1 - 10 of 19 articles
Objective: Second-generation antidepressants are commonly used to treat major depression in late-life. This systematic review and meta-analysis was undertaken to assess the evidence for efficacy of second-generation antidepressants in late-life major depression. Methods: The Cochrane Library...
Anxiety disorders are among the most common and disabling mental illnesses. While effective treatments exist, many patients—possibly even 50–60%—remain symptomatic despite first-line treatments. With the exception of obsessive compulsive disorder (OCD), there are generally no universal...
Background: A preliminary report in six patients suggested that deep brain stimulation (DBS) of the subcallosal cingulate gyrus (SCG) may provide benefit in treatment-resistant depression (TRD). We now report the results of these and an additional 14 patients with extended follow-up. Methods:...
Purpose: Previous analysis of data from CATIE showed that patients randomly assigned to switch to a new medication were more likely to discontinue study drug than those who stayed on the medication they had been taking prior to randomization. This study addresses additional outcomes measures...
Objective: The authors sought to determine by meta-analysis the efficacy and tolerability of adjunctive atypical antipsychotic agents in major depressive disorder. Method: Searches were conducted of MEDLINE/PubMed (1966 to January 2009), the Cochrane database, abstracts of major psychiatric...
Schizophrenia is a serious mental illness responsible for tremendous morbidity and decreases in quality of life and productivity. It is the eighth leading cause of disability-associated life years lost (1) and accounts for nearly 1.1% of overall losses according to the World Health Organization...
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