Nature Immunology

Dempsey, Laurie A.

doi: 10.1038/s41590-026-02426-5pmid: 41629654

Bernard, Nicholas J.

doi: 10.1038/s41590-026-02427-4pmid: 41629653

Staicu, Ioana

doi: 10.1038/s41590-026-02424-7pmid: 41629652

Houston, Stephanie

doi: 10.1038/s41590-026-02425-6pmid: 41629655

Wang, Yuande; Xu, Heping

doi: 10.1038/s41590-025-02384-4pmid: 41514063

A comprehensive single-cell atlas now reveals eosinophil heterogeneity across several mouse tissues, linking distinct cellular states to tissue residency and lifespan, and offering insights into their context-dependent phenotypic and functional adaptations.

Antar, Annukka A. R.; Pasetes, Elizabeth C.; Brennon, Kay’La M. Z.; Cox, Andrea L.

doi: 10.1038/s41590-025-02399-xpmid: 41535625

Distinct monocyte gene expression programs were identified in people with long COVID after mild-to-moderate COVID-19 versus severe acute COVID-19, providing evidence that immunological dysregulation after mild acute COVID-19 may be the result of distinct pathobiological pathways.

Veldhoen, Marc

doi: 10.1038/s41590-025-02392-4pmid: 41495317

A newly identified, TGFβ-inducible decoy receptor for IL-17 family cytokines reveals a feedback mechanism that limits mucosal inflammation, linking epithelial and lymphoid cell responses through a common cytokine axis that controls IL-17-driven immunity.

Chapman, Nicole M.; Chi, Hongbo

doi: 10.1038/s41590-025-02403-4pmid: 41540264

Immune dysfunction and aberrant metabolic remodeling are hallmarks of critical illness including sepsis. Metabolic adaptation of CD4+ T cells is now shown to contribute to immunosuppression and poor clinical outcomes in critical illness.

Ennerfelt, Hannah E.; Andreasson, Katrin I.

doi: 10.1038/s41590-025-02404-3pmid: 41593241

Comparative single-cell transcriptomic analysis identifies clonally expanded tissue-resident CD8+ T cells within the leptomeninges of individuals with neurodegenerative diseases. The findings suggest that this brain border region represents an active immune niche that contributes to neurodegeneration with disease-specific distinctions.

doi: 10.1038/s41590-025-02413-2pmid: 41507390

CD8+ T cells in tumors develop ‘metabolic exhaustion’ characterized by high levels of glycolysis and impaired fatty acid oxidation. Lipid peroxidation generates active aldehydes, which accumulate with exhaustion, further attenuate fatty acid oxidation and boost glycolysis, creating a vicious cycle. Blocking aldehydes restores metabolic balance and prevents T cell exhaustion.