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International Journal of Neuropsychopharmacology Volume 20 Issue 5

Subject Areas: Pharmacology (medical)
Publisher: Collegium Internationale Neuro-Psychopharmacologicum - Oxford University Press
ISSN: 1461-1457
SJR: 113

Open Access

Journal Article

Elevated DNA Oxidation and DNA Repair Enzyme Expression in Brain White Matter in Major Depressive Disorder

Szebeni, Attila; Szebeni, Katalin; DiPeri, Timothy P.; Johnson, Luke A.; Stockmeier, Craig A.; Crawford, Jessica D.; Chandley, Michelle J.; Hernandez, Liza J.; Burgess, Katherine C.; Brown, Russell W.; Ordway, Gregory A.

2016 International Journal of Neuropsychopharmacology

doi:10.1093/ijnp/pyw114 pmid:28034960

AbstractBackground:Pathology of white matter in brains of patients with major depressive disorder (MDD) is well-documented, but the cellular and molecular basis of this pathology are poorly understood.Methods:Levels of DNA oxidation and gene expression of DNA damage repair enzymes were measured...
Open Access

Journal Article

Altered Acoustic Startle Reflex, Prepulse Inhibition, and Peripheral Brain-Derived Neurotrophic Factor in Morphine Self-Administered Rats

Lee, Bong Hyo; Park, Thomas Y.; Lin, Erica; Li, He; Yang, Chae Ha; Choi, Kwang H.

2016 International Journal of Neuropsychopharmacology

doi:10.1093/ijnp/pyw107 pmid:27927738

AbstractBackground:Previous studies suggested that opiate withdrawal may increase anxiety and disrupt brain-derived neurotrophic factor function, but the effects of i.v. morphine self-administration on these measures remain unclear.Methods:Adult male Sprague-Dawley rats were implanted with a...
Open Access

Journal Article

Distinct Roles of Opioid and Dopamine Systems in Lateral Hypothalamic Intracranial Self-Stimulation

Ide, Soichiro; Takahashi, Takehiro; Takamatsu, Yukio; Uhl, George R.; Niki, Hiroaki; Sora, Ichiro; Ikeda, Kazutaka

2016 International Journal of Neuropsychopharmacology

doi:10.1093/ijnp/pyw113 pmid:28031268

AbstractBackground:Opioid and dopamine systems play crucial roles in reward. Similarities and differences in the neural mechanisms of reward that are mediated by these 2 systems have remained largely unknown. Thus, in the present study, we investigated the differences in reward function in both...
Open Access

Journal Article

Role of Prefrontal Serotonergic and Dopaminergic Systems in Encounter-Induced Hyperactivity in Methamphetamine-Sensitized Mice

Tanaka, Tatsunori; Ago, Yukio; Umehara, Chiaki; Imoto, Emina; Hasebe, Shigeru; Hashimoto, Hitoshi; Takuma, Kazuhiro; Matsuda, Toshio

2016 International Journal of Neuropsychopharmacology

doi:10.1093/ijnp/pyw115 pmid:28034961

AbstractBackground:Isolation-reared mice show social encounter-induced hyperactivity with activation of prefrontal serotonergic and dopaminergic systems, but it is not known whether this stress response is observed in other pathological conditions. Here we examined whether the social encounter...

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