Nature Genetics

doi: 10.1038/ng0509-505pmid: 19399030

Sequencing technologies have unleashed more than enough quantitative data to test systems models of genome function, and sequence data are now driving a new systems biology. The new RNA entities uncovered may require new concepts of how genomes regulate their own expression.

Stearns, Stephen C.

doi: 10.1038/ng0509-507pmid: N/A

Squire, Jeremy A

doi: 10.1038/ng0509-509pmid: 19399032

Two studies show that the common recurrent gene fusion between TMPRSS2 and ERG promotes prostate cancer in both mouse and humans when PTEN is concurrently lost. In human prostate cancer, the presence of both these aberrations may be indicative of poor prognosis, suggesting that preclinical therapeutic research should target both of these pathways.

Nelson, David L; Gibbs, Richard A

doi: 10.1038/ng0509-510pmid: 19399033

A new study reports large-scale systematic resequencing of the coding exons of the X chromosome in males with X-linked mental retardation (XLMR), illustrating the challenge of sorting through large amounts of benign variation in order to identify disease-causing sequence changes.

Vercelli, Donata

doi: 10.1038/ng0509-512pmid: 19399034

A new study defines the flaky tail mouse as a model for human atopic dermatitis caused by a null mutation in the gene encoding filaggrin, a key component of the epidermal barrier. Research in these mice will help explain how a disrupted barrier contributes to the pathogenesis of atopic dermatitis and to asthma arising in the context of atopic skin disease.

doi: 10.1038/ng0509-514pmid: N/A

Palavalli, Lavanya H; Prickett, Todd D; Wunderlich, John R; Wei, Xiaomu; Burrell, Allison S; Porter-Gill, Patricia; Davis, Sean; Wang, Chenwei; Cronin, Julia C; Agrawal, Neena S; Lin, Jimmy C; Westbroek, Wendy; Hoogstraten-Miller, Shelley; Molinolo, Alfredo A; Fetsch, Patricia;

van Haaften, Gijs; Dalgliesh, Gillian L; Davies, Helen; Chen, Lina; Bignell, Graham; Greenman, Chris; Edkins, Sarah; Hardy, Claire; O'Meara, Sarah; Teague, Jon; Butler, Adam; Hinton, Jonathan; Latimer, Calli; Andrews, Jenny; Barthorpe, Syd; Beare, Dave;

King, Jennifer C; Xu, Jin; Wongvipat, John; Hieronymus, Haley; Carver, Brett S; Leung, David H; Taylor, Barry S; Sander, Chris; Cardiff, Robert D; Couto, Suzana S; Gerald, William L; Sawyers, Charles L

doi: 10.1038/ng.371

Cho, Yoon Shin; Go, Min Jin; Kim, Young Jin; Heo, Jee Yeon; Oh, Ji Hee; Ban, Hyo-Jeong; Yoon, Dankyu; Lee, Mi Hee; Kim, Dong-Joon; Park, Miey; Cha, Seung-Hun; Kim, Jun-Woo; Han, Bok-Ghee; Min, Haesook; Ahn, Younjhin; Park, Man Suk;