Nature Genetics

doi: 10.1038/ng.3277pmid: 25807281

The largest-ever set of human genomes from a single population and the consequent insights into mutation, evolution, gene function and disease predisposition are reported in four linked papers. These results provide a strategy for the analysis of the full spectrum of genetic variation in any population and raise questions about how society should implement the knowledge gained.

Lock, Rebecca; Cichowski, Karen

doi: 10.1038/ng.3299pmid: 25916896

A new study identifies SPRY4 as a tumor suppressor in acute myeloid leukemia and shows that loss of SPRY4 acts as an alternative mechanism to drive RAS signaling. In addition, a paradigm of cooperativity in which combined loss of multiple negative regulators of the RAS pathway supplants the need for RAS mutations is suggested.

Kelsey, Gavin

doi: 10.1038/ng.3290pmid: 25916897

A hallmark of CpG islands is their unmethylated state, and determining how DNA methylation can invade these elements is therefore important for understanding developmental gene regulation and disease. A new study shows that FBXL10, a protein commonly altered by mutation in leukemia, is part of a mechanism that blocks methylation of CpG islands.

Faial, Tiago

doi: 10.1038/ng.3297pmid: N/A

Niemitz, Emily

doi: 10.1038/ng.3296pmid: N/A

Vogan, Kyle

doi: 10.1038/ng.3298pmid: N/A

LaFlamme, Brooke

doi: 10.1038/ng.3294pmid: N/A

Faial, Tiago

doi: 10.1038/ng.3295pmid: N/A

Gudbjartsson, Daniel F; Helgason, Hannes; Gudjonsson, Sigurjon A; Zink, Florian; Oddson, Asmundur; Gylfason, Arnaldur; Besenbacher, Soren; Magnusson, Gisli; Halldorsson, Bjarni V; Hjartarson, Eirikur; Sigurdsson, Gunnar Th; Stacey, Simon N; Frigge, Michael L; Holm, Hilma; Saemundsdottir, Jona;

Steinberg, Stacy; Stefansson, Hreinn; Jonsson, Thorlakur; Johannsdottir, Hrefna; Ingason, Andres; Helgason, Hannes; Sulem, Patrick; Magnusson, Olafur Th; Gudjonsson, Sigurjon A; Unnsteinsdottir, Unnur; Kong, Augustine; Helisalmi, Seppo; Soininen, Hilkka; Lah, James J; Aarsland, Dag;