 100 hits were critically analyzed. Ten links [duplicate links (n = 7), book reviews (n = 1), dead sites (n = 2)] were excluded, therefore 90 were analyzed. Subcategories assessed included: commercial (53.33%), university/medical center (24.44%), government (13.33%); non-governmental/ non-profit organizations (8.89%). Sub-type of information content assessed included: factual (74.44%), clinical trials (18.89%); stories (5.56%); question and answer (1.11%). Website rated as HONcode seal positive (14,44%) or seal negative (85,56%). Website content based on JAMA benchmarks: 0 benchmarks (4.44%), 1 benchmark (16.67%), 2 benchmarks (34.44%), 3 benchmarks (27.78%), 4 benchmarks (16.67%). DISCERN score rated: ‘low' score (16-32) = 12 websites (13.33%), ‘moderate' score (33-64 points) = 68 websites (75.56%), ‘high' score (≥ 65 points) = 10 websites (11.11%). Conclusion: Critical assessment of ‘Prostate Cancer' information on the internet, showed that overall quality was observed to be accurate, however majority of individual websites are unreliable as a source of information by itself for patients. Doctors and patients need to be aware of this ‘quality vs quantity' discrepancy when sourcing PCa information on the internet.
Agarwal PolyLoop Ligation Technique for the Management of the Distal Ureter during Laparoscopic Assisted NephroureterectomyAgarwal, Dinesh K.
2020 Current Urology
doi: 10.1159/000499270pmid: 31998053
Objective: Management of the distal ureter during radical nephroureterectomy remains a controversial issue. This article describes a simple endoscopic PolyLoop ligation technique for managing the distal ureter during radical nephroureterectomy. Technique: This endoscopic technique was used in 6 cases to manage the distal ureter during laparoscopic-assisted radical nephroureterectomy. The distal ureter with en bloc bladder cuff was managed endoscopically. The distal ureteric orifice with 1 cm bladder cuff was circumscribed using a Collins knife. Commercially available, Olympus detachable PolyLoop was used to ligate the ureteric stump to avoid urine spillage from the upper tract. Once ureteric stump was ligated with a PolyLoop, the distal ureter was mobilized by dividing the periureteric adhesions using a Collins knife. Results: Distal ureter was managed successfully in all 6 cases using commercially available detachable Polyloop from Olympus. There were no perioperative complications relating to this technique. Conclusion: The PolyLoop ligation technique offers a simple and safer alternative to manage the distal ureter during radical nephroureterectomy.
Bladder Stones Associated with an Aggressive Plasmacytoid Variant of Urothelial Cancer: A Rare Case and Literature ReviewAlsheikh, Mohammed; Zaman, Mohammad Faruquz; Gopinath, Preethi; Qteishat, Ahmed
2020 Current Urology
doi: 10.1159/000499268pmid: 31998055
Urothelial carcinoma is the most common histologic subtype of bladder cancer, accounting for approximately 90%. We herein report a case of a 78-year-old man with an unusual association of bladder stones with an aggressive plasmacytoid variant of urothelial cancer. Initially he presented in 2009 with a very large bladder stone and was treated by an open cystolithotomy. Histology from a bladder biopsy at that time was benign. He failed to attend follow-up appointments but subsequently he attended in 2016 with a recurrent urinary tract infection and an acute kidney injury. A CT scan showed multiple bladder stones. The cause of our patients' multiple bladder stones is unclear and unusual. He then underwent a further open cystolithotomy according to our multidisciplinary team recommendation. Post-operatively he unfortunately developed a non-healing vesicocutaneous fistula for which he was performed cystoscopy and biopsy but ended with transurethral resection due to the extent of abnormal/necrotic tissue. Histology confirmed a plasmacytoid variant of urothelial cancer. To our knowledge, this is the first case of an association of bladder stones with a plasmacytoid variant of urothelial cancer.