journal article
LitStream Collection
The Detection of Linkage in Human Genetics
doi: 10.1111/j.2517-6161.1953.tb00133.xpmid: N/A
There are three methods used in practice to detect human linkage. These are: (i) The sib‐pair method of Penrose, applicable to pairs of brothers and sisters, when the parents' genotypes are unknown or disregarded. (ii) The method of efficient scores (u‐functions), due to Fisher and Finney, applicable to families consisting of 2 or more children, together with either or both genotypes of the parents if known. (iii) The method of likelihood ratio, or backward odds, due to Haldane & Smith, and most suitable for large pedigrees: this links up with maximum likelihood estimation.