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Cardiovascular Toxicology Volume 16 Issue 4

Subject Areas: Molecular Biology
Publisher: Springer US - Springer Journals
ISSN: 1530-7905
SJR: 56

LitStream

Journal Article

Prenatal Exposure to Phthalic Acid Induces Increased Blood Pressure, Oxidative Stress, and Markers of Endothelial Dysfunction in Rat Offspring

Rahmani, Asghar; Soleimannejad, Koroush; Hafezi Ahmadi, Mohammad; Asadollahi, Khairollah; khalighi, Zahra

2015 Cardiovascular Toxicology

doi:10.1007/s12012-015-9337-8 pmid:26293546

Previous studies have reported the harmful effects of exposure to phthalic acid (PA) on heart. No studies have reported the effects of prenatal PA exposure on the structure or function of heart. The current study aimed to investigate the effects of prenatal PA exposure on the markers of...
LitStream

Journal Article

Notch3 Ameliorates Cardiac Fibrosis After Myocardial Infarction by Inhibiting the TGF-β1/Smad3 Pathway

Zhang, Mingming; Pan, Xietian; Zou, Qian; Xia, Yuesheng; Chen, Jiangwei; Hao, Qimeng; Wang, Haichang; Sun, Dongdong

2015 Cardiovascular Toxicology

doi:10.1007/s12012-015-9341-z pmid:26487518

Notch3 and TGF-β1 signaling play a key role in the pathogenesis and progression of chronic cardiovascular disease. However, whether Notch3 protects against myocardial infarction (MI) and the underlying mechanisms remains unknown. C57BL/6 mice were randomized to be treated with Notch3 siRNA...
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Journal Article

Triptolide Attenuates Myocardial Ischemia/Reperfusion Injuries in Rats by Inducing the Activation of Nrf2/HO-1 Defense Pathway

Yu, Haijie; Shi, Liye; Zhao, Shijie; Sun, Yujiao; Gao, Yuan; Sun, Yingxian; Qi, Guoxian

2015 Cardiovascular Toxicology

doi:10.1007/s12012-015-9342-y pmid:26391895

Triptolide is a bioactive component of Chinese herbal plant Tripterygium wilfordii Hook F that has recently been noted to attenuate hepatic and cerebral ischemia/reperfusion (I/R) injuries in rodents. To investigate whether triptolide could protect against myocardial I/R injuries, triptolide (25,...
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Journal Article

Anti-inflammatory, Antithrombotic and Cardiac Remodeling Preventive Effects of Eugenol in Isoproterenol-Induced Myocardial Infarction in Wistar Rat

Mnafgui, Kais; Hajji, Raouf; Derbali, Fatma; Gammoudi, Anis; Khabbabi, Gaddour; Ellefi, Hedi; Allouche, Noureddine; Kadri, Adel; Gharsallah, Neji

2015 Cardiovascular Toxicology

doi:10.1007/s12012-015-9343-x pmid:26391896

This study aimed to evaluate the antithrombotic, anti-inflammatory and anti-cardiac remodeling properties of eugenol in isoproterenol-induced myocardial infarction in rats. Male Wistar rats were randomly divided into four groups, control, iso [100 mg/kg body weight was injected subcutaneously...
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Journal Article

NF-κB Blockade in Hypothalamic Paraventricular Nucleus Inhibits High-Salt-Induced Hypertension Through NLRP3 and Caspase-1

Qi, Jie; Yu, Xiao-Jing; Shi, Xiao-Lian; Gao, Hong-Li; Yi, Qiu-Yue; Tan, Hong; Fan, Xiao-Yan; Zhang, Yan; Song, Xin-Ai; Cui, Wei; Liu, Jin-Jun; Kang, Yu-Ming

2015 Cardiovascular Toxicology

doi:10.1007/s12012-015-9344-9 pmid:26438340

High-salt-induced inflammation and oxidative stress in the hypothalamic paraventricular nucleus (PVN) contribute to the pathogenesis of salt-sensitive hypertension. In this study, we hypothesized that chronic inhibition of nuclear factor-κB (NF-κB) activity in the PVN delays the progression of...
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Journal Article

Utility of Cardiac Troponin to Predict Drug Overdose Mortality

Manini, Alex; Stimmel, Barry; Hoffman, Robert; Vlahov, David

2015 Cardiovascular Toxicology

doi:10.1007/s12012-015-9345-8 pmid:26541348

Drug overdose is now the leading cause of injury-related mortality in the USA, but the prognostic utility of cardiac biomarkers is unknown. We investigated whether serum cardiac troponin I (cTnI) was associated with overdose mortality. This prospective observational cohort studied adults with...
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Journal Article

Various Echocardiographic Patterns of Left Ventricular Systolic Dysfunction Induced by Carbon Monoxide Intoxication

Park, Jin-Sun; Seo, Kyoung-Woo; Choi, Byoung-Joo; Choi, So-Yeon; Yoon, Myeong-Ho; Hwang, Gyo-Seung; Tahk, Seung-Jea; Choi, Sang-Cheon; Min, Young-Gi; Shin, Joon-Han

2015 Cardiovascular Toxicology

doi:10.1007/s12012-015-9347-6 pmid:26498469

Carbon monoxide (CO) intoxication could cause significant cardiac injury. Although cardiac dysfunction after CO intoxication can be presented, the echocardiographic findings after CO intoxication are poorly defined. The purpose of this study was to evaluate the clinical patterns of left...
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Journal Article

Cardiomyopathy from 1,1-Difluoroethane Inhalation

Kumar, Suwen; Joginpally, Tejaswini; Kim, David; Yadava, Mrinal; Norgais, Konchok; Laird-Fick, Heather

2015 Cardiovascular Toxicology

doi:10.1007/s12012-015-9348-5 pmid:26613951

Consumer aerosol products can be inhaled for their psychoactive effects, but with attendant adverse health effects including “sudden sniffing death.” Cardiomyopathy has rarely been described in association with 1,1-difluoroethane (DFE), a common aerosol propellant. We report a 33-year-old male...
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Journal Article

Effects of 2-Hydroxypropyl-Beta-Cyclodextrin on Cardiovascular Signs of Amitriptyline Poisoning in a Rat Model

Aydin, Burc; Hocaoglu, Nil; Micili, Serap; Ergur, Bekir; Kalkan, Sule

2015 Cardiovascular Toxicology

doi:10.1007/s12012-015-9349-4 pmid:26621115

The aim of this study was to investigate the efficacy of 2-hydroxypropyl-beta-cyclodextrin (HPBCD) as an antidotal treatment for the in vivo cardiovascular effects of amitriptyline poisoning. Experiments were carried out on 33 Wistar rats. To evaluate cardiovascular effects of HPBCD, rats were...
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Journal Article

Methamphetamine-Associated Congestive Heart Failure: Increasing Prevalence and Relationship of Clinical Outcomes to Continued Use or Abstinence

Sliman, Sean; Waalen, Jill; Shaw, David

2015 Cardiovascular Toxicology

doi:10.1007/s12012-015-9350-y pmid:26661075

The purpose of this study was to determine the prevalence of methamphetamine-associated congestive heart failure (MAC) and to evaluate the relationship between methamphetamine abuse and EF and functional status over time. A retrospective review of records from 2009 to 2014 was carried out....

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