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Autologous and allogeneic bone marrow transplantation are widely used for treatment of a number of hematologic malignancies, including aggressive non-Hodgkin's lymphomas. However, relatively small numbers of patients with low grade lymphoma or chronic lymphocytic leukemia have been treated...
Breast cancer is currently the primary indication for high-dose chemotherapy with autologous hematopoietic progenitor cell support. Recent advances include the first randomized trial comparing high-dose chemotherapy with conventional-dose chemotherapy in patients with metastatic disease, new and...
Allogeneic bone marrow transplantation has been used successfully for the treatment of a variety of inherited diseases. The goal of transplantation in this setting is to provide a sufficient degree of sustained marrow engraftment to allow longterm amelioration of the inherited disease phenotype....
Graft-versus-host disease (GVHD) continues to be a major obstacle to the success of allogeneic bone marrow transplantation. Furthermore, several clinical strategies being employed at this time in the field of bone marrow transplantation have had an impact on GVHD. In addition to the usual...
Adoptive immunotherapy denotes the transfer of immunocompetent cells for the treatment of leukemia, cancer, or viral disease. It has regained much interest through the success of treating recurrent leukemia after allogeneic bone marrow transplantation with the transfusion of donor lymphocytes....
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