doi: 10.1038/embor.2012.194pmid: 23282936
Despite early failures, somatic gene therapy has recently shown renewed promise. Howy suggests that the day may come when germline gene therapy needs also to be reconsidered.
doi: 10.1038/embor.2012.190pmid: 23174674
The French government has ambitious goals to make France a leading nation for synthetic biology research, but it still needs to put its money where its mouth is and provide the field with dedicated funding and other support.
doi: 10.1038/embor.2012.202pmid: 23229586
The safety of genetically modified crops remains a contested issue, given the potential risk for human health and the environment. To further reduce any risks and alleviate public concerns, terminator technology could be used both to tag and control genetically modified plants.
doi: 10.1038/embor.2012.198pmid: 23229589
The differentiation of pluripotent stem cells into various progeny is perplexing. In vivo, nature imposes strict fate constraints. In vitro, PSCs differentiate into almost any phenotype. Might the concept of ‘cellular promiscuity’ explain these surprising behaviours?
Lauwers, Elsa; Verstreken, Patrik
doi: 10.1038/embor.2012.193pmid: 23196365
Maintaining active zone structure is crucial for synaptic function. In this issue of EMBO reports, NMNAT is shown to act as a chaperone that protects the active zone structural protein Bruchpilot from degradation.
Bernardi, Paolo; Giorgio, Valentina
doi: 10.1038/embor.2012.200pmid: 23229583
The seventeenth European Bioenergetics Conference (EBEC) took place in September 2012 at the Albert‐Ludwigs‐University in Freiburg, Germany, and was hosted by Thorsten Friedrich. The conference is a biannual event that brings together researchers from across the globe to discuss progress in this diverse and challenging field.
Carter, C Sue; Porges, Stephen W
doi: 10.1038/embor.2012.191pmid: 23184088
The old saying that ‘love heals’ has some truth to it. The intricate dance between two neuropeptides both regulates our ability to love and influences our health and well‐being.
O'Brien, Kristin M; Crockett, Elizabeth L
doi: 10.1038/embor.2012.203pmid: 23229590
The waters around the Antarctic are a treasure trove of fauna specially adapted to extreme cold temperatures. However, as with many other marine ecosystems, its life forms are threatened by human actions.
Uhlenhaut, Christine; Burger, Reinhard; Schaade, Lars
doi: 10.1038/embor.2012.195pmid: 23229584
Concerns over biosecurity remain unresolved, as the debate around the recent publications on human transmissible H5N1 flu demonstrated. A range of measures and the involvement of all stakeholders are needed to better protect society from malicious abuse of biological research.
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