Angewandte Chemie International Edition

de Meijere, Armin; Khlebnikov, Alexander F.; Kozhushkov, Sergei I.; Miyazawa, Kazutoshi; Frank, Daniel; Schreiner, Peter R.; Rinderspacher, B. Christopher; Yufit, Dmitrii S.; Howard, Judith A. K.

doi: 10.1002/anie.200490166pmid: N/A

The rigid helical frameworks of the molecules of (M)‐(−)‐(7)triangulane‐1,9‐dimethanol associate through hydrogen bonds between their terminal hydroxy groups in supramolecular helices, two of which form a supramolecular double helix. In the cover picture, this is compared with the design by Leonardo da Vinci of a double‐spiral staircase. The hydrocarbon (M)‐(−)‐(9)triangulane does not organize itself as a supramolecular double helix. For more information see the Communication by de Meijere et al. on page 6553 ff. The cover picture was created by Dipl.‐Chem. Heiko Schill.

doi: 10.1002/anie.200490167pmid: N/A

doi: 10.1002/anie.200462572pmid: 15578780

Siegel, Jay S.

doi: 10.1002/anie.200385077pmid: N/A

Essen, Lars‐Oliver

doi: 10.1002/anie.200485156pmid: N/A

Meierhenrich, Uwe J.; Golebiowski, Jérôme; Fernandez, Xavier; Cabrol‐Bass, Daniel

doi: 10.1002/anie.200462322pmid: 15578781

The Nobel Price in Medicine this year went to Richard Axel and Linda Buck, who elucidated the molecular basis of the olfactory reception of fragrances and the neuronal preprocessing of information in the olfactory system. From the viewpoint of a chemist, these studies offer fascinating perspectives. For example, they enable an understanding of the perception of odors by transmembrane proteins (see picture).

Biel, Markus; Wascholowski, Veit; Giannis, Athanassios

doi: 10.1002/anie.200462346pmid: 15578782

The kiss of death for a protein is to be labeled with ubiquitin (Ub, see picture). The protein can then be recognized and degraded by the 26S proteasome, an important target in drug research, as it regulates the concentration of certain proteins. Recognition by the proteasome is hindered by two novel proteasome inhibitors, ubistatins A und B, which were identified through a chemical genetic approach.

Thomas, John Meurig

doi: 10.1002/anie.200461824pmid: 15578783

Noble gases and Nobel prizes: To mark the 100th anniversary of the awarding of the Nobel Prize to Lord Rayleigh (see picture; right) and Sir William Ramsay (left) for their discovery and characterization of the noble gases, tribute is paid to two scientific greats whose work goes far beyond their prize‐winning discovery.

Budisa, Nediljko

doi: 10.1002/anie.200300646pmid: 15578784

Protein synthesis and its relation to the genetic code was for a long time a central issue in biology. Rapid experimental progress throughout the past decade, crowned with the recently elucidated ribosomal structures, provided an almost complete description of this process. In addition important experiments provided solid evidence that the natural protein translation machinery can be reprogrammed to encode genetically a vast number of non‐coded (i.e. noncanonical) amino acids. Indeed, in the set of 20 canonical amino acids as prescribed by the universal genetic code, many desirable functionalities, such as halogeno, keto, cyano, azido, nitroso, nitro, and silyl groups, as well as CC or CC bonds, are absent. The ability to encode genetically such chemical diversity will enable us to reprogram living cells, such as bacteria, to express tailor‐made proteins exhibiting functional diversity. Accordingly, genetic code engineering has developed into an exciting emerging research field at the interface of biology, chemistry, and physics.

Lee, Myongsoo; Park, Myoung‐Hwan; Oh, Nam‐Keun; Zin, Wang‐Cheol; Jung, Hee‐Tae; Yoon, Dong Ki

doi: 10.1002/anie.200460378pmid: 15389888

Self‐assembly of rod‐coil molecules with an ester linkage gave a honeycomblike supramolecular structure with 3D hexagonal symmetry. Hydrolysis of the ester linkages and removal of the coil segments (light blue) from the perforated lamellar structure afforded crystalline sheets (dark blue) with in‐plane arrays of nanopores whose hydrophobic interiors entrap nonpolar molecules.